PubMed

ADDITIVE EFFECTS OF GENETIC VARIATION IN GCK AND G6PC2 ON INSULIN SECRETION AND FASTING GLUCOSE.

Li X, Shu YH, Xiang AH, Trigo E, Kuusisto J, Hartiala J, Swift AJ, Kawakubo M, Stringham HM, Bonnycastle LL, Lawrence JM, Laakso M, Allayee H, Buchanan TA, Watanabe RM.

Diabetes. 2009 Sep 9. [Epub ahead of print]PMID: 19741163 [PubMed - as supplied by publisher]Related articles

Evidence for sex-specific associations between variation in acid phosphatase locus 1 (ACP1) and insulin sensitivity in Mexican-Americans.

Shu YH, Hartiala J, Xiang AH, Trigo E, Lawrence JM, Allayee H, Buchanan TA, Bottini N, Watanabe RM.

J Clin Endocrinol Metab. 2009 Oct;94(10):4094-102. Epub 2009 Jul 21.PMID: 19622628 [PubMed - indexed for MEDLINE]Related articles

Obesity attenuates the contribution of African admixture to the insulin secretory profile in peripubertal children: a longitudinal analysis.

Casazza K, Phadke RP, Fernandez JR, Watanabe RM, Goran MI, Gower BA.

Obesity (Silver Spring). 2009 Jul;17(7):1318-25. Epub 2009 Feb 5.PMID: 19197265 [PubMed - indexed for MEDLINE]Related articles

Variation in IGF2BP2 interacts with adiposity to alter insulin sensitivity in Mexican Americans.

Li X, Allayee H, Xiang AH, Trigo E, Hartiala J, Lawrence JM, Buchanan TA, Watanabe RM.

Obesity (Silver Spring). 2009 Apr;17(4):729-36. Epub 2009 Jan 15.PMID: 19148120 [PubMed - indexed for MEDLINE]Related articles

Six new loci associated with body mass index highlight a neuronal influence on body weight regulation.

Willer CJ, Speliotes EK, Loos RJ, Li S, Lindgren CM, Heid IM, Berndt SI, Elliott AL, Jackson AU, Lamina C, Lettre G, Lim N, Lyon HN, McCarroll SA, Papadakis K, Qi L, Randall JC, Roccasecca RM, Sanna S, Scheet P, Weedon MN, Wheeler E, Zhao JH, Jacobs LC, Prokopenko I, Soranzo N, Tanaka T, Timpson NJ, Almgren P, Bennett A, Bergman RN, Bingham SA, Bonnycastle LL, Brown M, Burtt NP, Chines P, Coin L, Collins FS, Connell JM, Cooper C, Smith GD, Dennison EM, Deodhar P, Elliott P, Erdos MR, Estrada K, Evans DM, Gianniny L, Gieger C, Gillson CJ, Guiducci C, Hackett R, Hadley D, Hall AS, Havulinna AS, Hebebrand J, Hofman A, Isomaa B, Jacobs KB, Johnson T, Jousilahti P, Jovanovic Z, Khaw KT, Kraft P, Kuokkanen M, Kuusisto J, Laitinen J, Lakatta EG, Luan J, Luben RN, Mangino M, McArdle WL, Meitinger T, Mulas A, Munroe PB, Narisu N, Ness AR, Northstone K, O'Rahilly S, Purmann C, Rees MG, Ridderstråle M, Ring SM, Rivadeneira F, Ruokonen A, Sandhu MS, Saramies J, Scott LJ, Scuteri A, Silander K, Sims MA, Song K, Stephens J, Stevens S, Stringham HM, Tung YC, Valle TT, Van Duijn CM, Vimaleswaran KS, Vollenweider P, Waeber G, Wallace C, Watanabe RM, Waterworth DM, Watkins N; Wellcome Trust Case Control Consortium, Witteman JC, Zeggini E, Zhai G, Zillikens MC, Altshuler D, Caulfield MJ, Chanock SJ, Farooqi IS, Ferrucci L, Guralnik JM, Hattersley AT, Hu FB, Jarvelin MR, Laakso M, Mooser V, Ong KK, Ouwehand WH, Salomaa V, Samani NJ, Spector TD, Tuomi T, Tuomilehto J, Uda M, Uitterlinden AG, Wareham NJ, Deloukas P, Frayling TM, Groop LC, Hayes RB, Hunter DJ, Mohlke KL, Peltonen L, Schlessinger D, Strachan DP, Wichmann HE, McCarthy MI, Boehnke M, Barroso I, Abecasis GR, Hirschhorn JN; Genetic Investigation of ANthropometric Traits Consortium.

Nat Genet. 2009 Jan;41(1):25-34. Epub 2008 Dec 14.PMID: 19079261 [PubMed - indexed for MEDLINE]Related articlesFree article

Common variant in MTNR1B associated with increased risk of type 2 diabetes and impaired early insulin secretion.

Lyssenko V, Nagorny CL, Erdos MR, Wierup N, Jonsson A, Spégel P, Bugliani M, Saxena R, Fex M, Pulizzi N, Isomaa B, Tuomi T, Nilsson P, Kuusisto J, Tuomilehto J, Boehnke M, Altshuler D, Sundler F, Eriksson JG, Jackson AU, Laakso M, Marchetti P, Watanabe RM, Mulder H, Groop L.

Nat Genet. 2009 Jan;41(1):82-8. Epub 2008 Dec 7.PMID: 19060908 [PubMed - indexed for MEDLINE]Related articles

Variants in MTNR1B influence fasting glucose levels.

Prokopenko I, Langenberg C, Florez JC, Saxena R, Soranzo N, Thorleifsson G, Loos RJ, Manning AK, Jackson AU, Aulchenko Y, Potter SC, Erdos MR, Sanna S, Hottenga JJ, Wheeler E, Kaakinen M, Lyssenko V, Chen WM, Ahmadi K, Beckmann JS, Bergman RN, Bochud M, Bonnycastle LL, Buchanan TA, Cao A, Cervino A, Coin L, Collins FS, Crisponi L, de Geus EJ, Dehghan A, Deloukas P, Doney AS, Elliott P, Freimer N, Gateva V, Herder C, Hofman A, Hughes TE, Hunt S, Illig T, Inouye M, Isomaa B, Johnson T, Kong A, Krestyaninova M, Kuusisto J, Laakso M, Lim N, Lindblad U, Lindgren CM, McCann OT, Mohlke KL, Morris AD, Naitza S, Orrù M, Palmer CN, Pouta A, Randall J, Rathmann W, Saramies J, Scheet P, Scott LJ, Scuteri A, Sharp S, Sijbrands E, Smit JH, Song K, Steinthorsdottir V, Stringham HM, Tuomi T, Tuomilehto J, Uitterlinden AG, Voight BF, Waterworth D, Wichmann HE, Willemsen G, Witteman JC, Yuan X, Zhao JH, Zeggini E, Schlessinger D, Sandhu M, Boomsma DI, Uda M, Spector TD, Penninx BW, Altshuler D, Vollenweider P, Jarvelin MR, Lakatta E, Waeber G, Fox CS, Peltonen L, Groop LC, Mooser V, Cupples LA, Thorsteinsdottir U, Boehnke M, Barroso I, Van Duijn C, Dupuis J, Watanabe RM, Stefansson K, McCarthy MI, Wareham NJ, Meigs JB, Abecasis GR.

Nat Genet. 2009 Jan;41(1):77-81. Epub 2008 Dec 7.PMID: 19060907 [PubMed - indexed for MEDLINE]Related articles

OGTT-derived measures of insulin sensitivity are confounded by factors other than insulin sensitivity itself.

Hücking K, Watanabe RM, Stefanovski D, Bergman RN.

Obesity (Silver Spring). 2008 Aug;16(8):1938-45. Epub 2008 Jul 10.PMID: 18670420 [PubMed - indexed for MEDLINE]Related articles

Variations in the G6PC2/ABCB11 genomic region are associated with fasting glucose levels.

Chen WM, Erdos MR, Jackson AU, Saxena R, Sanna S, Silver KD, Timpson NJ, Hansen T, Orrù M, Grazia Piras M, Bonnycastle LL, Willer CJ, Lyssenko V, Shen H, Kuusisto J, Ebrahim S, Sestu N, Duren WL, Spada MC, Stringham HM, Scott LJ, Olla N, Swift AJ, Najjar S, Mitchell BD, Lawlor DA, Smith GD, Ben-Shlomo Y, Andersen G, Borch-Johnsen K, Jørgensen T, Saramies J, Valle TT, Buchanan TA, Shuldiner AR, Lakatta E, Bergman RN, Uda M, Tuomilehto J, Pedersen O, Cao A, Groop L, Mohlke KL, Laakso M, Schlessinger D, Collins FS, Altshuler D, Abecasis GR, Boehnke M, Scuteri A, Watanabe RM.

J Clin Invest. 2008 Jul;118(7):2620-8.PMID: 18521185 [PubMed - indexed for MEDLINE]Related articlesFree article

Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes.

Zeggini E, Scott LJ, Saxena R, Voight BF, Marchini JL, Hu T, de Bakker PI, Abecasis GR, Almgren P, Andersen G, Ardlie K, Boström KB, Bergman RN, Bonnycastle LL, Borch-Johnsen K, Burtt NP, Chen H, Chines PS, Daly MJ, Deodhar P, Ding CJ, Doney AS, Duren WL, Elliott KS, Erdos MR, Frayling TM, Freathy RM, Gianniny L, Grallert H, Grarup N, Groves CJ, Guiducci C, Hansen T, Herder C, Hitman GA, Hughes TE, Isomaa B, Jackson AU, Jørgensen T, Kong A, Kubalanza K, Kuruvilla FG, Kuusisto J, Langenberg C, Lango H, Lauritzen T, Li Y, Lindgren CM, Lyssenko V, Marvelle AF, Meisinger C, Midthjell K, Mohlke KL, Morken MA, Morris AD, Narisu N, Nilsson P, Owen KR, Palmer CN, Payne F, Perry JR, Pettersen E, Platou C, Prokopenko I, Qi L, Qin L, Rayner NW, Rees M, Roix JJ, Sandbaek A, Shields B, Sjögren M, Steinthorsdottir V, Stringham HM, Swift AJ, Thorleifsson G, Thorsteinsdottir U, Timpson NJ, Tuomi T, Tuomilehto J, Walker M, Watanabe RM, Weedon MN, Willer CJ; Wellcome Trust Case Control Consortium, Illig T, Hveem K, Hu FB, Laakso M, Stefansson K, Pedersen O, Wareham NJ, Barroso I, Hattersley AT, Collins FS, Groop L, McCarthy MI, Boehnke M, Altshuler D.

Nat Genet. 2008 May;40(5):638-45. Epub 2008 Mar 30.PMID: 18372903 [PubMed - indexed for MEDLINE]Related articlesFree article

Reduction in added sugar intake and improvement in insulin secretion in overweight latina adolescents.

Davis JN, Ventura EE, Shaibi GQ, Weigensberg MJ, Spruijt-Metz D, Watanabe RM, Goran MI.

Metab Syndr Relat Disord. 2007 Jun;5(2):183-93.PMID: 18370826 [PubMed - in process]Related articles

Allgrove syndrome in a Mexican American family is caused by an ancestral mutation derived from North Africa.

Chang AJ, Kline MM, Currie Y, Perez MO, Hartiala J, Wijesuriya H, Buchanan TA, Watanabe RM, Allayee H.

Clin Genet. 2008 Apr;73(4):385-7. Epub 2008 Feb 5. No abstract available. PMID: 18261130 [PubMed - indexed for MEDLINE]Related articles

Common variants in the GDF5-UQCC region are associated with variation in human height.

Sanna S, Jackson AU, Nagaraja R, Willer CJ, Chen WM, Bonnycastle LL, Shen H, Timpson N, Lettre G, Usala G, Chines PS, Stringham HM, Scott LJ, Dei M, Lai S, Albai G, Crisponi L, Naitza S, Doheny KF, Pugh EW, Ben-Shlomo Y, Ebrahim S, Lawlor DA, Bergman RN, Watanabe RM, Uda M, Tuomilehto J, Coresh J, Hirschhorn JN, Shuldiner AR, Schlessinger D, Collins FS, Davey Smith G, Boerwinkle E, Cao A, Boehnke M, Abecasis GR, Mohlke KL.

Nat Genet. 2008 Feb;40(2):198-203. Epub 2008 Jan 13.PMID: 18193045 [PubMed - indexed for MEDLINE]Related articles

Newly identified loci that influence lipid concentrations and risk of coronary artery disease.

Willer CJ, Sanna S, Jackson AU, Scuteri A, Bonnycastle LL, Clarke R, Heath SC, Timpson NJ, Najjar SS, Stringham HM, Strait J, Duren WL, Maschio A, Busonero F, Mulas A, Albai G, Swift AJ, Morken MA, Narisu N, Bennett D, Parish S, Shen H, Galan P, Meneton P, Hercberg S, Zelenika D, Chen WM, Li Y, Scott LJ, Scheet PA, Sundvall J, Watanabe RM, Nagaraja R, Ebrahim S, Lawlor DA, Ben-Shlomo Y, Davey-Smith G, Shuldiner AR, Collins R, Bergman RN, Uda M, Tuomilehto J, Cao A, Collins FS, Lakatta E, Lathrop GM, Boehnke M, Schlessinger D, Mohlke KL, Abecasis GR.

Nat Genet. 2008 Feb;40(2):161-9. Epub 2008 Jan 13.PMID: 18193043 [PubMed - indexed for MEDLINE]Related articles

Evidence of interaction between PPARG2 and HNF4A contributing to variation in insulin sensitivity in Mexican Americans.

Black MH, Fingerlin TE, Allayee H, Zhang W, Xiang AH, Trigo E, Hartiala J, Lehtinen AB, Haffner SM, Bergman RN, McEachin RC, Kjos SL, Lawrence JM, Buchanan TA, Watanabe RM.

Diabetes. 2008 Apr;57(4):1048-56. Epub 2007 Dec 27.PMID: 18162503 [PubMed - indexed for MEDLINE]Related articlesFree article

Prioritized subset analysis: improving power in genome-wide association studies.

Li C, Li M, Lange EM, Watanabe RM.

Hum Hered. 2008;65(3):129-41. Epub 2007 Oct 12.PMID: 17934316 [PubMed - indexed for MEDLINE]Related articlesFree article

Variants in the plasmacytoma variant translocation gene (PVT1) are associated with end-stage renal disease attributed to type 1 diabetes.

Millis MP, Bowen D, Kingsley C, Watanabe RM, Wolford JK.

Diabetes. 2007 Dec;56(12):3027-32. Epub 2007 Sep 19.PMID: 17881614 [PubMed - indexed for MEDLINE]Related articlesFree article

Genetics of gestational diabetes mellitus and type 2 diabetes.

Watanabe RM, Black MH, Xiang AH, Allayee H, Lawrence JM, Buchanan TA.

Diabetes Care. 2007 Jul;30 Suppl 2:S134-40. Review. No abstract available. Erratum in: Diabetes Care. 2007 Dec;30(12):3154. PMID: 17596461 [PubMed - indexed for MEDLINE]Related articlesFree article

A genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variants.

Scott LJ, Mohlke KL, Bonnycastle LL, Willer CJ, Li Y, Duren WL, Erdos MR, Stringham HM, Chines PS, Jackson AU, Prokunina-Olsson L, Ding CJ, Swift AJ, Narisu N, Hu T, Pruim R, Xiao R, Li XY, Conneely KN, Riebow NL, Sprau AG, Tong M, White PP, Hetrick KN, Barnhart MW, Bark CW, Goldstein JL, Watkins L, Xiang F, Saramies J, Buchanan TA, Watanabe RM, Valle TT, Kinnunen L, Abecasis GR, Pugh EW, Doheny KF, Bergman RN, Tuomilehto J, Collins FS, Boehnke M.

Science. 2007 Jun 1;316(5829):1341-5. Epub 2007 Apr 26.PMID: 17463248 [PubMed - indexed for MEDLINE]Related articlesFree article

Transcription factor 7-like 2 (TCF7L2) is associated with gestational diabetes mellitus and interacts with adiposity to alter insulin secretion in Mexican Americans.

Watanabe RM, Allayee H, Xiang AH, Trigo E, Hartiala J, Lawrence JM, Buchanan TA.

Diabetes. 2007 May;56(5):1481-5. Epub 2007 Feb 22.PMID: 17317761 [PubMed - indexed for MEDLINE]Related articlesFree article

Screening of 134 single nucleotide polymorphisms (SNPs) previously associated with type 2 diabetes replicates association with 12 SNPs in nine genes.

Willer CJ, Bonnycastle LL, Conneely KN, Duren WL, Jackson AU, Scott LJ, Narisu N, Chines PS, Skol A, Stringham HM, Petrie J, Erdos MR, Swift AJ, Enloe ST, Sprau AG, Smith E, Tong M, Doheny KF, Pugh EW, Watanabe RM, Buchanan TA, Valle TT, Bergman RN, Tuomilehto J, Mohlke KL, Collins FS, Boehnke M.

Diabetes. 2007 Jan;56(1):256-64.PMID: 17192490 [PubMed - indexed for MEDLINE]Related articlesFree article

Subsets of Finns with high HDL to total cholesterol ratio show evidence for linkage to type 2 diabetes on chromosome 6q.

Shtir C, Nagakawa IS, Duren WL, Conneely KN, Scott LJ, Silander K, Valle TT, Tuomilehto J, Buchanan TA, Bergman RN, Collins FS, Boehnke M, Watanabe RM.

Hum Hered. 2007;63(1):17-25. Epub 2006 Dec 14.PMID: 17179727 [PubMed - indexed for MEDLINE]Related articlesFree article

Common variants in maturity-onset diabetes of the young genes contribute to risk of type 2 diabetes in Finns.

Bonnycastle LL, Willer CJ, Conneely KN, Jackson AU, Burrill CP, Watanabe RM, Chines PS, Narisu N, Scott LJ, Enloe ST, Swift AJ, Duren WL, Stringham HM, Erdos MR, Riebow NL, Buchanan TA, Valle TT, Tuomilehto J, Bergman RN, Mohlke KL, Boehnke M, Collins FS.

Diabetes. 2006 Sep;55(9):2534-40.PMID: 16936201 [PubMed - indexed for MEDLINE]Related articlesFree article

Impact of ABCB1 (MDR1) haplotypes on tacrolimus dosing in adult lung transplant patients who are CYP3A5 *3/*3 non-expressors.

Wang J, Zeevi A, McCurry K, Schuetz E, Zheng H, Iacono A, McDade K, Zaldonis D, Webber S, Watanabe RM, Burckart GJ.

Transpl Immunol. 2006 Jan;15(3):235-40. Epub 2005 Sep 8.PMID: 16431292 [PubMed - indexed for MEDLINE]Related articles

Sequence variation in PPARG may underlie differential response to troglitazone.

Wolford JK, Yeatts KA, Dhanjal SK, Black MH, Xiang AH, Buchanan TA, Watanabe RM.

Diabetes. 2005 Nov;54(11):3319-25.PMID: 16249460 [PubMed - indexed for MEDLINE]Related articlesFree article

Mitochondrial polymorphisms and susceptibility to type 2 diabetes-related traits in Finns.

Mohlke KL, Jackson AU, Scott LJ, Peck EC, Suh YD, Chines PS, Watanabe RM, Buchanan TA, Conneely KN, Erdos MR, Narisu N, Enloe S, Valle TT, Tuomilehto J, Bergman RN, Boehnke M, Collins FS.

Hum Genet. 2005 Nov;118(2):245-54. Epub 2005 Nov 15.PMID: 16142453 [PubMed - indexed for MEDLINE]Related articles

Variation in the resistin gene is associated with obesity and insulin-related phenotypes in Finnish subjects.

Conneely KN, Silander K, Scott LJ, Mohlke KL, Lazaridis KN, Valle TT, Tuomilehto J, Bergman RN, Watanabe RM, Buchanan TA, Collins FS, Boehnke M.

Diabetologia. 2004 Oct;47(10):1782-8. Epub 2004 Oct 27.PMID: 15517149 [PubMed - indexed for MEDLINE]Related articlesFree article

The multiphasic profile of free fatty acids during the intravenous glucose tolerance test is unresponsive to exogenous insulin.

Sumner AE, Bergman RN, Vega GL, Genovese DJ, Cochran CS, Pacak K, Watanabe RM, Boston RC.

Metabolism. 2004 Sep;53(9):1202-7.PMID: 15334385 [PubMed - indexed for MEDLINE]Related articles

Ordered subset analysis in genetic linkage mapping of complex traits.

Hauser ER, Watanabe RM, Duren WL, Bass MP, Langefeld CD, Boehnke M.

Genet Epidemiol. 2004 Jul;27(1):53-63.PMID: 15185403 [PubMed - indexed for MEDLINE]Related articles

Acute alcohol consumption improves insulin action without affecting insulin secretion in type 2 diabetic subjects.

Avogaro A, Watanabe RM, Dall'Arche A, De Kreutzenberg SV, Tiengo A, Pacini G.

Diabetes Care. 2004 Jun;27(6):1369-74.PMID: 15161790 [PubMed - indexed for MEDLINE]Related articlesFree article

Changes in insulin sensitivity in response to troglitazone do not differ between subjects with and without the common, functional Pro12Ala peroxisome proliferator-activated receptor-gamma2 gene variant: results from the Troglitazone in Prevention of Diabetes (TRIPOD) study.

Snitker S, Watanabe RM, Ani I, Xiang AH, Marroquin A, Ochoa C, Goico J, Shuldiner AR, Buchanan TA; Troglitazone in Prevention of Diabetes (TRIPOD) study.

Diabetes Care. 2004 Jun;27(6):1365-8.PMID: 15161789 [PubMed - indexed for MEDLINE]Related articlesFree article

Genetic variation near the hepatocyte nuclear factor-4 alpha gene predicts susceptibility to type 2 diabetes.

Silander K, Mohlke KL, Scott LJ, Peck EC, Hollstein P, Skol AD, Jackson AU, Deloukas P, Hunt S, Stavrides G, Chines PS, Erdos MR, Narisu N, Conneely KN, Li C, Fingerlin TE, Dhanjal SK, Valle TT, Bergman RN, Tuomilehto J, Watanabe RM, Boehnke M, Collins FS.

Diabetes. 2004 Apr;53(4):1141-9.PMID: 15047633 [PubMed - indexed for MEDLINE]Related articlesFree article

A large set of Finnish affected sibling pair families with type 2 diabetes suggests susceptibility loci on chromosomes 6, 11, and 14.

Silander K, Scott LJ, Valle TT, Mohlke KL, Stringham HM, Wiles KR, Duren WL, Doheny KF, Pugh EW, Chines P, Narisu N, White PP, Fingerlin TE, Jackson AU, Li C, Ghosh S, Magnuson VL, Colby K, Erdos MR, Hill JE, Hollstein P, Humphreys KM, Kasad RA, Lambert J, Lazaridis KN, Lin G, Morales-Mena A, Patzkowski K, Pfahl C, Porter R, Rha D, Segal L, Suh YD, Tovar J, Unni A, Welch C, Douglas JA, Epstein MP, Hauser ER, Hagopian W, Buchanan TA, Watanabe RM, Bergman RN, Tuomilehto J, Collins FS, Boehnke M.

Diabetes. 2004 Mar;53(3):821-9.PMID: 14988269 [PubMed - indexed for MEDLINE]Related articlesFree article

MINMOD Millennium: a computer program to calculate glucose effectiveness and insulin sensitivity from the frequently sampled intravenous glucose tolerance test.

Boston RC, Stefanovski D, Moate PJ, Sumner AE, Watanabe RM, Bergman RN.

Diabetes Technol Ther. 2003;5(6):1003-15.PMID: 14709204 [PubMed - indexed for MEDLINE]Related articles

Minimal model-based insulin sensitivity has greater heritability and a different genetic basis than homeostasis model assessment or fasting insulin.

Bergman RN, Zaccaro DJ, Watanabe RM, Haffner SM, Saad MF, Norris JM, Wagenknecht LE, Hokanson JE, Rotter JI, Rich SS.

Diabetes. 2003 Aug;52(8):2168-74.PMID: 12882937 [PubMed - indexed for MEDLINE]Related articlesFree article

Variation in three single nucleotide polymorphisms in the calpain-10 gene not associated with type 2 diabetes in a large Finnish cohort.

Fingerlin TE, Erdos MR, Watanabe RM, Wiles KR, Stringham HM, Mohlke KL, Silander K, Valle TT, Buchanan TA, Tuomilehto J, Bergman RN, Boehnke M, Collins FS.

Diabetes. 2002 May;51(5):1644-8.PMID: 11978669 [PubMed - indexed for MEDLINE]Related articlesFree article

Glucose tolerance during moderate alcohol intake: insights on insulin action from glucose/lactate dynamics.

Avogaro A, Watanabe RM, Gottardo L, de Kreutzenberg S, Tiengo A, Pacini G.

J Clin Endocrinol Metab. 2002 Mar;87(3):1233-8.PMID: 11889193 [PubMed - indexed for MEDLINE]Related articlesFree article

Linkage disequilibrium between microsatellite markers extends beyond 1 cM on chromosome 20 in Finns.

Mohlke KL, Lange EM, Valle TT, Ghosh S, Magnuson VL, Silander K, Watanabe RM, Chines PS, Bergman RN, Tuomilehto J, Collins FS, Boehnke M.

Genome Res. 2001 Jul;11(7):1221-6.PMID: 11435404 [PubMed - indexed for MEDLINE]Related articlesFree article

The peroxisome proliferator-activated receptor-gamma2 Pro12A1a variant: association with type 2 diabetes and trait differences.

Douglas JA, Erdos MR, Watanabe RM, Braun A, Johnston CL, Oeth P, Mohlke KL, Valle TT, Ehnholm C, Buchanan TA, Bergman RN, Collins FS, Boehnke M, Tuomilehto J.

Diabetes. 2001 Apr;50(4):886-90.PMID: 11289057 [PubMed - indexed for MEDLINE]Related articlesFree article

The Finland-United States investigation of non-insulin-dependent diabetes mellitus genetics (FUSION) study. II. An autosomal genome scan for diabetes-related quantitative-trait loci.

Watanabe RM, Ghosh S, Langefeld CD, Valle TT, Hauser ER, Magnuson VL, Mohlke KL, Silander K, Ally DS, Chines P, Blaschak-Harvan J, Douglas JA, Duren WL, Epstein MP, Fingerlin TE, Kaleta HS, Lange EM, Li C, McEachin RC, Stringham HM, Trager E, White PP, Balow Jr J, Birznieks G, Chang J, Eldridge W.

Am J Hum Genet. 2000 Nov;67(5):1186-200. Epub 2000 Oct 13.PMID: 11032784 [PubMed - indexed for MEDLINE]Related articlesFree article

The Finland-United States investigation of non-insulin-dependent diabetes mellitus genetics (FUSION) study. I. An autosomal genome scan for genes that predispose to type 2 diabetes.

Ghosh S, Watanabe RM, Valle TT, Hauser ER, Magnuson VL, Langefeld CD, Ally DS, Mohlke KL, Silander K, Kohtamäki K, Chines P, Balow Jr J, Birznieks G, Chang J, Eldridge W, Erdos MR, Karanjawala ZE, Knapp JI, Kudelko K, Martin C, Morales-Mena A, Musick A, Musick T, Pfahl C, Porter R, Rayman JB.

Am J Hum Genet. 2000 Nov;67(5):1174-85. Epub 2000 Oct 13.PMID: 11032783 [PubMed - indexed for MEDLINE]Related articlesFree article

Accurate measurement of endogenous insulin secretion does not require separate assessment of C-peptide kinetics.

Watanabe RM, Bergman RN.

Diabetes. 2000 Mar;49(3):373-82.PMID: 10868958 [PubMed - indexed for MEDLINE]Related articlesFree article

Application of an ordered subset analysis approach to the genetics of alcoholism.

Watanabe RM, Ghosh S, Birznieks G, Duren WL, Mitchell BD.

Genet Epidemiol. 1999;17 Suppl 1:S385-90.PMID: 10597467 [PubMed - indexed for MEDLINE]Related articles

Identifying influential individuals in linkage analysis: application to a quantitative trait locus detected in the COGA data.

Mitchell BD, Ghosh S, Watanabe RM, Slifer SH, Hsueh WC, Birznieks G.

Genet Epidemiol. 1999;17 Suppl 1:S259-64.PMID: 10597446 [PubMed - indexed for MEDLINE]Related articles

The effect of phenotype variation on detection of linkage in the COGA data.

Birznieks G, Ghosh S, Watanabe RM, Mitchell BD.

Genet Epidemiol. 1999;17 Suppl 1:S61-6.PMID: 10597413 [PubMed - indexed for MEDLINE]Related articles

Familiality of quantitative metabolic traits in Finnish families with non-insulin-dependent diabetes mellitus. Finland-United States Investigation of NIDDM Genetics (FUSION) Study investigators.

Watanabe RM, Valle T, Hauser ER, Ghosh S, Eriksson J, Kohtamäki K, Ehnholm C, Tuomilehto J, Collins FS, Bergman RN, Boehnke M.

Hum Hered. 1999 Jun;49(3):159-68.PMID: 10364681 [PubMed - indexed for MEDLINE]Related articlesFree article

The W64R variant of the beta3-adrenergic receptor is not associated with type II diabetes or obesity in a large Finnish sample.

Ghosh S, Langefeld CD, Ally D, Watanabe RM, Hauser ER, Magnuson VL, Nylund SJ, Valle T, Eriksson J, Bergman RN, Tuomilehto J, Collins FS, Boehnke M.

Diabetologia. 1999 Feb;42(2):238-44.PMID: 10064105 [PubMed - indexed for MEDLINE]Related articles

Type 2 diabetes: evidence for linkage on chromosome 20 in 716 Finnish affected sib pairs.

Ghosh S, Watanabe RM, Hauser ER, Valle T, Magnuson VL, Erdos MR, Langefeld CD, Balow J Jr, Ally DS, Kohtamaki K, Chines P, Birznieks G, Kaleta HS, Musick A, Te C, Tannenbaum J, Eldridge W, Shapiro S, Martin C, Witt A, So A, Chang J, Shurtleff B, Porter R, Kudelko K, Unni A, Segal L, Sharaf R, Blaschak-Harvan J, Eriksson J, Tenkula T, Vidgren G, Ehnholm C, Tuomilehto-Wolf E, Hagopian W, Buchanan TA, Tuomilehto J, Bergman RN, Collins FS, Boehnke M.

Proc Natl Acad Sci U S A. 1999 Mar 2;96(5):2198-203.PMID: 10051618 [PubMed - indexed for MEDLINE]Related articlesFree article

A large sample of finnish diabetic sib-pairs reveals no evidence for a non-insulin-dependent diabetes mellitus susceptibility locus at 2qter.

Ghosh S, Hauser ER, Magnuson VL, Valle T, Ally DS, Karanjawala ZE, Rayman JB, Knapp JI, Musick A, Tannenbaum J, Te C, Eldridge W, Shapiro S, Musick T, Martin C, So A, Witt A, Harvan JB, Watanabe RM, Hagopian W, Eriksson J, Nylund SJ, Kohtamaki K, Tuomilehto-Wolf E, Boehnke M, et al.

J Clin Invest. 1998 Aug 15;102(4):704-9.PMID: 9710438 [PubMed - indexed for MEDLINE]Related articlesFree article

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