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    Results: 1 to 50 of 64

    1.

    Genetic evidence that raised Sex Hormone Binding Globulin (SHBG) levels reduce the risk of type 2 diabetes.

    Perry JR, Weedon MN, Langenberg C, Jackson AU, Lyssenko V, Sparsø T, Thorleifsson G, Grallert H, Ferrucci L, Maggio M, Paolisso G, Walker M, Palmer CN, Payne F, Young E, Herder C, Narisu N, Morken MA, Bonnycastle LL, Owen KR, Shields B, Knight B, Bennett A, Groves CJ, Ruokonen A, Jarvelin MR, Pearson E, Pascoe L, Ferrannini E, Bornstein SR, Stringham HM, Scott LJ, Kuusisto J, Nilsson P, Neptin M, Gjesing AP, Pisinger C, Lauritzen T, Sandbaek A, Sampson M; MAGIC, Zeggini E, Lindgren CM, Steinthorsdottir V, Thorsteinsdottir U, Hansen T, Schwarz P, Illig T, Laakso M, Stefansson K, Morris AD, Groop L, Pedersen O, Boehnke M, Barroso I, Wareham NJ, Hattersley AT, McCarthy MI, Frayling TM.

    Hum Mol Genet. 2009 Nov 18. [Epub ahead of print]PMID: 19933169 [PubMed - as supplied by publisher]

    2.

    Genetic association analysis of LARS2 with type 2 diabetes.

    Reiling E, Jafar-Mohammadi B, van 't Riet E, Weedon MN, van Vliet-Ostaptchouk JV, Hansen T, Saxena R, van Haeften TW, Arp PA, Das S, Nijpels G, Groenewoud MJ, van Hove EC, Uitterlinden AG, Smit JW, Morris AD, Doney AS, Palmer CN, Guiducci C, Hattersley AT, Frayling TM, Pedersen O, Slagboom PE, Altshuler DM, Groop L, Romijn JA, Maassen JA, Hofker MH, Dekker JM, McCarthy MI, 't Hart LM.

    Diabetologia. 2009 Oct 22. [Epub ahead of print]PMID: 19847392 [PubMed - as supplied by publisher]Related articles

    3.

    Phosphodiesterase 8B gene polymorphism is associated with subclinical hypothyroidism in pregnancy.

    Shields BM, Freathy RM, Knight BA, Hill A, Weedon MN, Frayling TM, Hattersley AT, Vaidya B.

    J Clin Endocrinol Metab. 2009 Nov;94(11):4608-12. Epub 2009 Oct 9.PMID: 19820008 [PubMed - in process]Related articles

    4.

    Polygenic Risk Variants for Type 2 Diabetes Susceptibility Modify Age at Diagnosis in Monogenic HNF1A Diabetes.

    Lango Allen H, Johansson S, Ellard S, Shields B, Hertel JK, Ræder H, Colclough K, Molven A, Frayling TM, Njølstad PR, Hattersley AT, Weedon MN.

    Diabetes. 2009 Sep 30. [Epub ahead of print]PMID: 19794065 [PubMed - as supplied by publisher]Related articles

    5.

    Circulating beta-carotene levels and type 2 diabetes-cause or effect?

    Perry JR, Ferrucci L, Bandinelli S, Guralnik J, Semba RD, Rice N, Melzer D; DIAGRAM Consortium, Saxena R, Scott LJ, McCarthy MI, Hattersley AT, Zeggini E, Weedon MN, Frayling TM.

    Diabetologia. 2009 Oct;52(10):2117-21. Epub 2009 Aug 7.PMID: 19662379 [PubMed - in process]Related articles

    6.

    Genome-wide association scan meta-analysis identifies three Loci influencing adiposity and fat distribution.

    Lindgren CM, Heid IM, Randall JC, Lamina C, Steinthorsdottir V, Qi L, Speliotes EK, Thorleifsson G, Willer CJ, Herrera BM, Jackson AU, Lim N, Scheet P, Soranzo N, Amin N, Aulchenko YS, Chambers JC, Drong A, Luan J, Lyon HN, Rivadeneira F, Sanna S, Timpson NJ, Zillikens MC, Zhao JH, Almgren P, Bandinelli S, Bennett AJ, Bergman RN, Bonnycastle LL, Bumpstead SJ, Chanock SJ, Cherkas L, Chines P, Coin L, Cooper C, Crawford G, Doering A, Dominiczak A, Doney AS, Ebrahim S, Elliott P, Erdos MR, Estrada K, Ferrucci L, Fischer G, Forouhi NG, Gieger C, Grallert H, Groves CJ, Grundy S, Guiducci C, Hadley D, Hamsten A, Havulinna AS, Hofman A, Holle R, Holloway JW, Illig T, Isomaa B, Jacobs LC, Jameson K, Jousilahti P, Karpe F, Kuusisto J, Laitinen J, Lathrop GM, Lawlor DA, Mangino M, McArdle WL, Meitinger T, Morken MA, Morris AP, Munroe P, Narisu N, Nordström A, Nordström P, Oostra BA, Palmer CN, Payne F, Peden JF, Prokopenko I, Renström F, Ruokonen A, Salomaa V, Sandhu MS, Scott LJ, Scuteri A, Silander K, Song K, Yuan X, Stringham HM, Swift AJ, Tuomi T, Uda M, Vollenweider P, Waeber G, Wallace C, Walters GB, Weedon MN; Wellcome Trust Case Control Consortium, Witteman JC, Zhang C, Zhang W, Caulfield MJ, Collins FS, Davey Smith G, Day IN, Franks PW, Hattersley AT, Hu FB, Jarvelin MR, Kong A, Kooner JS, Laakso M, Lakatta E, Mooser V, Morris AD, Peltonen L, Samani NJ, Spector TD, Strachan DP, Tanaka T, Tuomilehto J, Uitterlinden AG, van Duijn CM, Wareham NJ, Hugh Watkins; Procardis Consortia, Waterworth DM, Boehnke M, Deloukas P, Groop L, Hunter DJ, Thorsteinsdottir U, Schlessinger D, Wichmann HE, Frayling TM, Abecasis GR, Hirschhorn JN, Loos RJ, Stefansson K, Mohlke KL, Barroso I, McCarthy MI; Giant Consortium.

    PLoS Genet. 2009 Jun;5(6):e1000508. Epub 2009 Jun 26. Erratum in: PLoS Genet. 2009 Jul;5(7). doi: 10.1371/annotation/b6e8f9f6-2496-4a40-b0e3-e1d1390c1928. PMID: 19557161 [PubMed - indexed for MEDLINE]Related articlesFree article

    7.

    Meta-analysis of genome-wide association data identifies two loci influencing age at menarche.

    Perry JR, Stolk L, Franceschini N, Lunetta KL, Zhai G, McArdle PF, Smith AV, Aspelund T, Bandinelli S, Boerwinkle E, Cherkas L, Eiriksdottir G, Estrada K, Ferrucci L, Folsom AR, Garcia M, Gudnason V, Hofman A, Karasik D, Kiel DP, Launer LJ, van Meurs J, Nalls MA, Rivadeneira F, Shuldiner AR, Singleton A, Soranzo N, Tanaka T, Visser JA, Weedon MN, Wilson SG, Zhuang V, Streeten EA, Harris TB, Murray A, Spector TD, Demerath EW, Uitterlinden AG, Murabito JM.

    Nat Genet. 2009 May 17. [Epub ahead of print]PMID: 19448620 [PubMed - as supplied by publisher]Related articles

    8.

    A common genetic variant in the 15q24 nicotinic acetylcholine receptor gene cluster (CHRNA5-CHRNA3-CHRNB4) is associated with a reduced ability of women to quit smoking in pregnancy.

    Freathy RM, Ring SM, Shields B, Galobardes B, Knight B, Weedon MN, Smith GD, Frayling TM, Hattersley AT.

    Hum Mol Genet. 2009 Aug 1;18(15):2922-7. Epub 2009 May 9.PMID: 19429911 [PubMed - indexed for MEDLINE]Related articlesFree article

    9.

    Interrogating type 2 diabetes genome-wide association data using a biological pathway-based approach.

    Perry JR, McCarthy MI, Hattersley AT, Zeggini E; Wellcome Trust Case Control Consortium, Weedon MN, Frayling TM.

    Diabetes. 2009 Jun;58(6):1463-7. Epub 2009 Feb 27.PMID: 19252133 [PubMed - indexed for MEDLINE]Related articlesFree article

    10.

    Type 2 diabetes risk alleles are associated with reduced size at birth.

    Freathy RM, Bennett AJ, Ring SM, Shields B, Groves CJ, Timpson NJ, Weedon MN, Zeggini E, Lindgren CM, Lango H, Perry JR, Pouta A, Ruokonen A, Hyppönen E, Power C, Elliott P, Strachan DP, Järvelin MR, Smith GD, McCarthy MI, Frayling TM, Hattersley AT.

    Diabetes. 2009 Jun;58(6):1428-33. Epub 2009 Feb 19.PMID: 19228808 [PubMed - indexed for MEDLINE]Related articlesFree article

    11.

    Predicting human height by Victorian and genomic methods.

    Aulchenko YS, Struchalin MV, Belonogova NM, Axenovich TI, Weedon MN, Hofman A, Uitterlinden AG, Kayser M, Oostra BA, van Duijn CM, Janssens AC, Borodin PM.

    Eur J Hum Genet. 2009 Aug;17(8):1070-5. Epub 2009 Feb 18.PMID: 19223933 [PubMed - indexed for MEDLINE]Related articles

    12.

    Six new loci associated with body mass index highlight a neuronal influence on body weight regulation.

    Willer CJ, Speliotes EK, Loos RJ, Li S, Lindgren CM, Heid IM, Berndt SI, Elliott AL, Jackson AU, Lamina C, Lettre G, Lim N, Lyon HN, McCarroll SA, Papadakis K, Qi L, Randall JC, Roccasecca RM, Sanna S, Scheet P, Weedon MN, Wheeler E, Zhao JH, Jacobs LC, Prokopenko I, Soranzo N, Tanaka T, Timpson NJ, Almgren P, Bennett A, Bergman RN, Bingham SA, Bonnycastle LL, Brown M, Burtt NP, Chines P, Coin L, Collins FS, Connell JM, Cooper C, Smith GD, Dennison EM, Deodhar P, Elliott P, Erdos MR, Estrada K, Evans DM, Gianniny L, Gieger C, Gillson CJ, Guiducci C, Hackett R, Hadley D, Hall AS, Havulinna AS, Hebebrand J, Hofman A, Isomaa B, Jacobs KB, Johnson T, Jousilahti P, Jovanovic Z, Khaw KT, Kraft P, Kuokkanen M, Kuusisto J, Laitinen J, Lakatta EG, Luan J, Luben RN, Mangino M, McArdle WL, Meitinger T, Mulas A, Munroe PB, Narisu N, Ness AR, Northstone K, O'Rahilly S, Purmann C, Rees MG, Ridderstråle M, Ring SM, Rivadeneira F, Ruokonen A, Sandhu MS, Saramies J, Scott LJ, Scuteri A, Silander K, Sims MA, Song K, Stephens J, Stevens S, Stringham HM, Tung YC, Valle TT, Van Duijn CM, Vimaleswaran KS, Vollenweider P, Waeber G, Wallace C, Watanabe RM, Waterworth DM, Watkins N; Wellcome Trust Case Control Consortium, Witteman JC, Zeggini E, Zhai G, Zillikens MC, Altshuler D, Caulfield MJ, Chanock SJ, Farooqi IS, Ferrucci L, Guralnik JM, Hattersley AT, Hu FB, Jarvelin MR, Laakso M, Mooser V, Ong KK, Ouwehand WH, Salomaa V, Samani NJ, Spector TD, Tuomi T, Tuomilehto J, Uda M, Uitterlinden AG, Wareham NJ, Deloukas P, Frayling TM, Groop LC, Hayes RB, Hunter DJ, Mohlke KL, Peltonen L, Schlessinger D, Strachan DP, Wichmann HE, McCarthy MI, Boehnke M, Barroso I, Abecasis GR, Hirschhorn JN; Genetic Investigation of ANthropometric Traits Consortium.

    Nat Genet. 2009 Jan;41(1):25-34. Epub 2008 Dec 14.PMID: 19079261 [PubMed - indexed for MEDLINE]Related articlesFree article

    13.

    Adiposity-related heterogeneity in patterns of type 2 diabetes susceptibility observed in genome-wide association data.

    Timpson NJ, Lindgren CM, Weedon MN, Randall J, Ouwehand WH, Strachan DP, Rayner NW, Walker M, Hitman GA, Doney AS, Palmer CN, Morris AD, Hattersley AT, Zeggini E, Frayling TM, McCarthy MI.

    Diabetes. 2009 Feb;58(2):505-10. Epub 2008 Dec 3.PMID: 19056611 [PubMed - indexed for MEDLINE]Related articlesFree article

    14.

    The association of common genetic variants in the APOA5, LPL and GCK genes with longitudinal changes in metabolic and cardiovascular traits.

    Webster RJ, Warrington NM, Weedon MN, Hattersley AT, McCaskie PA, Beilby JP, Palmer LJ, Frayling TM.

    Diabetologia. 2009 Jan;52(1):106-14. Epub 2008 Nov 19.PMID: 19018513 [PubMed - indexed for MEDLINE]Related articles

    15.

    FTO gene variants are strongly associated with type 2 diabetes in South Asian Indians.

    Yajnik CS, Janipalli CS, Bhaskar S, Kulkarni SR, Freathy RM, Prakash S, Mani KR, Weedon MN, Kale SD, Deshpande J, Krishnaveni GV, Veena SR, Fall CH, McCarthy MI, Frayling TM, Hattersley AT, Chandak GR.

    Diabetologia. 2009 Feb;52(2):247-52. Epub 2008 Nov 13.PMID: 19005641 [PubMed - indexed for MEDLINE]Related articlesFree article

    16.

    Reaching new heights: insights into the genetics of human stature.

    Weedon MN, Frayling TM.

    Trends Genet. 2008 Dec;24(12):595-603. Epub 2008 Oct 22. Review.PMID: 18950892 [PubMed - indexed for MEDLINE]Related articles

    17.

    Gene variants influencing measures of inflammation or predisposing to autoimmune and inflammatory diseases are not associated with the risk of type 2 diabetes.

    Rafiq S, Melzer D, Weedon MN, Lango H, Saxena R, Scott LJ; DIAGRAM Consortium, Palmer CN, Morris AD, McCarthy MI, Ferrucci L, Hattersley AT, Zeggini E, Frayling TM.

    Diabetologia. 2008 Dec;51(12):2205-13. Epub 2008 Oct 14.PMID: 18853133 [PubMed - indexed for MEDLINE]Related articles

    18.

    Population-specific risk of type 2 diabetes conferred by HNF4A P2 promoter variants: a lesson for replication studies.

    Barroso I, Luan J, Wheeler E, Whittaker P, Wasson J, Zeggini E, Weedon MN, Hunt S, Venkatesh R, Frayling TM, Delgado M, Neuman RJ, Zhao J, Sherva R, Glaser B, Walker M, Hitman G, McCarthy MI, Hattersley AT, Permutt MA, Wareham NJ, Deloukas P.

    Diabetes. 2008 Nov;57(11):3161-5. Epub 2008 Aug 26.PMID: 18728231 [PubMed - indexed for MEDLINE]Related articlesFree article

    19.

    Beta cell glucose sensitivity is decreased by 39% in non-diabetic individuals carrying multiple diabetes-risk alleles compared with those with no risk alleles.

    Pascoe L, Frayling TM, Weedon MN, Mari A, Tura A, Ferrannini E, Walker M; RISC Consortium.

    Diabetologia. 2008 Nov;51(11):1989-92. Epub 2008 Aug 22.PMID: 18719881 [PubMed - indexed for MEDLINE]Related articles

    20.

    Assessing the combined impact of 18 common genetic variants of modest effect sizes on type 2 diabetes risk.

    Lango H; UK Type 2 Diabetes Genetics Consortium, Palmer CN, Morris AD, Zeggini E, Hattersley AT, McCarthy MI, Frayling TM, Weedon MN.

    Diabetes. 2008 Nov;57(11):3129-35. Epub 2008 Jun 30.PMID: 18591388 [PubMed - indexed for MEDLINE]Related articlesFree article

    21.

    A common variation in deiodinase 1 gene DIO1 is associated with the relative levels of free thyroxine and triiodothyronine.

    Panicker V, Cluett C, Shields B, Murray A, Parnell KS, Perry JR, Weedon MN, Singleton A, Hernandez D, Evans J, Durant C, Ferrucci L, Melzer D, Saravanan P, Visser TJ, Ceresini G, Hattersley AT, Vaidya B, Dayan CM, Frayling TM.

    J Clin Endocrinol Metab. 2008 Aug;93(8):3075-81. Epub 2008 May 20.PMID: 18492748 [PubMed - indexed for MEDLINE]Related articlesFree article

    22.

    A genome-wide association study identifies protein quantitative trait loci (pQTLs).

    Melzer D, Perry JR, Hernandez D, Corsi AM, Stevens K, Rafferty I, Lauretani F, Murray A, Gibbs JR, Paolisso G, Rafiq S, Simon-Sanchez J, Lango H, Scholz S, Weedon MN, Arepalli S, Rice N, Washecka N, Hurst A, Britton A, Henley W, van de Leemput J, Li R, Newman AB, Tranah G, Harris T, Panicker V, Dayan C, Bennett A, McCarthy MI, Ruokonen A, Jarvelin MR, Guralnik J, Bandinelli S, Frayling TM, Singleton A, Ferrucci L.

    PLoS Genet. 2008 May 9;4(5):e1000072.PMID: 18464913 [PubMed - indexed for MEDLINE]Related articlesFree article

    23.

    Common variants near MC4R are associated with fat mass, weight and risk of obesity.

    Loos RJ, Lindgren CM, Li S, Wheeler E, Zhao JH, Prokopenko I, Inouye M, Freathy RM, Attwood AP, Beckmann JS, Berndt SI; Prostate, Lung, Colorectal, and Ovarian (PLCO) Cancer Screening Trial, Jacobs KB, Chanock SJ, Hayes RB, Bergmann S, Bennett AJ, Bingham SA, Bochud M, Brown M, Cauchi S, Connell JM, Cooper C, Smith GD, Day I, Dina C, De S, Dermitzakis ET, Doney AS, Elliott KS, Elliott P, Evans DM, Sadaf Farooqi I, Froguel P, Ghori J, Groves CJ, Gwilliam R, Hadley D, Hall AS, Hattersley AT, Hebebrand J, Heid IM; KORA, Lamina C, Gieger C, Illig T, Meitinger T, Wichmann HE, Herrera B, Hinney A, Hunt SE, Jarvelin MR, Johnson T, Jolley JD, Karpe F, Keniry A, Khaw KT, Luben RN, Mangino M, Marchini J, McArdle WL, McGinnis R, Meyre D, Munroe PB, Morris AD, Ness AR, Neville MJ, Nica AC, Ong KK, O'Rahilly S, Owen KR, Palmer CN, Papadakis K, Potter S, Pouta A, Qi L; Nurses' Health Study, Randall JC, Rayner NW, Ring SM, Sandhu MS, Scherag A, Sims MA, Song K, Soranzo N, Speliotes EK; Diabetes Genetics Initiative, Syddall HE, Teichmann SA, Timpson NJ, Tobias JH, Uda M; SardiNIA Study, Vogel CI, Wallace C, Waterworth DM, Weedon MN; Wellcome Trust Case Control Consortium, Willer CJ; FUSION, Wraight, Yuan X, Zeggini E, Hirschhorn JN, Strachan DP, Ouwehand WH, Caulfield MJ, Samani NJ, Frayling TM, Vollenweider P, Waeber G, Mooser V, Deloukas P, McCarthy MI, Wareham NJ, Barroso I, Jacobs KB, Chanock SJ, Hayes RB, Lamina C, Gieger C, Illig T, Meitinger T, Wichmann HE, Kraft P, Hankinson SE, Hunter DJ, Hu FB, Lyon HN, Voight BF, Ridderstrale M, Groop L, Scheet P, Sanna S, Abecasis GR, Albai G, Nagaraja R, Schlessinger D, Jackson AU, Tuomilehto J, Collins FS, Boehnke M, Mohlke KL.

    Nat Genet. 2008 Jun;40(6):768-75. Epub 2008 May 4.PMID: 18454148 [PubMed - indexed for MEDLINE]Related articlesFree article

    24.

    Genome-wide association analysis identifies 20 loci that influence adult height.

    Weedon MN, Lango H, Lindgren CM, Wallace C, Evans DM, Mangino M, Freathy RM, Perry JR, Stevens S, Hall AS, Samani NJ, Shields B, Prokopenko I, Farrall M, Dominiczak A; Diabetes Genetics Initiative; Wellcome Trust Case Control Consortium, Johnson T, Bergmann S, Beckmann JS, Vollenweider P, Waterworth DM, Mooser V, Palmer CN, Morris AD, Ouwehand WH; Cambridge GEM Consortium, Zhao JH, Li S, Loos RJ, Barroso I, Deloukas P, Sandhu MS, Wheeler E, Soranzo N, Inouye M, Wareham NJ, Caulfield M, Munroe PB, Hattersley AT, McCarthy MI, Frayling TM.

    Nat Genet. 2008 May;40(5):575-83. Epub 2008 Apr 6.PMID: 18391952 [PubMed - indexed for MEDLINE]Related articlesFree article

    25.

    Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes.

    Zeggini E, Scott LJ, Saxena R, Voight BF, Marchini JL, Hu T, de Bakker PI, Abecasis GR, Almgren P, Andersen G, Ardlie K, Boström KB, Bergman RN, Bonnycastle LL, Borch-Johnsen K, Burtt NP, Chen H, Chines PS, Daly MJ, Deodhar P, Ding CJ, Doney AS, Duren WL, Elliott KS, Erdos MR, Frayling TM, Freathy RM, Gianniny L, Grallert H, Grarup N, Groves CJ, Guiducci C, Hansen T, Herder C, Hitman GA, Hughes TE, Isomaa B, Jackson AU, Jørgensen T, Kong A, Kubalanza K, Kuruvilla FG, Kuusisto J, Langenberg C, Lango H, Lauritzen T, Li Y, Lindgren CM, Lyssenko V, Marvelle AF, Meisinger C, Midthjell K, Mohlke KL, Morken MA, Morris AD, Narisu N, Nilsson P, Owen KR, Palmer CN, Payne F, Perry JR, Pettersen E, Platou C, Prokopenko I, Qi L, Qin L, Rayner NW, Rees M, Roix JJ, Sandbaek A, Shields B, Sjögren M, Steinthorsdottir V, Stringham HM, Swift AJ, Thorleifsson G, Thorsteinsdottir U, Timpson NJ, Tuomi T, Tuomilehto J, Walker M, Watanabe RM, Weedon MN, Willer CJ; Wellcome Trust Case Control Consortium, Illig T, Hveem K, Hu FB, Laakso M, Stefansson K, Pedersen O, Wareham NJ, Barroso I, Hattersley AT, Collins FS, Groop L, McCarthy MI, Boehnke M, Altshuler D.

    Nat Genet. 2008 May;40(5):638-45. Epub 2008 Mar 30.PMID: 18372903 [PubMed - indexed for MEDLINE]Related articlesFree article

    26.

    Common variation in the FTO gene alters diabetes-related metabolic traits to the extent expected given its effect on BMI.

    Freathy RM, Timpson NJ, Lawlor DA, Pouta A, Ben-Shlomo Y, Ruokonen A, Ebrahim S, Shields B, Zeggini E, Weedon MN, Lindgren CM, Lango H, Melzer D, Ferrucci L, Paolisso G, Neville MJ, Karpe F, Palmer CN, Morris AD, Elliott P, Jarvelin MR, Smith GD, McCarthy MI, Hattersley AT, Frayling TM.

    Diabetes. 2008 May;57(5):1419-26. Epub 2008 Mar 17.PMID: 18346983 [PubMed - indexed for MEDLINE]Related articlesFree article

    27.

    What will whole genome searches for susceptibility genes for common complex disease offer to clinical practice?

    Lango H, Weedon MN.

    J Intern Med. 2008 Jan;263(1):16-27. Review.PMID: 18088250 [PubMed - indexed for MEDLINE]Related articles

    28.

    Association scan of 14,500 nonsynonymous SNPs in four diseases identifies autoimmunity variants.

    Wellcome Trust Case Control Consortium; Australo-Anglo-American Spondylitis Consortium (TASC), Burton PR, Clayton DG, Cardon LR, Craddock N, Deloukas P, Duncanson A, Kwiatkowski DP, McCarthy MI, Ouwehand WH, Samani NJ, Todd JA, Donnelly P, Barrett JC, Davison D, Easton D, Evans DM, Leung HT, Marchini JL, Morris AP, Spencer CC, Tobin MD, Attwood AP, Boorman JP, Cant B, Everson U, Hussey JM, Jolley JD, Knight AS, Koch K, Meech E, Nutland S, Prowse CV, Stevens HE, Taylor NC, Walters GR, Walker NM, Watkins NA, Winzer T, Jones RW, McArdle WL, Ring SM, Strachan DP, Pembrey M, Breen G, St Clair D, Caesar S, Gordon-Smith K, Jones L, Fraser C, Green EK, Grozeva D, Hamshere ML, Holmans PA, Jones IR, Kirov G, Moskivina V, Nikolov I, O'Donovan MC, Owen MJ, Collier DA, Elkin A, Farmer A, Williamson R, McGuffin P, Young AH, Ferrier IN, Ball SG, Balmforth AJ, Barrett JH, Bishop TD, Iles MM, Maqbool A, Yuldasheva N, Hall AS, Braund PS, Dixon RJ, Mangino M, Stevens S, Thompson JR, Bredin F, Tremelling M, Parkes M, Drummond H, Lees CW, Nimmo ER, Satsangi J, Fisher SA, Forbes A, Lewis CM, Onnie CM, Prescott NJ, Sanderson J, Matthew CG, Barbour J, Mohiuddin MK, Todhunter CE, Mansfield JC, Ahmad T, Cummings FR, Jewell DP, Webster J, Brown MJ, Lathrop MG, Connell J, Dominiczak A, Marcano CA, Burke B, Dobson R, Gungadoo J, Lee KL, Munroe PB, Newhouse SJ, Onipinla A, Wallace C, Xue M, Caulfield M, Farrall M, Barton A; Biologics in RA Genetics and Genomics Study Syndicate (BRAGGS) Steering Committee, Bruce IN, Donovan H, Eyre S, Gilbert PD, Hilder SL, Hinks AM, John SL, Potter C, Silman AJ, Symmons DP, Thomson W, Worthington J, Dunger DB, Widmer B, Frayling TM, Freathy RM, Lango H, Perry JR, Shields BM, Weedon MN, Hattersley AT, Hitman GA, Walker M, Elliott KS, Groves CJ, Lindgren CM, Rayner NW, Timpson NJ, Zeggini E, Newport M, Sirugo G, Lyons E, Vannberg F, Hill AV, Bradbury LA, Farrar C, Pointon JJ, Wordsworth P, Brown MA, Franklyn JA, Heward JM, Simmonds MJ, Gough SC, Seal S; Breast Cancer Susceptibility Collaboration (UK), Stratton MR, Rahman N, Ban M, Goris A, Sawcer SJ, Compston A, Conway D, Jallow M, Newport M, Sirugo G, Rockett KA, Bumpstead SJ, Chaney A, Downes K, Ghori MJ, Gwilliam R, Hunt SE, Inouye M, Keniry A, King E, McGinnis R, Potter S, Ravindrarajah R, Whittaker P, Widden C, Withers D, Cardin NJ, Davison D, Ferreira T, Pereira-Gale J, Hallgrimsdo'ttir IB, Howie BN, Su Z, Teo YY, Vukcevic D, Bentley D, Brown MA, Compston A, Farrall M, Hall AS, Hattersley AT, Hill AV, Parkes M, Pembrey M, Stratton MR, Mitchell SL, Newby PR, Brand OJ, Carr-Smith J, Pearce SH, McGinnis R, Keniry A, Deloukas P, Reveille JD, Zhou X, Sims AM, Dowling A, Taylor J, Doan T, Davis JC, Savage L, Ward MM, Learch TL, Weisman MH, Brown M.

    Nat Genet. 2007 Nov;39(11):1329-37. Epub 2007 Oct 21.PMID: 17952073 [PubMed - indexed for MEDLINE]Related articlesFree article

    29.

    The importance of TCF7L2.

    Weedon MN.

    Diabet Med. 2007 Oct;24(10):1062-6. Review.PMID: 17888129 [PubMed - indexed for MEDLINE]Related articles

    30.

    Common variants of the novel type 2 diabetes genes CDKAL1 and HHEX/IDE are associated with decreased pancreatic beta-cell function.

    Pascoe L, Tura A, Patel SK, Ibrahim IM, Ferrannini E, Zeggini E, Weedon MN, Mari A, Hattersley AT, McCarthy MI, Frayling TM, Walker M; RISC Consortium; U.K. Type 2 Diabetes Genetics Consortium.

    Diabetes. 2007 Dec;56(12):3101-4. Epub 2007 Sep 5.PMID: 17804762 [PubMed - indexed for MEDLINE]Related articlesFree article

    31.

    A common variant of HMGA2 is associated with adult and childhood height in the general population.

    Weedon MN, Lettre G, Freathy RM, Lindgren CM, Voight BF, Perry JR, Elliott KS, Hackett R, Guiducci C, Shields B, Zeggini E, Lango H, Lyssenko V, Timpson NJ, Burtt NP, Rayner NW, Saxena R, Ardlie K, Tobias JH, Ness AR, Ring SM, Palmer CN, Morris AD, Peltonen L, Salomaa V; Diabetes Genetics Initiative; Wellcome Trust Case Control Consortium, Davey Smith G, Groop LC, Hattersley AT, McCarthy MI, Hirschhorn JN, Frayling TM.

    Nat Genet. 2007 Oct;39(10):1245-50. Epub 2007 Sep 2.PMID: 17767157 [PubMed - indexed for MEDLINE]Related articles

    32.

    The transcription factor 7-like 2 (TCF7L2) gene is associated with Type 2 diabetes in UK community-based cases, but the risk allele frequency is reduced compared with UK cases selected for genetic studies.

    De Silva NM, Steele A, Shields B, Knight B, Parnell K, Weedon MN, Hattersley AT, Frayling TM.

    Diabet Med. 2007 Oct;24(10):1067-72. Epub 2007 Aug 24.PMID: 17725629 [PubMed - indexed for MEDLINE]Related articles

    33.

    A common variant of the interleukin 6 receptor (IL-6r) gene increases IL-6r and IL-6 levels, without other inflammatory effects.

    Rafiq S, Frayling TM, Murray A, Hurst A, Stevens K, Weedon MN, Henley W, Ferrucci L, Bandinelli S, Corsi AM, Guralnik JM, Melzer D.

    Genes Immun. 2007 Oct;8(7):552-9. Epub 2007 Aug 2.PMID: 17671508 [PubMed - indexed for MEDLINE]Related articlesFree article

    34.

    Common variants in WFS1 confer risk of type 2 diabetes.

    Sandhu MS, Weedon MN, Fawcett KA, Wasson J, Debenham SL, Daly A, Lango H, Frayling TM, Neumann RJ, Sherva R, Blech I, Pharoah PD, Palmer CN, Kimber C, Tavendale R, Morris AD, McCarthy MI, Walker M, Hitman G, Glaser B, Permutt MA, Hattersley AT, Wareham NJ, Barroso I.

    Nat Genet. 2007 Aug;39(8):951-3. Epub 2007 Jul 1.PMID: 17603484 [PubMed - indexed for MEDLINE]Related articlesFree article

    35.

    Type 2 diabetes TCF7L2 risk genotypes alter birth weight: a study of 24,053 individuals.

    Freathy RM, Weedon MN, Bennett A, Hypponen E, Relton CL, Knight B, Shields B, Parnell KS, Groves CJ, Ring SM, Pembrey ME, Ben-Shlomo Y, Strachan DP, Power C, Jarvelin MR, McCarthy MI, Davey Smith G, Hattersley AT, Frayling TM.

    Am J Hum Genet. 2007 Jun;80(6):1150-61. Epub 2007 Apr 23.PMID: 17503332 [PubMed - indexed for MEDLINE]Related articlesFree article

    36.

    Replication of genome-wide association signals in UK samples reveals risk loci for type 2 diabetes.

    Zeggini E, Weedon MN, Lindgren CM, Frayling TM, Elliott KS, Lango H, Timpson NJ, Perry JR, Rayner NW, Freathy RM, Barrett JC, Shields B, Morris AP, Ellard S, Groves CJ, Harries LW, Marchini JL, Owen KR, Knight B, Cardon LR, Walker M, Hitman GA, Morris AD, Doney AS; Wellcome Trust Case Control Consortium (WTCCC), McCarthy MI, Hattersley AT.

    Science. 2007 Jun 1;316(5829):1336-41. Epub 2007 Apr 26. Erratum in: Science. 2007 Aug 24;317(5841):1035-6. PMID: 17463249 [PubMed - indexed for MEDLINE]Related articlesFree article

    37.

    Common genetic variation in the gene encoding interleukin-1-receptor antagonist (IL-1RA) is associated with altered circulating IL-1RA levels.

    Rafiq S, Stevens K, Hurst AJ, Murray A, Henley W, Weedon MN, Bandinelli S, Corsi AM, Guralnik JM, Ferruci L, Melzer D, Frayling TM.

    Genes Immun. 2007 Jun;8(4):344-51. Epub 2007 Apr 19.PMID: 17443229 [PubMed - indexed for MEDLINE]Related articles

    38.

    A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity.

    Frayling TM, Timpson NJ, Weedon MN, Zeggini E, Freathy RM, Lindgren CM, Perry JR, Elliott KS, Lango H, Rayner NW, Shields B, Harries LW, Barrett JC, Ellard S, Groves CJ, Knight B, Patch AM, Ness AR, Ebrahim S, Lawlor DA, Ring SM, Ben-Shlomo Y, Jarvelin MR, Sovio U, Bennett AJ, Melzer D, Ferrucci L, Loos RJ, Barroso I, Wareham NJ, Karpe F, Owen KR, Cardon LR, Walker M, Hitman GA, Palmer CN, Doney AS, Morris AD, Smith GD, Hattersley AT, McCarthy MI.

    Science. 2007 May 11;316(5826):889-94. Epub 2007 Apr 12.PMID: 17434869 [PubMed - indexed for MEDLINE]Related articlesFree article

    39.

    Insights on pathogenesis of type 2 diabetes from MODY genetics.

    Weedon MN, Frayling TM.

    Curr Diab Rep. 2007 Apr;7(2):131-8. Review.PMID: 17425917 [PubMed - indexed for MEDLINE]Related articles

    40.

    Relationship between E23K (an established type II diabetes-susceptibility variant within KCNJ11), polycystic ovary syndrome and androgen levels.

    Barber TM, Bennett AJ, Gloyn AL, Groves CJ, Sovio U, Ruokonen A, Martikainen H, Pouta A, Taponen S, Weedon MN, Hartikainen AL, Wass JA, Järvelin MR, Zeggini E, Franks S, McCarthy MI.

    Eur J Hum Genet. 2007 Jun;15(6):679-84. Epub 2007 Mar 7.PMID: 17342155 [PubMed - indexed for MEDLINE]Related articlesFree article

    41.

    Evaluation of common variants in the six known maturity-onset diabetes of the young (MODY) genes for association with type 2 diabetes.

    Winckler W, Weedon MN, Graham RR, McCarroll SA, Purcell S, Almgren P, Tuomi T, Gaudet D, Boström KB, Walker M, Hitman G, Hattersley AT, McCarthy MI, Ardlie KG, Hirschhorn JN, Daly MJ, Frayling TM, Groop L, Altshuler D.

    Diabetes. 2007 Mar;56(3):685-93.PMID: 17327436 [PubMed - indexed for MEDLINE]Related articlesFree article

    42.

    An interleukin-18 polymorphism is associated with reduced serum concentrations and better physical functioning in older people.

    Frayling TM, Rafiq S, Murray A, Hurst AJ, Weedon MN, Henley W, Bandinelli S, Corsi AM, Ferrucci L, Guralnik JM, Wallace RB, Melzer D.

    J Gerontol A Biol Sci Med Sci. 2007 Jan;62(1):73-8.PMID: 17301041 [PubMed - indexed for MEDLINE]Related articlesFree article

    43.

    A common haplotype of the glucokinase gene alters fasting glucose and birth weight: association in six studies and population-genetics analyses.

    Weedon MN, Clark VJ, Qian Y, Ben-Shlomo Y, Timpson N, Ebrahim S, Lawlor DA, Pembrey ME, Ring S, Wilkin TJ, Voss LD, Jeffery AN, Metcalf B, Ferrucci L, Corsi AM, Murray A, Melzer D, Knight B, Shields B, Smith GD, Hattersley AT, Di Rienzo A, Frayling TM.

    Am J Hum Genet. 2006 Dec;79(6):991-1001. Epub 2006 Oct 6.PMID: 17186458 [PubMed - indexed for MEDLINE]Related articlesFree article

    44.

    Effects of the diabetes linked TCF7L2 polymorphism in a representative older population.

    Melzer D, Murray A, Hurst AJ, Weedon MN, Bandinelli S, Corsi AM, Ferrucci L, Paolisso G, Guralnik JM, Frayling TM.

    BMC Med. 2006 Dec 20;4:34.PMID: 17181866 [PubMed - indexed for MEDLINE]Related articlesFree article

    45.

    A study of association between common variation in the growth hormone-chorionic somatomammotropin hormone gene cluster and adult fasting insulin in a UK Caucasian population.

    Freathy RM, Mitchell SM, Knight B, Shields B, Weedon MN, Hattersley AT, Frayling TM.

    J Negat Results Biomed. 2006 Nov 24;5:18.PMID: 17125497 [PubMed - indexed for MEDLINE]Related articlesFree article

    46.

    No evidence of association of ENPP1 variants with type 2 diabetes or obesity in a study of 8,089 U.K. Caucasians.

    Weedon MN, Shields B, Hitman G, Walker M, McCarthy MI, Hattersley AT, Frayling TM.

    Diabetes. 2006 Nov;55(11):3175-9.PMID: 17065358 [PubMed - indexed for MEDLINE]Related articlesFree article

    47.

    Triglyceride associated polymorphisms of the APOA5 gene have very different allele frequencies in Pune, India compared to Europeans.

    Chandak GR, Ward KJ, Yajnik CS, Pandit AN, Bavdekar A, Joglekar CV, Fall CH, Mohankrishna P, Wilkin TJ, Metcalf BS, Weedon MN, Frayling TM, Hattersley AT.

    BMC Med Genet. 2006 Oct 10;7:76.PMID: 17032446 [PubMed - indexed for MEDLINE]Related articlesFree article

    48.

    Combining information from common type 2 diabetes risk polymorphisms improves disease prediction.

    Weedon MN, McCarthy MI, Hitman G, Walker M, Groves CJ, Zeggini E, Rayner NW, Shields B, Owen KR, Hattersley AT, Frayling TM.

    PLoS Med. 2006 Oct;3(10):e374.PMID: 17020404 [PubMed - indexed for MEDLINE]Related articlesFree article

    49.

    Association analysis of 6,736 U.K. subjects provides replication and confirms TCF7L2 as a type 2 diabetes susceptibility gene with a substantial effect on individual risk.

    Groves CJ, Zeggini E, Minton J, Frayling TM, Weedon MN, Rayner NW, Hitman GA, Walker M, Wiltshire S, Hattersley AT, McCarthy MI.

    Diabetes. 2006 Sep;55(9):2640-4. Erratum in: Diabetes. 2006 Dec;55(12):3635. PMID: 16936215 [PubMed - indexed for MEDLINE]Related articlesFree article

    50.

    Assessment of the role of common genetic variation in the transient neonatal diabetes mellitus (TNDM) region in type 2 diabetes: a comparative genomic and tagging single nucleotide polymorphism approach.

    Gloyn AL, Mackay DJ, Weedon MN, McCarthy MI, Walker M, Hitman G, Knight BA, Owen KR, Hattersley AT, Frayling TM.

    Diabetes. 2006 Aug;55(8):2272-6.PMID: 16873690 [PubMed - indexed for MEDLINE]Related articlesFree article

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