PubMed

Single pancreatic beta cells co-express multiple islet hormone genes in mice.

Katsuta H, Akashi T, Katsuta R, Nagaya M, Kim D, Arinobu Y, Hara M, Bonner-Weir S, Sharma AJ, Akashi K, Weir GC.

Diabetologia. 2009 Oct 23. [Epub ahead of print]PMID: 19851748 [PubMed - as supplied by publisher]Related articles

Towards better understanding of the contributions of overwork and glucotoxicity to the beta-cell inadequacy of type 2 diabetes.

Weir GC, Marselli L, Marchetti P, Katsuta H, Jung MH, Bonner-Weir S.

Diabetes Obes Metab. 2009 Nov;11 Suppl 4:82-90.PMID: 19817791 [PubMed - in process]Related articles

Laser capture microdissection of human pancreatic beta-cells and RNA preparation for gene expression profiling.

Marselli L, Sgroi DC, Bonner-Weir S, Weir GC.

Methods Mol Biol. 2009;560:87-98.PMID: 19504246 [PubMed - in process]Related articles

Control of inflammation with alpha1-antitrypsin: a potential treatment for islet transplantation and new-onset type 1 diabetes.

Weir GC, Koulamnda M.

Curr Diab Rep. 2009 Apr;9(2):100-2. No abstract available. PMID: 19323953 [PubMed - indexed for MEDLINE]Related articles

Differentiation of COPAS-sorted non-endocrine pancreatic cells into insulin-positive cells in the mouse.

Kikugawa R, Katsuta H, Akashi T, Yatoh S, Weir GC, Sharma A, Bonner-Weir S.

Diabetologia. 2009 Apr;52(4):645-52. Epub 2009 Jan 30.PMID: 19183938 [PubMed - indexed for MEDLINE]Related articles

Adult mouse intrahepatic biliary epithelial cells induced in vitro to become insulin-producing cells.

Nagaya M, Katsuta H, Kaneto H, Bonner-Weir S, Weir GC.

J Endocrinol. 2009 Apr;201(1):37-47. Epub 2009 Jan 23.PMID: 19168505 [PubMed - indexed for MEDLINE]Related articles

Insulin regulates SOCS2 expression and the mitogenic effect of IGF-1 in mesangial cells.

Isshiki K, He Z, Maeno Y, Ma RC, Yasuda Y, Kuroki T, White GS, Patti ME, Weir GC, King GL.

Kidney Int. 2008 Dec;74(11):1434-43. Epub 2008 Aug 13.PMID: 19008912 [PubMed - indexed for MEDLINE]Related articlesFree article

An appreciation of Robert Turner.

O'Rahilly S, Weir GC, Matthews DR.

Diabetes. 2008 Nov;57(11):2918-21. No abstract available. PMID: 18971441 [PubMed - indexed for MEDLINE]Related articlesFree article

Malic enzyme is present in mouse islets and modulates insulin secretion.

Xu J, Han J, Long YS, Lock J, Weir GC, Epstein PN, Liu YQ.

Diabetologia. 2008 Dec;51(12):2281-9. Epub 2008 Sep 19.PMID: 18802677 [PubMed - indexed for MEDLINE]Related articlesFree article

Bone marrow or foetal liver cells fail to induce islet regeneration in diabetic Akita mice.

Akashi T, Shigematsu H, Hamamoto Y, Iwasaki H, Yatoh S, Bonner-Weir S, Akashi K, Weir GC.

Diabetes Metab Res Rev. 2008 Oct;24(7):585-90.PMID: 18727153 [PubMed - indexed for MEDLINE]Related articles

Increased interleukin (IL)-1beta messenger ribonucleic acid expression in beta -cells of individuals with type 2 diabetes and regulation of IL-1beta in human islets by glucose and autostimulation.

Böni-Schnetzler M, Thorne J, Parnaud G, Marselli L, Ehses JA, Kerr-Conte J, Pattou F, Halban PA, Weir GC, Donath MY.

J Clin Endocrinol Metab. 2008 Oct;93(10):4065-74. Epub 2008 Jul 29.PMID: 18664535 [PubMed - indexed for MEDLINE]Related articlesFree article

Pig islet xenograft rejection in a mouse model with an established human immune system.

Tonomura N, Shimizu A, Wang S, Yamada K, Tchipashvili V, Weir GC, Yang YG.

Xenotransplantation. 2008 Mar;15(2):129-35.PMID: 18447886 [PubMed - indexed for MEDLINE]Related articles

A model for diabetic nephropathy: advantages of the inducible cAMP early repressor transgenic mouse over the streptozotocin-induced diabetic mouse.

Inada A, Kanamori H, Arai H, Akashi T, Araki M, Weir GC, Fukatsu A.

J Cell Physiol. 2008 May;215(2):383-91.PMID: 18270980 [PubMed - indexed for MEDLINE]Related articles

Gene expression of purified beta-cell tissue obtained from human pancreas with laser capture microdissection.

Marselli L, Thorne J, Ahn YB, Omer A, Sgroi DC, Libermann T, Otu HH, Sharma A, Bonner-Weir S, Weir GC.

J Clin Endocrinol Metab. 2008 Mar;93(3):1046-53. Epub 2007 Dec 11.PMID: 18073315 [PubMed - indexed for MEDLINE]Related articlesFree article

The endoplasmic reticulum in pancreatic beta cells of type 2 diabetes patients.

Marchetti P, Bugliani M, Lupi R, Marselli L, Masini M, Boggi U, Filipponi F, Weir GC, Eizirik DL, Cnop M.

Diabetologia. 2007 Dec;50(12):2486-94. Epub 2007 Sep 30.PMID: 17906960 [PubMed - indexed for MEDLINE]Related articles

Influence of diabetes on the loss of beta cell differentiation after islet transplantation in rats.

Laybutt DR, Hawkins YC, Lock J, Lebet J, Sharma A, Bonner-Weir S, Weir GC.

Diabetologia. 2007 Oct;50(10):2117-25. Epub 2007 Jul 20.PMID: 17641871 [PubMed - indexed for MEDLINE]Related articles

Normal relationship of beta- and non-beta-cells not needed for successful islet transplantation.

King AJ, Fernandes JR, Hollister-Lock J, Nienaber CE, Bonner-Weir S, Weir GC.

Diabetes. 2007 Sep;56(9):2312-8. Epub 2007 Jun 11.PMID: 17563059 [PubMed - indexed for MEDLINE]Related articlesFree article

A stirred microchamber for oxygen consumption rate measurements with pancreatic islets.

Papas KK, Pisania A, Wu H, Weir GC, Colton CK.

Biotechnol Bioeng. 2007 Dec 1;98(5):1071-82.PMID: 17497731 [PubMed - indexed for MEDLINE]Related articles

Differentiation of affinity-purified human pancreatic duct cells to beta-cells.

Yatoh S, Dodge R, Akashi T, Omer A, Sharma A, Weir GC, Bonner-Weir S.

Diabetes. 2007 Jul;56(7):1802-9. Epub 2007 May 1.PMID: 17473224 [PubMed - indexed for MEDLINE]Related articlesFree article

Effects of insulin replacements, inhibitors of angiotensin, and PKCbeta's actions to normalize cardiac gene expression and fuel metabolism in diabetic rats.

Arikawa E, Ma RC, Isshiki K, Luptak I, He Z, Yasuda Y, Maeno Y, Patti ME, Weir GC, Harris RA, Zammit VA, Tian R, King GL.

Diabetes. 2007 May;56(5):1410-20. Epub 2007 Mar 15.PMID: 17363743 [PubMed - indexed for MEDLINE]Related articlesFree article

Downregulation of GLP-1 and GIP receptor expression by hyperglycemia: possible contribution to impaired incretin effects in diabetes.

Xu G, Kaneto H, Laybutt DR, Duvivier-Kali VF, Trivedi N, Suzuma K, King GL, Weir GC, Bonner-Weir S.

Diabetes. 2007 Jun;56(6):1551-8. Epub 2007 Mar 14.PMID: 17360984 [PubMed - indexed for MEDLINE]Related articlesFree article

Human islet oxygen consumption rate and DNA measurements predict diabetes reversal in nude mice.

Papas KK, Colton CK, Nelson RA, Rozak PR, Avgoustiniatos ES, Scott WE 3rd, Wildey GM, Pisania A, Weir GC, Hering BJ.

Am J Transplant. 2007 Mar;7(3):707-13. Epub 2007 Jan 4.PMID: 17229069 [PubMed - indexed for MEDLINE]Related articles

A dominant role for glucose in beta cell compensation of insulin resistance.

Weir GC, Bonner-Weir S.

J Clin Invest. 2007 Jan;117(1):81-3.PMID: 17200709 [PubMed - indexed for MEDLINE]Related articlesFree article

Changes in gene expression in beta cells after islet isolation and transplantation using laser-capture microdissection.

Ahn YB, Xu G, Marselli L, Toschi E, Sharma A, Bonner-Weir S, Sgroi DC, Weir GC.

Diabetologia. 2007 Feb;50(2):334-42. Epub 2006 Dec 16.PMID: 17180350 [PubMed - indexed for MEDLINE]Related articles

NeuroD and reaggregation induce beta-cell specific gene expression in cultured hepatocytes.

Yatoh S, Akashi T, Chan PP, Kaneto H, Sharma A, Bonner-Weir S, Weir GC.

Diabetes Metab Res Rev. 2007 Mar;23(3):239-49.PMID: 16921545 [PubMed - indexed for MEDLINE]Related articles

Evidence for a role of the ubiquitin-proteasome pathway in pancreatic islets.

López-Avalos MD, Duvivier-Kali VF, Xu G, Bonner-Weir S, Sharma A, Weir GC.

Diabetes. 2006 May;55(5):1223-31.PMID: 16644676 [PubMed - indexed for MEDLINE]Related articlesFree article

GLP-1/exendin-4 facilitates beta-cell neogenesis in rat and human pancreatic ducts.

Xu G, Kaneto H, Lopez-Avalos MD, Weir GC, Bonner-Weir S.

Diabetes Res Clin Pract. 2006 Jul;73(1):107-10. Epub 2006 Jan 6. No abstract available. PMID: 16406191 [PubMed - indexed for MEDLINE]Related articles

The HNF-1 target collectrin controls insulin exocytosis by SNARE complex formation.

Fukui K, Yang Q, Cao Y, Takahashi N, Hatakeyama H, Wang H, Wada J, Zhang Y, Marselli L, Nammo T, Yoneda K, Onishi M, Higashiyama S, Matsuzawa Y, Gonzalez FJ, Weir GC, Kasai H, Shimomura I, Miyagawa J, Wollheim CB, Yamagata K.

Cell Metab. 2005 Dec;2(6):373-84.PMID: 16330323 [PubMed - indexed for MEDLINE]Related articles

High-density culture of human islets on top of silicone rubber membranes.

Papas KK, Avgoustiniatos ES, Tempelman LA, Weir GC, Colton CK, Pisania A, Rappel MJ, Friberg AS, Bauer AC, Hering BJ.

Transplant Proc. 2005 Oct;37(8):3412-4.PMID: 16298611 [PubMed - indexed for MEDLINE]Related articles

Islet transplantation outcomes in mice are better with fresh islets and exendin-4 treatment.

King A, Lock J, Xu G, Bonner-Weir S, Weir GC.

Diabetologia. 2005 Oct;48(10):2074-9. Epub 2005 Aug 23.PMID: 16132945 [PubMed - indexed for MEDLINE]Related articles

Establishment of a diabetic mouse model with progressive diabetic nephropathy.

Inada A, Nagai K, Arai H, Miyazaki J, Nomura K, Kanamori H, Toyokuni S, Yamada Y, Bonner-Weir S, Weir GC, Fukatsu A, Seino Y.

Am J Pathol. 2005 Aug;167(2):327-36.PMID: 16049320 [PubMed - indexed for MEDLINE]Related articlesFree article

New sources of pancreatic beta-cells.

Bonner-Weir S, Weir GC.

Nat Biotechnol. 2005 Jul;23(7):857-61. Review.PMID: 16003374 [PubMed - indexed for MEDLINE]Related articles

Islet transplantation: progress and challenge.

Gaglia JL, Shapiro AM, Weir GC.

Arch Med Res. 2005 May-Jun;36(3):273-80. Review.PMID: 15925017 [PubMed - indexed for MEDLINE]Related articles

The Nkx6.1 homeodomain transcription factor suppresses glucagon expression and regulates glucose-stimulated insulin secretion in islet beta cells.

Schisler JC, Jensen PB, Taylor DG, Becker TC, Knop FK, Takekawa S, German M, Weir GC, Lu D, Mirmira RG, Newgard CB.

Proc Natl Acad Sci U S A. 2005 May 17;102(20):7297-302. Epub 2005 May 9.PMID: 15883383 [PubMed - indexed for MEDLINE]Related articlesFree article

Induced ICER Igamma down-regulates cyclin A expression and cell proliferation in insulin-producing beta cells.

Inada A, Weir GC, Bonner-Weir S.

Biochem Biophys Res Commun. 2005 Apr 15;329(3):925-9.PMID: 15752744 [PubMed - indexed for MEDLINE]Related articles

Mechanism of insulin gene regulation by the pancreatic transcription factor Pdx-1: application of pre-mRNA analysis and chromatin immunoprecipitation to assess formation of functional transcriptional complexes.

Iype T, Francis J, Garmey JC, Schisler JC, Nesher R, Weir GC, Becker TC, Newgard CB, Griffen SC, Mirmira RG.

J Biol Chem. 2005 Apr 29;280(17):16798-807. Epub 2005 Mar 2.PMID: 15743769 [PubMed - indexed for MEDLINE]Related articlesFree article

Long-term normoglycemia in rats receiving transplants with encapsulated islets.

Omer A, Duvivier-Kali V, Fernandes J, Tchipashvili V, Colton CK, Weir GC.

Transplantation. 2005 Jan 15;79(1):52-8.PMID: 15714169 [PubMed - indexed for MEDLINE]Related articles

Survival of microencapsulated adult pig islets in mice in spite of an antibody response.

Duvivier-Kali VF, Omer A, Lopez-Avalos MD, O'Neil JJ, Weir GC.

Am J Transplant. 2004 Dec;4(12):1991-2000.PMID: 15575901 [PubMed - indexed for MEDLINE]Related articles

Five stages of evolving beta-cell dysfunction during progression to diabetes.

Weir GC, Bonner-Weir S.

Diabetes. 2004 Dec;53 Suppl 3:S16-21. Review.PMID: 15561905 [PubMed - indexed for MEDLINE]Related articlesFree article

Transplantation of islets transduced with CTLA4-Ig and TGFbeta using adenovirus and lentivirus vectors.

Fernandes JR, Duvivier-Kali VF, Keegan M, Hollister-Lock J, Omer A, Su S, Bonner-Weir S, Feng S, Lee JS, Mulligan RC, Weir GC.

Transpl Immunol. 2004 Nov;13(3):191-200.PMID: 15381202 [PubMed - indexed for MEDLINE]Related articles

Beta-cell precursors--a work in progress.

Weir GC, Bonner-Weir S.

Nat Biotechnol. 2004 Sep;22(9):1095-6. No abstract available. PMID: 15340475 [PubMed - indexed for MEDLINE]Related articles

Can we make surrogate beta-cells better than the original?

Weir GC.

Semin Cell Dev Biol. 2004 Jun;15(3):347-57.PMID: 15125898 [PubMed - indexed for MEDLINE]Related articles

Expression of the intermediate filament vimentin in proliferating duct cells as a marker of pancreatic precursor cells.

Ko SH, Suh SH, Kim BJ, Ahn YB, Song KH, Yoo SJ, Son HS, Cha BY, Lee KW, Son HY, Kang SK, Bonner-Weir S, Weir GC, Yoon KH, Park CG.

Pancreas. 2004 Mar;28(2):121-8.PMID: 15028943 [PubMed - indexed for MEDLINE]Related articles

Exercise induces hypoglycemia in rats with islet transplantation.

Omer A, Duvivier-Kali VF, Aschenbach W, Tchipashvili V, Goodyear LJ, Weir GC.

Diabetes. 2004 Feb;53(2):360-5.PMID: 14747286 [PubMed - indexed for MEDLINE]Related articlesFree article

Importance of hyperglycemia on the primary function of allogeneic islet transplants.

Makhlouf L, Duvivier-Kali VF, Bonner-Weir S, Dieperink H, Weir GC, Sayegh MH.

Transplantation. 2003 Aug 27;76(4):657-64.PMID: 12973104 [PubMed - indexed for MEDLINE]Related articles

PDX-1 protein containing its own antennapedia-like protein transduction domain can transduce pancreatic duct and islet cells.

Noguchi H, Kaneto H, Weir GC, Bonner-Weir S.

Diabetes. 2003 Jul;52(7):1732-7.PMID: 12829640 [PubMed - indexed for MEDLINE]Related articlesFree article

Macrophage depletion improves survival of porcine neonatal pancreatic cell clusters contained in alginate macrocapsules transplanted into rats.

Omer A, Keegan M, Czismadia E, De Vos P, Van Rooijen N, Bonner-Weir S, Weir GC.

Xenotransplantation. 2003 May;10(3):240-51.PMID: 12694544 [PubMed - indexed for MEDLINE]Related articles

Induction of Mad expression leads to augmentation of insulin gene transcription.

Patané G, Kaneto H, Toschi E, Sharma A, Gupta S, Weir GC.

Biochem Biophys Res Commun. 2003 Apr 18;303(4):1199-208.PMID: 12684063 [PubMed - indexed for MEDLINE]Related articles

Development and retroviral transduction of porcine neonatal pancreatic islet cells in monolayer culture.

Tatarkiewicz K, López-Avalos MD, Yoon KH, Trivedi N, Quickel RR, Bonner-Weir S, Weir GC.

Dev Growth Differ. 2003 Feb;45(1):39-50.PMID: 12630945 [PubMed - indexed for MEDLINE]Related articles

Survival and maturation of microencapsulated porcine neonatal pancreatic cell clusters transplanted into immunocompetent diabetic mice.

Omer A, Duvivier-Kali VF, Trivedi N, Wilmot K, Bonner-Weir S, Weir GC.

Diabetes. 2003 Jan;52(1):69-75.PMID: 12502495 [PubMed - indexed for MEDLINE]Related articlesFree article