PubMed

Nutrition and Alzheimer's disease: pre-clinical concepts.

Kamphuis PJ, Wurtman RJ.

Eur J Neurol. 2009 Sep;16 Suppl 1:12-8.PMID: 19703215 [PubMed - in process]Related articles

Use of phosphatide precursors to promote synaptogenesis.

Wurtman RJ, Cansev M, Sakamoto T, Ulus IH.

Annu Rev Nutr. 2009;29:59-87. Review.PMID: 19400698 [PubMed - indexed for MEDLINE]Related articles

Synapse formation is enhanced by oral administration of uridine and DHA, the circulating precursors of brain phosphatides.

Wurtman RJ, Cansev M, Ulus IH.

J Nutr Health Aging. 2009 Mar;13(3):189-97. Review.PMID: 19262950 [PubMed - indexed for MEDLINE]Related articles

Giving uridine and/or docosahexaenoic acid orally to rat dams during gestation and nursing increases synaptic elements in brains of weanling pups.

Cansev M, Marzloff G, Sakamoto T, Ulus IH, Wurtman RJ.

Dev Neurosci. 2009;31(3):181-92. Epub 2009 Jan 15.PMID: 19145070 [PubMed - indexed for MEDLINE]Related articles

Administration of docosahexaenoic acid, uridine and choline increases levels of synaptic membranes and dendritic spines in rodent brain.

Wurtman RJ, Cansev M, Sakamoto T, Ulus IH.

World Rev Nutr Diet. 2009;99:71-96. Epub 2009 Jan 9. Review. No abstract available. PMID: 19136840 [PubMed - indexed for MEDLINE]Related articles

Synapse formation and cognitive brain development: effect of docosahexaenoic acid and other dietary constituents.

Wurtman RJ.

Metabolism. 2008 Oct;57 Suppl 2:S6-10. Review.PMID: 18803968 [PubMed - indexed for MEDLINE]Related articlesFree article

Restorative effects of uridine plus docosahexaenoic acid in a rat model of Parkinson's disease.

Cansev M, Ulus IH, Wang L, Maher TJ, Wurtman RJ.

Neurosci Res. 2008 Nov;62(3):206-9. Epub 2008 Aug 3.PMID: 18761383 [PubMed - indexed for MEDLINE]Related articlesFree article

Oral administration of circulating precursors for membrane phosphatides can promote the synthesis of new brain synapses.

Cansev M, Wurtman RJ, Sakamoto T, Ulus IH.

Alzheimers Dement. 2008 Jan;4(1 Suppl 1):S153-68. Epub 2007 Dec 21. Review.PMID: 18631994 [PubMed - indexed for MEDLINE]Related articlesFree article

A roadmap for the prevention of dementia: the inaugural Leon Thal Symposium.

Khachaturian ZS, Petersen RC, Gauthier S, Buckholtz N, Corey-Bloom JP, Evans B, Fillit H, Foster N, Greenberg B, Grundman M, Sano M, Simpkins J, Schneider LS, Weiner MW, Galasko D, Hyman B, Kuller L, Schenk D, Snyder S, Thomas RG, Tuszynski MH, Vellas B, Wurtman RJ, Snyder PJ, Frank RA, Albert M, Doody R, Ferris S, Kaye J, Koo E, Morrison-Bogorad M, Reisberg B, Salmon DP, Gilman S, Mohs R, Aisen PS, Breitner JC, Cummings JL, Kawas C, Phelps C, Poirier J, Sabbagh M, Touchon J, Khachaturian AS, Bain LJ.

Alzheimers Dement. 2008 May;4(3):156-63. No abstract available. PMID: 18631960 [PubMed - indexed for MEDLINE]Related articlesFree article

Endogenous melatonin levels and the fate of exogenous melatonin: age effects.

Zhdanova IV, Wurtman RJ, Balcioglu A, Kartashov AI, Lynch HJ.

J Gerontol A Biol Sci Med Sci. 1998 Jul;53(4):B293-8.PMID: 18314560 [PubMed - indexed for MEDLINE]Related articles

Oral supplementation with docosahexaenoic acid and uridine-5'-monophosphate increases dendritic spine density in adult gerbil hippocampus.

Sakamoto T, Cansev M, Wurtman RJ.

Brain Res. 2007 Nov 28;1182:50-9. Epub 2007 Sep 21.PMID: 17950710 [PubMed - indexed for MEDLINE]Related articlesFree article

Chronic administration of docosahexaenoic acid or eicosapentaenoic acid, but not arachidonic acid, alone or in combination with uridine, increases brain phosphatide and synaptic protein levels in gerbils.

Cansev M, Wurtman RJ.

Neuroscience. 2007 Aug 24;148(2):421-31. Epub 2007 Aug 1.PMID: 17683870 [PubMed - indexed for MEDLINE]Related articlesFree article

Polyunsaturated fatty acids stimulate phosphatidylcholine synthesis in PC12 cells.

Richardson UI, Wurtman RJ.

Biochim Biophys Acta. 2007 Apr;1771(4):558-63. Epub 2007 Feb 6.PMID: 17350887 [PubMed - indexed for MEDLINE]Related articlesFree article

Oral L-glutamine increases GABA levels in striatal tissue and extracellular fluid.

Wang L, Maher TJ, Wurtman RJ.

FASEB J. 2007 Apr;21(4):1227-32. Epub 2007 Jan 11.PMID: 17218538 [PubMed - indexed for MEDLINE]Related articlesFree article

Dietary supplementation with uridine-5'-monophosphate (UMP), a membrane phosphatide precursor, increases acetylcholine level and release in striatum of aged rat.

Wang L, Albrecht MA, Wurtman RJ.

Brain Res. 2007 Feb 16;1133(1):42-8. Epub 2006 Dec 19.PMID: 17184749 [PubMed - indexed for MEDLINE]Related articlesFree article

Chronic administration of UMP ameliorates the impairment of hippocampal-dependent memory in impoverished rats.

Teather LA, Wurtman RJ.

J Nutr. 2006 Nov;136(11):2834-7.PMID: 17056809 [PubMed - indexed for MEDLINE]Related articlesFree article

Narcolepsy and the hypocretins.

Wurtman RJ.

Metabolism. 2006 Oct;55(10 Suppl 2):S36-9. Review.PMID: 16979425 [PubMed - indexed for MEDLINE]Related articles

Inhibition of platelet-activating factor receptors in hippocampal plasma membranes attenuates the inflammatory nociceptive response in rats.

Teather LA, Afonso VM, Wurtman RJ.

Brain Res. 2006 Jun 30;1097(1):230-3. Epub 2006 Jun 13.PMID: 16774744 [PubMed - indexed for MEDLINE]Related articles

Cytidine and uridine increase striatal CDP-choline levels without decreasing acetylcholine synthesis or release.

Ulus IH, Watkins CJ, Cansev M, Wurtman RJ.

Cell Mol Neurobiol. 2006 Jul-Aug;26(4-6):563-77. Epub 2006 Apr 25.PMID: 16636900 [PubMed - indexed for MEDLINE]Related articles

Synaptic proteins and phospholipids are increased in gerbil brain by administering uridine plus docosahexaenoic acid orally.

Wurtman RJ, Ulus IH, Cansev M, Watkins CJ, Wang L, Marzloff G.

Brain Res. 2006 May 9;1088(1):83-92. Epub 2006 Apr 21.PMID: 16631143 [PubMed - indexed for MEDLINE]Related articles

The 3-hydroxy-3-methylglutaryl co-enzyme A reductase inhibitor pravastatin enhances neurite outgrowth in hippocampal neurons.

Pooler AM, Xi SC, Wurtman RJ.

J Neurochem. 2006 May;97(3):716-23. Epub 2006 Mar 29. Erratum in: J Neurochem. 2006 Aug;98(3):992. PMID: 16573653 [PubMed - indexed for MEDLINE]Related articles

Oral uridine-5'-monophosphate (UMP) increases brain CDP-choline levels in gerbils.

Cansev M, Watkins CJ, van der Beek EM, Wurtman RJ.

Brain Res. 2005 Oct 5;1058(1-2):101-8. Epub 2005 Aug 29.PMID: 16126180 [PubMed - indexed for MEDLINE]Related articles

Dietary uridine-5'-monophosphate supplementation increases potassium-evoked dopamine release and promotes neurite outgrowth in aged rats.

Wang L, Pooler AM, Albrecht MA, Wurtman RJ.

J Mol Neurosci. 2005;27(1):137-45.PMID: 16055952 [PubMed - indexed for MEDLINE]Related articles

Uridine enhances neurite outgrowth in nerve growth factor-differentiated PC12 [corrected]

Pooler AM, Guez DH, Benedictus R, Wurtman RJ.

Neuroscience. 2005;134(1):207-14. Erratum in: Neuroscience. 2005;135(2):657. PMID: 15939540 [PubMed - indexed for MEDLINE]Related articles

Genes, stress, and depression.

Wurtman RJ.

Metabolism. 2005 May;54(5 Suppl 1):16-9. Review.PMID: 15877307 [PubMed - indexed for MEDLINE]Related articles

Effects of exogenous melatonin on sleep: a meta-analysis.

Brzezinski A, Vangel MG, Wurtman RJ, Norrie G, Zhdanova I, Ben-Shushan A, Ford I.

Sleep Med Rev. 2005 Feb;9(1):41-50.PMID: 15649737 [PubMed - indexed for MEDLINE]Related articles

Dietary CDP-choline supplementation prevents memory impairment caused by impoverished environmental conditions in rats.

Teather LA, Wurtman RJ.

Learn Mem. 2005 Jan-Feb;12(1):39-43. Epub 2005 Jan 12.PMID: 15647594 [PubMed - indexed for MEDLINE]Related articlesFree article

Prostaglandin E2 regulates amyloid precursor protein expression via the EP2 receptor in cultured rat microglia.

Pooler AM, Arjona AA, Lee RK, Wurtman RJ.

Neurosci Lett. 2004 May 20;362(2):127-30.PMID: 15193769 [PubMed - indexed for MEDLINE]Related articles

A Drosophila temperature-sensitive seizure mutant in phosphoglycerate kinase disrupts ATP generation and alters synaptic function.

Wang P, Saraswati S, Guan Z, Watkins CJ, Wurtman RJ, Littleton JT.

J Neurosci. 2004 May 12;24(19):4518-29.PMID: 15140922 [PubMed - indexed for MEDLINE]Related articlesFree article

An animal model of antipsychotic-induced weight gain.

Arjona AA, Zhang SX, Adamson B, Wurtman RJ.

Behav Brain Res. 2004 Jun 4;152(1):121-7.PMID: 15135975 [PubMed - indexed for MEDLINE]Related articles

5-Hydroxy-L-tryptophan suppresses food intake in food-deprived and stressed rats.

Amer A, Breu J, McDermott J, Wurtman RJ, Maher TJ.

Pharmacol Biochem Behav. 2004 Jan;77(1):137-43.PMID: 14724051 [PubMed - indexed for MEDLINE]Related articles

Dietary cytidine (5')-diphosphocholine supplementation protects against development of memory deficits in aging rats.

Teather LA, Wurtman RJ.

Prog Neuropsychopharmacol Biol Psychiatry. 2003 Jun;27(4):711-7.PMID: 12787861 [PubMed - indexed for MEDLINE]Related articles

Stimulation of CDP-choline synthesis by uridine or cytidine in PC12 rat pheochromocytoma cells.

Richardson UI, Watkins CJ, Pierre C, Ulus IH, Wurtman RJ.

Brain Res. 2003 May 9;971(2):161-7.PMID: 12706232 [PubMed - indexed for MEDLINE]Related articles

Cyclooxygenase-2 mediates platelet-activating factor-induced prostaglandin E2 release from rat primary astrocytes.

Teather LA, Wurtman RJ.

Neurosci Lett. 2003 Apr 17;340(3):177-80.PMID: 12672535 [PubMed - indexed for MEDLINE]Related articles

Effects of normal meals rich in carbohydrates or proteins on plasma tryptophan and tyrosine ratios.

Wurtman RJ, Wurtman JJ, Regan MM, McDermott JM, Tsay RH, Breu JJ.

Am J Clin Nutr. 2003 Jan;77(1):128-32.PMID: 12499331 [PubMed - indexed for MEDLINE]Related articlesFree article

Environmental conditions influence hippocampus-dependent behaviours and brain levels of amyloid precursor protein in rats.

Teather LA, Magnusson JE, Chow CM, Wurtman RJ.

Eur J Neurosci. 2002 Dec;16(12):2405-15.PMID: 12492435 [PubMed - indexed for MEDLINE]Related articles

Platelet-activating factor antagonists decrease the inflammatory nociceptive response in rats.

Teather LA, Magnusson JE, Wurtman RJ.

Psychopharmacology (Berl). 2002 Oct;163(3-4):430-3. Epub 2002 Mar 13.PMID: 12373444 [PubMed - indexed for MEDLINE]Related articles

Effect of a 5-HT(2C) serotonin agonist, dexnorfenfluramine, on amyloid precursor protein metabolism in guinea pigs.

Arjona AA, Pooler AM, Lee RK, Wurtman RJ.

Brain Res. 2002 Sep 27;951(1):135-40.PMID: 12231467 [PubMed - indexed for MEDLINE]Related articles

Platelet-activating factor increases prostaglandin E(2) release from astrocyte-enriched cortical cell cultures.

Teather LA, Lee RK, Wurtman RJ.

Brain Res. 2002 Aug 9;946(1):87-95.PMID: 12133598 [PubMed - indexed for MEDLINE]Related articles

Stress and the adrenocortical control of epinephrine synthesis.

Wurtman RJ.

Metabolism. 2002 Jun;51(6 Suppl 1):11-4. Review.PMID: 12040535 [PubMed - indexed for MEDLINE]Related articles

Melatonin treatment for age-related insomnia.

Zhdanova IV, Wurtman RJ, Regan MM, Taylor JA, Shi JP, Leclair OU.

J Clin Endocrinol Metab. 2001 Oct;86(10):4727-30.PMID: 11600532 [PubMed - indexed for MEDLINE]Related articlesFree article

Behavioral effects of melatonin treatment in non-human primates.

Zhdanova IV, Cantor ML, Leclair OU, Kartashov AI, Wurtman RJ.

Sleep Res Online. 1998;1(3):114-8.PMID: 11382867 [PubMed - indexed for MEDLINE]Related articles

Cytidine (5')diphosphocholine modulates dopamine K(+)-evoked release in striatum measured by microdialysis.

Agut J, Ortiz JA, Wurtman RJ.

Ann N Y Acad Sci. 2000;920:332-5.PMID: 11193174 [PubMed - indexed for MEDLINE]Related articles

Regulation of APP synthesis and secretion by neuroimmunophilin ligands and cyclooxygenase inhibitors.

Lee RK, Wurtman RJ.

Ann N Y Acad Sci. 2000;920:261-8. Review.PMID: 11193162 [PubMed - indexed for MEDLINE]Related articles

Sibutramine, a serotonin uptake inhibitor, increases dopamine concentrations in rat striatal and hypothalamic extracellular fluid.

Balcioglu A, Wurtman RJ.

Neuropharmacology. 2000 Sep;39(12):2352-9.PMID: 10974319 [PubMed - indexed for MEDLINE]Related articles

Effect of oral CDP-choline on plasma choline and uridine levels in humans.

Wurtman RJ, Regan M, Ulus I, Yu L.

Biochem Pharmacol. 2000 Oct 1;60(7):989-92.PMID: 10974208 [PubMed - indexed for MEDLINE]Related articles

Striatal serotonin receptors and dopamine release.

Balcioglu A, Wurtman RJ.

J Neurochem. 2000 Aug;75(2):886. No abstract available. PMID: 10899968 [PubMed - indexed for MEDLINE]Related articles

Age-related decreases in melatonin secretion--clinical consequences.

Wurtman RJ.

J Clin Endocrinol Metab. 2000 Jun;85(6):2135-6. No abstract available. PMID: 10852441 [PubMed - indexed for MEDLINE]Related articlesFree article

Amyloid precursor protein and membrane phospholipids in primary cortical neurons increase with development, or after exposure to nerve growth factor or Abeta(1-40).

Wang C, Wurtman RJ, Lee RK.

Brain Res. 2000 May 26;865(2):157-67.PMID: 10821917 [PubMed - indexed for MEDLINE]Related articles

Characterization of phentermine and related compounds as monoamine oxidase (MAO) inhibitors.

Ulus IH, Maher TJ, Wurtman RJ.

Biochem Pharmacol. 2000 Jun 15;59(12):1611-21.PMID: 10799660 [PubMed - indexed for MEDLINE]Related articles