PubMed

Antibody-mediated blockade of IL-15 reverses the autoimmune intestinal damage in transgenic mice that overexpress IL-15 in enterocytes.

Yokoyama S, Watanabe N, Sato N, Perera PY, Filkoski L, Tanaka T, Miyasaka M, Waldmann TA, Hiroi T, Perera LP.

Proc Natl Acad Sci U S A. 2009 Sep 15;106(37):15849-54. Epub 2009 Sep 1.PMID: 19805228 [PubMed - indexed for MEDLINE]Related articlesFree article

Antibody-based therapy of leukaemia.

Morris JC, Waldmann TA.

Expert Rev Mol Med. 2009 Sep 30;11:e29.PMID: 19788782 [PubMed - in process]Related articles

MTS dye based colorimetric CTLL-2 cell proliferation assay for product release and stability monitoring of interleukin-15: assay qualification, standardization and statistical analysis.

Soman G, Yang X, Jiang H, Giardina S, Vyas V, Mitra G, Yovandich J, Creekmore SP, Waldmann TA, Quiñones O, Alvord WG.

J Immunol Methods. 2009 Aug 31;348(1-2):83-94. Epub 2009 Jul 30.PMID: 19646987 [PubMed - indexed for MEDLINE]Related articles

Preclinical evaluation of an anti-CD25 monoclonal antibody, 7G7/B6, armed with the beta-emitter, yttrium-90, as a radioimmunotherapeutic agent for treating lymphoma.

Zhang M, Yao Z, Garmestani K, Yu S, Goldman CK, Paik CH, Brechbiel MW, Carrasquillo JA, Waldmann TA.

Cancer Biother Radiopharm. 2009 Jun;24(3):303-9.PMID: 19538052 [PubMed - indexed for MEDLINE]Related articles

Plasmid-encoded interleukin-15 receptor alpha enhances specific immune responses induced by a DNA vaccine in vivo.

Kraynyak KA, Kutzler MA, Cisper NJ, Laddy DJ, Morrow MP, Waldmann TA, Weiner DB.

Hum Gene Ther. 2009 Oct;20(10):1143-56.PMID: 19530914 [PubMed - in process]Related articles

Interleukin-15 combined with an anti-CD40 antibody provides enhanced therapeutic efficacy for murine models of colon cancer.

Zhang M, Yao Z, Dubois S, Ju W, Müller JR, Waldmann TA.

Proc Natl Acad Sci U S A. 2009 May 5;106(18):7513-8. Epub 2009 Apr 21.PMID: 19383782 [PubMed - indexed for MEDLINE]Related articlesFree article

Effect of anti-CD25 antibody daclizumab in the inhibition of inflammation and stabilization of disease progression in multiple sclerosis.

Bielekova B, Howard T, Packer AN, Richert N, Blevins G, Ohayon J, Waldmann TA, McFarland HF, Martin R.

Arch Neurol. 2009 Apr;66(4):483-9.PMID: 19364933 [PubMed - indexed for MEDLINE]Related articles

A multi-valent vaccinia virus-based tuberculosis vaccine molecularly adjuvanted with interleukin-15 induces robust immune responses in mice.

Perera PY, Derrick SC, Kolibab K, Momoi F, Yamamoto M, Morris SL, Waldmann TA, Perera LP.

Vaccine. 2009 Mar 26;27(15):2121-7. Epub 2009 Feb 6.PMID: 19356615 [PubMed - indexed for MEDLINE]Related articles

EBV-related lymphoproliferative disease complicating therapy with the anti-CD2 monoclonal antibody, siplizumab, in patients with T-cell malignancies.

O'Mahony D, Morris JC, Stetler-Stevenson M, Matthews H, Brown MR, Fleisher T, Pittaluga S, Raffeld M, Albert PS, Reitsma D, Kaucic K, Hammershaimb L, Waldmann TA, Janik JE.

Clin Cancer Res. 2009 Apr 1;15(7):2514-22. Epub 2009 Mar 17.PMID: 19293260 [PubMed - indexed for MEDLINE]Related articles

Vaccinia virus-based multivalent H5N1 avian influenza vaccines adjuvanted with IL-15 confer sterile cross-clade protection in mice.

Poon LL, Leung YH, Nicholls JM, Perera PY, Lichy JH, Yamamoto M, Waldmann TA, Peiris JS, Perera LP.

J Immunol. 2009 Mar 1;182(5):3063-71.PMID: 19234203 [PubMed - indexed for MEDLINE]Related articles

Gene expression profiling of ATL patients: compilation of disease-related genes and evidence for TCF4 involvement in BIRC5 gene expression and cell viability.

Pise-Masison CA, Radonovich M, Dohoney K, Morris JC, O'Mahony D, Lee MJ, Trepel J, Waldmann TA, Janik JE, Brady JN.

Blood. 2009 Apr 23;113(17):4016-26. Epub 2009 Jan 8.PMID: 19131553 [PubMed - indexed for MEDLINE]Related articles

Effective treatment of a murine model of adult T-cell leukemia using depsipeptide and its combination with unmodified daclizumab directed toward CD25.

Chen J, Zhang M, Ju W, Waldmann TA.

Blood. 2009 Feb 5;113(6):1287-93. Epub 2008 Oct 23.PMID: 18948574 [PubMed - indexed for MEDLINE]Related articles

IL-15 serves as a costimulator in determining the activity of autoreactive CD8 T cells in an experimental mouse model of graft-versus-host-like disease.

Miyagawa F, Tagaya Y, Kim BS, Patel HJ, Ishida K, Ohteki T, Waldmann TA, Katz SI.

J Immunol. 2008 Jul 15;181(2):1109-19.PMID: 18606663 [PubMed - indexed for MEDLINE]Related articlesFree article

High-dose humanized anti-IL-2 receptor alpha antibody (daclizumab) for the treatment of active, non-infectious uveitis.

Yeh S, Wroblewski K, Buggage R, Li Z, Kurup SK, Sen HN, Dahr S, Sran P, Reed GF, Robinson R, Ragheb JA, Waldmann TA, Nussenblatt RB.

J Autoimmun. 2008 Sep;31(2):91-7. Epub 2008 Jun 20.PMID: 18571896 [PubMed - indexed for MEDLINE]Related articlesFree article

Receptor-directed therapy of T-cell leukemias and lymphomas.

Morris JC, Waldmann TA, Janik JE.

J Immunotoxicol. 2008 Apr;5(2):235-48. Review.PMID: 18569395 [PubMed - indexed for MEDLINE]Related articles

IL-15 expands unconventional CD8alphaalphaNK1.1+ T cells but not Valpha14Jalpha18+ NKT cells.

Terabe M, Tagaya Y, Zhu Q, Granger L, Roederer M, Waldmann TA, Berzofsky JA.

J Immunol. 2008 Jun 1;180(11):7276-86.PMID: 18490727 [PubMed - indexed for MEDLINE]Related articlesFree article

IL-15 as a mediator of CD4+ help for CD8+ T cell longevity and avoidance of TRAIL-mediated apoptosis.

Oh S, Perera LP, Terabe M, Ni L, Waldmann TA, Berzofsky JA.

Proc Natl Acad Sci U S A. 2008 Apr 1;105(13):5201-6. Epub 2008 Mar 24.PMID: 18362335 [PubMed - indexed for MEDLINE]Related articlesFree article

Induction of the IL-9 gene by HTLV-I Tax stimulates the spontaneous proliferation of primary adult T-cell leukemia cells by a paracrine mechanism.

Chen J, Petrus M, Bryant BR, Phuc Nguyen V, Stamer M, Goldman CK, Bamford R, Morris JC, Janik JE, Waldmann TA.

Blood. 2008 May 15;111(10):5163-72. Epub 2008 Mar 13.PMID: 18339896 [PubMed - indexed for MEDLINE]Related articlesFree article

Nanometer-scale organization of the alpha subunits of the receptors for IL2 and IL15 in human T lymphoma cells.

de Bakker BI, Bodnár A, van Dijk EM, Vámosi G, Damjanovich S, Waldmann TA, van Hulst NF, Jenei A, Garcia-Parajo MF.

J Cell Sci. 2008 Mar 1;121(Pt 5):627-33.PMID: 18287585 [PubMed - indexed for MEDLINE]Related articlesFree article

A biophysical approach to IL-2 and IL-15 receptor function: localization, conformation and interactions.

Bodnár A, Nizsalóczki E, Mocsár G, Szalóki N, Waldmann TA, Damjanovich S, Vámosi G.

Immunol Lett. 2008 Mar 15;116(2):117-25. Epub 2008 Jan 31. Review.PMID: 18280585 [PubMed - indexed for MEDLINE]Related articles

Preassociation of IL-15 with IL-15R alpha-IgG1-Fc enhances its activity on proliferation of NK and CD8+/CD44high T cells and its antitumor action.

Dubois S, Patel HJ, Zhang M, Waldmann TA, Müller JR.

J Immunol. 2008 Feb 15;180(4):2099-106.PMID: 18250415 [PubMed - indexed for MEDLINE]Related articlesFree article

Effective treatment of established human breast tumor xenografts in immunodeficient mice with a single dose of the alpha-emitting radioisotope astatine-211 conjugated to anti-HER2/neu diabodies.

Robinson MK, Shaller C, Garmestani K, Plascjak PS, Hodge KM, Yuan QA, Marks JD, Waldmann TA, Brechbiel MW, Adams GP.

Clin Cancer Res. 2008 Feb 1;14(3):875-82.PMID: 18245551 [PubMed - indexed for MEDLINE]Related articlesFree article

Protection against simian/human immunodeficiency virus (SHIV) 89.6P in macaques after coimmunization with SHIV antigen and IL-15 plasmid.

Boyer JD, Robinson TM, Kutzler MA, Vansant G, Hokey DA, Kumar S, Parkinson R, Wu L, Sidhu MK, Pavlakis GN, Felber BK, Brown C, Silvera P, Lewis MG, Monforte J, Waldmann TA, Eldridge J, Weiner DB.

Proc Natl Acad Sci U S A. 2007 Nov 20;104(47):18648-53. Epub 2007 Nov 13.PMID: 18000037 [PubMed - indexed for MEDLINE]Related articlesFree article

Colorectal carcinoma rearranges cell surface protein topology and density in CD4+ T cells.

Bene L, Kanyári Z, Bodnár A, Kappelmayer J, Waldmann TA, Vámosi G, Damjanovich L.

Biochem Biophys Res Commun. 2007 Sep 14;361(1):202-7. Epub 2007 Jul 16.PMID: 17658476 [PubMed - indexed for MEDLINE]Related articles

Development of smallpox vaccine candidates with integrated interleukin-15 that demonstrate superior immunogenicity, efficacy, and safety in mice.

Perera LP, Waldmann TA, Mosca JD, Baldwin N, Berzofsky JA, Oh SK.

J Virol. 2007 Aug;81(16):8774-83. Epub 2007 Jun 6.PMID: 17553867 [PubMed - indexed for MEDLINE]Related articlesFree article

Daclizumab (anti-Tac, Zenapax) in the treatment of leukemia/lymphoma.

Waldmann TA.

Oncogene. 2007 May 28;26(25):3699-703. Review.PMID: 17530023 [PubMed - indexed for MEDLINE]Related articles

Effective therapy of murine models of human leukemia and lymphoma with radiolabeled anti-CD30 antibody, HeFi-1.

Zhang M, Yao Z, Patel H, Garmestani K, Zhang Z, Talanov VS, Plascjak PS, Goldman CK, Janik JE, Brechbiel MW, Waldmann TA.

Proc Natl Acad Sci U S A. 2007 May 15;104(20):8444-8. Epub 2007 May 8.PMID: 17488826 [PubMed - indexed for MEDLINE]Related articlesFree article

A pilot study of CTLA-4 blockade after cancer vaccine failure in patients with advanced malignancy.

O'Mahony D, Morris JC, Quinn C, Gao W, Wilson WH, Gause B, Pittaluga S, Neelapu S, Brown M, Fleisher TA, Gulley JL, Schlom J, Nussenblatt R, Albert P, Davis TA, Lowy I, Petrus M, Waldmann TA, Janik JE.

Clin Cancer Res. 2007 Feb 1;13(3):958-64.PMID: 17289891 [PubMed - indexed for MEDLINE]Related articlesFree article

Anti-Tac (daclizumab, Zenapax) in the treatment of leukemia, autoimmune diseases, and in the prevention of allograft rejection: a 25-year personal odyssey.

Waldmann TA.

J Clin Immunol. 2007 Jan;27(1):1-18. Epub 2007 Jan 11. Review.PMID: 17216565 [PubMed - indexed for MEDLINE]Related articles

The IL-15/IL-15Ralpha on cell surfaces enables sustained IL-15 activity and contributes to the long survival of CD8 memory T cells.

Sato N, Patel HJ, Waldmann TA, Tagaya Y.

Proc Natl Acad Sci U S A. 2007 Jan 9;104(2):588-93. Epub 2007 Jan 3.PMID: 17202253 [PubMed - indexed for MEDLINE]Related articlesFree article

The anti-CD25 monoclonal antibody 7G7/B6, armed with the alpha-emitter 211At, provides effective radioimmunotherapy for a murine model of leukemia.

Zhang M, Yao Z, Zhang Z, Garmestani K, Talanov VS, Plascjak PS, Yu S, Kim HS, Goldman CK, Paik CH, Brechbiel MW, Carrasquillo JA, Waldmann TA.

Cancer Res. 2006 Aug 15;66(16):8227-32.PMID: 16912202 [PubMed - indexed for MEDLINE]Related articlesFree article

ITK and IL-15 support two distinct subsets of CD8+ T cells.

Dubois S, Waldmann TA, Müller JR.

Proc Natl Acad Sci U S A. 2006 Aug 8;103(32):12075-80. Epub 2006 Jul 31.PMID: 16880398 [PubMed - indexed for MEDLINE]Related articlesFree article

The biology of interleukin-2 and interleukin-15: implications for cancer therapy and vaccine design.

Waldmann TA.

Nat Rev Immunol. 2006 Aug;6(8):595-601. Review.PMID: 16868550 [PubMed - indexed for MEDLINE]Related articles

Development of antibodies and chimeric molecules for cancer immunotherapy.

Waldmann TA, Morris JC.

Adv Immunol. 2006;90:83-131. Review.PMID: 16730262 [PubMed - indexed for MEDLINE]Related articles

Preparation and in vivo evaluation of a novel stabilized linker for 211At labeling of protein.

Talanov VS, Garmestani K, Regino CA, Milenic DE, Plascjak PS, Waldmann TA, Brechbiel MW.

Nucl Med Biol. 2006 May;33(4):469-80. Epub 2006 May 2.PMID: 16720238 [PubMed - indexed for MEDLINE]Related articles

Regulatory CD56(bright) natural killer cells mediate immunomodulatory effects of IL-2Ralpha-targeted therapy (daclizumab) in multiple sclerosis.

Bielekova B, Catalfamo M, Reichert-Scrivner S, Packer A, Cerna M, Waldmann TA, McFarland H, Henkart PA, Martin R.

Proc Natl Acad Sci U S A. 2006 Apr 11;103(15):5941-6. Epub 2006 Apr 3.PMID: 16585503 [PubMed - indexed for MEDLINE]Related articlesFree article

Effective treatment of a murine model of adult T-cell leukemia using 211At-7G7/B6 and its combination with unmodified anti-Tac (daclizumab) directed toward CD25.

Zhang Z, Zhang M, Garmestani K, Talanov VS, Plascjak PS, Beck B, Goldman C, Brechbiel MW, Waldmann TA.

Blood. 2006 Aug 1;108(3):1007-12. Epub 2006 Mar 28.PMID: 16569769 [PubMed - indexed for MEDLINE]Related articlesFree article

Persistent inhibition of telomerase reprograms adult T-cell leukemia to p53-dependent senescence.

Datta A, Bellon M, Sinha-Datta U, Bazarbachi A, Lepelletier Y, Canioni D, Waldmann TA, Hermine O, Nicot C.

Blood. 2006 Aug 1;108(3):1021-9. Epub 2006 Mar 28.PMID: 16569765 [PubMed - indexed for MEDLINE]Related articlesFree article

Effective therapy for a murine model of human anaplastic large-cell lymphoma with the anti-CD30 monoclonal antibody, HeFi-1, does not require activating Fc receptors.

Zhang M, Yao Z, Zhang Z, Garmestani K, Goldman CK, Ravetch JV, Janik J, Brechbiel MW, Waldmann TA.

Blood. 2006 Jul 15;108(2):705-10. Epub 2006 Mar 21.PMID: 16551968 [PubMed - indexed for MEDLINE]Related articlesFree article

Familial hypercatabolic hypoproteinemia caused by deficiency of the neonatal Fc receptor, FcRn, due to a mutant beta2-microglobulin gene.

Wani MA, Haynes LD, Kim J, Bronson CL, Chaudhury C, Mohanty S, Waldmann TA, Robinson JM, Anderson CL.

Proc Natl Acad Sci U S A. 2006 Mar 28;103(13):5084-9. Epub 2006 Mar 20. Erratum in: Proc Natl Acad Sci U S A. 2006 Jul 5;103(27):10526. PMID: 16549777 [PubMed - indexed for MEDLINE]Related articlesFree article

Effective cancer therapy through immunomodulation.

Waldmann TA.

Annu Rev Med. 2006;57:65-81. Review.PMID: 16409137 [PubMed - indexed for MEDLINE]Related articles

Preclinical and phase I clinical trial of blockade of IL-15 using Mikbeta1 monoclonal antibody in T cell large granular lymphocyte leukemia.

Morris JC, Janik JE, White JD, Fleisher TA, Brown M, Tsudo M, Goldman CK, Bryant B, Petrus M, Top L, Lee CC, Gao W, Waldmann TA.

Proc Natl Acad Sci U S A. 2006 Jan 10;103(2):401-6. Epub 2005 Dec 30.PMID: 16387851 [PubMed - indexed for MEDLINE]Related articlesFree article

Detection of lymph node involvement in hematologic malignancies using micromagnetic resonance lymphangiography with a gadolinum-labeled dendrimer nanoparticle.

Kobayashi H, Kawamoto S, Brechbiel MW, Bernardo M, Sato N, Waldmann TA, Tagaya Y, Choyke PL.

Neoplasia. 2005 Nov;7(11):984-91.PMID: 16331884 [PubMed - indexed for MEDLINE]Related articlesFree article

Antileukemic effect of daclizumab in CD25 high-expressing leukemias and impact of tumor burden on antibody dosing.

Koon HB, Severy P, Hagg DS, Butler K, Hill T, Jones AG, Waldmann TA, Junghans RP.

Leuk Res. 2006 Feb;30(2):190-203. Epub 2005 Sep 13.PMID: 16165209 [PubMed - indexed for MEDLINE]Related articles

Targeting the interleukin-15 system in rheumatoid arthritis.

Waldmann TA.

Arthritis Rheum. 2005 Sep;52(9):2585-8. No abstract available. PMID: 16142738 [PubMed - indexed for MEDLINE]Related articlesFree article

Central memory self/tumor-reactive CD8+ T cells confer superior antitumor immunity compared with effector memory T cells.

Klebanoff CA, Gattinoni L, Torabi-Parizi P, Kerstann K, Cardones AR, Finkelstein SE, Palmer DC, Antony PA, Hwang ST, Rosenberg SA, Waldmann TA, Restifo NP.

Proc Natl Acad Sci U S A. 2005 Jul 5;102(27):9571-6. Epub 2005 Jun 24.PMID: 15980149 [PubMed - indexed for MEDLINE]Related articlesFree article

Coimmunization with an optimized IL-15 plasmid results in enhanced function and longevity of CD8 T cells that are partially independent of CD4 T cell help.

Kutzler MA, Robinson TM, Chattergoon MA, Choo DK, Choo AY, Choe PY, Ramanathan MP, Parkinson R, Kudchodkar S, Tamura Y, Sidhu M, Roopchand V, Kim JJ, Pavlakis GN, Felber BK, Waldmann TA, Boyer JD, Weiner DB.

J Immunol. 2005 Jul 1;175(1):112-23.PMID: 15972637 [PubMed - indexed for MEDLINE]Related articlesFree article

Detection of receptor trimers on the cell surface by flow cytometric fluorescence energy homotransfer measurements.

Bene L, Szöllosi J, Szentesi G, Damjanovich L, Gáspár R Jr, Waldmann TA, Damjanovich S.

Biochim Biophys Acta. 2005 Jun 30;1744(2):176-98. Epub 2005 Mar 2.PMID: 15950751 [PubMed - indexed for MEDLINE]Related articles

Survival adjustment of mature dendritic cells by IL-15.

Dubois SP, Waldmann TA, Müller JR.

Proc Natl Acad Sci U S A. 2005 Jun 14;102(24):8662-7. Epub 2005 Jun 2.PMID: 15932944 [PubMed - indexed for MEDLINE]Related articlesFree article

Anti-HER2 radioimmunotherapy.

Brechbiel MW, Waldmann TA.

Breast Dis. 2000;11:125-32.PMID: 15687598 [PubMed]Related articles