PubMed

Distinct muscarinic acetylcholine receptor subtypes contribute to stability and growth, but not compensatory plasticity, of neuromuscular synapses.

Wright MC, Potluri S, Wang X, Dentcheva E, Gautam D, Tessler A, Wess J, Rich MM, Son YJ.

J Neurosci. 2009 Nov 25;29(47):14942-55.PMID: 19940190 [PubMed - in process]Related articles

A chemical-genetic approach to study G protein regulation of beta cell function in vivo.

Guettier JM, Gautam D, Scarselli M, de Azua IR, Li JH, Rosemond E, Ma X, Gonzalez FJ, Armbruster BN, Lu H, Roth BL, Wess J.

Proc Natl Acad Sci U S A. 2009 Nov 10;106(45):19197-202. Epub 2009 Oct 26.PMID: 19858481 [PubMed - in process]Related articlesFree article

Structural basis of the selectivity of the beta(2)-adrenergic receptor for fluorinated catecholamines.

Pooput C, Rosemond E, Karpiak J, Deflorian F, Vilar S, Costanzi S, Wess J, Kirk KL.

Bioorg Med Chem. 2009 Dec 1;17(23):7987-92. Epub 2009 Oct 13.PMID: 19857969 [PubMed - in process]Related articles

Increased amphetamine-induced locomotor activity, sensitization, and accumbal dopamine release in M(5) muscarinic receptor knockout mice.

Schmidt LS, Miller AD, Lester DB, Bay-Richter C, Schülein C, Frikke-Schmidt H, Wess J, Blaha CD, Woldbye DP, Fink-Jensen A, Wortwein G.

Psychopharmacology (Berl). 2009 Oct 10. [Epub ahead of print]PMID: 19820917 [PubMed - as supplied by publisher]Related articles

Hepatic muscarinic acetylcholine receptors are not critically involved in maintaining glucose homeostasis in mice.

Li JH, Gautam D, Han SJ, Guettier JM, Cui Y, Lu H, Deng C, O'Hare J, Jou W, Gavrilova O, Buettner C, Wess J.

Diabetes. 2009 Dec;58(12):2776-87. Epub 2009 Sep 14.PMID: 19752163 [PubMed - in process]Related articles

A selective EP4 PGE2 receptor agonist alleviates disease in a new mouse model of X-linked nephrogenic diabetes insipidus.

Li JH, Chou CL, Li B, Gavrilova O, Eisner C, Schnermann J, Anderson SA, Deng CX, Knepper MA, Wess J.

J Clin Invest. 2009 Sep 1. pii: 39680. doi: 10.1172/JCI39680. [Epub ahead of print]PMID: 19729836 [PubMed - as supplied by publisher]Related articlesFree article

Membrane depolarization causes a direct activation of G protein-coupled receptors leading to local Ca2+ release in smooth muscle.

Liu QH, Zheng YM, Korde AS, Yadav VR, Rathore R, Wess J, Wang YX.

Proc Natl Acad Sci U S A. 2009 Jul 7;106(27):11418-23. Epub 2009 Jun 19.PMID: 19549818 [PubMed - indexed for MEDLINE]Related articles

Cooperation between mast cells and neurons is essential for antigen-mediated bronchoconstriction.

Cyphert JM, Kovarova M, Allen IC, Hartney JM, Murphy DL, Wess J, Koller BH.

J Immunol. 2009 Jun 15;182(12):7430-9.PMID: 19494266 [PubMed - indexed for MEDLINE]Related articles

M3 muscarinic receptors mediate positive inotropic responses in mouse atria: a study with muscarinic receptor knockout mice.

Kitazawa T, Asakawa K, Nakamura T, Teraoka H, Unno T, Komori S, Yamada M, Wess J.

J Pharmacol Exp Ther. 2009 Aug;330(2):487-93. Epub 2009 May 8.PMID: 19429792 [PubMed - indexed for MEDLINE]Related articles

Cholinergic responses of ophthalmic arteries in M3 and M5 muscarinic acetylcholine receptor knockout mice.

Gericke A, Mayer VG, Steege A, Patzak A, Neumann U, Grus FH, Joachim SC, Choritz L, Wess J, Pfeiffer N.

Invest Ophthalmol Vis Sci. 2009 Oct;50(10):4822-7. Epub 2009 Apr 30.PMID: 19407017 [PubMed - indexed for MEDLINE]Related articles

Beneficial effects of estrogen in a mouse model of cerebrovascular insufficiency.

Kitamura N, Araya R, Kudoh M, Kishida H, Kimura T, Murayama M, Takashima A, Sakamaki Y, Hashikawa T, Ito S, Ohtsuki S, Terasaki T, Wess J, Yamada M.

PLoS One. 2009;4(4):e5159. Epub 2009 Apr 9.PMID: 19357782 [PubMed - indexed for MEDLINE]Related articlesFree article

Neuronal M3 muscarinic acetylcholine receptors are essential for somatotroph proliferation and normal somatic growth.

Gautam D, Jeon J, Starost MF, Han SJ, Hamdan FF, Cui Y, Parlow AF, Gavrilova O, Szalayova I, Mezey E, Wess J.

Proc Natl Acad Sci U S A. 2009 Apr 14;106(15):6398-403. Epub 2009 Mar 30.PMID: 19332789 [PubMed - indexed for MEDLINE]Related articlesFree article

Muscarinic receptor subtypes in cilia-driven transport and airway epithelial development.

Klein MK, Haberberger RV, Hartmann P, Faulhammer P, Lips KS, Krain B, Wess J, Kummer W, König P.

Eur Respir J. 2009 May;33(5):1113-21. Epub 2009 Feb 12.PMID: 19213795 [PubMed - indexed for MEDLINE]Related articles

Suitability of muscarinic acetylcholine receptor antibodies for immunohistochemistry evaluated on tissue sections of receptor gene-deficient mice.

Jositsch G, Papadakis T, Haberberger RV, Wolff M, Wess J, Kummer W.

Naunyn Schmiedebergs Arch Pharmacol. 2009 Apr;379(4):389-95. Epub 2008 Oct 31.PMID: 18974978 [PubMed - indexed for MEDLINE]Related articles

Conformational changes involved in G-protein-coupled-receptor activation.

Wess J, Han SJ, Kim SK, Jacobson KA, Li JH.

Trends Pharmacol Sci. 2008 Dec;29(12):616-25. Epub 2008 Oct 4. Review.PMID: 18838178 [PubMed - indexed for MEDLINE]Related articles

V2 vasopressin receptor deficiency causes changes in expression and function of renal and hypothalamic components involved in electrolyte and water homeostasis.

Schliebe N, Strotmann R, Busse K, Mitschke D, Biebermann H, Schomburg L, Köhrle J, Bär J, Römpler H, Wess J, Schöneberg T, Sangkuhl K.

Am J Physiol Renal Physiol. 2008 Oct;295(4):F1177-90. Epub 2008 Aug 20.PMID: 18715941 [PubMed - indexed for MEDLINE]Related articlesFree article

Engineering GPCR signaling pathways with RASSLs.

Conklin BR, Hsiao EC, Claeysen S, Dumuis A, Srinivasan S, Forsayeth JR, Guettier JM, Chang WC, Pei Y, McCarthy KD, Nissenson RA, Wess J, Bockaert J, Roth BL.

Nat Methods. 2008 Aug;5(8):673-8. Review.PMID: 18668035 [PubMed - indexed for MEDLINE]Related articlesFree article

Loss of muscarinic autoreceptor function impairs long-term depression but not long-term potentiation in the striatum.

Bonsi P, Martella G, Cuomo D, Platania P, Sciamanna G, Bernardi G, Wess J, Pisani A.

J Neurosci. 2008 Jun 11;28(24):6258-63.PMID: 18550768 [PubMed - indexed for MEDLINE]Related articlesFree article

Genetic ablation of M3 muscarinic receptors attenuates murine colon epithelial cell proliferation and neoplasia.

Raufman JP, Samimi R, Shah N, Khurana S, Shant J, Drachenberg C, Xie G, Wess J, Cheng K.

Cancer Res. 2008 May 15;68(10):3573-8.PMID: 18483237 [PubMed - indexed for MEDLINE]Related articlesFree article

Metabolic roles of the M3 muscarinic acetylcholine receptor studied with M3 receptor mutant mice: a review.

Gautam D, Jeon J, Li JH, Han SJ, Hamdan FF, Cui Y, Lu H, Deng C, Gavrilova O, Wess J.

J Recept Signal Transduct Res. 2008;28(1-2):93-108. Review.PMID: 18437633 [PubMed - indexed for MEDLINE]Related articles

Ultrasonic vocalizations induced by sex and amphetamine in M2, M4, M5 muscarinic and D2 dopamine receptor knockout mice.

Wang H, Liang S, Burgdorf J, Wess J, Yeomans J.

PLoS One. 2008 Apr 2;3(4):e1893.PMID: 18382674 [PubMed - indexed for MEDLINE]Related articlesFree article

Learning and memory impairments in a congenic C57BL/6 strain of mice that lacks the M2 muscarinic acetylcholine receptor subtype.

Bainbridge NK, Koselke LR, Jeon J, Bailey KR, Wess J, Crawley JN, Wrenn CC.

Behav Brain Res. 2008 Jun 26;190(1):50-8. Epub 2008 Feb 8.PMID: 18346798 [PubMed - indexed for MEDLINE]Related articlesFree article

Ligand-specific changes in M3 muscarinic acetylcholine receptor structure detected by a disulfide scanning strategy.

Li JH, Hamdan FF, Kim SK, Jacobson KA, Zhang X, Han SJ, Wess J.

Biochemistry. 2008 Mar 4;47(9):2776-88. Epub 2008 Feb 5.PMID: 18247581 [PubMed - indexed for MEDLINE]Related articles

Vagal tone dominates autonomic control of mouse heart rate at thermoneutrality.

Swoap SJ, Li C, Wess J, Parsons AD, Williams TD, Overton JM.

Am J Physiol Heart Circ Physiol. 2008 Apr;294(4):H1581-8. Epub 2008 Feb 1.PMID: 18245567 [PubMed - indexed for MEDLINE]Related articlesFree article

Muscarinic receptor subtypes involved in carbachol-induced contraction of mouse uterine smooth muscle.

Kitazawa T, Hirama R, Masunaga K, Nakamura T, Asakawa K, Cao J, Teraoka H, Unno T, Komori S, Yamada M, Wess J, Taneike T.

Naunyn Schmiedebergs Arch Pharmacol. 2008 Jun;377(4-6):503-13. Epub 2007 Dec 11.PMID: 18071676 [PubMed - indexed for MEDLINE]Related articles

An allosteric potentiator of M4 mAChR modulates hippocampal synaptic transmission.

Shirey JK, Xiang Z, Orton D, Brady AE, Johnson KA, Williams R, Ayala JE, Rodriguez AL, Wess J, Weaver D, Niswender CM, Conn PJ.

Nat Chem Biol. 2008 Jan;4(1):42-50. Epub 2007 Dec 2.PMID: 18059262 [PubMed - indexed for MEDLINE]Related articles

Deficiency of M2 muscarinic acetylcholine receptors increases susceptibility of ventricular function to chronic adrenergic stress.

LaCroix C, Freeling J, Giles A, Wess J, Li YF.

Am J Physiol Heart Circ Physiol. 2008 Feb;294(2):H810-20. Epub 2007 Nov 30.PMID: 18055517 [PubMed - indexed for MEDLINE]Related articlesFree article

Role of the M3 muscarinic acetylcholine receptor in beta-cell function and glucose homeostasis.

Gautam D, Han SJ, Duttaroy A, Mears D, Hamdan FF, Li JH, Cui Y, Jeon J, Wess J.

Diabetes Obes Metab. 2007 Nov;9 Suppl 2:158-69.PMID: 17919190 [PubMed - indexed for MEDLINE]Related articles

Control of glycinergic input to spinal dorsal horn neurons by distinct muscarinic receptor subtypes revealed using knockout mice.

Zhang HM, Zhou HY, Chen SR, Gautam D, Wess J, Pan HL.

J Pharmacol Exp Ther. 2007 Dec;323(3):963-71. Epub 2007 Sep 18.PMID: 17878406 [PubMed - indexed for MEDLINE]Related articlesFree article

Muscarinic acetylcholine receptors: mutant mice provide new insights for drug development.

Wess J, Eglen RM, Gautam D.

Nat Rev Drug Discov. 2007 Sep;6(9):721-33. Review.PMID: 17762886 [PubMed - indexed for MEDLINE]Related articles

Distinct structural changes in a G protein-coupled receptor caused by different classes of agonist ligands.

Li JH, Han SJ, Hamdan FF, Kim SK, Jacobson KA, Bloodworth LM, Zhang X, Wess J.

J Biol Chem. 2007 Sep 7;282(36):26284-93. Epub 2007 Jul 10.PMID: 17623649 [PubMed - indexed for MEDLINE]Related articlesFree article

Three distinct muscarinic signalling pathways for cationic channel activation in mouse gut smooth muscle cells.

Sakamoto T, Unno T, Kitazawa T, Taneike T, Yamada M, Wess J, Nishimura M, Komori S.

J Physiol. 2007 Jul 1;582(Pt 1):41-61. Epub 2007 Apr 26.PMID: 17463038 [PubMed - indexed for MEDLINE]Related articlesFree article

Expression of muscarinic and nicotinic acetylcholine receptors in the mouse urothelium.

Zarghooni S, Wunsch J, Bodenbenner M, Brüggmann D, Grando SA, Schwantes U, Wess J, Kummer W, Lips KS.

Life Sci. 2007 May 30;80(24-25):2308-13. Epub 2007 Feb 2.PMID: 17337281 [PubMed - indexed for MEDLINE]Related articles

Decreased prepulse inhibition and increased sensitivity to muscarinic, but not dopaminergic drugs in M5 muscarinic acetylcholine receptor knockout mice.

Thomsen M, Wörtwein G, Fink-Jensen A, Woldbye DP, Wess J, Caine SB.

Psychopharmacology (Berl). 2007 May;192(1):97-110. Epub 2007 Feb 20.PMID: 17310388 [PubMed - indexed for MEDLINE]Related articles

Analysis of CD8+ T cell-mediated anti-viral responses in mice with targeted deletions of the M1 or M5 muscarinic cholinergic receptors.

Vezys V, Masopust D, Desmarets M, Wess J, Zimring JC.

Life Sci. 2007 May 30;80(24-25):2330-3. Epub 2007 Jan 13.PMID: 17286988 [PubMed - indexed for MEDLINE]Related articlesFree article

Multiple residues in the second extracellular loop are critical for M3 muscarinic acetylcholine receptor activation.

Scarselli M, Li B, Kim SK, Wess J.

J Biol Chem. 2007 Mar 9;282(10):7385-96. Epub 2007 Jan 9.PMID: 17213190 [PubMed - indexed for MEDLINE]Related articlesFree article

Rapid identification of functionally critical amino acids in a G protein-coupled receptor.

Li B, Scarselli M, Knudsen CD, Kim SK, Jacobson KA, McMillin SM, Wess J.

Nat Methods. 2007 Feb;4(2):169-74. Epub 2007 Jan 7.PMID: 17206152 [PubMed - indexed for MEDLINE]Related articles

M1-M3 muscarinic acetylcholine receptor-deficient mice: novel phenotypes.

Gautam D, Duttaroy A, Cui Y, Han SJ, Deng C, Seeger T, Alzheimer C, Wess J.

J Mol Neurosci. 2006;30(1-2):157-60.PMID: 17192665 [PubMed - indexed for MEDLINE]Related articles

Role of acetylcholine and muscarinic receptors in serotonin-induced bronchoconstriction in the mouse.

Kummer W, Wiegand S, Akinci S, Schinkel AH, Wess J, Koepsell H, Haberberger RV, Lips KS.

J Mol Neurosci. 2006;30(1-2):67-8.PMID: 17192631 [PubMed - indexed for MEDLINE]Related articles

Functional roles of muscarinic M2 and M3 receptors in mouse stomach motility: studies with muscarinic receptor knockout mice.

Kitazawa T, Hashiba K, Cao J, Unno T, Komori S, Yamada M, Wess J, Taneike T.

Eur J Pharmacol. 2007 Jan 12;554(2-3):212-22. Epub 2006 Oct 17.PMID: 17113073 [PubMed - indexed for MEDLINE]Related articles

Roles of M2 and M3 muscarinic receptors in cholinergic nerve-induced contractions in mouse ileum studied with receptor knockout mice.

Unno T, Matsuyama H, Izumi Y, Yamada M, Wess J, Komori S.

Br J Pharmacol. 2006 Dec;149(8):1022-30. Epub 2006 Nov 13.PMID: 17099717 [PubMed - indexed for MEDLINE]Related articlesFree article

Beneficial metabolic effects of M3 muscarinic acetylcholine receptor deficiency.

Gautam D, Gavrilova O, Jeon J, Pack S, Jou W, Cui Y, Li JH, Wess J.

Cell Metab. 2006 Nov;4(5):363-75.PMID: 17084710 [PubMed - indexed for MEDLINE]Related articles

Muscarinic acetylcholine receptor knockout mice show distinct synaptic plasticity impairments in the visual cortex.

Origlia N, Kuczewski N, Aztiria E, Gautam D, Wess J, Domenici L.

J Physiol. 2006 Dec 15;577(Pt 3):829-40. Epub 2006 Oct 5.PMID: 17023506 [PubMed - indexed for MEDLINE]Related articlesFree article

Loss of M5 muscarinic acetylcholine receptors leads to cerebrovascular and neuronal abnormalities and cognitive deficits in mice.

Araya R, Noguchi T, Yuhki M, Kitamura N, Higuchi M, Saido TC, Seki K, Itohara S, Kawano M, Tanemura K, Takashima A, Yamada K, Kondoh Y, Kanno I, Wess J, Yamada M.

Neurobiol Dis. 2006 Nov;24(2):334-44. Epub 2006 Sep 7.PMID: 16956767 [PubMed - indexed for MEDLINE]Related articles

A critical role for beta cell M3 muscarinic acetylcholine receptors in regulating insulin release and blood glucose homeostasis in vivo.

Gautam D, Han SJ, Hamdan FF, Jeon J, Li B, Li JH, Cui Y, Mears D, Lu H, Deng C, Heard T, Wess J.

Cell Metab. 2006 Jun;3(6):449-61.PMID: 16753580 [PubMed - indexed for MEDLINE]Related articles

Role of acetylcholine and polyspecific cation transporters in serotonin-induced bronchoconstriction in the mouse.

Kummer W, Wiegand S, Akinci S, Wessler I, Schinkel AH, Wess J, Koepsell H, Haberberger RV, Lips KS.

Respir Res. 2006 Apr 12;7:65.PMID: 16608531 [PubMed - indexed for MEDLINE]Related articlesFree article

Signaling of the Human P2Y(1) Receptor Measured by a Yeast Growth Assay with Comparisons to Assays of Phospholipase C and Calcium Mobilization in 1321N1 Human Astrocytoma Cells.

Niebauer RT, Gao ZG, Li B, Wess J, Jacobson KA.

Purinergic Signal. 2005 Sep;1(3):241-7.PMID: 16467903 [PubMed - in process]Related articlesFree article

Use of an in situ disulfide cross-linking strategy to study the dynamic properties of the cytoplasmic end of transmembrane domain VI of the M3 muscarinic acetylcholine receptor.

Ward SD, Hamdan FF, Bloodworth LM, Siddiqui NA, Li JH, Wess J.

Biochemistry. 2006 Jan 24;45(3):676-85.PMID: 16411743 [PubMed - indexed for MEDLINE]Related articles

Opposing functions of spinal M2, M3, and M4 receptor subtypes in regulation of GABAergic inputs to dorsal horn neurons revealed by muscarinic receptor knockout mice.

Zhang HM, Chen SR, Matsui M, Gautam D, Wess J, Pan HL.

Mol Pharmacol. 2006 Mar;69(3):1048-55. Epub 2005 Dec 19.PMID: 16365281 [PubMed - indexed for MEDLINE]Related articlesFree article

Thromboxane A2 induces airway constriction through an M3 muscarinic acetylcholine receptor-dependent mechanism.

Allen IC, Hartney JM, Coffman TM, Penn RB, Wess J, Koller BH.

Am J Physiol Lung Cell Mol Physiol. 2006 Mar;290(3):L526-33. Epub 2005 Oct 21.PMID: 16243899 [PubMed - indexed for MEDLINE]Related articlesFree article