PubMed

Functional Effects of Polymorphisms in the Human Gene Encoding 11{beta}-Hydroxysteroid Dehydrogenase Type 1 (11{beta}-HSD1): A Sequence Variant at the Translation Start of 11{beta}-HSD1 Alters Enzyme Levels.

Malavasi EL, Kelly V, Nath N, Gambineri A, Dakin RS, Pagotto U, Pasquali R, Walker BR, Chapman KE.

Endocrinology. 2009 Nov 24. [Epub ahead of print]PMID: 19934376 [PubMed - as supplied by publisher]

Chronic hypoxia augments depolarization-induced Ca2+-sensitization in pulmonary vascular smooth muscle through superoxide-dependent stimulation of RhoA.

Broughton BR, Jernigan NL, Norton CE, Walker BR, Resta TC.

Am J Physiol Lung Cell Mol Physiol. 2009 Nov 6. [Epub ahead of print]PMID: 19897743 [PubMed - as supplied by publisher]Related articles

Rat Strain Differences in Pulmonary Artery Smooth Muscle Ca(2+) Entry Following Chronic Hypoxia.

Snow JB, Kanagy NL, Walker BR, Resta TC.

Microcirculation. 2009 Jul 22:1-12. [Epub ahead of print]PMID: 19626552 [PubMed - as supplied by publisher]Related articles

Lack of regulation of 11beta-hydroxysteroid dehydrogenase type 1 during short-term manipulation of GH in patients with hypopituitarism.

Sigurjonsdottir HA, Andrew R, Stimson RH, Johannsson G, Walker BR.

Eur J Endocrinol. 2009 Sep;161(3):375-80. Epub 2009 Jun 23.PMID: 19549748 [PubMed - indexed for MEDLINE]Related articlesFree article

Increased clearance of cortisol by 5beta-reductase in a subgroup of women with adrenal hyperandrogenism in polycystic ovary syndrome.

Gambineri A, Forlani G, Munarini A, Tomassoni F, Cognigni GE, Ciampaglia W, Pagotto U, Walker BR, Pasquali R.

J Endocrinol Invest. 2009 Mar;32(3):210-8.PMID: 19542736 [PubMed - indexed for MEDLINE]Related articles

ASIC1 contributes to pulmonary vascular smooth muscle store-operated Ca(2+) entry.

Jernigan NL, Paffett ML, Walker BR, Resta TC.

Am J Physiol Lung Cell Mol Physiol. 2009 Aug;297(2):L271-85. Epub 2009 May 29.PMID: 19482897 [PubMed - indexed for MEDLINE]Related articles

Circulating plasma cortisol concentrations are not associated with coronary artery disease or peripheral vascular disease.

Reynolds RM, Ilyas B, Price JF, Fowkes FG, Newby DE, Webb DJ, Walker BR.

QJM. 2009 Jul;102(7):469-75. Epub 2009 May 20.PMID: 19458201 [PubMed - in process]Related articles

Programming of hypertension: associations of plasma aldosterone in adult men and women with birthweight, cortisol, and blood pressure.

Reynolds RM, Walker BR, Phillips DI, Dennison EM, Fraser R, Mackenzie SM, Davies E, Connell JM.

Hypertension. 2009 Jun;53(6):932-6. Epub 2009 Apr 20.PMID: 19380612 [PubMed - indexed for MEDLINE]Related articles

Differential effects of abdominal adipose tissue distribution on insulin sensitivity in black and white South African women.

Goedecke JH, Levitt NS, Lambert EV, Utzschneider KM, Faulenbach MV, Dave JA, West S, Victor H, Evans J, Olsson T, Walker BR, Seckl JR, Kahn SE.

Obesity (Silver Spring). 2009 Aug;17(8):1506-12. Epub 2009 Mar 19.PMID: 19300428 [PubMed - indexed for MEDLINE]Related articles

Therapeutic manipulation of glucocorticoid metabolism in cardiovascular disease.

Hadoke PW, Iqbal J, Walker BR.

Br J Pharmacol. 2009 Mar;156(5):689-712. Epub 2009 Feb 23. Review.PMID: 19239478 [PubMed - indexed for MEDLINE]Related articles

Dysregulation of glucocorticoid metabolism in murine obesity: comparable effects of leptin resistance and deficiency.

Livingstone DE, Grassick SL, Currie GL, Walker BR, Andrew R.

J Endocrinol. 2009 May;201(2):211-8. Epub 2009 Feb 17.PMID: 19223399 [PubMed - indexed for MEDLINE]Related articlesFree article

Insulin response in relation to insulin sensitivity: an appropriate beta-cell response in black South African women.

Goedecke JH, Dave JA, Faulenbach MV, Utzschneider KM, Lambert EV, West S, Collins M, Olsson T, Walker BR, Seckl JR, Kahn SE, Levitt NS.

Diabetes Care. 2009 May;32(5):860-5. Epub 2009 Feb 5.PMID: 19196884 [PubMed - indexed for MEDLINE]Related articlesFree article

Cortisol inactivation by 11beta-hydroxysteroid dehydrogenase-2 may enhance endometrial angiogenesis via reduced thrombospondin-1 in heavy menstruation.

Rae M, Mohamad A, Price D, Hadoke PW, Walker BR, Mason JI, Hillier SG, Critchley HO.

J Clin Endocrinol Metab. 2009 Apr;94(4):1443-50. Epub 2009 Jan 21.PMID: 19158196 [PubMed - indexed for MEDLINE]Related articles

Quantitative analysis of RU38486 (mifepristone) by HPLC triple quadrupole mass spectrometry.

Homer NZ, Reynolds RM, Mattsson C, Bailey MA, Walker BR, Andrew R.

J Chromatogr B Analyt Technol Biomed Life Sci. 2009 Feb 15;877(5-6):497-501. Epub 2008 Dec 27.PMID: 19157997 [PubMed - indexed for MEDLINE]Related articles

Combined receptor antagonist stimulation of the hypothalamic-pituitary-adrenal axis test identifies impaired negative feedback sensitivity to cortisol in obese men.

Mattsson C, Reynolds RM, Simonyte K, Olsson T, Walker BR.

J Clin Endocrinol Metab. 2009 Apr;94(4):1347-52. Epub 2009 Jan 13.PMID: 19141586 [PubMed - indexed for MEDLINE]Related articles

Gender differences in mesenteric vasoconstrictor reactivity following chronic hypoxia.

Gonzales RJ, Bryant JM, Naik JS, Resta TC, Walker BR.

Microcirculation. 2008 Aug;15(6):473-84.PMID: 19086257 [PubMed - indexed for MEDLINE]Related articles

Antioxidant and vasodilatory effects of heme oxygenase on mesenteric vasoreactivity following chronic hypoxia.

Sweazea K, Walker BR.

Microcirculation. 2009 Feb;16(2):131-41. Epub 2008 Dec 27.PMID: 19031291 [PubMed - indexed for MEDLINE]Related articles

Cortisol release from adipose tissue by 11beta-hydroxysteroid dehydrogenase type 1 in humans.

Stimson RH, Andersson J, Andrew R, Redhead DN, Karpe F, Hayes PC, Olsson T, Walker BR.

Diabetes. 2009 Jan;58(1):46-53. Epub 2008 Oct 13.PMID: 18852329 [PubMed - indexed for MEDLINE]Related articlesFree article

Reactive oxygen species mediate RhoA/Rho kinase-induced Ca2+ sensitization in pulmonary vascular smooth muscle following chronic hypoxia.

Jernigan NL, Walker BR, Resta TC.

Am J Physiol Lung Cell Mol Physiol. 2008 Sep;295(3):L515-29. Epub 2008 Jul 11.PMID: 18621909 [PubMed - indexed for MEDLINE]Related articlesFree article

Cytokine-induced arginase activity in pulmonary endothelial cells is dependent on Src family tyrosine kinase activity.

Chang R, Chicoine LG, Cui H, Kanagy NL, Walker BR, Liu Y, English BK, Nelin LD.

Am J Physiol Lung Cell Mol Physiol. 2008 Oct;295(4):L688-97. Epub 2008 Jul 11.PMID: 18621907 [PubMed - indexed for MEDLINE]Related articlesFree article

Gender Differences in Mesenteric Vasoconstrictor Reactivity following Chronic Hypoxia.

Gonzales RJ, Bryant JM, Naik JS, Resta TC, Walker BR.

Microcirculation. 2008 Jun 24:1. [Epub ahead of print]PMID: 18608988 [PubMed - as supplied by publisher]Related articles

Endothelin type A receptor antagonist normalizes blood pressure in rats exposed to eucapnic intermittent hypoxia.

Allahdadi KJ, Cherng TW, Pai H, Silva AQ, Walker BR, Nelin LD, Kanagy NL.

Am J Physiol Heart Circ Physiol. 2008 Jul;295(1):H434-40. Epub 2008 May 30.PMID: 18515645 [PubMed - indexed for MEDLINE]Related articlesFree article

Glucocorticoids and fatty acid metabolism in humans: fuelling fat redistribution in the metabolic syndrome.

Macfarlane DP, Forbes S, Walker BR.

J Endocrinol. 2008 May;197(2):189-204.PMID: 18434349 [PubMed - indexed for MEDLINE]Related articlesFree article

11-Beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1) inhibitors in type 2 diabetes mellitus and obesity.

Hughes KA, Webster SP, Walker BR.

Expert Opin Investig Drugs. 2008 Apr;17(4):481-96. Review.PMID: 18363514 [PubMed - indexed for MEDLINE]Related articles

Idiopathic intracranial hypertension: can studies of obesity provide the key to understanding pathogenesis?

Ooi LY, Walker BR, Bodkin PA, Whittle IR.

Br J Neurosurg. 2008 Apr;22(2):187-94. Review.PMID: 18348012 [PubMed - indexed for MEDLINE]Related articles

Chronic hypoxia induces Rho kinase-dependent myogenic tone in small pulmonary arteries.

Broughton BR, Walker BR, Resta TC.

Am J Physiol Lung Cell Mol Physiol. 2008 Apr;294(4):L797-806. Epub 2008 Feb 8.PMID: 18263668 [PubMed - indexed for MEDLINE]Related articlesFree article

Blood vessel structure in hypertension.

Irving RJ, Walker BR.

Saudi J Kidney Dis Transpl. 1999 Jul-Sep;10(3):257-66. No abstract available. PMID: 18212434 [PubMed - in process]Related articlesFree article

A neuronal microtubule-interacting agent, NAPVSIPQ, reduces tau pathology and enhances cognitive function in a mouse model of Alzheimer's disease.

Matsuoka Y, Jouroukhin Y, Gray AJ, Ma L, Hirata-Fukae C, Li HF, Feng L, Lecanu L, Walker BR, Planel E, Arancio O, Gozes I, Aisen PS.

J Pharmacol Exp Ther. 2008 Apr;325(1):146-53. Epub 2008 Jan 16.PMID: 18199809 [PubMed - indexed for MEDLINE]Related articlesFree article

Eucapnic intermittent hypoxia augments endothelin-1 vasoconstriction in rats: role of PKCdelta.

Allahdadi KJ, Duling LC, Walker BR, Kanagy NL.

Am J Physiol Heart Circ Physiol. 2008 Feb;294(2):H920-7. Epub 2007 Dec 14.PMID: 18083893 [PubMed - indexed for MEDLINE]Related articlesFree article

Glucocorticoids and cardiovascular disease.

Walker BR.

Eur J Endocrinol. 2007 Nov;157(5):545-59. Review.PMID: 17984234 [PubMed - indexed for MEDLINE]Related articlesFree article

Differential effects of chronic hypoxia and intermittent hypocapnic and eucapnic hypoxia on pulmonary vasoreactivity.

Snow JB, Kitzis V, Norton CE, Torres SN, Johnson KD, Kanagy NL, Walker BR, Resta TC.

J Appl Physiol. 2008 Jan;104(1):110-8. Epub 2007 Oct 18.PMID: 17947499 [PubMed - indexed for MEDLINE]Related articlesFree article

Glucocorticoids and 11beta-hydroxysteroid dehydrogenase type 1 in obesity and the metabolic syndrome.

Stimson RH, Walker BR.

Minerva Endocrinol. 2007 Sep;32(3):141-59. Review.PMID: 17912154 [PubMed - indexed for MEDLINE]Related articles

Acute effects of glucocorticoids on endothelial fibrinolytic and vasodilator function in humans.

Dover AR, Hadoke PW, Walker BR, Newby DE.

J Cardiovasc Pharmacol. 2007 Sep;50(3):321-6.PMID: 17878762 [PubMed - indexed for MEDLINE]Related articles

Maturational changes in the regulation of pulmonary vascular tone by nitric oxide in neonatal rats.

Chicoine LG, Paffett ML, Girton MR, Metropoulus MJ, Joshi MS, Bauer JA, Nelin LD, Resta TC, Walker BR.

Am J Physiol Lung Cell Mol Physiol. 2007 Nov;293(5):L1261-70. Epub 2007 Sep 7.PMID: 17827249 [PubMed - indexed for MEDLINE]Related articlesFree article

Dietary macronutrient content alters cortisol metabolism independently of body weight changes in obese men.

Stimson RH, Johnstone AM, Homer NZ, Wake DJ, Morton NM, Andrew R, Lobley GE, Walker BR.

J Clin Endocrinol Metab. 2007 Nov;92(11):4480-4. Epub 2007 Sep 4.PMID: 17785367 [PubMed - indexed for MEDLINE]Related articlesFree article

ROK contribution to endothelin-mediated contraction in aorta and mesenteric arteries following intermittent hypoxia/hypercapnia in rats.

Allahdadi KJ, Walker BR, Kanagy NL.

Am J Physiol Heart Circ Physiol. 2007 Nov;293(5):H2911-8. Epub 2007 Aug 24.PMID: 17720771 [PubMed - indexed for MEDLINE]Related articlesFree article

Vascular adaptations to hypoxia: molecular and cellular mechanisms regulating vascular tone.

Paffett ML, Walker BR.

Essays Biochem. 2007;43:105-19. Review.PMID: 17705796 [PubMed - indexed for MEDLINE]Related articles

Reduced store-operated Ca2+ entry in pulmonary endothelial cells from chronically hypoxic rats.

Paffett ML, Naik JS, Resta TC, Walker BR.

Am J Physiol Lung Cell Mol Physiol. 2007 Nov;293(5):L1135-42. Epub 2007 Aug 10.PMID: 17693482 [PubMed - indexed for MEDLINE]Related articlesFree article

Effects of gonadectomy on glucocorticoid metabolism in obese Zucker rats.

Barat P, Livingstone DE, Elferink CM, McDonnell CR, Walker BR, Andrew R.

Endocrinology. 2007 Oct;148(10):4836-43. Epub 2007 Jul 12.PMID: 17628001 [PubMed - indexed for MEDLINE]Related articlesFree article

Omental 11beta-hydroxysteroid dehydrogenase 1 correlates with fat cell size independently of obesity.

Michailidou Z, Jensen MD, Dumesic DA, Chapman KE, Seckl JR, Walker BR, Morton NM.

Obesity (Silver Spring). 2007 May;15(5):1155-63.PMID: 17495191 [PubMed - indexed for MEDLINE]Related articles

Can cortisol predict the future in obesity?

Reynolds RM, Walker BR.

Clin Endocrinol (Oxf). 2007 Jul;67(1):1-2. Epub 2007 Apr 27. No abstract available. PMID: 17466008 [PubMed - indexed for MEDLINE]Related articles

Truncal distribution of fat mass, metabolic profile and hypothalamic-pituitary adrenal axis activity in prepubertal obese children.

Barat P, Gayard-Cros M, Andrew R, Corcuff JB, Jouret B, Barthe N, Perez P, Germain C, Tauber M, Walker BR, Mormede P, Duclos M.

J Pediatr. 2007 May;150(5):535-9, 539.e1.PMID: 17452232 [PubMed - indexed for MEDLINE]Related articles

Discovery and biological evaluation of adamantyl amide 11beta-HSD1 inhibitors.

Webster SP, Ward P, Binnie M, Craigie E, McConnell KM, Sooy K, Vinter A, Seckl JR, Walker BR.

Bioorg Med Chem Lett. 2007 May 15;17(10):2838-43. Epub 2007 Feb 25.PMID: 17350260 [PubMed - indexed for MEDLINE]Related articles

Extra-adrenal regeneration of glucocorticoids by 11beta-hydroxysteroid dehydrogenase type 1: physiological regulator and pharmacological target for energy partitioning.

Walker BR.

Proc Nutr Soc. 2007 Feb;66(1):1-8.PMID: 17343766 [PubMed - indexed for MEDLINE]Related articles

Effects of peroxisome proliferator-activated receptor-alpha and -gamma agonists on 11beta-hydroxysteroid dehydrogenase type 1 in subcutaneous adipose tissue in men.

Wake DJ, Stimson RH, Tan GD, Homer NZ, Andrew R, Karpe F, Walker BR.

J Clin Endocrinol Metab. 2007 May;92(5):1848-56. Epub 2007 Feb 27.PMID: 17327378 [PubMed - indexed for MEDLINE]Related articlesFree article

Intra-adipose sex steroid metabolism and body fat distribution in idiopathic human obesity.

Wake DJ, Strand M, Rask E, Westerbacka J, Livingstone DE, Soderberg S, Andrew R, Yki-Jarvinen H, Olsson T, Walker BR.

Clin Endocrinol (Oxf). 2007 Mar;66(3):440-6.PMID: 17302881 [PubMed - indexed for MEDLINE]Related articles

Tissue production of cortisol by 11beta-hydroxysteroid dehydrogenase type 1 and metabolic disease.

Walker BR, Andrew R.

Ann N Y Acad Sci. 2006 Nov;1083:165-84. Review.PMID: 17148739 [PubMed - indexed for MEDLINE]Related articles

Effect of synthetic corticosteroids on vascular reactivity in the human forearm.

Mangos GJ, Walker BR, Williamson PA, Whitworth JA, Kelly JJ.

Clin Exp Hypertens. 2006 Nov;28(8):707-18.PMID: 17132537 [PubMed - indexed for MEDLINE]Related articles

Cortisol--cause and cure for metabolic syndrome?

Walker BR.

Diabet Med. 2006 Dec;23(12):1281-8.PMID: 17116176 [PubMed - indexed for MEDLINE]Related articles

11beta-hydroxysteroid dehydrogenase type 1 in adipose tissue and prospective changes in body weight and insulin resistance.

Koska J, de Courten B, Wake DJ, Nair S, Walker BR, Bunt JC, Permana PA, Lindsay RS, Tataranni PA.

Obesity (Silver Spring). 2006 Sep;14(9):1515-22.PMID: 17030962 [PubMed - indexed for MEDLINE]Related articles