PubMed

Discovery of 13-oxa prostaglandin analogs as antiglaucoma agents: synthesis and biological activity.

Feng Z, Hellberg MR, Sharif NA, McLaughlin MA, Williams GW, Scott D, Wallace T.

Bioorg Med Chem. 2009 Jan 15;17(2):576-84. Epub 2008 Dec 6.PMID: 19101156 [PubMed - indexed for MEDLINE]Related articles

Re: Syndesmotic ankle sprains in athletes.

van den Bekerom MP, van Dijk CN.

Am J Sports Med. 2008 Dec;36(12):E1; author reply E1. No abstract available. PMID: 19074400 [PubMed - indexed for MEDLINE]Related articles

The editor's roundtable: nonsteroidal antiinflammatory drugs and cardiovascular risk.

Friedewald VE Jr, Bennett JS, Packer M, Roberts WC, Williams GW.

Am J Cardiol. 2008 Oct 15;102(8):1046-55. Review. No abstract available. PMID: 18929707 [PubMed - indexed for MEDLINE]Related articles

Neutrophil interactions with keratocytes during corneal epithelial wound healing: a role for CD18 integrins.

Petrescu MS, Larry CL, Bowden RA, Williams GW, Gagen D, Li Z, Smith CW, Burns AR.

Invest Ophthalmol Vis Sci. 2007 Nov;48(11):5023-9.PMID: 17962453 [PubMed - indexed for MEDLINE]Related articlesFree article

The other side of clinical trial monitoring; assuring data quality and procedural adherence.

Williams GW.

Clin Trials. 2006;3(6):530-7. Review.PMID: 17170037 [PubMed - indexed for MEDLINE]Related articles

Preclinical pharmacology of AL-12182, a new ocular hypotensive 11-oxa prostaglandin analog.

Sharif NA, McLaughlin MA, Kelly CR, Xu S, Crider JY, Williams GW, Parker JL.

J Ocul Pharmacol Ther. 2006 Oct;22(5):291-309.PMID: 17076623 [PubMed - indexed for MEDLINE]Related articles

A comparison of valdecoxib and naproxen in the treatment of rheumatoid arthritis symptoms.

Williams GW, Kivitz AJ, Brown MT, Verburg KM.

Clin Ther. 2006 Feb;28(2):204-21.PMID: 16678642 [PubMed - indexed for MEDLINE]Related articles

The Editor's roundtable: cyclooxygenase-2 inhibitors and cardiovascular risk.

Bresalier RS, Friedewald VE Jr, Rakel RE, Roberts WC, Williams GW.

Am J Cardiol. 2005 Dec 1;96(11):1589-604. Epub 2005 Oct 21. No abstract available. PMID: 16310447 [PubMed - indexed for MEDLINE]Related articles

An update on nonsteroidal anti-inflammatory drugs and cyclooxygenase-2 inhibitors.

Williams GW.

Curr Pain Headache Rep. 2005 Dec;9(6):377-89. Review.PMID: 16282038 [PubMed - indexed for MEDLINE]Related articles

Ocular hypotensive DP-class prostaglandin receptor affinities determined by quantitative autoradiography on human eye sections.

Sharif NA, Davis TL, Williams GW.

J Ocul Pharmacol Ther. 2005 Apr;21(2):121-32.PMID: 15857278 [PubMed - indexed for MEDLINE]Related articles

An oligonucleotide microarray for transcriptome analysis of Schistosoma mansoni and its application/use to investigate gender-associated gene expression.

Fitzpatrick JM, Johnston DA, Williams GW, Williams DJ, Freeman TC, Dunne DW, Hoffmann KF.

Mol Biochem Parasitol. 2005 May;141(1):1-13.PMID: 15811522 [PubMed - indexed for MEDLINE]Related articles

D-dimer concentrations in normal pregnancy: new diagnostic thresholds are needed.

Kline JA, Williams GW, Hernandez-Nino J.

Clin Chem. 2005 May;51(5):825-9. Epub 2005 Mar 11.PMID: 15764641 [PubMed - indexed for MEDLINE]Related articlesFree article

Molecular pharmacology of the DP/EP2 class prostaglandin AL-6598 and quantitative autoradiographic visualization of DP and EP2 receptor sites in human eyes.

Sharif NA, Williams GW, Crider JY, Xu SX, Davis TL.

J Ocul Pharmacol Ther. 2004 Dec;20(6):489-508.PMID: 15684809 [PubMed - indexed for MEDLINE]Related articles

Cloned human 5-HT1A receptor pharmacology determined using agonist binding and measurement of cAMP accumulation.

Sharif NA, Drace CD, Williams GW, Crider JY.

J Pharm Pharmacol. 2004 Oct;56(10):1267-74.PMID: 15482641 [PubMed - indexed for MEDLINE]Related articles

AL-12182, a novel 11-oxa prostaglandin analog with topical ocular hypotensive activity in the monkey.

Selliah RD, Hellberg MR, Sharif NA, McLaughlin MA, Williams GW, Scott DA, Earnest D, Haggard KS, Dean WD, Delgado P, Gaines MS, Conrow RE, Klimko PG.

Bioorg Med Chem Lett. 2004 Sep 6;14(17):4525-8.PMID: 15357985 [PubMed - indexed for MEDLINE]Related articles

Pelican: pedigree editor for linkage computer analysis.

Dudbridge F, Carver T, Williams GW.

Bioinformatics. 2004 Sep 22;20(14):2327-8. Epub 2004 Apr 1.PMID: 15059819 [PubMed - indexed for MEDLINE]Related articlesFree article

Ocular hypotensive FP prostaglandin (PG) analogs: PG receptor subtype binding affinities and selectivities, and agonist potencies at FP and other PG receptors in cultured cells.

Sharif NA, Kelly CR, Crider JY, Williams GW, Xu SX.

J Ocul Pharmacol Ther. 2003 Dec;19(6):501-15.PMID: 14733708 [PubMed - indexed for MEDLINE]Related articles

Comparing the efficacy of cyclooxygenase 2-specific inhibitors in treating osteoarthritis: appropriate trial design considerations and results of a randomized, placebo-controlled trial.

Gibofsky A, Williams GW, McKenna F, Fort JG.

Arthritis Rheum. 2003 Nov;48(11):3102-11.PMID: 14613272 [PubMed - indexed for MEDLINE]Related articlesFree article

Pharmacological characterization of a serotonin receptor (5-HT7) stimulating cAMP production in human corneal epithelial cells.

Crider JY, Williams GW, Drace CD, Katoli P, Senchyna M, Sharif NA.

Invest Ophthalmol Vis Sci. 2003 Nov;44(11):4837-44.PMID: 14578406 [PubMed - indexed for MEDLINE]Related articlesFree article

Bimatoprost (Lumigan((R))) is an agonist at the cloned human ocular FP prostaglandin receptor: real-time FLIPR-based intracellular Ca(2+) mobilization studies.

Sharif NA, Kelly CR, Williams GW.

Prostaglandins Leukot Essent Fatty Acids. 2003 Jan;68(1):27-33.PMID: 12538087 [PubMed - indexed for MEDLINE]Related articles

Real-time intracellular Ca2+ mobilization by travoprost acid, bimatoprost, unoprostone, and other analogs via endogenous mouse, rat, and cloned human FP prostaglandin receptors.

Kelly CR, Williams GW, Sharif NA.

J Pharmacol Exp Ther. 2003 Jan;304(1):238-45.PMID: 12490597 [PubMed - indexed for MEDLINE]Related articlesFree article

BLAST and go?

Mullan LJ, Williams GW.

Brief Bioinform. 2002 Jun;3(2):200-2. No abstract available. PMID: 12139439 [PubMed - indexed for MEDLINE]Related articlesFree article

3-Oxa-15-cyclohexyl prostaglandin DP receptor agonists as topical antiglaucoma agents.

Hellberg MR, Conrow RE, Sharif NA, McLaughlin MA, Bishop JE, Crider JY, Dean WD, DeWolf KA, Pierce DR, Sallee VL, Selliah RD, Severns BS, Sproull SJ, Williams GW, Zinke PW, Klimko PG.

Bioorg Med Chem. 2002 Jun;10(6):2031-49.PMID: 11937363 [PubMed - indexed for MEDLINE]Related articles

Bimatoprost and its free acid are prostaglandin FP receptor agonists.

Sharif NA, Williams GW, Kelly CR.

Eur J Pharmacol. 2001 Dec 7;432(2-3):211-3.PMID: 11740958 [PubMed - indexed for MEDLINE]Related articles

"Natural history" clinical trials: an enduring contribution to modern medical practice.

Scolnick EM, Slater EE, Williams GW.

Adv Protein Chem. 2001;56:1-12. Review. No abstract available. PMID: 11329850 [PubMed - indexed for MEDLINE]Related articles

Comparison of once-daily and twice-daily administration of celecoxib for the treatment of osteoarthritis of the knee.

Williams GW, Hubbard RC, Yu SS, Zhao W, Geis GS.

Clin Ther. 2001 Feb;23(2):213-27.PMID: 11293555 [PubMed - indexed for MEDLINE]Related articles

Pharmacology and autoradiography of human DP prostanoid receptors using [(3)H]-BWA868C, a DP receptor-selective antagonist radioligand.

Sharif NA, Williams GW, Davis TL.

Br J Pharmacol. 2000 Nov;131(6):1025-38.PMID: 11082108 [PubMed - indexed for MEDLINE]Related articlesFree article

GHOST: a gene homology online search tool.

Curwen VA, Williams GW, Bard JB.

Trends Genet. 2000 Jul;16(7):321-3. No abstract available. PMID: 10858663 [PubMed - indexed for MEDLINE]Related articles

Affinities, selectivities, potencies, and intrinsic activities of natural and synthetic prostanoids using endogenous receptors: focus on DP class prostanoids.

Sharif NA, Crider JY, Xu SX, Williams GW.

J Pharmacol Exp Ther. 2000 May;293(2):321-8.PMID: 10772998 [PubMed - indexed for MEDLINE]Related articlesFree article

Treatment of osteoarthritis with a once-daily dosing regimen of celecoxib: a randomized, controlled trial.

Williams GW, Ettlinger RE, Ruderman EM, Hubbard RC, Lonien ME, Yu SS, Zhao W, Geis GS.

J Clin Rheumatol. 2000 Apr;6(2):65-74.PMID: 19078452 [PubMed - in process]Related articles

[3H]AL-5848 ([3H]9beta-(+)-Fluprostenol). Carboxylic acid of travoprost (AL-6221), a novel FP prostaglandin to study the pharmacology and autoradiographic localization of the FP receptor.

Sharif NA, Davis TL, Williams GW.

J Pharm Pharmacol. 1999 Jun;51(6):685-94.PMID: 10454045 [PubMed - indexed for MEDLINE]Related articles

Pharmacology of [3H]prostaglandin E1/[3H]prostaglandin E2 and [3H]prostaglandin F2alpha binding to EP3 and FP prostaglandin receptor binding sites in bovine corpus luteum: characterization and correlation with functional data.

Sharif NA, Xu SX, Williams GW, Crider JY, Griffin BW, Davis TL.

J Pharmacol Exp Ther. 1998 Aug;286(2):1094-102.PMID: 9694973 [PubMed - indexed for MEDLINE]Related articlesFree article

FP prostaglandin receptors mediating inositol phosphates generation and calcium mobilization in Swiss 3T3 cells: a pharmacological study.

Griffin BW, Williams GW, Crider JY, Sharif NA.

J Pharmacol Exp Ther. 1997 May;281(2):845-54.PMID: 9152393 [PubMed - indexed for MEDLINE]Related articlesFree article

A new chromatographic method for measurement of rubidium transport activities in cultured bovine retinal pigment epithelial cells.

Crider JY, Williams GW, Yorio T, Sharif NA, Griffin BW.

Ophthalmic Res. 1997;29(3):117-23.PMID: 9211463 [PubMed - indexed for MEDLINE]Related articles

Inhibition of male sex behavior by androgen receptor blockade in preoptic area or hypothalamus, but not amygdala or septum.

McGinnis MY, Williams GW, Lumia AR.

Physiol Behav. 1996 Sep;60(3):783-9.PMID: 8873251 [PubMed - indexed for MEDLINE]Related articles

Low back pain: cost-effective diagnosis and treatment.

Williams GW.

Contemp Intern Med. 1995 Aug;7(8):26-36, 41-2. Review.PMID: 10150686 [PubMed - indexed for MEDLINE]Related articles

Affinities of muscarinic drugs for [3H]N-methylscopolamine (NMS) and [3H]oxotremorine (OXO) binding to a mixture of M1-M4 muscarinic receptors: use of NMS/OXO-M ratios to group compounds into potential agonist, partial agonist, and antagonist classes.

Sharif NA, Williams GW, DeSantis LM.

Neurochem Res. 1995 Jun;20(6):669-74.PMID: 7566362 [PubMed - indexed for MEDLINE]Related articles

Acute hypokalemia is well tolerated in infants during liver transplantation.

Belani KG, Reardon RF, Payne WD, Williams GW, Palahniuk RJ.

Transplant Proc. 1994 Feb;26(1):147-50. No abstract available. PMID: 8108914 [PubMed - indexed for MEDLINE]Related articles

Comparison of the pharmacokinetics and pharmacodynamics of the aldose reductase inhibitors, AL03152 (RS), AL03802 (R), and AL03803 (S).

Park YH, Mayer PR, Barker R, DuPriest M, Griffin BW, Williams GW, York BM, Slattery JT.

Pharm Res. 1993 Apr;10(4):593-7.PMID: 8483844 [PubMed - indexed for MEDLINE]Related articles

Monitoring of clinical trials and interim analyses from a drug sponsor's point of view.

Williams GW, Davis RL, Getson AJ, Gould AL, Hwang IK, Matthews H, Shih WJ, Snapinn SM, Walton-Bowen KL.

Stat Med. 1993 Mar;12(5-6):481-92. Review.PMID: 8493426 [PubMed - indexed for MEDLINE]Related articles

The effects of olfactory bulbectomy and chronic psychosocial stress on serum glucocorticoids and sexual behavior in female rats.

Williams GW, McGinnis MY, Lumia AR.

Physiol Behav. 1992 Oct;52(4):755-60.PMID: 1409949 [PubMed - indexed for MEDLINE]Related articles

Doppler velocimetry in concordant and discordant twin gestations.

Shah YG, Gragg LA, Moodley S, Williams GW.

Obstet Gynecol. 1992 Aug;80(2):272-6.PMID: 1635743 [PubMed - indexed for MEDLINE]Related articles

The UK Human Genome Mapping Project online computing service.

Rysavy FR, Bishop MJ, Gibbs GP, Williams GW.

Comput Appl Biosci. 1992 Apr;8(2):149-54.PMID: 1591610 [PubMed - indexed for MEDLINE]Related articles

Design of a clinical trial to test a treatment of the underlying cause of emphysema.

Anthonisen N, Connett J, Friedman B, Glass M, Kilday DP, Mingo TS, Rudolphus A, Williams GW.

Ann N Y Acad Sci. 1991 Dec 31;624 Suppl:31-4. No abstract available. PMID: 1686163 [PubMed - indexed for MEDLINE]Related articles

Effects of ovarian hormones on sexual receptivity, proceptivity, and motivation in olfactory bulbectomized female rats.

Williams GW, Goldman J, McGinnis MY, Possidente B, Lumia AR.

Physiol Behav. 1991 Oct;50(4):751-5.PMID: 1775549 [PubMed - indexed for MEDLINE]Related articles

Design and statistical issues of the Modification of Diet in Renal Disease Trial. The Modification of Diet in Renal Disease Study Group.

Beck GJ, Berg RL, Coggins CH, Gassman JJ, Hunsicker LG, Schluchter MD, Williams GW.

Control Clin Trials. 1991 Oct;12(5):566-86.PMID: 1664792 [PubMed - indexed for MEDLINE]Related articles

Glomerular function in Pima Indians with noninsulin-dependent diabetes mellitus of recent onset.

Myers BD, Nelson RG, Williams GW, Bennett PH, Hardy SA, Berg RL, Loon N, Knowler WC, Mitch WE.

J Clin Invest. 1991 Aug;88(2):524-30.PMID: 1864963 [PubMed - indexed for MEDLINE]Related articlesFree article

Steroid-related osteonecrosis of the knee. Two case reports and a literature review.

Kelman GJ, Williams GW, Colwell CW Jr, Walker RH.

Clin Orthop Relat Res. 1990 Aug;(257):171-6. Review.PMID: 2199116 [PubMed - indexed for MEDLINE]Related articles

Clinical diagnoses and EEG interpretation.

Williams GW, Lesser RP, Silvers JB, Brickner A, Goormastic M, Fatica KJ, Klass DW.

Cleve Clin J Med. 1990 Jul-Aug;57(5):437-40.PMID: 2372923 [PubMed - indexed for MEDLINE]Related articles

Alpha 1-antitrypsin deficiency registry.

Stoller JK, Williams GW, Crystal RG.

Chest. 1990 May;97(5):1278. No abstract available. PMID: 2331946 [PubMed - indexed for MEDLINE]Related articles