PubMed

Update on heparin: what do we need to know?

Weitz DS, Weitz JI.

J Thromb Thrombolysis. 2009 Nov 2. [Epub ahead of print]PMID: 19882363 [PubMed - as supplied by publisher]Related articles

Otamixaban in acute coronary syndromes.

Eikelboom JW, Weitz JI.

Lancet. 2009 Sep 5;374(9692):762-4. Epub 2009 Aug 28. Review. No abstract available. PMID: 19717186 [PubMed - indexed for MEDLINE]Related articles

Catheter thrombosis and percutaneous coronary intervention: fundamental perspectives on blood, artificial surfaces and antithrombotic drugs.

Chan MY, Weitz JI, Merhi Y, Harrington RA, Becker RC.

J Thromb Thrombolysis. 2009 Oct;28(3):366-80.PMID: 19597766 [PubMed - in process]Related articles

Long range communication between exosites 1 and 2 modulates thrombin function.

Petrera NS, Stafford AR, Leslie BA, Kretz CA, Fredenburgh JC, Weitz JI.

J Biol Chem. 2009 Sep 18;284(38):25620-9. Epub 2009 Jul 9.PMID: 19589779 [PubMed - indexed for MEDLINE]Related articles

New antithrombotic drugs.

Gross PL, Weitz JI.

Clin Pharmacol Ther. 2009 Aug;86(2):139-46. Epub 2009 Jun 24. Review.PMID: 19553932 [PubMed - indexed for MEDLINE]Related articles

Unanswered questions in venous thromboembolism.

Weitz JI.

Thromb Res. 2009;123 Suppl 4:S2-S10. Review.PMID: 19303498 [PubMed - indexed for MEDLINE]Related articles

Inferior vena cava ligation rapidly induces tissue factor expression and venous thrombosis in rats.

Zhou J, May L, Liao P, Gross PL, Weitz JI.

Arterioscler Thromb Vasc Biol. 2009 Jun;29(6):863-9. Epub 2009 Mar 5.PMID: 19265029 [PubMed - indexed for MEDLINE]Related articles

Anticoagulation for ST-segment elevation myocardial infarction.

Eikelboom JW, Weitz JI.

Circulation. 2009 Mar 10;119(9):1186-8. Epub 2009 Feb 23. No abstract available. PMID: 19237653 [PubMed - indexed for MEDLINE]Related articles

Prevention and treatment of venous thromboembolism during pregnancy.

Weitz JI.

Catheter Cardiovasc Interv. 2009 Jul 1;74 Suppl 1:S22-6. Review.PMID: 19213066 [PubMed - indexed for MEDLINE]Related articles

Multimerin 1 binds factor V and activated factor V with high affinity and inhibits thrombin generation.

Jeimy SB, Fuller N, Tasneem S, Segers K, Stafford AR, Weitz JI, Camire RM, Nicolaes GA, Hayward CP.

Thromb Haemost. 2008 Dec;100(6):1058-67.PMID: 19132231 [PubMed - indexed for MEDLINE]Related articles

Dabigatran etexilate for prevention of venous thromboembolism.

Eikelboom JE, Weitz JI.

Thromb Haemost. 2009 Jan;101(1):2-4. No abstract available. PMID: 19132179 [PubMed - indexed for MEDLINE]Related articles

Comparative pharmacodynamics and pharmacokinetics of oral direct thrombin and factor xa inhibitors in development.

Eriksson BI, Quinlan DJ, Weitz JI.

Clin Pharmacokinet. 2009;48(1):1-22. doi: 10.2165/0003088-200948010-00001. Review.PMID: 19071881 [PubMed - indexed for MEDLINE]Related articles

G-protein-coupled receptors as signaling targets for antiplatelet therapy.

Smyth SS, Woulfe DS, Weitz JI, Gachet C, Conley PB, Goodman SG, Roe MT, Kuliopulos A, Moliterno DJ, French PA, Steinhubl SR, Becker RC; 2008 Platelet Colloquium Participants.

Arterioscler Thromb Vasc Biol. 2009 Apr;29(4):449-57. Epub 2008 Nov 20. Review.PMID: 19023091 [PubMed - indexed for MEDLINE]Related articles

Inhibition of osteolytic bone metastasis by unfractionated heparin.

Yee CK, Butcher M, Zeadin M, Weitz JI, Shaughnessy SG.

Clin Exp Metastasis. 2008;25(8):903-11. Epub 2008 Sep 24.PMID: 18814041 [PubMed - indexed for MEDLINE]Related articles

Influence of thrombophilia on risk of recurrent venous thromboembolism while on warfarin: results from a randomized trial.

Kearon C, Julian JA, Kovacs MJ, Anderson DR, Wells P, Mackinnon B, Weitz JI, Crowther MA, Dolan S, Turpie AG, Geerts W, Solymoss S, van Nguyen P, Demers C, Kahn SR, Kassis J, Rodger M, Hambleton J, Gent M, Ginsberg JS; ELATE Investigators.

Blood. 2008 Dec 1;112(12):4432-6. Epub 2008 Sep 12.PMID: 18791166 [PubMed - indexed for MEDLINE]Related articles

Contribution of host-derived tissue factor to tumor neovascularization.

Yu J, May L, Milsom C, Anderson GM, Weitz JI, Luyendyk JP, Broze G, Mackman N, Rak J.

Arterioscler Thromb Vasc Biol. 2008 Nov;28(11):1975-81. Epub 2008 Sep 4.PMID: 18772494 [PubMed - indexed for MEDLINE]Related articlesFree article

New antithrombotic drugs: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines (8th Edition).

Weitz JI, Hirsh J, Samama MM; American College of Chest Physicians.

Chest. 2008 Jun;133(6 Suppl):234S-256S. Erratum in: Chest. 2008 Aug;134(2):473. PMID: 18574267 [PubMed - indexed for MEDLINE]Related articlesFree article

Parenteral anticoagulants: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines (8th Edition).

Hirsh J, Bauer KA, Donati MB, Gould M, Samama MM, Weitz JI; American College of Chest Physicians.

Chest. 2008 Jun;133(6 Suppl):141S-159S. Erratum in: Chest. 2008 Aug;134(2):473. PMID: 18574264 [PubMed - indexed for MEDLINE]Related articles

Selective factor Xa inhibition for thromboprophylaxis.

Eikelboom JW, Weitz JI.

Lancet. 2008 Jul 5;372(9632):6-8. Epub 2008 Jun 24. No abstract available. PMID: 18582929 [PubMed - indexed for MEDLINE]Related articles

New anticoagulants for treatment of venous thromboembolism.

Gross PL, Weitz JI.

Arterioscler Thromb Vasc Biol. 2008 Mar;28(3):380-6. Review.PMID: 18296593 [PubMed - indexed for MEDLINE]Related articlesFree article

Bivalent binding to gammaA/gamma'-fibrin engages both exosites of thrombin and protects it from inhibition by the antithrombin-heparin complex.

Fredenburgh JC, Stafford AR, Leslie BA, Weitz JI.

J Biol Chem. 2008 Feb 1;283(5):2470-7. Epub 2007 Nov 30.PMID: 18055456 [PubMed - indexed for MEDLINE]Related articlesFree article

Elevated tissue factor procoagulant activity in CD133-positive cancer cells.

Milsom C, Anderson GM, Weitz JI, Rak J.

J Thromb Haemost. 2007 Dec;5(12):2550-2. Epub 2007 Sep 19. No abstract available. PMID: 17883595 [PubMed - indexed for MEDLINE]Related articles

Factor Xa or thrombin: is thrombin a better target?

Weitz JI.

J Thromb Haemost. 2007 Jul;5 Suppl 1:65-7.PMID: 17635711 [PubMed - indexed for MEDLINE]Related articles

A replacement for warfarin: the search continues.

Eikelboom JW, Weitz JI.

Circulation. 2007 Jul 10;116(2):131-3. Epub 2007 Jun 18. No abstract available. PMID: 17576860 [PubMed - indexed for MEDLINE]Related articlesFree article

In the presence of phospholipids, glycosaminoglycans potentiate factor Xa-mediated protein C activation by modulating factor Xa activity.

McRae SJ, Stafford AR, Fredenburgh JC, Weitz JI.

Biochemistry. 2007 Apr 3;46(13):4195-203. Epub 2007 Mar 8.PMID: 17343367 [PubMed - indexed for MEDLINE]Related articles

Beyond heparin and warfarin: the new generation of anticoagulants.

Weitz JI, Linkins LA.

Expert Opin Investig Drugs. 2007 Mar;16(3):271-82. Review.PMID: 17302522 [PubMed - indexed for MEDLINE]Related articles

A non-anticoagulant synthetic pentasaccharide reduces inflammation in a murine model of kidney ischemia-reperfusion injury.

Frank RD, Holscher T, Schabbauer G, Tencati M, Pawlinski R, Weitz JI, Mackman N.

Thromb Haemost. 2006 Dec;96(6):802-6.PMID: 17139376 [PubMed - indexed for MEDLINE]Related articles

HD1, a thrombin-directed aptamer, binds exosite 1 on prothrombin with high affinity and inhibits its activation by prothrombinase.

Kretz CA, Stafford AR, Fredenburgh JC, Weitz JI.

J Biol Chem. 2006 Dec 8;281(49):37477-85. Epub 2006 Oct 17.PMID: 17046833 [PubMed - indexed for MEDLINE]Related articlesFree article

Emerging anticoagulants for the treatment of venous thromboembolism.

Weitz JI.

Thromb Haemost. 2006 Sep;96(3):274-84. Review.PMID: 16953267 [PubMed - indexed for MEDLINE]Related articles

Initial treatment of venous thromboembolism.

Becattini C, Agnelli G, Emmerich J, Bura A, Weitz JI.

Thromb Haemost. 2006 Sep;96(3):242-50. Review.PMID: 16953263 [PubMed - indexed for MEDLINE]Related articles

Emerging themes in the treatment of venous thromboembolism.

Weitz JI.

Thromb Haemost. 2006 Sep;96(3):239-41. No abstract available. PMID: 16953262 [PubMed - indexed for MEDLINE]Related articles

OASIS-6: should patients with acute ST-segment elevation myocardial infarction be treated with fondaparinux?

Linkins LA, Weitz JI.

Nat Clin Pract Cardiovasc Med. 2006 Sep;3(9):478-9. No abstract available. PMID: 16932763 [PubMed]Related articles

The status of new anticoagulants.

Bates SM, Weitz JI.

Br J Haematol. 2006 Jul;134(1):3-19. Review.PMID: 16803562 [PubMed - indexed for MEDLINE]Related articles

An evaluation of D-dimer in the diagnosis of pulmonary embolism: a randomized trial.

Kearon C, Ginsberg JS, Douketis J, Turpie AG, Bates SM, Lee AY, Crowther MA, Weitz JI, Brill-Edwards P, Wells P, Anderson DR, Kovacs MJ, Linkins LA, Julian JA, Bonilla LR, Gent M; Canadian Pulmonary Embolism Diagnosis Study (CANPEDS) Group.

Ann Intern Med. 2006 Jun 6;144(11):812-21.PMID: 16754923 [PubMed - indexed for MEDLINE]Related articlesFree article

Heparin synergistically enhances interleukin-11 signaling through up-regulation of the MAPK pathway.

Rajgopal R, Butcher M, Weitz JI, Shaughnessy SG.

J Biol Chem. 2006 Jul 28;281(30):20780-7. Epub 2006 May 23.PMID: 16720575 [PubMed - indexed for MEDLINE]Related articlesFree article

Changing paradigms in the management of venous thromboembolism.

Weitz JI.

Am Heart Hosp J. 2006 Spring;4(2):135-41. Review. No abstract available. PMID: 16687960 [PubMed - indexed for MEDLINE]Related articles

Incorporation of fragment X into fibrin clots renders them more susceptible to lysis by plasmin.

Schaefer AV, Leslie BA, Rischke JA, Stafford AR, Fredenburgh JC, Weitz JI.

Biochemistry. 2006 Apr 4;45(13):4257-65.PMID: 16566600 [PubMed - indexed for MEDLINE]Related articles

Pharmacology and clinical potential of direct thrombin inhibitors.

Linkins LA, Weitz JI.

Curr Pharm Des. 2005;11(30):3877-84. Review.PMID: 16305518 [PubMed - indexed for MEDLINE]Related articles

New anticoagulants: an update.

Crowther M, Weitz JI.

Clin Adv Hematol Oncol. 2004 Nov;2(11):743-9. Review.PMID: 16170892 [PubMed - indexed for MEDLINE]Related articles

New anticoagulants.

Weitz JI, Bates SM.

J Thromb Haemost. 2005 Aug;3(8):1843-53. Review.PMID: 16102051 [PubMed - indexed for MEDLINE]Related articles

Coagulation assays.

Bates SM, Weitz JI.

Circulation. 2005 Jul 26;112(4):e53-60. No abstract available. PMID: 16043649 [PubMed - indexed for MEDLINE]Related articlesFree article

Randomized, blinded trial comparing fondaparinux with unfractionated heparin in patients undergoing contemporary percutaneous coronary intervention: Arixtra Study in Percutaneous Coronary Intervention: a Randomized Evaluation (ASPIRE) Pilot Trial.

Mehta SR, Steg PG, Granger CB, Bassand JP, Faxon DP, Weitz JI, Afzal R, Rush B, Peters RJ, Natarajan MK, Velianou JL, Goodhart DM, Labinaz M, Tanguay JF, Fox KA, Yusuf S; ASPIRE Investigators.

Circulation. 2005 Mar 22;111(11):1390-7.PMID: 15781750 [PubMed - indexed for MEDLINE]Related articlesFree article

Heparin compromises streptokinase-induced arterial patency in rabbits.

Vlasin M, Rak J, Weitz JI, Peng L, Gumulec J, Johnston M, Klement P.

Thromb Res. 2005;115(5):427-34.PMID: 15733977 [PubMed - indexed for MEDLINE]Related articles

New anticoagulants: beyond heparin, low-molecular-weight heparin and warfarin.

Bates SM, Weitz JI.

Br J Pharmacol. 2005 Apr;144(8):1017-28. Review.PMID: 15711585 [PubMed - indexed for MEDLINE]Related articlesFree article

New anticoagulant therapy.

Linkins LA, Weitz JI.

Annu Rev Med. 2005;56:63-77. Review.PMID: 15660502 [PubMed - indexed for MEDLINE]Related articles

Modes and consequences of thrombin's interaction with fibrin.

Fredenburgh JC, Stafford AR, Pospisil CH, Weitz JI.

Biophys Chem. 2004 Dec 20;112(2-3):277-84. Review.PMID: 15572259 [PubMed - indexed for MEDLINE]Related articles

Thrombophilia and new anticoagulant drugs.

Weitz JI, Middeldorp S, Geerts W, Heit JA.

Hematology Am Soc Hematol Educ Program. 2004:424-38. Review.PMID: 15561696 [PubMed - indexed for MEDLINE]Related articlesFree article

Oncogenic events regulate tissue factor expression in colorectal cancer cells: implications for tumor progression and angiogenesis.

Yu JL, May L, Lhotak V, Shahrzad S, Shirasawa S, Weitz JI, Coomber BL, Mackman N, Rak JW.

Blood. 2005 Feb 15;105(4):1734-41. Epub 2004 Oct 19.PMID: 15494427 [PubMed - indexed for MEDLINE]Related articlesFree article

Antithrombotic therapy during percutaneous coronary intervention: the Seventh ACCP Conference on Antithrombotic and Thrombolytic Therapy.

Popma JJ, Berger P, Ohman EM, Harrington RA, Grines C, Weitz JI.

Chest. 2004 Sep;126(3 Suppl):576S-599S. Review.PMID: 15383485 [PubMed - indexed for MEDLINE]Related articlesFree article

New anticoagulant drugs: the Seventh ACCP Conference on Antithrombotic and Thrombolytic Therapy.

Weitz JI, Hirsh J, Samama MM.

Chest. 2004 Sep;126(3 Suppl):265S-286S. Review.PMID: 15383475 [PubMed - indexed for MEDLINE]Related articlesFree article