PubMed

Reply to 'Arsenic patent keeps drug for rare cancer out of reach for many'.

Warrell RP Jr.

Nat Med. 2007 Nov;13(11):1278. No abstract available. PMID: 17987017 [PubMed - indexed for MEDLINE]Related articles

Randomized, double-blind, phase II trial of gallium nitrate compared with pamidronate for acute control of cancer-related hypercalcemia.

Cvitkovic F, Armand JP, Tubiana-Hulin M, Rossi JF, Warrell RP Jr.

Cancer J. 2006 Jan-Feb;12(1):47-53.PMID: 16613662 [PubMed - indexed for MEDLINE]Related articles

Acute promyelocytic leukemia cell line AP-1060 established as a cytokine-dependent culture from a patient clinically resistant to all-trans retinoic acid and arsenic trioxide.

Sun Y, Kim SH, Zhou DC, Ding W, Paietta E, Guidez F, Zelent A, Ramesh KH, Cannizzaro L, Warrell RP, Gallagher RE.

Leukemia. 2004 Jul;18(7):1258-69.PMID: 15116119 [PubMed - indexed for MEDLINE]Related articles

Frequent mutations in the ligand-binding domain of PML-RARalpha after multiple relapses of acute promyelocytic leukemia: analysis for functional relationship to response to all-trans retinoic acid and histone deacetylase inhibitors in vitro and in vivo.

Zhou DC, Kim SH, Ding W, Schultz C, Warrell RP Jr, Gallagher RE.

Blood. 2002 Feb 15;99(4):1356-63.PMID: 11830487 [PubMed - indexed for MEDLINE]Related articlesFree article

Histone deacetylase inhibitors induce remission in transgenic models of therapy-resistant acute promyelocytic leukemia.

He LZ, Tolentino T, Grayson P, Zhong S, Warrell RP Jr, Rifkind RA, Marks PA, Richon VM, Pandolfi PP.

J Clin Invest. 2001 Nov;108(9):1321-30.PMID: 11696577 [PubMed - indexed for MEDLINE]Related articlesFree article

Prognostic significance of minimal residual disease detection and PML/RAR-alpha isoform type: long-term follow-up in acute promyelocytic leukemia.

Jurcic JG, Nimer SD, Scheinberg DA, DeBlasio T, Warrell RP Jr, Miller WH Jr.

Blood. 2001 Nov 1;98(9):2651-6.PMID: 11675334 [PubMed - indexed for MEDLINE]Related articlesFree article

United States multicenter study of arsenic trioxide in relapsed acute promyelocytic leukemia.

Soignet SL, Frankel SR, Douer D, Tallman MS, Kantarjian H, Calleja E, Stone RM, Kalaycio M, Scheinberg DA, Steinherz P, Sievers EL, Coutré S, Dahlberg S, Ellison R, Warrell RP Jr.

J Clin Oncol. 2001 Sep 15;19(18):3852-60.PMID: 11559723 [PubMed - indexed for MEDLINE]Related articles

Differentiating agents in pediatric malignancies: all-trans-retinoic acid and arsenic in acute promyelocytic leukemia.

Calleja EM, Warrell RP Jr.

Curr Oncol Rep. 2000 Nov;2(6):519-23. Review.PMID: 11122887 [PubMed - indexed for MEDLINE]Related articles

Inhaled aerosolization of all-trans-retinoic acid for targeted pulmonary delivery.

Brooks AD, Tong W, Benedetti F, Kaneda Y, Miller V, Warrell RP Jr.

Cancer Chemother Pharmacol. 2000;46(4):313-8.PMID: 11052629 [PubMed - indexed for MEDLINE]Related articles

Arsenicals in hematologic cancers.

Novick SC, Warrell RP Jr.

Semin Oncol. 2000 Oct;27(5):495-501. Review.PMID: 11049017 [PubMed - indexed for MEDLINE]Related articles

Retinoic acid (RA) and As2O3 treatment in transgenic models of acute promyelocytic leukemia (APL) unravel the distinct nature of the leukemogenic process induced by the PML-RARalpha and PLZF-RARalpha oncoproteins.

Rego EM, He LZ, Warrell RP Jr, Wang ZG, Pandolfi PP.

Proc Natl Acad Sci U S A. 2000 Aug 29;97(18):10173-8.PMID: 10954752 [PubMed - indexed for MEDLINE]Related articlesFree article

Arsenic trioxide induces dose- and time-dependent apoptosis of endothelium and may exert an antileukemic effect via inhibition of angiogenesis.

Roboz GJ, Dias S, Lam G, Lane WJ, Soignet SL, Warrell RP Jr, Rafii S.

Blood. 2000 Aug 15;96(4):1525-30.PMID: 10942401 [PubMed - indexed for MEDLINE]Related articlesFree article

Arsenicals and inhibitors of histone deacetylase as anticancer therapy.

Warrell RP Jr.

Haematologica. 1999 Jun;84 Suppl EHA-4:75-7. Review. No abstract available. PMID: 10907475 [PubMed - indexed for MEDLINE]Related articles

Leukocytosis and the retinoic acid syndrome in patients with acute promyelocytic leukemia treated with arsenic trioxide.

Camacho LH, Soignet SL, Chanel S, Ho R, Heller G, Scheinberg DA, Ellison R, Warrell RP Jr.

J Clin Oncol. 2000 Jul;18(13):2620-5.PMID: 10893295 [PubMed - indexed for MEDLINE]Related articles

Initial clinical trial of a high-affinity retinoic acid receptor ligand (LGD1550).

Soignet SL, Miller VA, Pfister DG, Bienvenu BJ, Ho R, Parker BA, Amyotte SA, Cato A 3rd, Warrell RP Jr.

Clin Cancer Res. 2000 May;6(5):1731-5.PMID: 10815891 [PubMed - indexed for MEDLINE]Related articlesFree article

Clinical study of an organic arsenical, melarsoprol, in patients with advanced leukemia.

Soignet SL, Tong WP, Hirschfeld S, Warrell RP Jr.

Cancer Chemother Pharmacol. 1999;44(5):417-21.PMID: 10501916 [PubMed - indexed for MEDLINE]Related articles

Therapeutic targeting of transcription in acute promyelocytic leukemia by use of an inhibitor of histone deacetylase.

Warrell RP Jr, He LZ, Richon V, Calleja E, Pandolfi PP.

J Natl Cancer Inst. 1998 Nov 4;90(21):1621-5.PMID: 9811311 [PubMed - indexed for MEDLINE]Related articlesFree article

Complete remission after treatment of acute promyelocytic leukemia with arsenic trioxide.

Soignet SL, Maslak P, Wang ZG, Jhanwar S, Calleja E, Dardashti LJ, Corso D, DeBlasio A, Gabrilove J, Scheinberg DA, Pandolfi PP, Warrell RP Jr.

N Engl J Med. 1998 Nov 5;339(19):1341-8.PMID: 9801394 [PubMed - indexed for MEDLINE]Related articlesFree article

Clinical study of 9-cis retinoic acid (LGD1057) in acute promyelocytic leukemia.

Soignet SL, Benedetti F, Fleischauer A, Parker BA, Truglia JA, Ra Crisp M, Warrell RP Jr.

Leukemia. 1998 Oct;12(10):1518-21.PMID: 9766493 [PubMed - indexed for MEDLINE]Related articles

Arsenic trioxide and melarsoprol induce programmed cell death in myeloid leukemia cell lines and function in a PML and PML-RARalpha independent manner.

Wang ZG, Rivi R, Delva L, König A, Scheinberg DA, Gambacorti-Passerini C, Gabrilove JL, Warrell RP Jr, Pandolfi PP.

Blood. 1998 Sep 1;92(5):1497-504.PMID: 9716575 [PubMed - indexed for MEDLINE]Related articlesFree article

Gallium nitrate for the treatment of bone metastases.

Warrell RP Jr.

Cancer. 1997 Oct 15;80(8 Suppl):1680-5. Review.PMID: 9362436 [PubMed - indexed for MEDLINE]Related articlesFree article

Comparative activity of melarsoprol and arsenic trioxide in chronic B-cell leukemia lines.

König A, Wrazel L, Warrell RP Jr, Rivi R, Pandolfi PP, Jakubowski A, Gabrilove JL.

Blood. 1997 Jul 15;90(2):562-70.PMID: 9226155 [PubMed - indexed for MEDLINE]Related articlesFree article

Clinical and molecular aspects of retinoid therapy for acute promyelocytic leukemia.

Warrell RP Jr.

Int J Cancer. 1997 Feb 7;70(4):496-7.PMID: 9033666 [PubMed - indexed for MEDLINE]Related articles

Initial clinical trial of a selective retinoid X receptor ligand, LGD1069.

Miller VA, Benedetti FM, Rigas JR, Verret AL, Pfister DG, Straus D, Kris MG, Crisp M, Heyman R, Loewen GR, Truglia JA, Warrell RP Jr.

J Clin Oncol. 1997 Feb;15(2):790-5.PMID: 9053506 [PubMed - indexed for MEDLINE]Related articles

All-trans retinoic acid significantly increases 5-year survival in patients with acute promyelocytic leukemia: long-term follow-up of the New York study.

Soignet S, Fleischauer A, Polyak T, Heller G, Warrell RP Jr.

Cancer Chemother Pharmacol. 1997;40 Suppl:S25-9.PMID: 9272130 [PubMed - indexed for MEDLINE]Related articles

Pathophysiology and management of bone disease in multiple myeloma.

Niesvizky R, Warrell RP Jr.

Cancer Invest. 1997;15(1):85-90. Review. No abstract available. PMID: 9028394 [PubMed - indexed for MEDLINE]Related articles

Metabolic phenotypes of retinoic acid and the risk of lung cancer.

Rigas JR, Miller VA, Zhang ZF, Klimstra DS, Tong WP, Kris MG, Warrell RP Jr.

Cancer Res. 1996 Jun 15;56(12):2692-6.PMID: 8665495 [PubMed - indexed for MEDLINE]Related articlesFree article

Initial clinical trial of the retinoid receptor pan agonist 9-cis retinoic acid.

Miller VA, Rigas JR, Benedetti FM, Verret AL, Tong WP, Kris MG, Gill GM, Loewen GR, Truglia JA, Ulm EH, Warrell RP Jr.

Clin Cancer Res. 1996 Mar;2(3):471-5.PMID: 9816192 [PubMed - indexed for MEDLINE]Related articlesFree article

Pathogenesis and management of acute promyelocytic leukemia.

Warrell RP Jr.

Annu Rev Med. 1996;47:555-65. Review.PMID: 8712802 [PubMed - indexed for MEDLINE]Related articles

Probing the pathobiology of response to all-trans retinoic acid in acute promyelocytic leukemia: premature chromosome condensation/fluorescence in situ hybridization analysis.

Vyas RC, Frankel SR, Agbor P, Miller WH Jr, Warrell RP Jr, Hittelman WN.

Blood. 1996 Jan 1;87(1):218-26.PMID: 8547645 [PubMed - indexed for MEDLINE]Related articlesFree article

Acute renal failure associated with the retinoic acid syndrome in acute promyelocytic leukemia.

Flombaum CD, Isaacs M, Reich L, Berman E, Warrell RP.

Am J Kidney Dis. 1996 Jan;27(1):134-7.PMID: 8546128 [PubMed - indexed for MEDLINE]Related articles

Radiolabeled anti-CD33 monoclonal antibody M195 for myeloid leukemias.

Jurcic JG, Caron PC, Nikula TK, Papadopoulos EB, Finn RD, Gansow OA, Miller WH Jr, Geerlings MW, Warrell RP Jr, Larson SM, et al.

Cancer Res. 1995 Dec 1;55(23 Suppl):5908s-5910s.PMID: 7493368 [PubMed - indexed for MEDLINE]Related articlesFree article

Rapid diagnosis of acute promyelocytic leukemia by immunohistochemical localization of PML/RAR-alpha protein.

Dyck JA, Warrell RP Jr, Evans RM, Miller WH Jr.

Blood. 1995 Aug 1;86(3):862-7.PMID: 7620182 [PubMed - indexed for MEDLINE]Related articlesFree article

Sequential targeted therapy for relapsed acute promyelocytic leukemia with all-trans retinoic acid and anti-CD33 monoclonal antibody M195.

Jurcic JG, Caron PC, Miller WH Jr, Yao TJ, Maslak P, Finn RD, Larson SM, Warrell RP Jr, Scheinberg DA.

Leukemia. 1995 Feb;9(2):244-8.PMID: 7869759 [PubMed - indexed for MEDLINE]Related articles

Clinical and pharmacology study of chloroquinoxaline sulfonamide given on a weekly schedule.

Rigas JR, Francis PA, Miller VA, Tong WP, Roistacher N, Kris MG, Orazem JP, Young CW, Warrell RP Jr.

Cancer Chemother Pharmacol. 1995;35(6):483-8.PMID: 7882456 [PubMed - indexed for MEDLINE]Related articles

Hypercalcaemia and increased serum interleukin-6 levels induced by all-trans retinoic acid in patients with multiple myeloma.

Niesvizky R, Siegel DS, Busquets X, Nichols G, Muindi J, Warrell RP Jr, Michaeli J.

Br J Haematol. 1995 Jan;89(1):217-8.PMID: 7833269 [PubMed - indexed for MEDLINE]Related articles

Early mortality and the retinoic acid syndrome in acute promyelocytic leukemia: impact of leukocytosis, low-dose chemotherapy, PMN/RAR-alpha isoform, and CD13 expression in patients treated with all-trans retinoic acid.

Vahdat L, Maslak P, Miller WH Jr, Eardley A, Heller G, Scheinberg DA, Warrell RP Jr.

Blood. 1994 Dec 1;84(11):3843-9. Review.PMID: 7949141 [PubMed - indexed for MEDLINE]Related articlesFree article

Therapeutic and neurotoxic effects of 2-chlorodeoxyadenosine in adults with acute myeloid leukemia.

Vahdat L, Wong ET, Wile MJ, Rosenblum M, Foley KM, Warrell RP Jr.

Blood. 1994 Nov 15;84(10):3429-34.PMID: 7949097 [PubMed - indexed for MEDLINE]Related articlesFree article

Clinical pharmacology of all-trans retinoic acid.

Muindi JR, Young CW, Warrell RP Jr.

Leukemia. 1994 Nov;8(11):1807-12. Review.PMID: 7967726 [PubMed - indexed for MEDLINE]Related articles

Two cases of extramedullary acute promyelocytic leukemia. Cytogenetics, molecular biology, and phenotypic and clinical studies.

Weiss MA, Warrell RP Jr.

Cancer. 1994 Oct 1;74(7):1882-6. Review.PMID: 8082094 [PubMed - indexed for MEDLINE]Related articles

Applications for retinoids in cancer therapy.

Warrell RP Jr.

Semin Hematol. 1994 Oct;31(4 Suppl 5):1-13. Review.PMID: 7831579 [PubMed - indexed for MEDLINE]Related articles

Morbidity and costs of remission induction therapy with all-trans retinoic acid compared with standard chemotherapy in acute promyelocytic leukemia.

Eardley AM, Heller G, Warrell RP Jr.

Leukemia. 1994 Jun;8(6):934-9.PMID: 8207987 [PubMed - indexed for MEDLINE]Related articles

Treatment of acute promyelocytic leukemia with all-trans retinoic acid: an update of the New York experience.

Warrell RP Jr, Maslak P, Eardley A, Heller G, Miller WH Jr, Frankel SR.

Leukemia. 1994 Jun;8(6):929-33.PMID: 8207986 [PubMed - indexed for MEDLINE]Related articles

Elevated plasma lipid peroxide content correlates with rapid plasma clearance of all-trans-retinoic acid in patients with advanced cancer.

Muindi JF, Scher HI, Rigas JR, Warrell RP Jr, Young CW.

Cancer Res. 1994 Apr 15;54(8):2125-8.PMID: 8174117 [PubMed - indexed for MEDLINE]Related articlesFree article

All-trans retinoic acid for acute promyelocytic leukemia. Results of the New York Study.

Frankel SR, Eardley A, Heller G, Berman E, Miller WH Jr, Dmitrovsky E, Warrell RP Jr.

Ann Intern Med. 1994 Feb 15;120(4):278-86.PMID: 8291820 [PubMed - indexed for MEDLINE]Related articlesFree article

Modulation of all-trans retinoic acid pharmacokinetics by liarozole.

Miller VA, Rigas JR, Muindi JR, Tong WP, Venkatraman E, Kris MG, Warrell RP Jr.

Cancer Chemother Pharmacol. 1994;34(6):522-6.PMID: 7923564 [PubMed - indexed for MEDLINE]Related articles

The 'standard of care' in acute promyelocytic leukemia.

Warrell RP Jr.

Leukemia. 1994;8 Suppl 2:S56-8; discussion S62. No abstract available. PMID: 7815838 [PubMed - indexed for MEDLINE]Related articles

Treatment of acute promyelocytic leukemia with all-trans retinoic acid: an update of the New York experience.

Warrell RP Jr, Maslak P, Eardley A, Heller G, Miller WH Jr, Frankel SR.

Leukemia. 1994;8 Suppl 2:S33-7.PMID: 7815834 [PubMed - indexed for MEDLINE]Related articles

Clinical pharmacology of all-trans retinoic acid.

Muindi JR, Young CW, Warrell RP Jr.

Leukemia. 1994;8 Suppl 3:S16-21.PMID: 7808019 [PubMed - indexed for MEDLINE]Related articles

Low-dose gallium nitrate for prevention of osteolysis in myeloma: results of a pilot randomized study.

Warrell RP Jr, Lovett D, Dilmanian FA, Schneider R, Heelan RT.

J Clin Oncol. 1993 Dec;11(12):2443-50.PMID: 8246033 [PubMed - indexed for MEDLINE]Related articles