PubMed

HIF prolyl-4-hydroxylase interacting proteins: consequences for drug targeting.

Wenger RH, Camenisch G, Stiehl DP, Katschinski DM.

Curr Pharm Des. 2009;15(33):3886-94.PMID: 19671040 [PubMed - in process]Related articles

Longitudinal and multimodal in vivo imaging of tumor hypoxia and its downstream molecular events.

Lehmann S, Stiehl DP, Honer M, Dominietto M, Keist R, Kotevic I, Wollenick K, Ametamey S, Wenger RH, Rudin M.

Proc Natl Acad Sci U S A. 2009 Aug 18;106(33):14004-9. Epub 2009 Jul 31.PMID: 19666490 [PubMed - indexed for MEDLINE]Related articles

Onconeuronal cerebellar degeneration-related antigen, Cdr2, is strongly expressed in papillary renal cell carcinoma and leads to attenuated hypoxic response.

Balamurugan K, Luu VD, Kaufmann MR, Hofmann VS, Boysen G, Barth S, Bordoli MR, Stiehl DP, Moch H, Schraml P, Wenger RH, Camenisch G.

Oncogene. 2009 Sep 17;28(37):3274-85. Epub 2009 Jul 6.PMID: 19581925 [PubMed - indexed for MEDLINE]Related articles

Hypoxia-inducible factor prolyl-4-hydroxylase PHD2 protein abundance depends on integral membrane anchoring of FKBP38.

Barth S, Edlich F, Berchner-Pfannschmidt U, Gneuss S, Jahreis G, Hasgall PA, Fandrey J, Wenger RH, Camenisch G.

J Biol Chem. 2009 Aug 21;284(34):23046-58. Epub 2009 Jun 22.PMID: 19546213 [PubMed - indexed for MEDLINE]Related articles

Taking advantage of tumor cell adaptations to hypoxia for developing new tumor markers and treatment strategies.

Ebbesen P, Pettersen EO, Gorr TA, Jobst G, Williams K, Kieninger J, Wenger RH, Pastorekova S, Dubois L, Lambin P, Wouters BG, Van Den Beucken T, Supuran CT, Poellinger L, Ratcliffe P, Kanopka A, Görlach A, Gasmann M, Harris AL, Maxwell P, Scozzafava A.

J Enzyme Inhib Med Chem. 2009 Apr;24 Suppl 1:1-39. Review.PMID: 19330638 [PubMed - indexed for MEDLINE]Related articles

The PAS-domain kinase PASKIN: a new sensor in energy homeostasis.

Schläfli P, Borter E, Spielmann P, Wenger RH.

Cell Mol Life Sci. 2009 Mar;66(5):876-83. Review.PMID: 19189049 [PubMed - indexed for MEDLINE]Related articles

Impaired DNA double-strand break repair contributes to chemoresistance in HIF-1 alpha-deficient mouse embryonic fibroblasts.

Wirthner R, Wrann S, Balamurugan K, Wenger RH, Stiehl DP.

Carcinogenesis. 2008 Dec;29(12):2306-16. Epub 2008 Oct 8.PMID: 18842680 [PubMed - indexed for MEDLINE]Related articles

Determination and modulation of prolyl-4-hydroxylase domain oxygen sensor activity.

Wirthner R, Balamurugan K, Stiehl DP, Barth S, Spielmann P, Oehme F, Flamme I, Katschinski DM, Wenger RH, Camenisch G.

Methods Enzymol. 2007;435:43-60.PMID: 17998048 [PubMed - indexed for MEDLINE]Related articles

Oxygen-dependent ATF-4 stability is mediated by the PHD3 oxygen sensor.

Köditz J, Nesper J, Wottawa M, Stiehl DP, Camenisch G, Franke C, Myllyharju J, Wenger RH, Katschinski DM.

Blood. 2007 Nov 15;110(10):3610-7. Epub 2007 Aug 7.PMID: 17684156 [PubMed - indexed for MEDLINE]Related articlesFree article

Regulated function of the prolyl-4-hydroxylase domain (PHD) oxygen sensor proteins.

Nytko KJ, Spielmann P, Camenisch G, Wenger RH, Stiehl DP.

Antioxid Redox Signal. 2007 Sep;9(9):1329-38.PMID: 17627474 [PubMed - indexed for MEDLINE]Related articles

Time course of hypoxia-induced lung injury in rats.

Rassler B, Marx G, Reissig C, Rohling MA, Tannapfel A, Wenger RH, Zimmer HG.

Respir Physiol Neurobiol. 2007 Oct 15;159(1):45-54. Epub 2007 May 18.PMID: 17597012 [PubMed - indexed for MEDLINE]Related articles

Male germ cell expression of the PAS domain kinase PASKIN and its novel target eukaryotic translation elongation factor eEF1A1.

Eckhardt K, Troger J, Reissmann J, Katschinski DM, Wagner KF, Stengel P, Paasch U, Hunziker P, Borter E, Barth S, Schlafli P, Spielmann P, Stiehl DP, Camenisch G, Wenger RH.

Cell Physiol Biochem. 2007;20(1-4):227-40.PMID: 17595531 [PubMed - indexed for MEDLINE]Related articles

The peptidyl prolyl cis/trans isomerase FKBP38 determines hypoxia-inducible transcription factor prolyl-4-hydroxylase PHD2 protein stability.

Barth S, Nesper J, Hasgall PA, Wirthner R, Nytko KJ, Edlich F, Katschinski DM, Stiehl DP, Wenger RH, Camenisch G.

Mol Cell Biol. 2007 May;27(10):3758-68. Epub 2007 Mar 12.PMID: 17353276 [PubMed - indexed for MEDLINE]Related articlesFree article

Lack of hypoxia-inducible factor-1 alpha impairs midbrain neural precursor cells involving vascular endothelial growth factor signaling.

Milosevic J, Maisel M, Wegner F, Leuchtenberger J, Wenger RH, Gerlach M, Storch A, Schwarz J.

J Neurosci. 2007 Jan 10;27(2):412-21.PMID: 17215402 [PubMed - indexed for MEDLINE]Related articlesFree article

Glucose-stimulated insulin production in mice deficient for the PAS kinase PASKIN.

Borter E, Niessen M, Zuellig R, Spinas GA, Spielmann P, Camenisch G, Wenger RH.

Diabetes. 2007 Jan;56(1):113-7.PMID: 17192472 [PubMed - indexed for MEDLINE]Related articlesFree article

Cutting edge: hypoxia-inducible factor 1alpha and its activation-inducible short isoform I.1 negatively regulate functions of CD4+ and CD8+ T lymphocytes.

Lukashev D, Klebanov B, Kojima H, Grinberg A, Ohta A, Berenfeld L, Wenger RH, Ohta A, Sitkovsky M.

J Immunol. 2006 Oct 15;177(8):4962-5.PMID: 17015677 [PubMed - indexed for MEDLINE]Related articlesFree article

Induction of activating transcription factor 3 by anoxia is independent of p53 and the hypoxic HIF signalling pathway.

Ameri K, Hammond EM, Culmsee C, Raida M, Katschinski DM, Wenger RH, Wagner E, Davis RJ, Hai T, Denko N, Harris AL.

Oncogene. 2007 Jan 11;26(2):284-9. Epub 2006 Jul 17.PMID: 16847457 [PubMed - indexed for MEDLINE]Related articles

Increased prolyl 4-hydroxylase domain proteins compensate for decreased oxygen levels. Evidence for an autoregulatory oxygen-sensing system.

Stiehl DP, Wirthner R, Köditz J, Spielmann P, Camenisch G, Wenger RH.

J Biol Chem. 2006 Aug 18;281(33):23482-91. Epub 2006 Jun 21.PMID: 16790428 [PubMed - indexed for MEDLINE]Related articlesFree article

TSGA10 prevents nuclear localization of the hypoxia-inducible factor (HIF)-1alpha.

Hägele S, Behnam B, Borter E, Wolfe J, Paasch U, Lukashev D, Sitkovsky M, Wenger RH, Katschinski DM.

FEBS Lett. 2006 Jun 26;580(15):3731-8. Epub 2006 Jun 5.PMID: 16777103 [PubMed - indexed for MEDLINE]Related articles

Induction of the hypoxia-inducible factor system by low levels of heat shock protein 90 inhibitors.

Ibrahim NO, Hahn T, Franke C, Stiehl DP, Wirthner R, Wenger RH, Katschinski DM.

Cancer Res. 2005 Dec 1;65(23):11094-100.PMID: 16322259 [PubMed - indexed for MEDLINE]Related articlesFree article

Integration of oxygen signaling at the consensus HRE.

Wenger RH, Stiehl DP, Camenisch G.

Sci STKE. 2005 Oct 18;2005(306):re12. Review.PMID: 16234508 [PubMed - indexed for MEDLINE]Related articles

Mitochondria: oxygen sinks rather than sensors?

Wenger RH.

Med Hypotheses. 2006;66(2):380-3. Epub 2005 Oct 17.PMID: 16229963 [PubMed - indexed for MEDLINE]Related articles

The hypoxic testis and post-meiotic expression of PAS domain proteins.

Wenger RH, Katschinski DM.

Semin Cell Dev Biol. 2005 Aug-Oct;16(4-5):547-53. Review.PMID: 15936961 [PubMed - indexed for MEDLINE]Related articles

Copper-dependent activation of hypoxia-inducible factor (HIF)-1: implications for ceruloplasmin regulation.

Martin F, Linden T, Katschinski DM, Oehme F, Flamme I, Mukhopadhyay CK, Eckhardt K, Tröger J, Barth S, Camenisch G, Wenger RH.

Blood. 2005 Jun 15;105(12):4613-9. Epub 2005 Mar 1.PMID: 15741220 [PubMed - indexed for MEDLINE]Related articlesFree article

[Oxygen homeostasis in tissues and cells: how hypoxia regulates gene expression]

Wenger RH.

Anasthesiol Intensivmed Notfallmed Schmerzther. 2004 Sep;39 Suppl 1:S38-43. German. PMID: 15490340 [PubMed - indexed for MEDLINE]Related articles

Interaction of the PAS B domain with HSP90 accelerates hypoxia-inducible factor-1alpha stabilization.

Katschinski DM, Le L, Schindler SG, Thomas T, Voss AK, Wenger RH.

Cell Physiol Biochem. 2004;14(4-6):351-60.PMID: 15319539 [PubMed - indexed for MEDLINE]Related articles

Cardiac remodeling in erythropoietin-transgenic mice.

Briest W, Homagk L, Baba HA, Deten A, Rassler B, Tannapfel A, Wagner KF, Wenger RH, Zimmer HG.

Cell Physiol Biochem. 2004;14(4-6):277-84.PMID: 15319531 [PubMed - indexed for MEDLINE]Related articles

Mitochondrial reactive oxygen species control the transcription factor CHOP-10/GADD153 and adipocyte differentiation: a mechanism for hypoxia-dependent effect.

Carrière A, Carmona MC, Fernandez Y, Rigoulet M, Wenger RH, Pénicaud L, Casteilla L.

J Biol Chem. 2004 Sep 24;279(39):40462-9. Epub 2004 Jul 20.PMID: 15265861 [PubMed - indexed for MEDLINE]Related articlesFree article

Simultaneous exposure of rats to dioxin and carbon monoxide reduces the xenobiotic but not the hypoxic response.

Hofer T, Pohjanvirta R, Spielmann P, Viluksela M, Buchmann DP, Wenger RH, Gassmann M.

Biol Chem. 2004 Mar-Apr;385(3-4):291-4.PMID: 15134343 [PubMed - indexed for MEDLINE]Related articles

A dominant-negative isoform of hypoxia-inducible factor-1 alpha specifically expressed in human testis.

Depping R, Hägele S, Wagner KF, Wiesner RJ, Camenisch G, Wenger RH, Katschinski DM.

Biol Reprod. 2004 Jul;71(1):331-9. Epub 2004 Mar 17.PMID: 15031145 [PubMed - indexed for MEDLINE]Related articlesFree article

Norepinephrine-induced acute heart failure in transgenic mice overexpressing erythropoietin.

Deten A, Shibata J, Scholz D, Briest W, Wagner KF, Wenger RH, Zimmer HG.

Cardiovasc Res. 2004 Jan 1;61(1):105-14.PMID: 14732207 [PubMed - indexed for MEDLINE]Related articlesFree article

Physiologic responses to hypoxia and implications for hypoxia-inducible factors in the pathogenesis of rheumatoid arthritis.

Distler JH, Wenger RH, Gassmann M, Kurowska M, Hirth A, Gay S, Distler O.

Arthritis Rheum. 2004 Jan;50(1):10-23. Review. No abstract available. PMID: 14730595 [PubMed - indexed for MEDLINE]Related articlesFree article

Oxygen-regulated expression of TGF-beta 3, a growth factor involved in trophoblast differentiation.

Schäffer L, Scheid A, Spielmann P, Breymann C, Zimmermann R, Meuli M, Gassmann M, Marti HH, Wenger RH.

Placenta. 2003 Nov;24(10):941-50.PMID: 14580376 [PubMed - indexed for MEDLINE]Related articles

Targeted disruption of the mouse PAS domain serine/threonine kinase PASKIN.

Katschinski DM, Marti HH, Wagner KF, Shibata J, Eckhardt K, Martin F, Depping R, Paasch U, Gassmann M, Ledermann B, Desbaillets I, Wenger RH.

Mol Cell Biol. 2003 Oct;23(19):6780-9.PMID: 12972598 [PubMed - indexed for MEDLINE]Related articlesFree article

Mechanisms of hypoxic gene regulation of angiogenesis factor Cyr61 in melanoma cells.

Kunz M, Moeller S, Koczan D, Lorenz P, Wenger RH, Glocker MO, Thiesen HJ, Gross G, Ibrahim SM.

J Biol Chem. 2003 Nov 14;278(46):45651-60. Epub 2003 Aug 25.PMID: 12939282 [PubMed - indexed for MEDLINE]Related articlesFree article

Iron chelation, angiogenesis and tumor therapy.

Linden T, Wenger RH.

Int J Cancer. 2003 Sep 1;106(3):458-9. No abstract available. PMID: 12845689 [PubMed - indexed for MEDLINE]Related articles

Chronic mild hypoxia protects heart-derived H9c2 cells against acute hypoxia/reoxygenation by regulating expression of the SUR2A subunit of the ATP-sensitive K+ channel.

Crawford RM, Jovanović S, Budas GR, Davies AM, Lad H, Wenger RH, Robertson KA, Roy DJ, Ranki HJ, Jovanović A.

J Biol Chem. 2003 Aug 15;278(33):31444-55. Epub 2003 Jun 5.PMID: 12791696 [PubMed - indexed for MEDLINE]Related articlesFree article

The hypoxia-inducible factor-1 alpha is a negative factor for tumor therapy.

Unruh A, Ressel A, Mohamed HG, Johnson RS, Nadrowitz R, Richter E, Katschinski DM, Wenger RH.

Oncogene. 2003 May 22;22(21):3213-20.PMID: 12761491 [PubMed - indexed for MEDLINE]Related articles

The cellular oxygen tension regulates expression of the endoplasmic oxidoreductase ERO1-Lalpha.

Gess B, Hofbauer KH, Wenger RH, Lohaus C, Meyer HE, Kurtz A.

Eur J Biochem. 2003 May;270(10):2228-35.PMID: 12752442 [PubMed - indexed for MEDLINE]Related articlesFree article

The antimycotic ciclopirox olamine induces HIF-1alpha stability, VEGF expression, and angiogenesis.

Linden T, Katschinski DM, Eckhardt K, Scheid A, Pagel H, Wenger RH.

FASEB J. 2003 Apr;17(6):761-3. Epub 2003 Feb 19.PMID: 12594177 [PubMed - indexed for MEDLINE]Related articlesFree article

Hemostasis and coagulation at a hematocrit level of 0.85: functional consequences of erythrocytosis.

Shibata J, Hasegawa J, Siemens HJ, Wolber E, Dibbelt L, Li D, Katschinski DM, Fandrey J, Jelkmann W, Gassmann M, Wenger RH, Wagner KF.

Blood. 2003 Jun 1;101(11):4416-22. Epub 2003 Feb 6.PMID: 12576335 [PubMed - indexed for MEDLINE]Related articlesFree article

Characterization of HIF-1 alpha overexpressing HeLa cells and implications for gene therapy.

Hofer T, Desbaillets I, Höpfl G, Wenger RH, Gassmann M.

Comp Biochem Physiol C Toxicol Pharmacol. 2002 Dec;133(4):475-81. Review.PMID: 12458176 [PubMed - indexed for MEDLINE]Related articles

Hypoxic up-regulation of erythroid 5-aminolevulinate synthase.

Hofer T, Wenger RH, Kramer MF, Ferreira GC, Gassmann M.

Blood. 2003 Jan 1;101(1):348-50. Epub 2002 Aug 29.PMID: 12393745 [PubMed - indexed for MEDLINE]Related articlesFree article

Cellular adaptation to hypoxia: O2-sensing protein hydroxylases, hypoxia-inducible transcription factors, and O2-regulated gene expression.

Wenger RH.

FASEB J. 2002 Aug;16(10):1151-62. Review.PMID: 12153983 [PubMed - indexed for MEDLINE]Related articlesFree article

DNA-binding activity of hypoxia-inducible factors (HIFs).

Camenisch G, Wenger RH, Gassmann M.

Methods Mol Biol. 2002;196:117-29. No abstract available. PMID: 12152189 [PubMed - indexed for MEDLINE]Related articles

Rescue of hypoxia-inducible factor-1alpha-deficient tumor growth by wild-type cells is independent of vascular endothelial growth factor.

Höpfl G, Wenger RH, Ziegler U, Stallmach T, Gardelle O, Achermann R, Wergin M, Kaser-Hotz B, Saunders HM, Williams KJ, Stratford IJ, Gassmann M, Desbaillets I.

Cancer Res. 2002 May 15;62(10):2962-70.PMID: 12019179 [PubMed - indexed for MEDLINE]Related articlesFree article

Normoxic induction of the hypoxia-inducible factor 1alpha by insulin and interleukin-1beta involves the phosphatidylinositol 3-kinase pathway.

Stiehl DP, Jelkmann W, Wenger RH, Hellwig-Bürgel T.

FEBS Lett. 2002 Feb 13;512(1-3):157-62.PMID: 11852072 [PubMed - indexed for MEDLINE]Related articles

Isoform-specific expression of hypoxia-inducible factor-1alpha during the late stages of mouse spermiogenesis.

Marti HH, Katschinski DM, Wagner KF, Schäffer L, Stier B, Wenger RH.

Mol Endocrinol. 2002 Feb;16(2):234-43.PMID: 11818497 [PubMed - indexed for MEDLINE]Related articlesFree article

Physiologically low oxygen concentrations in fetal skin regulate hypoxia-inducible factor 1 and transforming growth factor-beta3.

Scheid A, Wenger RH, Schäffer L, Camenisch I, Distler O, Ferenc A, Cristina H, Ryan HE, Johnson RS, Wagner KF, Stauffer UG, Bauer C, Gassmann M, Meuli M.

FASEB J. 2002 Mar;16(3):411-3. Epub 2002 Jan 14.PMID: 11790723 [PubMed - indexed for MEDLINE]Related articlesFree article

Heat induction of the unphosphorylated form of hypoxia-inducible factor-1alpha is dependent on heat shock protein-90 activity.

Katschinski DM, Le L, Heinrich D, Wagner KF, Hofer T, Schindler SG, Wenger RH.

J Biol Chem. 2002 Mar 15;277(11):9262-7. Epub 2002 Jan 4.PMID: 11779866 [PubMed - indexed for MEDLINE]Related articlesFree article