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    Results: 1 to 50 of 130

    1.

    Acetaminophen dosing of humans results in blood transcriptome and metabolome changes consistent with impaired oxidative phosphorylation.

    Fannin RD, Russo M, O'Connell TM, Gerrish K, Winnike JH, Macdonald J, Newton J, Malik S, Sieber SO, Parker J, Shah R, Zhou T, Watkins PB, Paules RS.

    Hepatology. 2009 Sep 25. [Epub ahead of print]PMID: 19918972 [PubMed - as supplied by publisher]Related articles

    2.

    Effects of a prolonged standardized diet on normalizing the human metabolome.

    Winnike JH, Busby MG, Watkins PB, O'Connell TM.

    Am J Clin Nutr. 2009 Oct 28. [Epub ahead of print]PMID: 19864408 [PubMed - as supplied by publisher]Related articles

    3.

    Biomarkers for the diagnosis and management of drug-induced liver injury.

    Watkins PB.

    Semin Liver Dis. 2009 Nov;29(4):393-9. Epub 2009 Oct 13.PMID: 19826973 [PubMed - in process]Related articles

    4.

    Mouse population-guided resequencing reveals that variants in CD44 contribute to acetaminophen-induced liver injury in humans.

    Harrill AH, Watkins PB, Su S, Ross PK, Harbourt DE, Stylianou IM, Boorman GA, Russo MW, Sackler RS, Harris SC, Smith PC, Tennant R, Bogue M, Paigen K, Harris C, Contractor T, Wiltshire T, Rusyn I, Threadgill DW.

    Genome Res. 2009 Sep;19(9):1507-15. Epub 2009 May 5.PMID: 19416960 [PubMed - in process]Related articles

    5.

    Toxicogenomics: transcription profiling for toxicology assessment.

    Zhou T, Chou J, Watkins PB, Kaufmann WK.

    EXS. 2009;99:325-66. Review.PMID: 19157067 [PubMed - indexed for MEDLINE]Related articles

    6.

    Drug-Induced Liver Injury Network (DILIN) prospective study: rationale, design and conduct.

    Fontana RJ, Watkins PB, Bonkovsky HL, Chalasani N, Davern T, Serrano J, Rochon J; DILIN Study Group.

    Drug Saf. 2009;32(1):55-68. doi: 10.2165/00002018-200932010-00005.PMID: 19132805 [PubMed - indexed for MEDLINE]Related articles

    7.

    Causes, clinical features, and outcomes from a prospective study of drug-induced liver injury in the United States.

    Chalasani N, Fontana RJ, Bonkovsky HL, Watkins PB, Davern T, Serrano J, Yang H, Rochon J; Drug Induced Liver Injury Network (DILIN).

    Gastroenterology. 2008 Dec;135(6):1924-34, 1934.e1-4. Epub 2008 Sep 17.PMID: 18955056 [PubMed - indexed for MEDLINE]Related articles

    8.

    Using controlled clinical trials to learn more about acute drug-induced liver injury.

    Watkins PB, Seligman PJ, Pears JS, Avigan MI, Senior JR.

    Hepatology. 2008 Nov;48(5):1680-9.PMID: 18853438 [PubMed - indexed for MEDLINE]Related articles

    9.

    Reliability of the Roussel Uclaf Causality Assessment Method for assessing causality in drug-induced liver injury.

    Rochon J, Protiva P, Seeff LB, Fontana RJ, Liangpunsakul S, Watkins PB, Davern T, McHutchison JG; Drug-Induced Liver Injury Network (DILIN).

    Hepatology. 2008 Oct;48(4):1175-83.PMID: 18798340 [PubMed - indexed for MEDLINE]Related articles

    10.

    Drug-induced liver injury network.

    Watkins PB.

    Am J Gastroenterol. 2008 Jun;103(6):1574-5. No abstract available. PMID: 18510620 [PubMed - indexed for MEDLINE]Related articles

    11.

    Further characterization of a furanocoumarin-free grapefruit juice on drug disposition: studies with cyclosporine.

    Paine MF, Widmer WW, Pusek SN, Beavers KL, Criss AB, Snyder J, Watkins PB.

    Am J Clin Nutr. 2008 Apr;87(4):863-71.PMID: 18400708 [PubMed - indexed for MEDLINE]Related articlesFree article

    12.

    The Environmental Polymorphisms Registry: a DNA resource to study genetic susceptibility loci.

    Chulada PC, Vahdat HL, Sharp RR, DeLozier TC, Watkins PB, Pusek SN, Blackshear PJ.

    Hum Genet. 2008 Mar;123(2):207-14. Epub 2008 Jan 10.PMID: 18193459 [PubMed - indexed for MEDLINE]Related articles

    13.

    Blood gene expression signatures predict exposure levels.

    Bushel PR, Heinloth AN, Li J, Huang L, Chou JW, Boorman GA, Malarkey DE, Houle CD, Ward SM, Wilson RE, Fannin RD, Russo MW, Watkins PB, Tennant RW, Paules RS.

    Proc Natl Acad Sci U S A. 2007 Nov 13;104(46):18211-6. Epub 2007 Nov 2.PMID: 17984051 [PubMed - indexed for MEDLINE]Related articlesFree article

    14.

    Identifying genetic risk factors for serious adverse drug reactions: current progress and challenges.

    Wilke RA, Lin DW, Roden DM, Watkins PB, Flockhart D, Zineh I, Giacomini KM, Krauss RM.

    Nat Rev Drug Discov. 2007 Nov;6(11):904-16. Review. Erratum in: Nat Rev Drug Discov. 2008 Feb;7(2):185. PMID: 17971785 [PubMed - indexed for MEDLINE]Related articlesFree article

    15.

    The influence of CYP3A5 expression on the extent of hepatic CYP3A inhibition is substrate-dependent: an in vitro-in vivo evaluation.

    Isoherranen N, Ludington SR, Givens RC, Lamba JK, Pusek SN, Dees EC, Blough DK, Iwanaga K, Hawke RL, Schuetz EG, Watkins PB, Thummel KE, Paine MF.

    Drug Metab Dispos. 2008 Jan;36(1):146-54. Epub 2007 Oct 22.PMID: 17954524 [PubMed - indexed for MEDLINE]Related articlesFree article

    16.

    Tolcapone: an efficacy and safety review (2007).

    Olanow CW, Watkins PB.

    Clin Neuropharmacol. 2007 Sep-Oct;30(5):287-94. Review.PMID: 17909307 [PubMed - indexed for MEDLINE]Related articles

    17.

    Clinical pattern of zileuton-associated liver injury: results of a 12-month study in patients with chronic asthma.

    Watkins PB, Dube LM, Walton-Bowen K, Cameron CM, Kasten LE.

    Drug Saf. 2007;30(9):805-15.PMID: 17722971 [PubMed - indexed for MEDLINE]Related articles

    18.

    Differential inhibition of rat and human Na+-dependent taurocholate cotransporting polypeptide (NTCP/SLC10A1)by bosentan: a mechanism for species differences in hepatotoxicity.

    Leslie EM, Watkins PB, Kim RB, Brouwer KL.

    J Pharmacol Exp Ther. 2007 Jun;321(3):1170-8. Epub 2007 Mar 20.PMID: 17374746 [PubMed - indexed for MEDLINE]Related articlesFree article

    19.

    Aminotransferase elevations in healthy adults receiving 4 grams of acetaminophen daily: a randomized controlled trial.

    Watkins PB, Kaplowitz N, Slattery JT, Colonese CR, Colucci SV, Stewart PW, Harris SC.

    JAMA. 2006 Jul 5;296(1):87-93.PMID: 16820551 [PubMed - indexed for MEDLINE]Related articlesFree article

    20.

    Increased CYP3A4 copy number in TONG/HCC cells but not in DNA from other humans.

    Lamba JK, Chen X, Lan LB, Kim JW, Wei Wang X, Relling MV, Kazuto Y, Watkins PB, Strom S, Sun D, Schuetz JD, Schuetz EG.

    Pharmacogenet Genomics. 2006 Jun;16(6):415-27.PMID: 16708050 [PubMed - indexed for MEDLINE]Related articles

    21.

    Steroid and xenobiotic receptor and vitamin D receptor crosstalk mediates CYP24 expression and drug-induced osteomalacia.

    Zhou C, Assem M, Tay JC, Watkins PB, Blumberg B, Schuetz EG, Thummel KE.

    J Clin Invest. 2006 Jun;116(6):1703-12. Epub 2006 May 11.PMID: 16691293 [PubMed - indexed for MEDLINE]Related articlesFree article

    22.

    A furanocoumarin-free grapefruit juice establishes furanocoumarins as the mediators of the grapefruit juice-felodipine interaction.

    Paine MF, Widmer WW, Hart HL, Pusek SN, Beavers KL, Criss AB, Brown SS, Thomas BF, Watkins PB.

    Am J Clin Nutr. 2006 May;83(5):1097-105. Erratum in: Am J Clin Nutr. 2006 Jul;84(1):264. PMID: 16685052 [PubMed - indexed for MEDLINE]Related articlesFree article

    23.

    MDR1 genotype is associated with hepatic cytochrome P450 3A4 basal and induction phenotype.

    Lamba J, Strom S, Venkataramanan R, Thummel KE, Lin YS, Liu W, Cheng C, Lamba V, Watkins PB, Schuetz E.

    Clin Pharmacol Ther. 2006 Apr;79(4):325-38. Epub 2006 Feb 20.PMID: 16580901 [PubMed - indexed for MEDLINE]Related articles

    24.

    Drug-induced liver injury: summary of a single topic clinical research conference.

    Watkins PB, Seeff LB.

    Hepatology. 2006 Mar;43(3):618-31.PMID: 16496329 [PubMed - indexed for MEDLINE]Related articles

    25.

    Variation in oral clearance of saquinavir is predicted by CYP3A5*1 genotype but not by enterocyte content of cytochrome P450 3A5.

    Mouly SJ, Matheny C, Paine MF, Smith G, Lamba J, Lamba V, Pusek SN, Schuetz EG, Stewart PW, Watkins PB.

    Clin Pharmacol Ther. 2005 Dec;78(6):605-18.PMID: 16338276 [PubMed - indexed for MEDLINE]Related articles

    26.

    Intestinal and hepatic CYP3A4 catalyze hydroxylation of 1alpha,25-dihydroxyvitamin D(3): implications for drug-induced osteomalacia.

    Xu Y, Hashizume T, Shuhart MC, Davis CL, Nelson WL, Sakaki T, Kalhorn TF, Watkins PB, Schuetz EG, Thummel KE.

    Mol Pharmacol. 2006 Jan;69(1):56-65. Epub 2005 Oct 5.PMID: 16207822 [PubMed - indexed for MEDLINE]Related articlesFree article

    27.

    CYP3A probes can quantitatively predict the in vivo kinetics of other CYP3A substrates and can accurately assess CYP3A induction and inhibition.

    Kharasch ED, Thummel KE, Watkins PB.

    Mol Interv. 2005 Jun;5(3):151-3.PMID: 15994453 [PubMed - indexed for MEDLINE]Related articlesFree article

    28.

    Idiosyncratic liver injury: challenges and approaches.

    Watkins PB.

    Toxicol Pathol. 2005;33(1):1-5.PMID: 15805049 [PubMed - indexed for MEDLINE]Related articles

    29.

    Insight into hepatotoxicity: The troglitazone experience.

    Watkins PB.

    Hepatology. 2005 Feb;41(2):229-30. No abstract available. PMID: 15657920 [PubMed - indexed for MEDLINE]Related articles

    30.

    Role of cytochrome P450 phenotyping in cancer treatment.

    Dees EC, Watkins PB.

    J Clin Oncol. 2005 Feb 20;23(6):1053-5. Epub 2005 Jan 18. No abstract available. PMID: 15657406 [PubMed - indexed for MEDLINE]Related articles

    31.

    Do men and women differ in proximal small intestinal CYP3A or P-glycoprotein expression?

    Paine MF, Ludington SS, Chen ML, Stewart PW, Huang SM, Watkins PB.

    Drug Metab Dispos. 2005 Mar;33(3):426-33. Epub 2004 Dec 17.PMID: 15608139 [PubMed - indexed for MEDLINE]Related articlesFree article

    32.

    Two major grapefruit juice components differ in time to onset of intestinal CYP3A4 inhibition.

    Paine MF, Criss AB, Watkins PB.

    J Pharmacol Exp Ther. 2005 Mar;312(3):1151-60. Epub 2004 Oct 14.PMID: 15485894 [PubMed - indexed for MEDLINE]Related articlesFree article

    33.

    New insights into drug absorption: studies with sirolimus.

    Paine MF, Leung LY, Watkins PB.

    Ther Drug Monit. 2004 Oct;26(5):463-7. Review.PMID: 15385826 [PubMed - indexed for MEDLINE]Related articles

    34.

    Two major grapefruit juice components differ in intestinal CYP3A4 inhibition kinetic and binding properties.

    Paine MF, Criss AB, Watkins PB.

    Drug Metab Dispos. 2004 Oct;32(10):1146-53. Epub 2004 Jul 21.PMID: 15269184 [PubMed - indexed for MEDLINE]Related articlesFree article

    35.

    6'7'-Dihydroxybergamottin contributes to the grapefruit juice effect.

    Kakar SM, Paine MF, Stewart PW, Watkins PB.

    Clin Pharmacol Ther. 2004 Jun;75(6):569-79.PMID: 15179411 [PubMed - indexed for MEDLINE]Related articles

    36.

    PharmGKB update: II. CYP3A5, cytochrome P450, family 3, subfamily A, polypeptide 5.

    Schuetz EG, Relling MV, Kishi S, Yang W, Das S, Chen P, Cook EH, Rosner GL, Pui CH, Blanco JG, Edick MJ, Hancock ML, Winick NJ, Dervieux T, Amylon MD, Bash RO, Behm FG, Camitta BM, Raimondi SC, Goh BC, Lee SC, Wang LZ, Fan L, Guo JY, Lamba J, Lim R, Lim HL, Ong AB, Lee HS, Kuehl P, Zhang J, Lin Y, Assem M, Schuetz J, Watkins PB, Daly A, Wrighton SA, Hall SD, Maurel P, Brimer C, Yasuda K, Venkataramanan R, Strom S, Thummel K, Boguski MS.

    Pharmacol Rev. 2004 Jun;56(2):159. No abstract available. PMID: 15169924 [PubMed - indexed for MEDLINE]Related articlesFree article

    37.

    Are patients with elevated liver tests at increased risk of drug-induced liver injury?

    Russo MW, Watkins PB.

    Gastroenterology. 2004 May;126(5):1477-80. No abstract available. PMID: 15131809 [PubMed - indexed for MEDLINE]Related articles

    38.

    Contributions of CYP3A4, P-glycoprotein, and serum protein binding to the intestinal first-pass extraction of saquinavir.

    Mouly SJ, Paine MF, Watkins PB.

    J Pharmacol Exp Ther. 2004 Mar;308(3):941-8. Epub 2004 Jan 8.PMID: 14718607 [PubMed - indexed for MEDLINE]Related articlesFree article

    39.

    Contribution of hepatic cytochrome P450 3A4 metabolic activity to the phenomenon of clopidogrel resistance.

    Lau WC, Gurbel PA, Watkins PB, Neer CJ, Hopp AS, Carville DG, Guyer KE, Tait AR, Bates ER.

    Circulation. 2004 Jan 20;109(2):166-71. Epub 2004 Jan 5.PMID: 14707025 [PubMed - indexed for MEDLINE]Related articlesFree article

    40.

    Pharmacogenetics and clinical gastroenterology.

    Givens RC, Watkins PB.

    Gastroenterology. 2003 Jul;125(1):240-8. Review.PMID: 12851888 [PubMed - indexed for MEDLINE]Related articles

    41.

    CYP3A5 genotype predicts renal CYP3A activity and blood pressure in healthy adults.

    Givens RC, Lin YS, Dowling AL, Thummel KE, Lamba JK, Schuetz EG, Stewart PW, Watkins PB.

    J Appl Physiol. 2003 Sep;95(3):1297-300. Epub 2003 May 16.PMID: 12754175 [PubMed - indexed for MEDLINE]Related articlesFree article

    42.

    Did this drug cause my patient's hepatitis?

    Kaplowitz N, Lewis JH, Watkins PB.

    Ann Intern Med. 2003 Jan 21;138(2):159-60; author reply 159-60. No abstract available. PMID: 12529106 [PubMed - indexed for MEDLINE]Related articlesFree article

    43.

    Atorvastatin reduces the ability of clopidogrel to inhibit platelet aggregation: a new drug-drug interaction.

    Lau WC, Waskell LA, Watkins PB, Neer CJ, Horowitz K, Hopp AS, Tait AR, Carville DG, Guyer KE, Bates ER.

    Circulation. 2003 Jan 7;107(1):32-7.PMID: 12515739 [PubMed - indexed for MEDLINE]Related articlesFree article

    44.

    Is quinine a suitable probe to assess the hepatic drug-metabolizing enzyme CYP3A4?

    Wanwimolruk S, Paine MF, Pusek SN, Watkins PB.

    Br J Clin Pharmacol. 2002 Dec;54(6):643-51.PMID: 12492613 [PubMed - indexed for MEDLINE]Related articlesFree article

    45.

    Cytochrome P450 3A4 and P-glycoprotein mediate the interaction between an oral erythromycin breath test and rifampin.

    Paine MF, Wagner DA, Hoffmaster KA, Watkins PB.

    Clin Pharmacol Ther. 2002 Nov;72(5):524-35.PMID: 12426516 [PubMed - indexed for MEDLINE]Related articles

    46.

    Growth hormone secretion pattern is an independent regulator of growth hormone actions in humans.

    Jaffe CA, Turgeon DK, Lown K, Demott-Friberg R, Watkins PB.

    Am J Physiol Endocrinol Metab. 2002 Nov;283(5):E1008-15.PMID: 12376329 [PubMed - indexed for MEDLINE]Related articlesFree article

    47.

    Hepatic but not intestinal CYP3A4 displays dose-dependent induction by efavirenz in humans.

    Mouly S, Lown KS, Kornhauser D, Joseph JL, Fiske WD, Benedek IH, Watkins PB.

    Clin Pharmacol Ther. 2002 Jul;72(1):1-9.PMID: 12151999 [PubMed - indexed for MEDLINE]Related articles

    48.

    Identification of a novel route of extraction of sirolimus in human small intestine: roles of metabolism and secretion.

    Paine MF, Leung LY, Lim HK, Liao K, Oganesian A, Zhang MY, Thummel KE, Watkins PB.

    J Pharmacol Exp Ther. 2002 Apr;301(1):174-86.PMID: 11907172 [PubMed - indexed for MEDLINE]Related articlesFree article

    49.

    Common allelic variants of cytochrome P4503A4 and their prevalence in different populations.

    Lamba JK, Lin YS, Thummel K, Daly A, Watkins PB, Strom S, Zhang J, Schuetz EG.

    Pharmacogenetics. 2002 Mar;12(2):121-32.PMID: 11875366 [PubMed - indexed for MEDLINE]Related articles

    50.

    In-vivo phenotyping for CYP3A by a single-point determination of midazolam plasma concentration.

    Lin YS, Lockwood GF, Graham MA, Brian WR, Loi CM, Dobrinska MR, Shen DD, Watkins PB, Wilkinson GR, Kharasch ED, Thummel KE.

    Pharmacogenetics. 2001 Dec;11(9):781-91.PMID: 11740342 [PubMed - indexed for MEDLINE]Related articles

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