PubMed

PKC inhibition ameliorates the cardiac phenotype in a mouse model of myotonic dystrophy type 1.

Wang GS, Kuyumcu-Martinez MN, Sarma S, Mathur N, Wehrens XH, Cooper TA.

J Clin Invest. 2009 Nov 9. pii: 37976. doi: 10.1172/JCI37976. [Epub ahead of print]PMID: 19907076 [PubMed - as supplied by publisher]Related articlesFree article

Animal models of arrhythmogenic cardiomyopathy.

McCauley MD, Wehrens XH.

Dis Model Mech. 2009 Nov-Dec;2(11-12):563-70.PMID: 19892887 [PubMed - in process]Related articles

Calmodulin kinase II-mediated sarcoplasmic reticulum Ca2+ leak promotes atrial fibrillation in mice.

Chelu MG, Sarma S, Sood S, Wang S, van Oort RJ, Skapura DG, Li N, Santonastasi M, Müller FU, Schmitz W, Schotten U, Anderson ME, Valderrábano M, Dobrev D, Wehrens XH.

J Clin Invest. 2009 Jul;119(7):1940-51.PMID: 19603549 [PubMed - indexed for MEDLINE]Related articlesFree article

Molecular evolution of the junctophilin gene family.

Garbino A, van Oort RJ, Dixit SS, Landstrom AP, Ackerman MJ, Wehrens XH.

Physiol Genomics. 2009 May 13;37(3):175-86. Epub 2009 Mar 24.PMID: 19318539 [PubMed - indexed for MEDLINE]Related articles

Calmodulin kinase II is required for fight or flight sinoatrial node physiology.

Wu Y, Gao Z, Chen B, Koval OM, Singh MV, Guan X, Hund TJ, Kutschke W, Sarma S, Grumbach IM, Wehrens XH, Mohler PJ, Song LS, Anderson ME.

Proc Natl Acad Sci U S A. 2009 Apr 7;106(14):5972-7. Epub 2009 Mar 10.PMID: 19276108 [PubMed - indexed for MEDLINE]Related articlesFree article

Exercise training during diabetes attenuates cardiac ryanodine receptor dysregulation.

Shao CH, Wehrens XH, Wyatt TA, Parbhu S, Rozanski GJ, Patel KP, Bidasee KR.

J Appl Physiol. 2009 Apr;106(4):1280-92. Epub 2009 Jan 8.PMID: 19131475 [PubMed - indexed for MEDLINE]Related articles

Alternative splicing: a key mechanism for ankyrin-B functional diversity?

van Oort RJ, Altamirano J, Lederer WJ, Wehrens XH.

J Mol Cell Cardiol. 2008 Dec;45(6):709-11. Epub 2008 Sep 18. No abstract available. PMID: 18838078 [PubMed - indexed for MEDLINE]Related articles

20p12.3 microdeletion predisposes to Wolff-Parkinson-White syndrome with variable neurocognitive deficits.

Lalani SR, Thakuria JV, Cox GF, Wang X, Bi W, Bray MS, Shaw C, Cheung SW, Chinault AC, Boggs BA, Ou Z, Brundage EK, Lupski JR, Gentile J, Waisbren S, Pursley A, Ma L, Khajavi M, Zapata G, Friedman R, Kim JJ, Towbin JA, Stankiewicz P, Schnittger S, Hansmann I, Ai T, Sood S, Wehrens XH, Martin JF, Belmont JW, Potocki L.

J Med Genet. 2009 Mar;46(3):168-75. Epub 2008 Sep 23.PMID: 18812404 [PubMed - indexed for MEDLINE]Related articles

Intracellular calcium leak due to FKBP12.6 deficiency in mice facilitates the inducibility of atrial fibrillation.

Sood S, Chelu MG, van Oort RJ, Skapura D, Santonastasi M, Dobrev D, Wehrens XH.

Heart Rhythm. 2008 Jul;5(7):1047-54. Epub 2008 Mar 27.PMID: 18598963 [PubMed - indexed for MEDLINE]Related articlesFree article

NFATc2 is a necessary mediator of calcineurin-dependent cardiac hypertrophy and heart failure.

Bourajjaj M, Armand AS, da Costa Martins PA, Weijts B, van der Nagel R, Heeneman S, Wehrens XH, De Windt LJ.

J Biol Chem. 2008 Aug 8;283(32):22295-303. Epub 2008 May 12.PMID: 18477567 [PubMed - indexed for MEDLINE]Related articlesFree article

Diseases associated with altered ryanodine receptor activity.

Durham WJ, Wehrens XH, Sood S, Hamilton SL.

Subcell Biochem. 2007;45:273-321. Review.PMID: 18193641 [PubMed - indexed for MEDLINE]Related articles

Sarcoplasmic reticulum calcium leak and cardiac arrhythmias.

Chelu MG, Wehrens XH.

Biochem Soc Trans. 2007 Nov;35(Pt 5):952-6. Review.PMID: 17956253 [PubMed - indexed for MEDLINE]Related articles

Mechanisms of human arrhythmia syndromes: abnormal cardiac macromolecular interactions.

Mohler PJ, Wehrens XH.

Physiology (Bethesda). 2007 Oct;22:342-50. Review.PMID: 17928548 [PubMed - indexed for MEDLINE]Related articlesFree article

Mutation-specific effects of lidocaine in Brugada syndrome.

Clancy CE, Wehrens XH.

Int J Cardiol. 2007 Oct 18;121(3):249-52. Epub 2007 Aug 29.PMID: 17761312 [PubMed - indexed for MEDLINE]Related articles

Istaroxime, a novel luso-inotropic agent for the treatment of acute heart failure.

Wehrens XH.

Curr Opin Investig Drugs. 2007 Sep;8(9):769-77. Review.PMID: 17729189 [PubMed - indexed for MEDLINE]Related articles

Phosphorylation of RyR2 and shortening of RyR2 cluster spacing in spontaneously hypertensive rat with heart failure.

Chen-Izu Y, Ward CW, Stark W Jr, Banyasz T, Sumandea MP, Balke CW, Izu LT, Wehrens XH.

Am J Physiol Heart Circ Physiol. 2007 Oct;293(4):H2409-17. Epub 2007 Jul 13.PMID: 17630346 [PubMed - indexed for MEDLINE]Related articlesFree article

Ryanodine receptors as pharmacological targets for heart disease.

Santonastasi M, Wehrens XH.

Acta Pharmacol Sin. 2007 Jul;28(7):937-44. Review.PMID: 17588328 [PubMed - indexed for MEDLINE]Related articlesFree article

The molecular basis of catecholaminergic polymorphic ventricular tachycardia: what are the different hypotheses regarding mechanisms?

Wehrens XH.

Heart Rhythm. 2007 Jun;4(6):794-7. Epub 2006 Dec 15. Review. No abstract available. PMID: 17556207 [PubMed - indexed for MEDLINE]Related articles

Mutations in JPH2-encoded junctophilin-2 associated with hypertrophic cardiomyopathy in humans.

Landstrom AP, Weisleder N, Batalden KB, Bos JM, Tester DJ, Ommen SR, Wehrens XH, Claycomb WC, Ko JK, Hwang M, Pan Z, Ma J, Ackerman MJ.

J Mol Cell Cardiol. 2007 Jun;42(6):1026-35. Epub 2007 Apr 18.PMID: 17509612 [PubMed - indexed for MEDLINE]Related articles

Leaky ryanodine receptors cause delayed afterdepolarizations and ventricular arrhythmias.

Wehrens XH.

Eur Heart J. 2007 May;28(9):1054-6. Epub 2007 Apr 25. No abstract available. PMID: 17459904 [PubMed - indexed for MEDLINE]Related articlesFree article

Subcellular targeting of phosphatases: a novel function of ankyrins.

van Oort RJ, Wehrens XH.

Am J Physiol Heart Circ Physiol. 2007 Jul;293(1):H15-6. Epub 2007 Apr 20. No abstract available. PMID: 17449551 [PubMed - indexed for MEDLINE]Related articlesFree article

Mice with the R176Q cardiac ryanodine receptor mutation exhibit catecholamine-induced ventricular tachycardia and cardiomyopathy.

Kannankeril PJ, Mitchell BM, Goonasekera SA, Chelu MG, Zhang W, Sood S, Kearney DL, Danila CI, De Biasi M, Wehrens XH, Pautler RG, Roden DM, Taffet GE, Dirksen RT, Anderson ME, Hamilton SL.

Proc Natl Acad Sci U S A. 2006 Aug 8;103(32):12179-84. Epub 2006 Jul 27.PMID: 16873551 [PubMed - indexed for MEDLINE]Related articlesFree article

Stabilization of cardiac ryanodine receptor prevents intracellular calcium leak and arrhythmias.

Lehnart SE, Terrenoire C, Reiken S, Wehrens XH, Song LS, Tillman EJ, Mancarella S, Coromilas J, Lederer WJ, Kass RS, Marks AR.

Proc Natl Acad Sci U S A. 2006 May 16;103(20):7906-10. Epub 2006 May 3.PMID: 16672364 [PubMed - indexed for MEDLINE]Related articlesFree article

Structural determinants of potassium channel blockade and drug-induced arrhythmias.

Wehrens XH.

Handb Exp Pharmacol. 2006;(171):123-57. Review.PMID: 16610343 [PubMed - indexed for MEDLINE]Related articles

Analysis of calstabin2 (FKBP12.6)-ryanodine receptor interactions: rescue of heart failure by calstabin2 in mice.

Huang F, Shan J, Reiken S, Wehrens XH, Marks AR.

Proc Natl Acad Sci U S A. 2006 Feb 28;103(9):3456-61. Epub 2006 Feb 15.PMID: 16481613 [PubMed - indexed for MEDLINE]Related articlesFree article

Ryanodine receptor/calcium release channel PKA phosphorylation: a critical mediator of heart failure progression.

Wehrens XH, Lehnart SE, Reiken S, Vest JA, Wronska A, Marks AR.

Proc Natl Acad Sci U S A. 2006 Jan 17;103(3):511-8. Epub 2006 Jan 6.PMID: 16407108 [PubMed - indexed for MEDLINE]Related articlesFree article

Phosphodiesterase 4D deficiency in the ryanodine-receptor complex promotes heart failure and arrhythmias.

Lehnart SE, Wehrens XH, Reiken S, Warrier S, Belevych AE, Harvey RD, Richter W, Jin SL, Conti M, Marks AR.

Cell. 2005 Oct 7;123(1):25-35. Erratum in: Cell. 2005 Nov 4;123(3):535-6. PMID: 16213210 [PubMed - indexed for MEDLINE]Related articles

Ryanodine receptor-targeted anti-arrhythmic therapy.

Wehrens XH, Lehnart SE, Marks AR.

Ann N Y Acad Sci. 2005 Jun;1047:366-75. Review.PMID: 16093511 [PubMed - indexed for MEDLINE]Related articles

Defective ryanodine receptor interdomain interactions may contribute to intracellular Ca2+ leak: a novel therapeutic target in heart failure.

Lehnart SE, Wehrens XH, Marks AR.

Circulation. 2005 Jun 28;111(25):3342-6. Review. No abstract available. PMID: 15983258 [PubMed - indexed for MEDLINE]Related articlesFree article

Enhancing calstabin binding to ryanodine receptors improves cardiac and skeletal muscle function in heart failure.

Wehrens XH, Lehnart SE, Reiken S, van der Nagel R, Morales R, Sun J, Cheng Z, Deng SX, de Windt LJ, Landry DW, Marks AR.

Proc Natl Acad Sci U S A. 2005 Jul 5;102(27):9607-12. Epub 2005 Jun 22.PMID: 15972811 [PubMed - indexed for MEDLINE]Related articlesFree article

Defective cardiac ryanodine receptor regulation during atrial fibrillation.

Vest JA, Wehrens XH, Reiken SR, Lehnart SE, Dobrev D, Chandra P, Danilo P, Ravens U, Rosen MR, Marks AR.

Circulation. 2005 Apr 26;111(16):2025-32.PMID: 15851612 [PubMed - indexed for MEDLINE]Related articlesFree article

Intracellular calcium release and cardiac disease.

Wehrens XH, Lehnart SE, Marks AR.

Annu Rev Physiol. 2005;67:69-98. Review.PMID: 15709953 [PubMed - indexed for MEDLINE]Related articles

Sudden unexplained death caused by cardiac ryanodine receptor (RyR2) mutations.

Wehrens XH, Marks AR.

Mayo Clin Proc. 2004 Nov;79(11):1367-71. No abstract available. PMID: 15544013 [PubMed - indexed for MEDLINE]Related articlesFree article

Calstabin deficiency, ryanodine receptors, and sudden cardiac death.

Lehnart SE, Wehrens XH, Marks AR.

Biochem Biophys Res Commun. 2004 Oct 1;322(4):1267-79. Review.PMID: 15336974 [PubMed - indexed for MEDLINE]Related articles

Novel therapeutic approaches for heart failure by normalizing calcium cycling.

Wehrens XH, Marks AR.

Nat Rev Drug Discov. 2004 Jul;3(7):565-73. Review. No abstract available. PMID: 15232578 [PubMed - indexed for MEDLINE]Related articles

Cardiac ryanodine receptor function and regulation in heart disease.

Lehnart SE, Wehrens XH, Kushnir A, Marks AR.

Ann N Y Acad Sci. 2004 May;1015:144-59. Review.PMID: 15201156 [PubMed - indexed for MEDLINE]Related articles

Sudden death in familial polymorphic ventricular tachycardia associated with calcium release channel (ryanodine receptor) leak.

Lehnart SE, Wehrens XH, Laitinen PJ, Reiken SR, Deng SX, Cheng Z, Landry DW, Kontula K, Swan H, Marks AR.

Circulation. 2004 Jun 29;109(25):3208-14. Epub 2004 Jun 14.PMID: 15197150 [PubMed - indexed for MEDLINE]Related articlesFree article

Cardiac rupture complicating myocardial infarction.

Wehrens XH, Doevendans PA.

Int J Cardiol. 2004 Jun;95(2-3):285-92. Review.PMID: 15193834 [PubMed - indexed for MEDLINE]Related articles

Molecular determinants of altered contractility in heart failure.

Wehrens XH, Marks AR.

Ann Med. 2004;36 Suppl 1:70-80. Review.PMID: 15176427 [PubMed - indexed for MEDLINE]Related articles

Fetal cardiovascular response to large placental chorioangiomas.

Wehrens XH, Offermans JP, Snijders M, Peeters LL.

J Perinat Med. 2004;32(2):107-12. Review.PMID: 15085884 [PubMed - indexed for MEDLINE]Related articles

Protection from cardiac arrhythmia through ryanodine receptor-stabilizing protein calstabin2.

Wehrens XH, Lehnart SE, Reiken SR, Deng SX, Vest JA, Cervantes D, Coromilas J, Landry DW, Marks AR.

Science. 2004 Apr 9;304(5668):292-6.PMID: 15073377 [PubMed - indexed for MEDLINE]Related articlesFree article

Ca2+/calmodulin-dependent protein kinase II phosphorylation regulates the cardiac ryanodine receptor.

Wehrens XH, Lehnart SE, Reiken SR, Marks AR.

Circ Res. 2004 Apr 2;94(6):e61-70. Epub 2004 Mar 11.PMID: 15016728 [PubMed - indexed for MEDLINE]Related articlesFree article

Altered function and regulation of cardiac ryanodine receptors in cardiac disease.

Wehrens XH, Marks AR.

Trends Biochem Sci. 2003 Dec;28(12):671-8. Review.PMID: 14659699 [PubMed - indexed for MEDLINE]Related articles

Myocardial disease in failing hearts: defective excitation-contraction coupling.

Wehrens XH, Marks AR.

Cold Spring Harb Symp Quant Biol. 2002;67:533-41. Review. No abstract available. PMID: 12858580 [PubMed - indexed for MEDLINE]Related articles

FKBP12.6 deficiency and defective calcium release channel (ryanodine receptor) function linked to exercise-induced sudden cardiac death.

Wehrens XH, Lehnart SE, Huang F, Vest JA, Reiken SR, Mohler PJ, Sun J, Guatimosim S, Song LS, Rosemblit N, D'Armiento JM, Napolitano C, Memmi M, Priori SG, Lederer WJ, Marks AR.

Cell. 2003 Jun 27;113(7):829-40.PMID: 12837242 [PubMed - indexed for MEDLINE]Related articles

Cardiac rupture.

Wehrens XH, Doevendans PA.

N Engl J Med. 2003 May 29;348(22):2264. No abstract available. PMID: 12773664 [PubMed - indexed for MEDLINE]Related articles

Beta-blockers restore calcium release channel function and improve cardiac muscle performance in human heart failure.

Reiken S, Wehrens XH, Vest JA, Barbone A, Klotz S, Mancini D, Burkhoff D, Marks AR.

Circulation. 2003 May 20;107(19):2459-66. Epub 2003 May 12.PMID: 12743001 [PubMed - indexed for MEDLINE]Related articlesFree article

Non-equilibrium gating in cardiac Na+ channels: an original mechanism of arrhythmia.

Clancy CE, Tateyama M, Liu H, Wehrens XH, Kass RS.

Circulation. 2003 May 6;107(17):2233-7. Epub 2003 Apr 14.PMID: 12695286 [PubMed - indexed for MEDLINE]Related articlesFree article

A novel mutation L619F in the cardiac Na+ channel SCN5A associated with long-QT syndrome (LQT3): a role for the I-II linker in inactivation gating.

Wehrens XH, Rossenbacker T, Jongbloed RJ, Gewillig M, Heidbüchel H, Doevendans PA, Vos MA, Wellens HJ, Kass RS.

Hum Mutat. 2003 May;21(5):552.PMID: 12673799 [PubMed - indexed for MEDLINE]Related articles

K+ channel structure-activity relationships and mechanisms of drug-induced QT prolongation.

Clancy CE, Kurokawa J, Tateyama M, Wehrens XH, Kass RS.

Annu Rev Pharmacol Toxicol. 2003;43:441-61. Epub 2002 Jan 10. Review.PMID: 12540747 [PubMed - indexed for MEDLINE]Related articles