PubMed

Pmch expression during early development is critical for normal energy homeostasis.

Mul J, Yi CX, van den Berg SA, Ruiter M, Toonen P, van der Elst M, Voshol PJ, Ellenbroek B, Kalsbeek A, la Fleur SE, Cuppen E.

Am J Physiol Endocrinol Metab. 2009 Nov 24. [Epub ahead of print]PMID: 19934402 [PubMed - as supplied by publisher]

Thyroid hormone effects on whole-body energy homeostasis and tissue-specific fatty acid uptake in vivo.

Klieverik LP, Coomans CP, Endert E, Sauerwein HP, Havekes LM, Voshol PJ, Rensen PC, Romijn JA, Kalsbeek A, Fliers E.

Endocrinology. 2009 Dec;150(12):5639-48. Epub 2009 Oct 23.PMID: 19854865 [PubMed - in process]Related articles

CETP does not affect triglyceride production or clearance in APOE*3-leiden mice.

Bijland S, van den Berg SA, Voshol PJ, van den Hoek AM, Princen HM, Havekes LM, Rensen PC, Willems van Dijk K.

J Lipid Res. 2009 Jun 29. [Epub ahead of print]PMID: 19564641 [PubMed - as supplied by publisher]Related articlesFree article

MIF deficiency reduces chronic inflammation in white adipose tissue and impairs the development of insulin resistance, glucose intolerance, and associated atherosclerotic disease.

Verschuren L, Kooistra T, Bernhagen J, Voshol PJ, Ouwens DM, van Erk M, de Vries-van der Weij J, Leng L, van Bockel JH, van Dijk KW, Fingerle-Rowson G, Bucala R, Kleemann R.

Circ Res. 2009 Jul 2;105(1):99-107. Epub 2009 May 28.PMID: 19478200 [PubMed - indexed for MEDLINE]Related articles

Effect of plasma triglyceride metabolism on lipid storage in adipose tissue: studies using genetically engineered mouse models.

Voshol PJ, Rensen PC, van Dijk KW, Romijn JA, Havekes LM.

Biochim Biophys Acta. 2009 Jun;1791(6):479-85. Epub 2009 Jan 8. Review.PMID: 19168150 [PubMed - indexed for MEDLINE]Related articles

Apolipoprotein E predisposes to obesity and related metabolic dysfunctions in mice.

Karagiannides I, Abdou R, Tzortzopoulou A, Voshol PJ, Kypreos KE.

FEBS J. 2008 Oct;275(19):4796-809. Epub 2008 Aug 27.PMID: 18754772 [PubMed - indexed for MEDLINE]Related articles

Mutation of the PDK1 PH domain inhibits protein kinase B/Akt, leading to small size and insulin resistance.

Bayascas JR, Wullschleger S, Sakamoto K, García-Martínez JM, Clacher C, Komander D, van Aalten DM, Boini KM, Lang F, Lipina C, Logie L, Sutherland C, Chudek JA, van Diepen JA, Voshol PJ, Lucocq JM, Alessi DR.

Mol Cell Biol. 2008 May;28(10):3258-72. Epub 2008 Mar 17.PMID: 18347057 [PubMed - indexed for MEDLINE]Related articlesFree article

ApoE2-associated hypertriglyceridemia is ameliorated by increased levels of apoA-V but unaffected by apoC-III deficiency.

Gerritsen G, van der Hoogt CC, Schaap FG, Voshol PJ, Kypreos KE, Maeda N, Groen AK, Havekes LM, Rensen PC, van Dijk KW.

J Lipid Res. 2008 May;49(5):1048-55. Epub 2008 Feb 10.PMID: 18263930 [PubMed - indexed for MEDLINE]Related articlesFree article

Dynamics of insulin signalling in liver during hyperinsulinemic euglycaemic clamp conditions in vivo and the effects of high-fat feeding in male mice.

Korsheninnikova E, Voshol PJ, Baan B, van der Zon GC, Havekes LM, Romijn JA, Maassen JA, Ouwens DM.

Arch Physiol Biochem. 2007 Oct-Dec;113(4-5):173-85.PMID: 18158643 [PubMed - indexed for MEDLINE]Related articles

Leptin deficiency per se dictates body composition and insulin action in ob/ob mice.

van den Hoek AM, Teusink B, Voshol PJ, Havekes LM, Romijn JA, Pijl H.

J Neuroendocrinol. 2008 Jan;20(1):120-7.PMID: 18081560 [PubMed - indexed for MEDLINE]Related articles

Angptl4 upregulates cholesterol synthesis in liver via inhibition of LPL- and HL-dependent hepatic cholesterol uptake.

Lichtenstein L, Berbée JF, van Dijk SJ, van Dijk KW, Bensadoun A, Kema IP, Voshol PJ, Müller M, Rensen PC, Kersten S.

Arterioscler Thromb Vasc Biol. 2007 Nov;27(11):2420-7. Epub 2007 Aug 30.PMID: 17761937 [PubMed - indexed for MEDLINE]Related articlesFree article

The Hyplip2 locus causes hypertriglyceridemia by decreased clearance of triglycerides.

Moen CJ, Tholens AP, Voshol PJ, de Haan W, Havekes LM, Gargalovic P, Lusis AJ, van Dyk KW, Frants RR, Hofker MH, Rensen PC.

J Lipid Res. 2007 Oct;48(10):2182-92. Epub 2007 Jul 3.PMID: 17609525 [PubMed - indexed for MEDLINE]Related articlesFree article

AMPK-mediated increase in myocardial long-chain fatty acid uptake critically depends on sarcolemmal CD36.

Habets DD, Coumans WA, Voshol PJ, den Boer MA, Febbraio M, Bonen A, Glatz JF, Luiken JJ.

Biochem Biophys Res Commun. 2007 Mar 30;355(1):204-10. Epub 2007 Feb 2.PMID: 17292863 [PubMed - indexed for MEDLINE]Related articles

A1 adenosine receptor partial agonist lowers plasma FFA and improves insulin resistance induced by high-fat diet in rodents.

Dhalla AK, Wong MY, Voshol PJ, Belardinelli L, Reaven GM.

Am J Physiol Endocrinol Metab. 2007 May;292(5):E1358-63. Epub 2007 Jan 16.PMID: 17227958 [PubMed - indexed for MEDLINE]Related articlesFree article

Insulin-mediated phosphorylation of the proline-rich Akt substrate PRAS40 is impaired in insulin target tissues of high-fat diet-fed rats.

Nascimento EB, Fodor M, van der Zon GC, Jazet IM, Meinders AE, Voshol PJ, Vlasblom R, Baan B, Eckel J, Maassen JA, Diamant M, Ouwens DM.

Diabetes. 2006 Dec;55(12):3221-8.PMID: 17130464 [PubMed - indexed for MEDLINE]Related articlesFree article

Sustained activation of the mammalian target of rapamycin nutrient sensing pathway is associated with hepatic insulin resistance, but not with steatosis, in mice.

Korsheninnikova E, van der Zon GC, Voshol PJ, Janssen GM, Havekes LM, Grefhorst A, Kuipers F, Reijngoud DJ, Romijn JA, Ouwens DM, Maassen JA.

Diabetologia. 2006 Dec;49(12):3049-57. Epub 2006 Sep 28.PMID: 17006666 [PubMed - indexed for MEDLINE]Related articles

Leptin deficiency unmasks the deleterious effects of impaired peroxisome proliferator-activated receptor gamma function (P465L PPARgamma) in mice.

Gray SL, Nora ED, Grosse J, Manieri M, Stoeger T, Medina-Gomez G, Burling K, Wattler S, Russ A, Yeo GS, Chatterjee VK, O'Rahilly S, Voshol PJ, Cinti S, Vidal-Puig A.

Diabetes. 2006 Oct;55(10):2669-77.PMID: 17003330 [PubMed - indexed for MEDLINE]Related articlesFree article

Chronic PYY3-36 treatment promotes fat oxidation and ameliorates insulin resistance in C57BL6 mice.

van den Hoek AM, Heijboer AC, Voshol PJ, Havekes LM, Romijn JA, Corssmit EP, Pijl H.

Am J Physiol Endocrinol Metab. 2007 Jan;292(1):E238-45. Epub 2006 Aug 29.PMID: 16940471 [PubMed - indexed for MEDLINE]Related articlesFree article

Dietary sphingolipids lower plasma cholesterol and triacylglycerol and prevent liver steatosis in APOE*3Leiden mice.

Duivenvoorden I, Voshol PJ, Rensen PC, van Duyvenvoorde W, Romijn JA, Emeis JJ, Havekes LM, Nieuwenhuizen WF.

Am J Clin Nutr. 2006 Aug;84(2):312-21.PMID: 16895877 [PubMed - indexed for MEDLINE]Related articlesFree article

Hepatic glucose production is more sensitive to insulin-mediated inhibition than hepatic VLDL-triglyceride production.

den Boer MA, Voshol PJ, Kuipers F, Romijn JA, Havekes LM.

Am J Physiol Endocrinol Metab. 2006 Dec;291(6):E1360-4. Epub 2006 Jul 18.PMID: 16849628 [PubMed - indexed for MEDLINE]Related articlesFree article

Deficiency of interleukin-18 in mice leads to hyperphagia, obesity and insulin resistance.

Netea MG, Joosten LA, Lewis E, Jensen DR, Voshol PJ, Kullberg BJ, Tack CJ, van Krieken H, Kim SH, Stalenhoef AF, van de Loo FA, Verschueren I, Pulawa L, Akira S, Eckel RH, Dinarello CA, van den Berg W, van der Meer JW.

Nat Med. 2006 Jun;12(6):650-6. Epub 2006 May 28.PMID: 16732281 [PubMed - indexed for MEDLINE]Related articles

Endogenous interleukin-10 protects against hepatic steatosis but does not improve insulin sensitivity during high-fat feeding in mice.

den Boer MA, Voshol PJ, Schröder-van der Elst JP, Korsheninnikova E, Ouwens DM, Kuipers F, Havekes LM, Romijn JA.

Endocrinology. 2006 Oct;147(10):4553-8. Epub 2006 May 18.PMID: 16709607 [PubMed - indexed for MEDLINE]Related articlesFree article

Hypercholesterolemia reduces collateral artery growth more dominantly than hyperglycemia or insulin resistance in mice.

van Weel V, de Vries M, Voshol PJ, Verloop RE, Eilers PH, van Hinsbergh VW, van Bockel JH, Quax PH.

Arterioscler Thromb Vasc Biol. 2006 Jun;26(6):1383-90. Epub 2006 Mar 30.PMID: 16574899 [PubMed - indexed for MEDLINE]Related articlesFree article

Ritonavir impairs lipoprotein lipase-mediated lipolysis and decreases uptake of fatty acids in adipose tissue.

den Boer MA, Berbée JF, Reiss P, van der Valk M, Voshol PJ, Kuipers F, Havekes LM, Rensen PC, Romijn JA.

Arterioscler Thromb Vasc Biol. 2006 Jan;26(1):124-9. Epub 2005 Nov 3.PMID: 16269669 [PubMed - indexed for MEDLINE]Related articlesFree article

Murine malaria parasite sequestration: CD36 is the major receptor, but cerebral pathology is unlinked to sequestration.

Franke-Fayard B, Janse CJ, Cunha-Rodrigues M, Ramesar J, Büscher P, Que I, Löwik C, Voshol PJ, den Boer MA, van Duinen SG, Febbraio M, Mota MM, Waters AP.

Proc Natl Acad Sci U S A. 2005 Aug 9;102(32):11468-73. Epub 2005 Jul 28.PMID: 16051702 [PubMed - indexed for MEDLINE]Related articlesFree article

CD36 deficiency in mice impairs lipoprotein lipase-mediated triglyceride clearance.

Goudriaan JR, den Boer MA, Rensen PC, Febbraio M, Kuipers F, Romijn JA, Havekes LM, Voshol PJ.

J Lipid Res. 2005 Oct;46(10):2175-81. Epub 2005 Jul 16.PMID: 16024917 [PubMed - indexed for MEDLINE]Related articlesFree article

High fat diet induced hepatic insulin resistance is not related to changes in hypothalamic mRNA expression of NPY, AgRP, POMC and CART in mice.

Heijboer AC, Voshol PJ, Donga E, van Eden CG, Havekes LM, Romijn JA, Pijl H, Corssmit EP.

Peptides. 2005 Dec;26(12):2554-8. Epub 2005 Jun 23.PMID: 15979206 [PubMed - indexed for MEDLINE]Related articles

Intracerebroventricular administration of melanotan II increases insulin sensitivity of glucose disposal in mice.

Heijboer AC, van den Hoek AM, Pijl H, Voshol PJ, Havekes LM, Romijn JA, Corssmit EP.

Diabetologia. 2005 Aug;48(8):1621-6. Epub 2005 Jun 22.PMID: 15971058 [PubMed - indexed for MEDLINE]Related articles

Metabolomics in the context of systems biology: bridging traditional Chinese medicine and molecular pharmacology.

Wang M, Lamers RJ, Korthout HA, van Nesselrooij JH, Witkamp RF, van der Heijden R, Voshol PJ, Havekes LM, Verpoorte R, van der Greef J.

Phytother Res. 2005 Mar;19(3):173-82. Review.PMID: 15934013 [PubMed - indexed for MEDLINE]Related articles

Bile duct proliferation associated with bile salt-induced hypercholeresis in Mdr2 P-glycoprotein-deficient mice.

Hulzebos CV, Voshol PJ, Wolters H, Kruit JK, Ottenhof R, Groen AK, Stellaard F, Verkade HJ, Kuipers F.

Liver Int. 2005 Jun;25(3):604-12.PMID: 15910498 [PubMed - indexed for MEDLINE]Related articles

Triglyceride-rich lipoprotein metabolism in unique VLDL receptor, LDL receptor, and LRP triple-deficient mice.

Espirito Santo SM, Rensen PC, Goudriaan JR, Bensadoun A, Bovenschen N, Voshol PJ, Havekes LM, van Vlijmen BJ.

J Lipid Res. 2005 Jun;46(6):1097-102. Epub 2005 Mar 16.PMID: 15772433 [PubMed - indexed for MEDLINE]Related articlesFree article

Response of apolipoprotein E*3-Leiden transgenic mice to dietary fatty acids: combining liver proteomics with physiological data.

de Roos B, Duivenvoorden I, Rucklidge G, Reid M, Ross K, Lamers RJ, Voshol PJ, Havekes LM, Teusink B.

FASEB J. 2005 May;19(7):813-5. Epub 2005 Mar 8.PMID: 15755870 [PubMed - indexed for MEDLINE]Related articlesFree article

Apolipoprotein C3 deficiency results in diet-induced obesity and aggravated insulin resistance in mice.

Duivenvoorden I, Teusink B, Rensen PC, Romijn JA, Havekes LM, Voshol PJ.

Diabetes. 2005 Mar;54(3):664-71.PMID: 15734841 [PubMed - indexed for MEDLINE]Related articlesFree article

Acute inhibition of hepatic beta-oxidation in APOE*3Leiden mice does not affect hepatic VLDL secretion or insulin sensitivity.

Duivenvoorden I, Teusink B, Rensen PC, Kuipers F, Romijn JA, Havekes LM, Voshol PJ.

J Lipid Res. 2005 May;46(5):988-93. Epub 2005 Feb 16.PMID: 15716584 [PubMed - indexed for MEDLINE]Related articlesFree article

Sixteen hours of fasting differentially affects hepatic and muscle insulin sensitivity in mice.

Heijboer AC, Donga E, Voshol PJ, Dang ZC, Havekes LM, Romijn JA, Corssmit EP.

J Lipid Res. 2005 Mar;46(3):582-8. Epub 2004 Dec 1.PMID: 15576835 [PubMed - indexed for MEDLINE]Related articlesFree article

Intracerebroventricular neuropeptide Y infusion precludes inhibition of glucose and VLDL production by insulin.

van den Hoek AM, Voshol PJ, Karnekamp BN, Buijs RM, Romijn JA, Havekes LM, Pijl H.

Diabetes. 2004 Oct;53(10):2529-34.PMID: 15448080 [PubMed - indexed for MEDLINE]Related articlesFree article

PYY3-36 reinforces insulin action on glucose disposal in mice fed a high-fat diet.

van den Hoek AM, Heijboer AC, Corssmit EP, Voshol PJ, Romijn JA, Havekes LM, Pijl H.

Diabetes. 2004 Aug;53(8):1949-52.PMID: 15277371 [PubMed - indexed for MEDLINE]Related articlesFree article

PPARalpha governs glycerol metabolism.

Patsouris D, Mandard S, Voshol PJ, Escher P, Tan NS, Havekes LM, Koenig W, März W, Tafuri S, Wahli W, Müller M, Kersten S.

J Clin Invest. 2004 Jul;114(1):94-103.PMID: 15232616 [PubMed - indexed for MEDLINE]Related articlesFree article

The role and mode of action of apolipoproteins CIII and AV: synergistic actors in triglyceride metabolism?

van Dijk KW, Rensen PC, Voshol PJ, Havekes LM.

Curr Opin Lipidol. 2004 Jun;15(3):239-46. Review.PMID: 15166778 [PubMed - indexed for MEDLINE]Related articles

The VLDL receptor plays a major role in chylomicron metabolism by enhancing LPL-mediated triglyceride hydrolysis.

Goudriaan JR, Espirito Santo SM, Voshol PJ, Teusink B, van Dijk KW, van Vlijmen BJ, Romijn JA, Havekes LM, Rensen PC.

J Lipid Res. 2004 Aug;45(8):1475-81. Epub 2004 May 16.PMID: 15145981 [PubMed - indexed for MEDLINE]Related articlesFree article

ApoAV reduces plasma triglycerides by inhibiting very low density lipoprotein-triglyceride (VLDL-TG) production and stimulating lipoprotein lipase-mediated VLDL-TG hydrolysis.

Schaap FG, Rensen PC, Voshol PJ, Vrins C, van der Vliet HN, Chamuleau RA, Havekes LM, Groen AK, van Dijk KW.

J Biol Chem. 2004 Jul 2;279(27):27941-7. Epub 2004 Apr 16.PMID: 15090553 [PubMed - indexed for MEDLINE]Related articlesFree article

Hepatic steatosis: a mediator of the metabolic syndrome. Lessons from animal models.

den Boer M, Voshol PJ, Kuipers F, Havekes LM, Romijn JA.

Arterioscler Thromb Vasc Biol. 2004 Apr;24(4):644-9. Epub 2004 Jan 8. Review.PMID: 14715643 [PubMed - indexed for MEDLINE]Related articlesFree article

Acipimox enhances spontaneous growth hormone secretion in obese women.

Kok P, Buijs MM, Kok SW, Van Ierssel IH, Frölich M, Roelfsema F, Voshol PJ, Meinders AE, Pijl H.

Am J Physiol Regul Integr Comp Physiol. 2004 Apr;286(4):R693-8. Epub 2003 Dec 11.PMID: 14670810 [PubMed - indexed for MEDLINE]Related articles

White adipose tissue: getting nervous.

Fliers E, Kreier F, Voshol PJ, Havekes LM, Sauerwein HP, Kalsbeek A, Buijs RM, Romijn JA.

J Neuroendocrinol. 2003 Nov;15(11):1005-10. Review.PMID: 14622429 [PubMed - indexed for MEDLINE]Related articles

A fish oil diet does not reverse insulin resistance despite decreased adipose tissue TNF-alpha protein concentration in ApoE-3*Leiden mice.

Muurling M, Mensink RP, Pijl H, Romijn JA, Havekes LM, Voshol PJ.

J Nutr. 2003 Nov;133(11):3350-5.PMID: 14608043 [PubMed - indexed for MEDLINE]Related articlesFree article

Overexpression of APOC1 in obob mice leads to hepatic steatosis and severe hepatic insulin resistance.

Muurling M, van den Hoek AM, Mensink RP, Pijl H, Romijn JA, Havekes LM, Voshol PJ.

J Lipid Res. 2004 Jan;45(1):9-16. Epub 2003 Oct 1.PMID: 14523051 [PubMed - indexed for MEDLINE]Related articlesFree article

CD36 deficiency increases insulin sensitivity in muscle, but induces insulin resistance in the liver in mice.

Goudriaan JR, Dahlmans VE, Teusink B, Ouwens DM, Febbraio M, Maassen JA, Romijn JA, Havekes LM, Voshol PJ.

J Lipid Res. 2003 Dec;44(12):2270-7. Epub 2003 Aug 16.PMID: 12923231 [PubMed - indexed for MEDLINE]Related articlesFree article

Rosiglitazone improves muscle insulin sensitivity, irrespective of increased triglyceride content, in ob/ob mice.

Muurling M, Mensink RP, Pijl H, Romijn JA, Havekes LM, Voshol PJ.

Metabolism. 2003 Aug;52(8):1078-83.PMID: 12898477 [PubMed - indexed for MEDLINE]Related articles

Increased hepatic insulin sensitivity together with decreased hepatic triglyceride stores in hormone-sensitive lipase-deficient mice.

Voshol PJ, Haemmerle G, Ouwens DM, Zimmermann R, Zechner R, Teusink B, Maassen JA, Havekes LM, Romijn JA.

Endocrinology. 2003 Aug;144(8):3456-62.PMID: 12865325 [PubMed - indexed for MEDLINE]Related articlesFree article

Contribution of fatty acids released from lipolysis of plasma triglycerides to total plasma fatty acid flux and tissue-specific fatty acid uptake.

Teusink B, Voshol PJ, Dahlmans VE, Rensen PC, Pijl H, Romijn JA, Havekes LM.

Diabetes. 2003 Mar;52(3):614-20.PMID: 12606500 [PubMed - indexed for MEDLINE]Related articlesFree article