PubMed

Mice expressing the Swedish APP mutation on a 129 genetic background demonstrate consistent behavioral deficits and pathological markers of Alzheimer's disease.

Rustay NR, Cronin EA, Curzon P, Markosyan S, Bitner RS, Ellis TA, Waring JF, Decker MW, Rueter LE, Browman KE.

Brain Res. 2009 Nov 24. [Epub ahead of print]PMID: 19944081 [PubMed - as supplied by publisher]Related articles

Use of toxicogenomics to understand mechanisms of drug-induced hepatotoxicity during drug discovery and development.

Blomme EA, Yang Y, Waring JF.

Toxicol Lett. 2009 Apr 10;186(1):22-31. Epub 2008 Oct 17. Review.PMID: 18996174 [PubMed - indexed for MEDLINE]Related articles

Coexposure of mice to trovafloxacin and lipopolysaccharide, a model of idiosyncratic hepatotoxicity, results in a unique gene expression profile and interferon gamma-dependent liver injury.

Shaw PJ, Ditewig AC, Waring JF, Liguori MJ, Blomme EA, Ganey PE, Roth RA.

Toxicol Sci. 2009 Jan;107(1):270-80. Epub 2008 Oct 16.PMID: 18930950 [PubMed - indexed for MEDLINE]Related articles

Gene expression profiles in livers from diclofenac-treated rats reveal intestinal bacteria-dependent and -independent pathways associated with liver injury.

Deng X, Liguori MJ, Sparkenbaugh EM, Waring JF, Blomme EA, Ganey PE, Roth RA.

J Pharmacol Exp Ther. 2008 Dec;327(3):634-44. Epub 2008 Sep 18.PMID: 18801949 [PubMed - indexed for MEDLINE]Related articlesFree article

Application of a high-content multiparameter cytotoxicity assay to prioritize compounds based on toxicity potential in humans.

Abraham VC, Towne DL, Waring JF, Warrior U, Burns DJ.

J Biomol Screen. 2008 Jul;13(6):527-37. Epub 2008 Jun 19.PMID: 18566484 [PubMed - indexed for MEDLINE]Related articles

Role of GSK-3beta activation and alpha7 nAChRs in Abeta(1-42)-induced tau phosphorylation in PC12 cells.

Hu M, Waring JF, Gopalakrishnan M, Li J.

J Neurochem. 2008 Aug;106(3):1371-7. Epub 2008 May 15.PMID: 18485099 [PubMed - indexed for MEDLINE]Related articles

Preclinical characterization of A-582941: a novel alpha7 neuronal nicotinic receptor agonist with broad spectrum cognition-enhancing properties.

Tietje KR, Anderson DJ, Bitner RS, Blomme EA, Brackemeyer PJ, Briggs CA, Browman KE, Bury D, Curzon P, Drescher KU, Frost JM, Fryer RM, Fox GB, Gronlien JH, Håkerud M, Gubbins EJ, Halm S, Harris R, Helfrich RJ, Kohlhaas KL, Law D, Malysz J, Marsh KC, Martin RL, Meyer MD, Molesky AL, Nikkel AL, Otte S, Pan L, Puttfarcken PS, Radek RJ, Robb HM, Spies E, Thorin-Hagene K, Waring JF, Ween H, Xu H, Gopalakrishnan M, Bunnelle WH.

CNS Neurosci Ther. 2008 Spring;14(1):65-82. Review.PMID: 18482100 [PubMed - indexed for MEDLINE]Related articles

Use of traditional end points and gene dysregulation to understand mechanisms of toxicity: toxicogenomics in mechanistic toxicology.

Buck WR, Waring JF, Blomme EA.

Methods Mol Biol. 2008;460:23-44.PMID: 18449481 [PubMed - indexed for MEDLINE]Related articles

Evaluation of the effects of serial phlebotomy on the transcriptome of major tissues and on the response to toxicants in rats.

Blomme EA, Ciurlionis R, Marsh KC, Waring JF, Yang Y.

Toxicol Lett. 2008 Jan 30;176(2):138-48. Epub 2007 Oct 9.PMID: 18164877 [PubMed - indexed for MEDLINE]Related articles

Analysis of gene expression profiles in rat hippocampus following treatment with nicotine and an alpha7 nAChR selective agonist.

Waring JF, Abel S, Li J, Bitner RS, Nikkel AL, Blomme EA, Anderson DJ, Gopalakrishnan M.

Neurosci Res. 2008 Mar;60(3):266-74. Epub 2007 Nov 22.PMID: 18164502 [PubMed - indexed for MEDLINE]Related articles

A human immunodeficiency virus protease inhibitor is a novel functional inhibitor of human pregnane X receptor.

Healan-Greenberg C, Waring JF, Kempf DJ, Blomme EA, Tirona RG, Kim RB.

Drug Metab Dispos. 2008 Mar;36(3):500-7. Epub 2007 Dec 20.PMID: 18096673 [PubMed - indexed for MEDLINE]Related articlesFree article

Gene expression analysis in rats treated with experimental acetyl-coenzyme A carboxylase inhibitors suggests interactions with the peroxisome proliferator-activated receptor alpha pathway.

Waring JF, Yang Y, Healan-Greenberg CH, Adler AL, Dickinson R, McNally T, Wang X, Weitzberg M, Xu X, Lisowski A, Warder SE, Gu YG, Zinker BA, Blomme EA, Camp HS.

J Pharmacol Exp Ther. 2008 Feb;324(2):507-16. Epub 2007 Nov 19.PMID: 18025247 [PubMed - indexed for MEDLINE]Related articlesFree article

Trovafloxacin-induced gene expression changes in liver-derived in vitro systems: comparison of primary human hepatocytes to HepG2 cells.

Liguori MJ, Blomme EA, Waring JF.

Drug Metab Dispos. 2008 Feb;36(2):223-33. Epub 2007 Oct 29.PMID: 17967932 [PubMed - indexed for MEDLINE]Related articlesFree article

G1P3, an IFN-induced survival factor, antagonizes TRAIL-induced apoptosis in human myeloma cells.

Cheriyath V, Glaser KB, Waring JF, Baz R, Hussein MA, Borden EC.

J Clin Invest. 2007 Oct;117(10):3107-17.PMID: 17823654 [PubMed - indexed for MEDLINE]Related articlesFree article

Gene expression profiling of rat liver reveals a mechanistic basis for ritonavir-induced hyperlipidemia.

Lum PY, He YD, Slatter JG, Waring JF, Zelinsky N, Cavet G, Dai X, Fong O, Gum R, Jin L, Adamson GE, Roberts CJ, Olsen DB, Hazuda DJ, Ulrich RG.

Genomics. 2007 Oct;90(4):464-73. Epub 2007 Aug 23.PMID: 17719200 [PubMed - indexed for MEDLINE]Related articles

Development of an approach for ab initio estimation of compound-induced liver injury based on global gene transcriptional profiles.

Dai X, He YD, Dai H, Lum PY, Roberts CJ, Waring JF, Ulrich RG.

Genome Inform. 2006;17(2):77-88.PMID: 17503381 [PubMed - indexed for MEDLINE]Related articles

Development of an in vitro gene expression assay for predicting hepatotoxicity.

Abel S, Yang Y, Waring JF.

ALTEX. 2006;23 Suppl:326-31.PMID: 17492207 [PubMed - in process]Related articles

N-{3-[2-(4-alkoxyphenoxy)thiazol-5-yl]-1-methylprop-2-ynyl}carboxy derivatives as acetyl-coA carboxylase inhibitors--improvement of cardiovascular and neurological liabilities via structural modifications.

Gu YG, Weitzberg M, Clark RF, Xu X, Li Q, Lubbers NL, Yang Y, Beno DW, Widomski DL, Zhang T, Hansen TM, Keyes RF, Waring JF, Carroll SL, Wang X, Wang R, Healan-Greenberg CH, Blomme EA, Beutel BA, Sham HL, Camp HS.

J Med Chem. 2007 Mar 8;50(5):1078-82. Epub 2007 Feb 14.PMID: 17298049 [PubMed - indexed for MEDLINE]Related articles

Investigations toward enhanced understanding of hepatic idiosyncratic drug reactions.

Liguori MJ, Waring JF.

Expert Opin Drug Metab Toxicol. 2006 Dec;2(6):835-46. Review.PMID: 17125404 [PubMed - indexed for MEDLINE]Related articles

Modest inflammation enhances diclofenac hepatotoxicity in rats: role of neutrophils and bacterial translocation.

Deng X, Stachlewitz RF, Liguori MJ, Blomme EA, Waring JF, Luyendyk JP, Maddox JF, Ganey PE, Roth RA.

J Pharmacol Exp Ther. 2006 Dec;319(3):1191-9. Epub 2006 Sep 21.PMID: 16990511 [PubMed - indexed for MEDLINE]Related articlesFree article

Development of a toxicogenomics in vitro assay for the efficient characterization of compounds.

Yang Y, Abel SJ, Ciurlionis R, Waring JF.

Pharmacogenomics. 2006 Mar;7(2):177-86.PMID: 16515397 [PubMed - indexed for MEDLINE]Related articles

Gene expression in human hepatocytes in suspension after isolation is similar to the liver of origin, is not affected by hepatocyte cold storage and cryopreservation, but is strongly changed after hepatocyte plating.

Richert L, Liguori MJ, Abadie C, Heyd B, Mantion G, Halkic N, Waring JF.

Drug Metab Dispos. 2006 May;34(5):870-9. Epub 2006 Feb 10.PMID: 16473918 [PubMed - indexed for MEDLINE]Related articlesFree article

Practical preclinical model for assessing the potential for unconjugated hyperbilirubinemia produced by human immunodeficiency virus protease inhibitors.

Kempf DJ, Waring JF, Morfitt DC, Werner P, Ebert B, Mitten M, Nguyen B, Randolph JT, DeGoey DA, Klein LL, Marsh K.

Antimicrob Agents Chemother. 2006 Feb;50(2):762-4.PMID: 16436740 [PubMed - indexed for MEDLINE]Related articlesFree article

Use of a mixed tissue RNA design for performance assessments on multiple microarray formats.

Thompson KL, Rosenzweig BA, Pine PS, Retief J, Turpaz Y, Afshari CA, Hamadeh HK, Damore MA, Boedigheimer M, Blomme E, Ciurlionis R, Waring JF, Fuscoe JC, Paules R, Tucker CJ, Fare T, Coffey EM, He Y, Collins PJ, Jarnagin K, Fujimoto S, Ganter B, Kiser G, Kaysser-Kranich T, Sina J, Sistare FD.

Nucleic Acids Res. 2005 Dec 23;33(22):e187.PMID: 16377776 [PubMed - indexed for MEDLINE]Related articlesFree article

Microarray analysis of lipopolysaccharide potentiation of trovafloxacin-induced liver injury in rats suggests a role for proinflammatory chemokines and neutrophils.

Waring JF, Liguori MJ, Luyendyk JP, Maddox JF, Ganey PE, Stachlewitz RF, North C, Blomme EA, Roth RA.

J Pharmacol Exp Ther. 2006 Mar;316(3):1080-7. Epub 2005 Nov 18.PMID: 16299187 [PubMed - indexed for MEDLINE]Related articlesFree article

Preclinical profiling and safety studies of ABT-769: a compound with potential for broad-spectrum antiepileptic activity.

Giardina WJ, Dart MJ, Harris RR, Bitner RS, Radek RJ, Fox GB, Chemburkar SR, Marsh KC, Waring JF, Hui JY, Chen J, Curzon P, Grayson GK, Komater VA, Ku Y, Lockwood M, Miner HM, Nikkel AL, Pan JB, Pu YM, Wang L, Bennani Y, Durmuller N, Jolly R, Roux S, Sullivan JP, Decker MW.

Epilepsia. 2005 Sep;46(9):1349-61.PMID: 16146429 [PubMed - indexed for MEDLINE]Related articles

Idiosyncratic toxicity: mechanistic insights gained from analysis of prior compounds.

Waring JF, Anderson MG.

Curr Opin Drug Discov Devel. 2005 Jan;8(1):59-65. Review.PMID: 15679173 [PubMed - indexed for MEDLINE]Related articles

Microarray analysis in human hepatocytes suggests a mechanism for hepatotoxicity induced by trovafloxacin.

Liguori MJ, Anderson MG, Bukofzer S, McKim J, Pregenzer JF, Retief J, Spear BB, Waring JF.

Hepatology. 2005 Jan;41(1):177-86.PMID: 15619227 [PubMed - indexed for MEDLINE]Related articles

Toxicogenomics in drug discovery: from preclinical studies to clinical trials.

Yang Y, Blomme EA, Waring JF.

Chem Biol Interact. 2004 Nov 1;150(1):71-85. Review.PMID: 15522262 [PubMed - indexed for MEDLINE]Related articles

Microvesicular steatosis induced by a short chain fatty acid: effects on mitochondrial function and correlation with gene expression.

Jolly RA, Ciurlionis R, Morfitt D, Helgren M, Patterson R, Ulrich RG, Waring JF.

Toxicol Pathol. 2004 Jul-Aug;32 Suppl 2:19-25.PMID: 15503661 [PubMed - indexed for MEDLINE]Related articles

Interlaboratory evaluation of rat hepatic gene expression changes induced by methapyrilene.

Waring JF, Ulrich RG, Flint N, Morfitt D, Kalkuhl A, Staedtler F, Lawton M, Beekman JM, Suter L.

Environ Health Perspect. 2004 Mar;112(4):439-48.PMID: 15033593 [PubMed - indexed for MEDLINE]Related articlesFree article

Clofibrate-induced gene expression changes in rat liver: a cross-laboratory analysis using membrane cDNA arrays.

Baker VA, Harries HM, Waring JF, Duggan CM, Ni HA, Jolly RA, Yoon LW, De Souza AT, Schmid JE, Brown RH, Ulrich RG, Rockett JC.

Environ Health Perspect. 2004 Mar;112(4):428-38.PMID: 15033592 [PubMed - indexed for MEDLINE]Related articlesFree article

Isolated human hepatocytes in culture display markedly different gene expression patterns depending on attachment status.

Waring JF, Ciurlionis R, Jolly RA, Heindel M, Gagne G, Fagerland JA, Ulrich RG.

Toxicol In Vitro. 2003 Oct-Dec;17(5-6):693-701.PMID: 14599465 [PubMed - indexed for MEDLINE]Related articles

PTP1B antisense-treated mice show regulation of genes involved in lipogenesis in liver and fat.

Waring JF, Ciurlionis R, Clampit JE, Morgan S, Gum RJ, Jolly RA, Kroeger P, Frost L, Trevillyan J, Zinker BA, Jirousek M, Ulrich RG, Rondinone CM.

Mol Cell Endocrinol. 2003 May 30;203(1-2):155-68.PMID: 12782412 [PubMed - indexed for MEDLINE]Related articles

Development of a DNA microarray for toxicology based on hepatotoxin-regulated sequences.

Waring JF, Cavet G, Jolly RA, McDowell J, Dai H, Ciurlionis R, Zhang C, Stoughton R, Lum P, Ferguson A, Roberts CJ, Ulrich RG.

EHP Toxicogenomics. 2003 Jan;111(1T):53-60.PMID: 12735110 [PubMed - indexed for MEDLINE]Related articles

Antisense protein tyrosine phosphatase 1B reverses activation of p38 mitogen-activated protein kinase in liver of ob/ob mice.

Gum RJ, Gaede LL, Heindel MA, Waring JF, Trevillyan JM, Zinker BA, Stark ME, Wilcox D, Jirousek MR, Rondinone CM, Ulrich RG.

Mol Endocrinol. 2003 Jun;17(6):1131-43. Epub 2003 Mar 20.PMID: 12649327 [PubMed - indexed for MEDLINE]Related articlesFree article

Gene expression profiling of multiple histone deacetylase (HDAC) inhibitors: defining a common gene set produced by HDAC inhibition in T24 and MDA carcinoma cell lines.

Glaser KB, Staver MJ, Waring JF, Stender J, Ulrich RG, Davidsen SK.

Mol Cancer Ther. 2003 Feb;2(2):151-63.PMID: 12589032 [PubMed - indexed for MEDLINE]Related articlesFree article

Identifying toxic mechanisms using DNA microarrays: evidence that an experimental inhibitor of cell adhesion molecule expression signals through the aryl hydrocarbon nuclear receptor.

Waring JF, Gum R, Morfitt D, Jolly RA, Ciurlionis R, Heindel M, Gallenberg L, Buratto B, Ulrich RG.

Toxicology. 2002 Dec 27;181-182:537-50.PMID: 12505364 [PubMed - indexed for MEDLINE]Related articles

PTP1B antisense oligonucleotide lowers PTP1B protein, normalizes blood glucose, and improves insulin sensitivity in diabetic mice.

Zinker BA, Rondinone CM, Trevillyan JM, Gum RJ, Clampit JE, Waring JF, Xie N, Wilcox D, Jacobson P, Frost L, Kroeger PE, Reilly RM, Koterski S, Opgenorth TJ, Ulrich RG, Crosby S, Butler M, Murray SF, McKay RA, Bhanot S, Monia BP, Jirousek MR.

Proc Natl Acad Sci U S A. 2002 Aug 20;99(17):11357-62. Epub 2002 Aug 8.PMID: 12169659 [PubMed - indexed for MEDLINE]Related articlesFree article

Protein tyrosine phosphatase 1B reduction regulates adiposity and expression of genes involved in lipogenesis.

Rondinone CM, Trevillyan JM, Clampit J, Gum RJ, Berg C, Kroeger P, Frost L, Zinker BA, Reilly R, Ulrich R, Butler M, Monia BP, Jirousek MR, Waring JF.

Diabetes. 2002 Aug;51(8):2405-11.PMID: 12145151 [PubMed - indexed for MEDLINE]Related articlesFree article

The promise of toxicogenomics.

Waring JF, Halbert DN.

Curr Opin Mol Ther. 2002 Jun;4(3):229-35. Review.PMID: 12139308 [PubMed - indexed for MEDLINE]Related articles

Clustering of hepatotoxins based on mechanism of toxicity using gene expression profiles.

Waring JF, Jolly RA, Ciurlionis R, Lum PY, Praestgaard JT, Morfitt DC, Buratto B, Roberts C, Schadt E, Ulrich RG.

Toxicol Appl Pharmacol. 2001 Aug 15;175(1):28-42.PMID: 11509024 [PubMed - indexed for MEDLINE]Related articles

Microarray analysis of hepatotoxins in vitro reveals a correlation between gene expression profiles and mechanisms of toxicity.

Waring JF, Ciurlionis R, Jolly RA, Heindel M, Ulrich RG.

Toxicol Lett. 2001 Mar 31;120(1-3):359-68.PMID: 11323195 [PubMed - indexed for MEDLINE]Related articles

A 3'-transcribed region of the HLA-A2 gene mediates posttranscriptional stimulation by IFN-gamma.

Snyder SR, Waring JF, Zhu SZ, Kaplan S, Schultz J, Ginder GD.

J Immunol. 2001 Mar 15;166(6):3966-74.PMID: 11238642 [PubMed - indexed for MEDLINE]Related articlesFree article

Identification of CCAAT displacement protein (CDP/cut) as a locus-specific repressor of major histocompatibility complex gene expression in human tumor cells.

Snyder SR, Wang J, Waring JF, Ginder GD.

J Biol Chem. 2001 Feb 16;276(7):5323-30. Epub 2000 Nov 17.PMID: 11084046 [PubMed - indexed for MEDLINE]Related articlesFree article

The impact of genomics-based technologies on drug safety evaluation.

Waring JF, Ulrich RG.

Annu Rev Pharmacol Toxicol. 2000;40:335-52. Review.PMID: 10836140 [PubMed - indexed for MEDLINE]Related articles

Interferon consensus sequence binding protein and interferon regulatory factor-4/Pip form a complex that represses the expression of the interferon-stimulated gene-15 in macrophages.

Rosenbauer F, Waring JF, Foerster J, Wietstruk M, Philipp D, Horak I.

Blood. 1999 Dec 15;94(12):4274-81.PMID: 10590072 [PubMed - indexed for MEDLINE]Related articlesFree article

Altered development and cytokine responses of myeloid progenitors in the absence of transcription factor, interferon consensus sequence binding protein.

Scheller M, Foerster J, Heyworth CM, Waring JF, Löhler J, Gilmore GL, Shadduck RK, Dexter TM, Horak I.

Blood. 1999 Dec 1;94(11):3764-71.PMID: 10572090 [PubMed - indexed for MEDLINE]Related articlesFree article

Lack of interferon consensus sequence binding protein (ICSBP) transcripts in human myeloid leukemias.

Schmidt M, Nagel S, Proba J, Thiede C, Ritter M, Waring JF, Rosenbauer F, Huhn D, Wittig B, Horak I, Neubauer A.

Blood. 1998 Jan 1;91(1):22-9.PMID: 9414265 [PubMed - indexed for MEDLINE]Related articlesFree article

Immunodeficiency and chronic myelogenous leukemia-like syndrome in mice with a targeted mutation of the ICSBP gene.

Holtschke T, Löhler J, Kanno Y, Fehr T, Giese N, Rosenbauer F, Lou J, Knobeloch KP, Gabriele L, Waring JF, Bachmann MF, Zinkernagel RM, Morse HC 3rd, Ozato K, Horak I.

Cell. 1996 Oct 18;87(2):307-17.PMID: 8861914 [PubMed - indexed for MEDLINE]Related articles