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Hyperglycaemic clamp test for diabetes risk assessment in IA-2-antibody-positive relatives of type 1 diabetic patients.

Vandemeulebroucke E, Keymeulen B, Decochez K, Weets I, De Block C, Féry F, Van de Velde U, Vermeulen I, De Pauw P, Mathieu C, Pipeleers DG, Gorus FK; The Belgian Diabetes Registry.

Diabetologia. 2009 Nov 7. [Epub ahead of print]PMID: 19898832 [PubMed - as supplied by publisher]Related articles

Insulin treatment in IA-2A-positive relatives of type 1 diabetic patients.

Vandemeulebroucke E, Gorus FK, Decochez K, Weets I, Keymeulen B, De Block C, Tits J, Pipeleers DG, Mathieu C; Belgian Diabetes Registry.

Diabetes Metab. 2009 Sep;35(4):319-27. Epub 2009 Jul 31.PMID: 19647467 [PubMed - in process]Related articles

IFIH1 gene polymorphisms in type 1 diabetes: genetic association analysis and genotype-phenotype correlation in the Belgian population.

Aminkeng F, Van Autreve JE, Weets I, Quartier E, Van Schravendijk C, Gorus FK, Van der Auwera BJ; Belgian Diabetes Registry.

Hum Immunol. 2009 Sep;70(9):706-10. Epub 2009 Jun 16.PMID: 19539001 [PubMed - in process]Related articles

Identity development, coping, and adjustment in emerging adults with a chronic illness: the sample case of type 1 diabetes.

Luyckx K, Seiffge-Krenke I, Schwartz SJ, Goossens L, Weets I, Hendrieckx C, Groven C.

J Adolesc Health. 2008 Nov;43(5):451-8. Epub 2008 Jun 24.PMID: 18848673 [PubMed - indexed for MEDLINE]Related articles

Adiponectin levels do not predict clinical onset of type 1 diabetes in antibody-positive relatives.

Truyen I, De Grijse J, Van Schravendijk C, De Smet D, Decochez K, Vandemeulebroucke E, Giri M, Keymeulen B, Mathieu C, Van Gaal L, De Pauw P, Weets I, Pipeleers DG, Gorus FK; Belgian Diabetes Registry.

Diabetologia. 2007 Oct;50(10):2143-6. Epub 2007 Aug 9.PMID: 17687539 [PubMed - indexed for MEDLINE]Related articles

The age at diagnosis of type 1 diabetes continues to decrease in Belgian boys but not in girls: a 15-year survey.

Weets I, Rooman R, Coeckelberghs M, De Block C, Van Gaal L, Kaufman JM, Keymeulen B, Mathieu C, Weber E, Pipeleers DG, Gorus FK; Belgian Diabetes Registry.

Diabetes Metab Res Rev. 2007 Nov;23(8):637-43.PMID: 17631647 [PubMed - indexed for MEDLINE]Related articles

Identification of prediabetes in first-degree relatives at intermediate risk of type I diabetes.

Truyen I, De Grijse J, Weets I, Kaufman L, Pipeleers L, Nanos N, Decochez K, Hilbrands R, Kaufman JM, Keymeulen B, Mathieu C, Van Gaal L, Pipeleers DG, Gorus FK; Belgian Diabetes Registry.

Clin Exp Immunol. 2007 Aug;149(2):243-50. Epub 2007 May 22.PMID: 17521324 [PubMed - indexed for MEDLINE]Related articlesFree article

MICA is associated with type 1 diabetes in the Belgian population, independent of HLA-DQ.

Van Autreve JE, Koeleman BP, Quartier E, Aminkeng F, Weets I, Gorus FK, Van der Auwera BJ; Belgian Diabetes Registry.

Hum Immunol. 2006 Jan-Feb;67(1-2):94-101. Epub 2006 Mar 31.PMID: 16698430 [PubMed - indexed for MEDLINE]Related articles

Sex- and season-dependent differences in C-peptide levels at diagnosis of immune-mediated type 1 diabetes.

Weets I, Truyen I, Verschraegen I, Van der Auwera B, De Schepper J, Dorchy H, Lebrethon MC, Van Gaal L, Van Rooy P, Pipeleers DG, Gorus FK; Belgian Diabetes Registry.

Diabetologia. 2006 Jun;49(6):1158-62. Epub 2006 Mar 29.PMID: 16570164 [PubMed - indexed for MEDLINE]Related articles

Proinsulin levels and the proinsulin:c-peptide ratio complement autoantibody measurement for predicting type 1 diabetes.

Truyen I, De Pauw P, Jørgensen PN, Van Schravendijk C, Ubani O, Decochez K, Vandemeulebroucke E, Weets I, Mao R, Pipeleers DG, Gorus FK; Belgian Diabetes Registry.

Diabetologia. 2005 Nov;48(11):2322-9. Epub 2005 Oct 7.PMID: 16211374 [PubMed - indexed for MEDLINE]Related articles

[Early diagnosis and prevention of type 1 diabetes: role of the Belgian Diabetes Registry]

Weets I, Truyen I, Philips JC, Gorus F.

Rev Med Liege. 2005 May-Jun;60(5-6):306-12. French. PMID: 16035286 [PubMed - indexed for MEDLINE]Related articles

Insulin needs after CD3-antibody therapy in new-onset type 1 diabetes.

Keymeulen B, Vandemeulebroucke E, Ziegler AG, Mathieu C, Kaufman L, Hale G, Gorus F, Goldman M, Walter M, Candon S, Schandene L, Crenier L, De Block C, Seigneurin JM, De Pauw P, Pierard D, Weets I, Rebello P, Bird P, Berrie E, Frewin M, Waldmann H, Bach JF, Pipeleers D, Chatenoud L.

N Engl J Med. 2005 Jun 23;352(25):2598-608.PMID: 15972866 [PubMed - indexed for MEDLINE]Related articlesFree article

Combined positivity for HLA DQ2/DQ8 and IA-2 antibodies defines population at high risk of developing type 1 diabetes.

Decochez K, Truyen I, van der Auwera B, Weets I, Vandemeulebroucke E, de Leeuw IH, Keymeulen B, Mathieu C, Rottiers R, Pipeleers DG, Gorus FK; Belgian Diabetes Registry.

Diabetologia. 2005 Apr;48(4):687-94. Epub 2005 Mar 9.PMID: 15756536 [PubMed - indexed for MEDLINE]Related articles

The rare HLA-DQA1*03-DQB1*02 haplotype confers susceptibility to type 1 diabetes in whites and is preferentially associated with early clinical disease onset in male subjects.

van Autreve JE, Weets I, Gulbis B, Vertongen F, Gorus FK, van der Auwera BJ; Belgian Diabetes Registry.

Hum Immunol. 2004 Jul;65(7):729-36.PMID: 15301863 [PubMed - indexed for MEDLINE]Related articles

Seasonality in clinical onset of type 1 diabetes in belgian patients above the age of 10 is restricted to HLA-DQ2/DQ8-negative males, which explains the male to female excess in incidence.

Weets I, Kaufman L, Van der Auwera B, Crenier L, Rooman RP, De Block C, Casteels K, Weber E, Coeckelberghs M, Laron Z, Pipeleers DG, Gorus FK; Belgian Diabetes Registry.

Diabetologia. 2004 Apr;47(4):614-21.PMID: 15298337 [PubMed - indexed for MEDLINE]Related articles

Epidemiology of type 1 and type 2 diabetes. The added value of diabetes registries for conducting clinical studies: the Belgian paradigm.

Gorus FK, Weets I, Couck P, Pipeleers DG; Belgian Diabetes Registry.

Acta Clin Belg. 2004 Jan-Feb;59(1):1-13. Review.PMID: 15065690 [PubMed - indexed for MEDLINE]Related articles

[Preventative biology of type 1 diabetes: implications for clinical preventative studies]

Gorus FK, Weets I, Decochez K, van der Auwera BJ.

Verh K Acad Geneeskd Belg. 2003;65(4):203-29; discussion 229-31. Review. Dutch. PMID: 14534938 [PubMed - indexed for MEDLINE]Related articles

IA-2 autoantibodies predict impending type I diabetes in siblings of patients.

Decochez K, De Leeuw IH, Keymeulen B, Mathieu C, Rottiers R, Weets I, Vandemeulebroucke E, Truyen I, Kaufman L, Schuit FC, Pipeleers DG, Gorus FK; Belgian Diabetes Registry.

Diabetologia. 2002 Dec;45(12):1658-66. Epub 2002 Nov 12.PMID: 12488955 [PubMed - indexed for MEDLINE]Related articles

Relation between disease phenotype and HLA-DQ genotype in diabetic patients diagnosed in early adulthood.

Weets I, Siraux V, Daubresse JC, De Leeuw IH, Féry F, Keymeulen B, Krzentowski G, Letiexhe M, Mathieu C, Nobels F, Rottiers R, Scheen A, Van Gaal L, Schuit FC, Van der Auwera B, Rui M, De Pauw P, Kaufman L, Gorus FK; Belgian Diabetes Registry.

J Clin Endocrinol Metab. 2002 Jun;87(6):2597-605.PMID: 12050221 [PubMed - indexed for MEDLINE]Related articlesFree article

The incidence of type 1 diabetes in the age group 0-39 years has not increased in Antwerp (Belgium) between 1989 and 2000: evidence for earlier disease manifestation.

Weets I, De Leeuw IH, Du Caju MV, Rooman R, Keymeulen B, Mathieu C, Rottiers R, Daubresse JC, Rocour-Brumioul D, Pipeleers DG, Gorus FK; Belgian Diabetes Registry.

Diabetes Care. 2002 May;25(5):840-6.PMID: 11978678 [PubMed - indexed for MEDLINE]Related articlesFree article

To: T.J. Wilkin (2001) The accelerator hypothesis: weight gain as the missing link between Type I and Type II diabetes. Diabetologia 44: 914-921.

Gorus FK, Weets I, Pipeleers DG.

Diabetologia. 2002 Feb;45(2):288-9; author reply 289. No abstract available. PMID: 11942314 [PubMed - indexed for MEDLINE]Related articles

Relative and absolute HLA-DQA1-DQB1 linked risk for developing type I diabetes before 40 years of age in the Belgian population: implications for future prevention studies.

Van der Auwera BJ, Schuit FC, Weets I, Ivens A, Van Autreve JE, Gorus FK; Belgian Diabetes Registry.

Hum Immunol. 2002 Jan;63(1):40-50.PMID: 11916169 [PubMed - indexed for MEDLINE]Related articles

Autoantibodies to a 38-kDa glycosylated islet cell membrane-associated antigen in (pre)type 1 diabetes: association with IA-2 and islet cell autoantibodies.

Winnock F, Christie MR, Batstra MR, Aanstoot HJ, Weets I, Decochez K, Jopart P, Nicolaij D, Gorus FK; Belgian Diabetes Registry.

Diabetes Care. 2001 Jul;24(7):1181-6.PMID: 11423499 [PubMed - indexed for MEDLINE]Related articlesFree article

Male-to-female excess in diabetes diagnosed in early adulthood is not specific for the immune-mediated form nor is it HLA-DQ restricted: possible relation to increased body mass index.

Weets I, Van Autreve J, Van der Auwera BJ, Schuit FC, Du Caju MV, Decochez K, De Leeuw IH, Keymeulen B, Mathieu C, Rottiers R, Dorchy H, Quartier E, Gorus FK; Belgian Diabetes Registry.

Diabetologia. 2001 Jan;44(1):40-7.PMID: 11206410 [PubMed - indexed for MEDLINE]Related articles

Use of an islet cell antibody assay to identify type 1 diabetic patients with rapid decrease in C-peptide levels after clinical onset. Belgian Diabetes Registry.

Decochez K, Keymeulen B, Somers G, Dorchy H, De Leeuw IH, Mathieu C, Rottiers R, Winnock F, ver Elst K, Weets I, Kaufman L, Pipeleers DG, Rottiers R; Belgian Diabetes Registry.

Diabetes Care. 2000 Aug;23(8):1072-8.PMID: 10937500 [PubMed - indexed for MEDLINE]Related articlesFree article

High frequency of persisting or increasing islet-specific autoantibody levels after diagnosis of type 1 diabetes presenting before 40 years of age. The Belgian Diabetes Registry.

Decochez K, Tits J, Coolens JL, Van Gaal L, Krzentowski G, Winnock F, Anckaert E, Weets I, Pipeleers DG, Gorus FK.

Diabetes Care. 2000 Jun;23(6):838-44.PMID: 10841006 [PubMed - indexed for MEDLINE]Related articlesFree article

HLA-DRB1*04 and susceptibility to type 1 diabetes mellitus in a German/Belgian family and German case-control study. The Belgian Diabetes Registry.

Donner H, Seidl C, Van der Auwera B, Braun J, Siegmund T, Herwig J, Weets I, Usadel KH, Badenhoop K.

Tissue Antigens. 2000 Mar;55(3):271-4.PMID: 10777104 [PubMed - indexed for MEDLINE]Related articles

The presence or absence of a retroviral long terminal repeat influences the genetic risk for type 1 diabetes conferred by human leukocyte antigen DQ haplotypes. Belgian Diabetes Registry.

Donner H, Tönjes RR, Van der Auwera B, Siegmund T, Braun J, Weets I, Herwig J, Kurth R, Usadel KH, Badenhoop K.

J Clin Endocrinol Metab. 1999 Apr;84(4):1404-8.PMID: 10199786 [PubMed - indexed for MEDLINE]Related articlesFree article

Evaluation of an immunoturbidimetric assay for haemoglobin A1c on a Cobas Mira S analyser.

Weets I, Gorus FK, Gerlo E.

Eur J Clin Chem Clin Biochem. 1996 May;34(5):449-53.PMID: 8790983 [PubMed - indexed for MEDLINE]Related articles