PubMed

Effects of exendin-4 on glucose tolerance, insulin secretion, and beta-cell proliferation depend on treatment dose, treatment duration and meal contents.

Arakawa M, Ebato C, Mita T, Hirose T, Kawamori R, Fujitani Y, Watada H.

Biochem Biophys Res Commun. 2009 Dec 18;390(3):809-14. Epub 2009 Oct 21.PMID: 19836346 [PubMed - in process]Related articles

Preliminary report: mitochondrial DNA 5178 polymorphism in male elite Japanese endurance runners.

Tamura Y, Watada H, Tanaka Y, Daimaru N, Nomiyama T, Sakuraba K, Sawaki K, Kawamori R.

Metabolism. 2009 Aug 28. [Epub ahead of print]PMID: 19717174 [PubMed - as supplied by publisher]Related articles

Effect of sulfonylureas on switching to insulin therapy (twice-daily biphasic insulin aspart 30): comparison of twice-daily biphasic insulin aspart 30 with or without glimepiride in type 2 diabetic patients poorly controlled with sub-maximal glimepiride.

Ebato C, Shimizu T, Arakawa M, Mita T, Fujitani Y, Watada H, Kawamori R, Hirose T.

Diabetes Res Clin Pract. 2009 Oct;86(1):31-6. Epub 2009 Aug 18.PMID: 19692134 [PubMed - in process]Related articles

[ARB as a drug for diabetic microangiopathy]

Nomiyama T, Watada H.

Nippon Rinsho. 2009 Apr;67(4):777-82. Review. Japanese. PMID: 19348242 [PubMed - indexed for MEDLINE]Related articles

Normal islet vascularization is dispensable for expansion of beta-cell mass in response to high-fat diet induced insulin resistance.

Toyofuku Y, Uchida T, Nakayama S, Hirose T, Kawamori R, Fujitani Y, Inoue M, Watada H.

Biochem Biophys Res Commun. 2009 Jun 5;383(3):303-7. Epub 2009 Mar 29.PMID: 19336220 [PubMed - indexed for MEDLINE]Related articles

Presence of alpha-smooth muscle actin-positive endothelial cells in the luminal surface of adult aorta.

Azuma K, Ichimura K, Mita T, Nakayama S, Jin WL, Hirose T, Fujitani Y, Sumiyoshi K, Shimada K, Daida H, Sakai T, Mitsumata M, Kawamori R, Watada H.

Biochem Biophys Res Commun. 2009 Mar 13;380(3):620-6. Epub 2009 Jan 27.PMID: 19285011 [PubMed - indexed for MEDLINE]Related articles

Association between atherosclerosis and newly classified chronic kidney disease stage for Japanese patients with type 2 diabetes.

Yamamoto R, Kanazawa A, Shimizu T, Hirose T, Tanaka Y, Kawamori R, Watada H.

Diabetes Res Clin Pract. 2009 Apr;84(1):39-45. Epub 2009 Feb 14.PMID: 19223087 [PubMed - indexed for MEDLINE]Related articles

Prevalence of abnormal glucose metabolism and insulin resistance among subtypes of ischemic stroke in Japanese patients.

Urabe T, Watada H, Okuma Y, Tanaka R, Ueno Y, Miyamoto N, Tanaka Y, Hattori N, Kawamori R.

Stroke. 2009 Apr;40(4):1289-95. Epub 2009 Jan 22.PMID: 19164796 [PubMed - indexed for MEDLINE]Related articles

The role of autophagy in pancreatic beta-cell and diabetes.

Fujitani Y, Kawamori R, Watada H.

Autophagy. 2009 Feb;5(2):280-2. Epub 2009 Feb 19.PMID: 19158492 [PubMed - indexed for MEDLINE]Related articles

Aldose reductase inhibitor, epalrestat, reduces lipid hydroperoxides in type 2 diabetes.

Ohmura C, Watada H, Azuma K, Shimizu T, Kanazawa A, Ikeda F, Yoshihara T, Fujitani Y, Hirose T, Tanaka Y, Kawamori R.

Endocr J. 2009 Mar;56(1):149-56. Epub 2008 Nov 8.PMID: 18997444 [PubMed - indexed for MEDLINE]Related articlesFree article

Letter by Watada et al regarding article, "Two-year clinical outcomes with drug-eluting stents for diabetic patients with de novo coronary lesion".

Watada H, Daida H, Kawamori R.

Circulation. 2008 Oct 28;118(18):e680; author reply e681. No abstract available. PMID: 18955674 [PubMed - indexed for MEDLINE]Related articlesFree article

In vivo and in vitro inhibition of monocyte adhesion to endothelial cells and endothelial adhesion molecules by eicosapentaenoic acid.

Yamada H, Yoshida M, Nakano Y, Suganami T, Satoh N, Mita T, Azuma K, Itoh M, Yamamoto Y, Kamei Y, Horie M, Watada H, Ogawa Y.

Arterioscler Thromb Vasc Biol. 2008 Dec;28(12):2173-9. Epub 2008 Oct 23.PMID: 18948636 [PubMed - indexed for MEDLINE]Related articles

Impact of whole body irradiation and vascular endothelial growth factor-A on increased beta cell mass after bone marrow transplantation in a mouse model of diabetes induced by streptozotocin.

Nakayama S, Uchida T, Choi JB, Fujitani Y, Ogihara T, Iwashita N, Azuma K, Mochizuki H, Hirose T, Kawamori R, Inoue M, Watada H.

Diabetologia. 2009 Jan;52(1):115-24. Epub 2008 Oct 23.PMID: 18946656 [PubMed - indexed for MEDLINE]Related articles

Autophagy is important in islet homeostasis and compensatory increase of beta cell mass in response to high-fat diet.

Ebato C, Uchida T, Arakawa M, Komatsu M, Ueno T, Komiya K, Azuma K, Hirose T, Tanaka K, Kominami E, Kawamori R, Fujitani Y, Watada H.

Cell Metab. 2008 Oct;8(4):325-32.PMID: 18840363 [PubMed - indexed for MEDLINE]Related articles

Miglitol suppresses the postprandial increase in interleukin 6 and enhances active glucagon-like peptide 1 secretion in viscerally obese subjects.

Arakawa M, Ebato C, Mita T, Fujitani Y, Shimizu T, Watada H, Kawamori R, Hirose T.

Metabolism. 2008 Sep;57(9):1299-306.PMID: 18702958 [PubMed - indexed for MEDLINE]Related articles

Dose-dependent requirement of patched homologue 1 in mouse pancreatic beta cell mass.

Nakayama S, Arakawa M, Uchida T, Ogihara T, Kanno R, Ikeda F, Azuma K, Hirose T, Kawamori R, Fujitani Y, Watada H.

Diabetologia. 2008 Oct;51(10):1883-92. Epub 2008 Jul 25.PMID: 18654758 [PubMed - indexed for MEDLINE]Related articles

Efficacy and safety of modified Yale insulin infusion protocol in Japanese diabetic patients after open-heart surgery.

Tamaki M, Shimizu T, Kanazawa A, Tamura Y, Hanzawa A, Ebato C, Itou C, Yasunari E, Sanke H, Abe H, Kawai J, Okayama K, Matsumoto K, Komiya K, Kawaguchi M, Inagaki N, Watanabe T, Kanazawa Y, Hirose T, Kawamori R, Watada H.

Diabetes Res Clin Pract. 2008 Sep;81(3):296-302. Epub 2008 Jun 16.PMID: 18556085 [PubMed - indexed for MEDLINE]Related articles

Combined expression of transcription factors induces AR42J-B13 cells to differentiate into insulin-producing cells.

Ogihara T, Fujitani Y, Uchida T, Kanno R, Choi JB, Hirose T, Kawamori R, Watada H.

Endocr J. 2008 Aug;55(4):691-8. Epub 2008 May 28.PMID: 18506085 [PubMed - indexed for MEDLINE]Related articlesFree article

Impact of oxidative stress and peroxisome proliferator-activated receptor gamma coactivator-1alpha in hepatic insulin resistance.

Kumashiro N, Tamura Y, Uchida T, Ogihara T, Fujitani Y, Hirose T, Mochizuki H, Kawamori R, Watada H.

Diabetes. 2008 Aug;57(8):2083-91. Epub 2008 May 16.PMID: 18487450 [PubMed - indexed for MEDLINE]Related articlesFree article

Effects of changes in basal/total daily insulin ratio in type 2 diabetes patients on intensive insulin therapy including insulin glargine (JUN-LAN Study 6).

Tamaki M, Shimizu T, Kanazawa A, Fujitani Y, Watada H, Kawamori R, Hirose T.

Diabetes Res Clin Pract. 2008 Aug;81(2):e1-3. Epub 2008 May 16.PMID: 18486257 [PubMed - indexed for MEDLINE]Related articles

Repetitive postprandial hypertriglyceridemia induces monocyte adhesion to aortic endothelial cells in Goto-Kakizaki rats.

Motojima K, Azuma K, Kitahara Y, Miura K, Mita T, Hirose T, Fujitani Y, Kawamori R, Watada H.

Endocr J. 2008 May;55(2):373-9. Epub 2008 Apr 1.PMID: 18379124 [PubMed - indexed for MEDLINE]Related articlesFree article

Comparison of effects of olmesartan and telmisartan on blood pressure and metabolic parameters in Japanese early-stage type-2 diabetics with hypertension.

Nakayama S, Watada H, Mita T, Ikeda F, Shimizu T, Uchino H, Fujitani Y, Hirose T, Kawamori R.

Hypertens Res. 2008 Jan;31(1):7-13.PMID: 18360012 [PubMed - indexed for MEDLINE]Related articles

Insulin exocytosis in Goto-Kakizaki rat beta-cells subjected to long-term glinide or sulfonylurea treatment.

Kawai J, Ohara-Imaizumi M, Nakamichi Y, Okamura T, Akimoto Y, Matsushima S, Aoyagi K, Kawakami H, Watanabe T, Watada H, Kawamori R, Nagamatsu S.

Biochem J. 2008 May 15;412(1):93-101.PMID: 18254725 [PubMed - indexed for MEDLINE]Related articlesFree article

Short-term effects of dietary fat on intramyocellular lipid in sprinters and endurance runners.

Tamura Y, Watada H, Igarashi Y, Nomiyama T, Onishi T, Takahashi K, Doi S, Katamoto S, Hirose T, Tanaka Y, Kawamori R.

Metabolism. 2008 Mar;57(3):373-9.PMID: 18249210 [PubMed - indexed for MEDLINE]Related articles

Long-term efficacy of insulin glargine after switching from NPH insulin as intensive replacement of basal insulin in Japanese diabetes mellitus. Comparison of efficacy between type 1 and type 2 diabetes (JUN-LAN Study 1.2).

Kanazawa Y, Igarashi Y, Komiya K, Sakurai Y, Shimizu T, Fujitani Y, Tanaka Y, Watada H, Kawamori R, Hirose T.

Endocr J. 2007;54(6):975-83. Epub 2007 Nov 14.PMID: 18000343 [PubMed - indexed for MEDLINE]Related articlesFree article

Retraction. Angiotensin II receptor blocker provides pancreatic beta-cell protection independent of blood pressure lowering in diabetic db/db mice.

Shao JQ, Iwashita N, Du H, Wang YT, Wang YY, Zhao M, Wang J, Watada H, Kawamori R.

Acta Pharmacol Sin. 2007 Oct;28(10):1705. No abstract available. PMID: 17974074 [PubMed - indexed for MEDLINE]Related articlesFree article

Effects of metformin on peripheral insulin sensitivity and intracellular lipid contents in muscle and liver of overweight Japanese subjects.

Tamura Y, Watada H, Sato F, Kumashiro N, Sakurai Y, Hirose T, Tanaka Y, Kawamori R.

Diabetes Obes Metab. 2008 Sep;10(9):733-8. Epub 2007 Oct 15.PMID: 17941868 [PubMed - indexed for MEDLINE]Related articles

Calcium channel blocker, azelnidipine, reduces lipid hydroperoxides in patients with type 2 diabetes independent of blood pressure.

Ohmura C, Watada H, Shimizu T, Sakai K, Uchino H, Fujitani Y, Kanazawa A, Hirose T, Kawamori R.

Endocr J. 2007 Dec;54(5):805-11. Epub 2007 Sep 25.PMID: 17895576 [PubMed - indexed for MEDLINE]Related articlesFree article

Lack of evident atherosclerosis despite multiple risk factors in glycogen storage disease type 1a with hyperadiponectinemia.

Tamaki M, Tamura Y, Ogihara T, Shimizu T, Uchino H, Hirose T, Kawamori R, Watada H.

Metabolism. 2007 Oct;56(10):1402-4.PMID: 17884452 [PubMed - indexed for MEDLINE]Related articles

Nateglinide reduces carotid intima-media thickening in type 2 diabetic patients under good glycemic control.

Mita T, Watada H, Shimizu T, Tamura Y, Sato F, Watanabe T, Choi JB, Hirose T, Tanaka Y, Kawamori R.

Arterioscler Thromb Vasc Biol. 2007 Nov;27(11):2456-62. Epub 2007 Sep 13.PMID: 17872451 [PubMed - indexed for MEDLINE]Related articlesFree article

2-Methoxyestradiol reduces monocyte adhesion to aortic endothelial cells in ovariectomized rats.

Kurokawa A, Azuma K, Mita T, Toyofuku Y, Fujitani Y, Hirose T, Iwabuchi K, Ogawa H, Takeda S, Kawamori R, Watada H.

Endocr J. 2007;54(6):1027-31. Epub 2007 Sep 8.PMID: 17827788 [PubMed - indexed for MEDLINE]Related articlesFree article

Glucose homeostasis in a diabetic patient during liver transplantation: a case report.

Arakawa M, Hirose T, Mita T, Shimizu T, Fujitani Y, Watada H, Kawamori R.

Endocr J. 2007 Dec;54(5):819-23. Epub 2007 Sep 4.PMID: 17785915 [PubMed - indexed for MEDLINE]Related articlesFree article

Angiotensin II type 1 receptor blocker reduces monocyte adhesion to endothelial cells in spontaneously hypertensive rats.

Ikeda F, Azuma K, Ogihara T, Toyofuku Y, Otsuka A, Mita T, Hirose T, Tanaka Y, Kawamori R, Watada H.

Endocr J. 2007 Aug;54(4):605-12. Epub 2007 Jul 20.PMID: 17641443 [PubMed - indexed for MEDLINE]Related articlesFree article

[Effects of angiotensin II type 1 receptor blocker on islet of diabetic db/db mice]

Shao JQ, Iwashita N, Du H, Wang YY, Zhao M, Wang J, Watada H, Kawamori R.

Zhonghua Nei Ke Za Zhi. 2007 Apr;46(4):306-10. Chinese. PMID: 17637271 [PubMed - indexed for MEDLINE]Related articles

Effects of diet-induced moderate weight reduction on intrahepatic and intramyocellular triglycerides and glucose metabolism in obese subjects.

Sato F, Tamura Y, Watada H, Kumashiro N, Igarashi Y, Uchino H, Maehara T, Kyogoku S, Sunayama S, Sato H, Hirose T, Tanaka Y, Kawamori R.

J Clin Endocrinol Metab. 2007 Aug;92(8):3326-9. Epub 2007 May 22.PMID: 17519317 [PubMed - indexed for MEDLINE]Related articlesFree article

[Organic solvent psychosis--report of two cases utilizing day care treatment]

Oomi Y, Ishikawa M, Watada H, Kitabayashi Y, Yamashita T, Fukui K.

Nihon Arukoru Yakubutsu Igakkai Zasshi. 2007 Apr;42(2):76-81. Japanese. No abstract available. PMID: 17508619 [PubMed - indexed for MEDLINE]Related articles

Swings in blood glucose levels accelerate atherogenesis in apolipoprotein E-deficient mice.

Mita T, Otsuka A, Azuma K, Uchida T, Ogihara T, Fujitani Y, Hirose T, Mitsumata M, Kawamori R, Watada H.

Biochem Biophys Res Commun. 2007 Jul 6;358(3):679-85. Epub 2007 May 4.PMID: 17506980 [PubMed - indexed for MEDLINE]Related articles

Glucose fluctuation on the progression of diabetic macroangiopathy--new findings from monocyte adhesion to endothelial cells.

Watada H, Azuma K, Kawamori R.

Diabetes Res Clin Pract. 2007 Sep;77 Suppl 1:S58-61. Epub 2007 Apr 25.PMID: 17462776 [PubMed - indexed for MEDLINE]Related articles

Preferable effect of pravastatin compared to atorvastatin on beta cell function in Japanese early-state type 2 diabetes with hypercholesterolemia.

Mita T, Watada H, Nakayama S, Abe M, Ogihara T, Shimizu T, Uchino H, Hirose T, Kawamori R.

Endocr J. 2007 Jun;54(3):441-7. Epub 2007 Apr 25.PMID: 17457013 [PubMed - indexed for MEDLINE]Related articlesFree article

Clinical characteristics influencing the effectiveness of metformin on Japanese type 2 diabetes receiving sulfonylureas.

Tomioka S, Ogata H, Tamura Y, Shimizu T, Watada H, Fujitani Y, Kawamori R, Hirose T.

Endocr J. 2007 Apr;54(2):247-53. Epub 2007 Feb 16.PMID: 17303931 [PubMed - indexed for MEDLINE]Related articlesFree article

Angiotensin II receptor blocker provides pancreatic beta-cell protection independent of blood pressure lowering in diabetic db/db mice.

Shao JQ, Iwashita N, Du H, Wang YT, Wang YY, Zhao M, Wang J, Watada H, Kawamori R.

Acta Pharmacol Sin. 2007 Feb;28(2):246-57. Retraction in: Shao JQ, Iwashita N, Du H, Wang YT, Wang YY, Zhao M, Wang J, Watada H, Kawamori R. Acta Pharmacol Sin. 2007 Oct;28(10):1705. PMID: 17241528 [PubMed - indexed for MEDLINE]Related articlesFree article

Long-term effect of combination therapy with mitiglinide and once daily insulin glargine in patients who were successfully switched from intensive insulin therapy in short-term study.

Kumashiro N, Yoshihara T, Kanazawa Y, Shimizu T, Watada H, Tanaka Y, Fujitani Y, Kawamori R, Hirose T.

Endocr J. 2007 Feb;54(1):163-6. Epub 2006 Dec 21.PMID: 17185877 [PubMed - indexed for MEDLINE]Related articlesFree article

Impaired insulin secretion in vivo but enhanced insulin secretion from isolated islets in pancreatic beta cell-specific vascular endothelial growth factor-A knock-out mice.

Iwashita N, Uchida T, Choi JB, Azuma K, Ogihara T, Ferrara N, Gerber H, Kawamori R, Inoue M, Watada H.

Diabetologia. 2007 Feb;50(2):380-9. Epub 2006 Dec 16.PMID: 17180351 [PubMed - indexed for MEDLINE]Related articles

Comparison of glycated albumin (GA) and glycated hemoglobin (HbA1c) in type 2 diabetic patients: usefulness of GA for evaluation of short-term changes in glycemic control.

Takahashi S, Uchino H, Shimizu T, Kanazawa A, Tamura Y, Sakai K, Watada H, Hirose T, Kawamori R, Tanaka Y.

Endocr J. 2007 Feb;54(1):139-44. Epub 2006 Dec 11.PMID: 17159300 [PubMed - indexed for MEDLINE]Related articlesFree article

Protein kinase Cdelta plays a non-redundant role in insulin secretion in pancreatic beta cells.

Uchida T, Iwashita N, Ohara-Imaizumi M, Ogihara T, Nagai S, Choi JB, Tamura Y, Tada N, Kawamori R, Nakayama KI, Nagamatsu S, Watada H.

J Biol Chem. 2007 Jan 26;282(4):2707-16. Epub 2006 Nov 29.PMID: 17135234 [PubMed - indexed for MEDLINE]Related articlesFree article

Amelioration of glucose tolerance by hepatic inhibition of nuclear factor kappaB in db/db mice.

Tamura Y, Ogihara T, Uchida T, Ikeda F, Kumashiro N, Nomiyama T, Sato F, Hirose T, Tanaka Y, Mochizuki H, Kawamori R, Watada H.

Diabetologia. 2007 Jan;50(1):131-41. Epub 2006 Nov 9.PMID: 17093946 [PubMed - indexed for MEDLINE]Related articles

[NEMOes, a new method to evaluate early atherosclerosis in rodent model]

Watada H, Kawamori R.

Nippon Rinsho. 2006 Nov;64(11):2165-75. Review. Japanese. PMID: 17087314 [PubMed - indexed for MEDLINE]Related articles

ELMO1 increases expression of extracellular matrix proteins and inhibits cell adhesion to ECMs.

Shimazaki A, Tanaka Y, Shinosaki T, Ikeda M, Watada H, Hirose T, Kawamori R, Maeda S.

Kidney Int. 2006 Nov;70(10):1769-76. Epub 2006 Oct 4.PMID: 17021600 [PubMed - indexed for MEDLINE]Related articles

Insulin and nateglinide reduce monocyte adhesion to endothelial cells in Goto-Kakizaki rats exhibiting repetitive blood glucose fluctuation.

Tanaka A, Azuma K, Toyofuku Y, Kurokawa A, Otsuka A, Mita T, Hirosea T, Fujitani Y, Miyauchi K, Daida H, Kawamori R, Watada H.

Biochem Biophys Res Commun. 2006 Nov 10;350(1):195-201. Epub 2006 Sep 18.PMID: 16997277 [PubMed - indexed for MEDLINE]Related articles

Association of C-reactive protein with early-stage carotid atherosclerosis in Japanese patients with early-state type 2 diabetes mellitus.

Mita T, Watada H, Uchino H, Shimizu T, Hirose T, Tanaka Y, Kawamori R.

Endocr J. 2006 Oct;53(5):693-8. Epub 2006 Aug 23.PMID: 16926521 [PubMed - indexed for MEDLINE]Related articlesFree article