PubMed

The vitamin B1 metabolism of Staphylococcus aureus is controlled at enzymatic and transcriptional levels.

Müller IB, Bergmann B, Groves MR, Couto I, Amaral L, Begley TP, Walter RD, Wrenger C.

PLoS One. 2009 Nov 3;4(11):e7656.PMID: 19888457 [PubMed - in process]Related articlesFree article

Poisoning pyridoxal 5-phosphate-dependent enzymes: a new strategy to target the malaria parasite Plasmodium falciparum.

Müller IB, Wu F, Bergmann B, Knöckel J, Walter RD, Gehring H, Wrenger C.

PLoS One. 2009;4(2):e4406. Epub 2009 Feb 6.PMID: 19197387 [PubMed - indexed for MEDLINE]Related articlesFree article

Critical appraisal: clinical considerations for restoring mandibular incisors with porcelain laminate veneers.

Walter RD, Raigrodski AJ.

J Esthet Restor Dent. 2008;20(4):276-81.PMID: 18768002 [PubMed]Related articles

Purification and biochemical characterization of cytosolic glutathione-S-transferase from filarial worms Setaria cervi.

Ahmad R, Srivastava AK, Walter RD.

Comp Biochem Physiol B Biochem Mol Biol. 2008 Nov;151(3):237-45. Epub 2008 Apr 8.PMID: 18752976 [PubMed - indexed for MEDLINE]Related articles

Assessing the polyamine metabolism of Plasmodium falciparum as chemotherapeutic target.

Müller IB, Das Gupta R, Lüersen K, Wrenger C, Walter RD.

Mol Biochem Parasitol. 2008 Jul;160(1):1-7. Epub 2008 Mar 25. Review.PMID: 18455248 [PubMed - indexed for MEDLINE]Related articles

The assembly of the plasmodial PLP synthase complex follows a defined course.

Müller IB, Knöckel J, Groves MR, Jordanova R, Ealick SE, Walter RD, Wrenger C.

PLoS One. 2008 Mar 19;3(3):e1815.PMID: 18350152 [PubMed - indexed for MEDLINE]Related articlesFree article

Vitamin B1 and B6 in the malaria parasite: requisite or dispensable?

Wrenger C, Knöckel J, Walter RD, Müller IB.

Braz J Med Biol Res. 2008 Feb;41(2):82-8. Epub 2008 Jan 11. Review.PMID: 18235965 [PubMed - indexed for MEDLINE]Related articlesFree article

Filling the gap of intracellular dephosphorylation in the Plasmodium falciparum vitamin B1 biosynthesis.

Knöckel J, Bergmann B, Müller IB, Rathaur S, Walter RD, Wrenger C.

Mol Biochem Parasitol. 2008 Feb;157(2):241-3. Epub 2007 Nov 1.PMID: 18067979 [PubMed - indexed for MEDLINE]Related articles

gamma-Substituted bis(pivaloyloxymethyl)ester analogues of fosmidomycin and FR900098.

Kurz T, Behrendt C, Pein M, Kaula U, Bergmann B, Walter RD.

Arch Pharm (Weinheim). 2007 Dec;340(12):661-6.PMID: 17994605 [PubMed - indexed for MEDLINE]Related articles

Oxidative stress in Caenorhabditis elegans: protective effects of the Omega class glutathione transferase (GSTO-1).

Burmeister C, Lüersen K, Heinick A, Hussein A, Domagalski M, Walter RD, Liebau E.

FASEB J. 2008 Feb;22(2):343-54. Epub 2007 Sep 27.PMID: 17901115 [PubMed - indexed for MEDLINE]Related articlesFree article

Crystal structure of Plasmodium falciparum spermidine synthase in complex with the substrate decarboxylated S-adenosylmethionine and the potent inhibitors 4MCHA and AdoDATO.

Dufe VT, Qiu W, Müller IB, Hui R, Walter RD, Al-Karadaghi S.

J Mol Biol. 2007 Oct 12;373(1):167-77. Epub 2007 Aug 2.PMID: 17822713 [PubMed - indexed for MEDLINE]Related articles

Synthesis and biological evaluation of potential modulators of malarial glutathione-S-transferase(s).

Ahmad R, Srivastava AK, Tripathi RP, Batra S, Walter RD.

J Enzyme Inhib Med Chem. 2007 Jun;22(3):327-42.PMID: 17674815 [PubMed - indexed for MEDLINE]Related articles

Conformationally restrained aromatic analogues of fosmidomycin and FR900098.

Kurz T, Schlüter K, Pein M, Behrendt C, Bergmann B, Walter RD.

Arch Pharm (Weinheim). 2007 Jul;340(7):339-44.PMID: 17611943 [PubMed - indexed for MEDLINE]Related articles

The apicomplexan parasite Toxoplasma gondii generates pyridoxal phosphate de novo.

Knöckel J, Müller IB, Bergmann B, Walter RD, Wrenger C.

Mol Biochem Parasitol. 2007 Mar;152(1):108-11. Epub 2006 Dec 20. No abstract available. PMID: 17222923 [PubMed - indexed for MEDLINE]Related articles

Structural and mechanistic insights into the action of Plasmodium falciparum spermidine synthase.

Burger PB, Birkholtz LM, Joubert F, Haider N, Walter RD, Louw AI.

Bioorg Med Chem. 2007 Feb 15;15(4):1628-37. Epub 2006 Dec 13.PMID: 17196392 [PubMed - indexed for MEDLINE]Related articles

The human malaria parasite Plasmodium falciparum expresses an atypical N-terminally extended pyrophosphokinase with specificity for thiamine.

Eschbach ML, Müller IB, Gilberger TW, Walter RD, Wrenger C.

Biol Chem. 2006 Dec;387(12):1583-91.PMID: 17132104 [PubMed - indexed for MEDLINE]Related articles

Arylmethyl substituted derivatives of Fosmidomycin: synthesis and antimalarial activity.

Schlüter K, Walter RD, Bergmann B, Kurz T.

Eur J Med Chem. 2006 Dec;41(12):1385-97. Epub 2006 Oct 18.PMID: 17055117 [PubMed - indexed for MEDLINE]Related articles

Synthesis and antimalarial activity of chain substituted pivaloyloxymethyl ester analogues of Fosmidomycin and FR900098.

Kurz T, Schlüter K, Kaula U, Bergmann B, Walter RD, Geffken D.

Bioorg Med Chem. 2006 Aug 1;14(15):5121-35. Epub 2006 May 5.PMID: 16679022 [PubMed - indexed for MEDLINE]Related articles

Vitamin B1 de novo synthesis in the human malaria parasite Plasmodium falciparum depends on external provision of 4-amino-5-hydroxymethyl-2-methylpyrimidine.

Wrenger C, Eschbach ML, Müller IB, Laun NP, Begley TP, Walter RD.

Biol Chem. 2006 Jan;387(1):41-51.PMID: 16497163 [PubMed - indexed for MEDLINE]Related articles

Novel properties of malarial S-adenosylmethionine decarboxylase as revealed by structural modelling.

Wells GA, Birkholtz LM, Joubert F, Walter RD, Louw AI.

J Mol Graph Model. 2006 Jan;24(4):307-18. Epub 2005 Oct 27.PMID: 16257247 [PubMed - indexed for MEDLINE]Related articles

Cloning, expression, characterisation and three-dimensional structure determination of Caenorhabditis elegans spermidine synthase.

Dufe VT, Lüersen K, Eschbach ML, Haider N, Karlberg T, Walter RD, Al-Karadaghi S.

FEBS Lett. 2005 Nov 7;579(27):6037-43. Epub 2005 Oct 5.PMID: 16226262 [PubMed - indexed for MEDLINE]Related articles

The highly abundant protein Ag-lbp55 from Ascaridia galli represents a novel type of lipid-binding proteins.

Jordanova R, Radoslavov G, Fischer P, Torda A, Lottspeich F, Boteva R, Walter RD, Bankov I, Liebau E.

J Biol Chem. 2005 Dec 16;280(50):41429-38. Epub 2005 Oct 6.PMID: 16210327 [PubMed - indexed for MEDLINE]Related articlesFree article

3-Aminooxy-1-aminopropane and derivatives have an antiproliferative effect on cultured Plasmodium falciparum by decreasing intracellular polyamine concentrations.

Das Gupta R, Krause-Ihle T, Bergmann B, Müller IB, Khomutov AR, Müller S, Walter RD, Lüersen K.

Antimicrob Agents Chemother. 2005 Jul;49(7):2857-64.PMID: 15980361 [PubMed - indexed for MEDLINE]Related articlesFree article

The spermidine synthase of the malaria parasite Plasmodium falciparum: molecular and biochemical characterisation of the polyamine synthesis enzyme.

Haider N, Eschbach ML, Dias Sde S, Gilberger TW, Walter RD, Lüersen K.

Mol Biochem Parasitol. 2005 Aug;142(2):224-36.PMID: 15913804 [PubMed - indexed for MEDLINE]Related articles

Structural metal dependency of the arginase from the human malaria parasite Plasmodium falciparum.

Müller IB, Walter RD, Wrenger C.

Biol Chem. 2005 Feb;386(2):117-26.PMID: 15843155 [PubMed - indexed for MEDLINE]Related articles

Functional analysis of the methylmalonyl-CoA epimerase from Caenorhabditis elegans.

Kühnl J, Bobik T, Procter JB, Burmeister C, Höppner J, Wilde I, Lüersen K, Torda AE, Walter RD, Liebau E.

FEBS J. 2005 Mar;272(6):1465-77.PMID: 15752362 [PubMed - indexed for MEDLINE]Related articlesFree article

Structure of the major cytosolic glutathione S-transferase from the parasitic nematode Onchocerca volvulus.

Perbandt M, Höppner J, Betzel C, Walter RD, Liebau E.

J Biol Chem. 2005 Apr 1;280(13):12630-6. Epub 2005 Jan 7.PMID: 15640152 [PubMed - indexed for MEDLINE]Related articlesFree article

Conformational and functional analysis of the lipid binding protein Ag-NPA-1 from the parasitic nematode Ascaridia galli.

Jordanova R, Radoslavov G, Fischer P, Liebau E, Walter RD, Bankov I, Boteva R.

FEBS J. 2005 Jan;272(1):180-9.PMID: 15634342 [PubMed - indexed for MEDLINE]Related articlesFree article

Analysis of the vitamin B6 biosynthesis pathway in the human malaria parasite Plasmodium falciparum.

Wrenger C, Eschbach ML, Müller IB, Warnecke D, Walter RD.

J Biol Chem. 2005 Feb 18;280(7):5242-8. Epub 2004 Dec 7.PMID: 15590634 [PubMed - indexed for MEDLINE]Related articlesFree article

Functional GATA- and initiator-like-elements exhibit a similar arrangement in the promoters of Caenorhabditis elegans polyamine synthesis enzymes.

Lüersen K, Eschbach ML, Liebau E, Walter RD.

Biol Chem. 2004 Aug;385(8):711-21.PMID: 15449707 [PubMed - indexed for MEDLINE]Related articles

[[1]Benzothieno[3,2-b]pyridin-4-yl-amine--synthesis and investigation of activity against malaria]

Görlitzer K, Meyer H, Walter RD, Jomaa H, Wiesner J.

Pharmazie. 2004 Jul;59(7):506-12. German. PMID: 15297995 [PubMed - indexed for MEDLINE]Related articles

Crystallization of the major cytosolic glutathione S-transferase from Onchocerca volvulus.

Höppner J, Perbandt M, Betzel Ch, Walter RD, Liebau E.

Acta Crystallogr D Biol Crystallogr. 2004 Aug;60(Pt 8):1496-7. Epub 2004 Jul 21.PMID: 15272188 [PubMed - indexed for MEDLINE]Related articles

[Pyrido [3,2-b]indol-4-yl-amines--synthesis and investigation of activity against malaria]

Görlitzer K, Kramer C, Meyer H, Walter RD, Jomaa H, Wiesner J.

Pharmazie. 2004 Apr;59(4):243-50. German. PMID: 15125565 [PubMed - indexed for MEDLINE]Related articles

Parasite-specific inserts in the bifunctional S-adenosylmethionine decarboxylase/ornithine decarboxylase of Plasmodium falciparum modulate catalytic activities and domain interactions.

Birkholtz LM, Wrenger C, Joubert F, Wells GA, Walter RD, Louw AI.

Biochem J. 2004 Jan 15;377(Pt 2):439-48.PMID: 12974675 [PubMed - indexed for MEDLINE]Related articlesFree article

The activator-binding site of Onchocerca volvulus S-adenosylmethionine decarboxylase, a potential drug target.

Ndjonka D, Zou Y, Bi X, Woster P, Walter RD, Lüersen K.

Biol Chem. 2003 Aug;384(8):1195-201.PMID: 12974388 [PubMed - indexed for MEDLINE]Related articles

Native and inhibited structure of a Mu class-related glutathione S-transferase from Plasmodium falciparum.

Perbandt M, Burmeister C, Walter RD, Betzel C, Liebau E.

J Biol Chem. 2004 Jan 9;279(2):1336-42. Epub 2003 Sep 12.PMID: 12972411 [PubMed - indexed for MEDLINE]Related articlesFree article

Brugia malayi and Wuchereria bancrofti: gene comparison and recombinant expression of pi-class related glutathione S-transferases.

Rathaur S, Fischer P, Domagalski M, Walter RD, Liebau E.

Exp Parasitol. 2003 Mar-Apr;103(3-4):177-81.PMID: 12880597 [PubMed - indexed for MEDLINE]Related articles

Crystallization and preliminary X-ray diffraction studies of the glutathione S-transferase from Plasmodium falciparum.

Burmeister C, Perbandt M, Betzel Ch, Walter RD, Liebau E.

Acta Crystallogr D Biol Crystallogr. 2003 Aug;59(Pt 8):1469-71. Epub 2003 Jul 23.PMID: 12876354 [PubMed - indexed for MEDLINE]Related articles

Thiol-based redox metabolism of protozoan parasites.

Müller S, Liebau E, Walter RD, Krauth-Siegel RL.

Trends Parasitol. 2003 Jul;19(7):320-8. Review.PMID: 12855383 [PubMed - indexed for MEDLINE]Related articles

A dominant role for extracellular glutathione S-transferase from Onchocerca volvulus is the production of prostaglandin D2.

Sommer A, Rickert R, Fischer P, Steinhart H, Walter RD, Liebau E.

Infect Immun. 2003 Jun;71(6):3603-6.PMID: 12761146 [PubMed - indexed for MEDLINE]Related articlesFree article

Caenorhabditis elegans S-adenosylmethionine decarboxylase is highly stimulated by putrescine but exhibits a low specificity for activator binding.

Ndjonka D, Da'dara A, Walter RD, Lüersen K.

Biol Chem. 2003 Jan;384(1):83-91.PMID: 12674502 [PubMed - indexed for MEDLINE]Related articles

Synthesis and antifilarial evaluation of N1,Nn- xylofuranosylated diaminoalkanes.

Tiwari VK, Tewari N, Katiyar D, Tripathi RP, Arora K, Gupta S, Ahmad R, Srivastava AK, Khan MA, Murthy PK, Walter RD.

Bioorg Med Chem. 2003 Apr 17;11(8):1789-800.PMID: 12659765 [PubMed - indexed for MEDLINE]Related articles

DBU-assisted cyclorelease elimination: combinatorial synthesis and gamma-glutamyl cysteine synthetase and glutathione-S-transeferase modulatory effect of C-nucleoside analogs.

Mishra RC, Tewari N, Arora K, Ahmad R, Tripathi RP, Tiwari VK, Walter RD, Srivastava AK.

Comb Chem High Throughput Screen. 2003 Feb;6(1):37-50.PMID: 12570751 [PubMed - indexed for MEDLINE]Related articles

The glutathione S-transferase from Plasmodium falciparum.

Liebau E, Bergmann B, Campbell AM, Teesdale-Spittle P, Brophy PM, Lüersen K, Walter RD.

Mol Biochem Parasitol. 2002 Sep-Oct;124(1-2):85-90. No abstract available. PMID: 12387854 [PubMed - indexed for MEDLINE]Related articles

Regulation of intracellular glutathione levels in erythrocytes infected with chloroquine-sensitive and chloroquine-resistant Plasmodium falciparum.

Meierjohann S, Walter RD, Müller S.

Biochem J. 2002 Dec 15;368(Pt 3):761-8.PMID: 12225291 [PubMed - indexed for MEDLINE]Related articlesFree article

Thioredoxin reductase is essential for the survival of Plasmodium falciparum erythrocytic stages.

Krnajski Z, Gilberger TW, Walter RD, Cowman AF, Müller S.

J Biol Chem. 2002 Jul 19;277(29):25970-5. Epub 2002 May 9.PMID: 12004069 [PubMed - indexed for MEDLINE]Related articlesFree article

Glutathione synthetase from Plasmodium falciparum.

Meierjohann S, Walter RD, Müller S.

Biochem J. 2002 May 1;363(Pt 3):833-8.PMID: 11964186 [PubMed - indexed for MEDLINE]Related articlesFree article

Call to consolidate achievements for onchocerciasis and lymphatic filariasis control.

Hoerauf A, Walter RD, Remme H, Lazdins J, Fleischer B.

Trends Parasitol. 2001 Dec;17(12):566-7.PMID: 11756020 [PubMed - indexed for MEDLINE]Related articles

Thioredoxin and glutathione system of malaria parasite Plasmodium falciparum.

Müller S, Gilberger TW, Krnajski Z, Lüersen K, Meierjohann S, Walter RD.

Protoplasma. 2001;217(1-3):43-9. Review.PMID: 11732337 [PubMed - indexed for MEDLINE]Related articles

Structural analysis and antibody response to the extracellular glutathione S-transferases from Onchocerca volvulus.

Sommer A, Nimtz M, Conradt HS, Brattig N, Boettcher K, Fischer P, Walter RD, Liebau E.

Infect Immun. 2001 Dec;69(12):7718-28.PMID: 11705953 [PubMed - indexed for MEDLINE]Related articlesFree article