PubMed

Protection against loss of innate defenses in adulthood by low advanced glycation end products (AGE) intake: role of the antiinflammatory AGE receptor-1.

Vlassara H, Cai W, Goodman S, Pyzik R, Yong A, Chen X, Zhu L, Neade T, Beeri M, Silverman JM, Ferrucci L, Tansman L, Striker GE, Uribarri J.

J Clin Endocrinol Metab. 2009 Nov;94(11):4483-91. Epub 2009 Oct 9.PMID: 19820033 [PubMed - in process]Related articles

Advanced glycation end product receptor-1 transgenic mice are resistant to inflammation, oxidative stress, and post-injury intimal hyperplasia.

Torreggiani M, Liu H, Wu J, Zheng F, Cai W, Striker G, Vlassara H.

Am J Pathol. 2009 Oct;175(4):1722-32. Epub 2009 Sep 24.PMID: 19779136 [PubMed - in process]Related articles

Oxidative stress-induced JNK activation contributes to proinflammatory phenotype of aging diabetic mesangial cells.

Wu J, Mei C, Vlassara H, Striker GE, Zheng F.

Am J Physiol Renal Physiol. 2009 Dec;297(6):F1622-31. Epub 2009 Sep 23.PMID: 19776174 [PubMed - in process]Related articles

Advanced glycation end products strongly activate platelets.

Gawlowski T, Stratmann B, Ruetter R, Buenting CE, Menart B, Weiss J, Vlassara H, Koschinsky T, Tschoepe D.

Eur J Nutr. 2009 Dec;48(8):475-81. Epub 2009 Jul 26.PMID: 19633966 [PubMed - in process]Related articles

Advanced glycation end products inhibit glucose-stimulated insulin secretion through nitric oxide-dependent inhibition of cytochrome c oxidase and adenosine triphosphate synthesis.

Zhao Z, Zhao C, Zhang XH, Zheng F, Cai W, Vlassara H, Ma ZA.

Endocrinology. 2009 Jun;150(6):2569-76. Epub 2009 Feb 26.PMID: 19246537 [PubMed - indexed for MEDLINE]Related articles

Chronic lymphocytic leukemia cells recognize conserved epitopes associated with apoptosis and oxidation.

Catera R, Silverman GJ, Hatzi K, Seiler T, Didier S, Zhang L, Hervé M, Meffre E, Oscier DG, Vlassara H, Scofield RH, Chen Y, Allen SL, Kolitz J, Rai KR, Chu CC, Chiorazzi N.

Mol Med. 2008 Nov-Dec;14(11-12):665-74. Epub 2008 Sep 25.PMID: 19009014 [PubMed - indexed for MEDLINE]Related articlesFree article

Oral glycotoxins determine the effects of calorie restriction on oxidant stress, age-related diseases, and lifespan.

Cai W, He JC, Zhu L, Chen X, Zheng F, Striker GE, Vlassara H.

Am J Pathol. 2008 Aug;173(2):327-36. Epub 2008 Jul 3.PMID: 18599606 [PubMed - indexed for MEDLINE]Related articlesFree article

Aging and glycoxidant stress.

Peppa M, Uribarri J, Vlassara H.

Hormones (Athens). 2008 Apr-Jun;7(2):123-32. Review.PMID: 18477549 [PubMed - indexed for MEDLINE]Related articlesFree article

Dietary advanced glycation endproducts and oxidative stress: in vivo effects on endothelial function and adipokines.

Stirban A, Negrean M, Götting C, Uribarri J, Gawlowski T, Stratmann B, Kleesiek K, Koschinsky T, Vlassara H, Tschoepe D.

Ann N Y Acad Sci. 2008 Apr;1126:276-9.PMID: 18448830 [PubMed - indexed for MEDLINE]Related articles

Advanced glycation end product homeostasis: exogenous oxidants and innate defenses.

Vlassara H, Uribarri J, Cai W, Striker G.

Ann N Y Acad Sci. 2008 Apr;1126:46-52.PMID: 18448795 [PubMed - indexed for MEDLINE]Related articles

Endothelial dysfunction in patients with chronic kidney disease results from advanced glycation end products (AGE)-mediated inhibition of endothelial nitric oxide synthase through RAGE activation.

Linden E, Cai W, He JC, Xue C, Li Z, Winston J, Vlassara H, Uribarri J.

Clin J Am Soc Nephrol. 2008 May;3(3):691-8. Epub 2008 Feb 6.PMID: 18256374 [PubMed - indexed for MEDLINE]Related articlesFree article

AGE-receptor-1 counteracts cellular oxidant stress induced by AGEs via negative regulation of p66shc-dependent FKHRL1 phosphorylation.

Cai W, He JC, Zhu L, Chen X, Striker GE, Vlassara H.

Am J Physiol Cell Physiol. 2008 Jan;294(1):C145-52. Epub 2007 Nov 21.PMID: 18032526 [PubMed - indexed for MEDLINE]Related articlesFree article

Glycotoxins in the diet promote diabetes and diabetic complications.

Vlassara H, Striker G.

Curr Diab Rep. 2007 Jun;7(3):235-41. Review.PMID: 17547841 [PubMed - indexed for MEDLINE]Related articles

Reduced oxidant stress and extended lifespan in mice exposed to a low glycotoxin diet: association with increased AGER1 expression.

Cai W, He JC, Zhu L, Chen X, Wallenstein S, Striker GE, Vlassara H.

Am J Pathol. 2007 Jun;170(6):1893-902.PMID: 17525257 [PubMed - indexed for MEDLINE]Related articlesFree article

Single oral challenge by advanced glycation end products acutely impairs endothelial function in diabetic and nondiabetic subjects.

Uribarri J, Stirban A, Sander D, Cai W, Negrean M, Buenting CE, Koschinsky T, Vlassara H.

Diabetes Care. 2007 Oct;30(10):2579-82. Epub 2007 May 11.PMID: 17496238 [PubMed - indexed for MEDLINE]Related articlesFree article

Effects of low- and high-advanced glycation endproduct meals on macro- and microvascular endothelial function and oxidative stress in patients with type 2 diabetes mellitus.

Negrean M, Stirban A, Stratmann B, Gawlowski T, Horstmann T, Götting C, Kleesiek K, Mueller-Roesel M, Koschinsky T, Uribarri J, Vlassara H, Tschoepe D.

Am J Clin Nutr. 2007 May;85(5):1236-43. Erratum in: Am J Clin Nutr. 2007 Oct;86(4):1256. PMID: 17490958 [PubMed - indexed for MEDLINE]Related articlesFree article

Circulating glycotoxins and dietary advanced glycation endproducts: two links to inflammatory response, oxidative stress, and aging.

Uribarri J, Cai W, Peppa M, Goodman S, Ferrucci L, Striker G, Vlassara H.

J Gerontol A Biol Sci Med Sci. 2007 Apr;62(4):427-33.PMID: 17452738 [PubMed - indexed for MEDLINE]Related articlesFree article

Prevention and reversal of diabetic nephropathy in db/db mice treated with alagebrium (ALT-711).

Peppa M, Brem H, Cai W, Zhang JG, Basgen J, Li Z, Vlassara H, Uribarri J.

Am J Nephrol. 2006;26(5):430-6. Epub 2006 Sep 13.PMID: 16974073 [PubMed - indexed for MEDLINE]Related articles

Advanced glycation end product (AGE) receptor 1 suppresses cell oxidant stress and activation signaling via EGF receptor.

Cai W, He JC, Zhu L, Lu C, Vlassara H.

Proc Natl Acad Sci U S A. 2006 Sep 12;103(37):13801-6. Epub 2006 Sep 5.PMID: 16954185 [PubMed - indexed for MEDLINE]Related articlesFree article

Benfotiamine prevents macro- and microvascular endothelial dysfunction and oxidative stress following a meal rich in advanced glycation end products in individuals with type 2 diabetes.

Stirban A, Negrean M, Stratmann B, Gawlowski T, Horstmann T, Götting C, Kleesiek K, Mueller-Roesel M, Koschinsky T, Uribarri J, Vlassara H, Tschoepe D.

Diabetes Care. 2006 Sep;29(9):2064-71.PMID: 16936154 [PubMed - indexed for MEDLINE]Related articlesFree article

Reduced acute vascular injury and atherosclerosis in hyperlipidemic mice transgenic for lysozyme.

Liu H, Zheng F, Li Z, Uribarri J, Ren B, Hutter R, Tunstead JR, Badimon J, Striker GE, Vlassara H.

Am J Pathol. 2006 Jul;169(1):303-13.PMID: 16816382 [PubMed - indexed for MEDLINE]Related articlesFree article

Diabetes and advanced glycoxidation end products.

Huebschmann AG, Regensteiner JG, Vlassara H, Reusch JE.

Diabetes Care. 2006 Jun;29(6):1420-32. Review. No abstract available. PMID: 16732039 [PubMed - indexed for MEDLINE]Related articlesFree article

Advanced glycation end products and diabetic complications: a general overview.

Peppa M, Vlassara H.

Hormones (Athens). 2005 Jan-Mar;4(1):28-37. Review.PMID: 16574629 [PubMed - indexed for MEDLINE]Related articlesFree article

Amelioration of oxidant stress by the defensin lysozyme.

Liu H, Zheng F, Cao Q, Ren B, Zhu L, Striker G, Vlassara H.

Am J Physiol Endocrinol Metab. 2006 May;290(5):E824-32. Epub 2005 Nov 29.PMID: 16317028 [PubMed - indexed for MEDLINE]Related articlesFree article

Insulin resistance and type 2 diabetes in high-fat-fed mice are linked to high glycotoxin intake.

Sandu O, Song K, Cai W, Zheng F, Uribarri J, Vlassara H.

Diabetes. 2005 Aug;54(8):2314-9.PMID: 16046296 [PubMed - indexed for MEDLINE]Related articlesFree article

Diet-derived advanced glycation end products are major contributors to the body's AGE pool and induce inflammation in healthy subjects.

Uribarri J, Cai W, Sandu O, Peppa M, Goldberg T, Vlassara H.

Ann N Y Acad Sci. 2005 Jun;1043:461-6. Review.PMID: 16037267 [PubMed - indexed for MEDLINE]Related articles

Advanced glycation in health and disease: role of the modern environment.

Vlassara H.

Ann N Y Acad Sci. 2005 Jun;1043:452-60. Review.PMID: 16037266 [PubMed - indexed for MEDLINE]Related articles

Differential expression of receptors for advanced glycation end-products in peritoneal mesothelial cells exposed to glucose degradation products.

Lai KN, Leung JC, Chan LY, Li FF, Tang SC, Lam MF, Tse KC, Yip TP, Chan TM, Wieslander A, Vlassara H.

Clin Exp Immunol. 2004 Dec;138(3):466-75.PMID: 15544624 [PubMed - indexed for MEDLINE]Related articlesFree article

Advanced glycation endproduct (AGE) receptor 1 is a negative regulator of the inflammatory response to AGE in mesangial cells.

Lu C, He JC, Cai W, Liu H, Zhu L, Vlassara H.

Proc Natl Acad Sci U S A. 2004 Aug 10;101(32):11767-72. Epub 2004 Aug 2.PMID: 15289604 [PubMed - indexed for MEDLINE]Related articlesFree article

Advanced glycoxidation end products in commonly consumed foods.

Goldberg T, Cai W, Peppa M, Dardaine V, Baliga BS, Uribarri J, Vlassara H.

J Am Diet Assoc. 2004 Aug;104(8):1287-91. Erratum in: J Am Diet Assoc. 2005 Apr;105(4):647. PMID: 15281050 [PubMed - indexed for MEDLINE]Related articles

High levels of dietary advanced glycation end products transform low-density lipoprotein into a potent redox-sensitive mitogen-activated protein kinase stimulant in diabetic patients.

Cai W, He JC, Zhu L, Peppa M, Lu C, Uribarri J, Vlassara H.

Circulation. 2004 Jul 20;110(3):285-91. Epub 2004 Jul 12.PMID: 15249511 [PubMed - indexed for MEDLINE]Related articlesFree article

Glycoxidation and diabetic complications: modern lessons and a warning?

Vlassara H, Uribarri J.

Rev Endocr Metab Disord. 2004 Aug;5(3):181-8. Review. No abstract available. PMID: 15211089 [PubMed - indexed for MEDLINE]Related articles

Glycoxidation and inflammation in renal failure patients.

Peppa M, Uribarri J, Cai W, Lu M, Vlassara H.

Am J Kidney Dis. 2004 Apr;43(4):690-5.PMID: 15042546 [PubMed - indexed for MEDLINE]Related articles

The role of advanced glycation end products in the development of atherosclerosis.

Peppa M, Uribarri J, Vlassara H.

Curr Diab Rep. 2004 Feb;4(1):31-6. Review.PMID: 14764277 [PubMed - indexed for MEDLINE]Related articles

Adverse effects of dietary glycotoxins on wound healing in genetically diabetic mice.

Peppa M, Brem H, Ehrlich P, Zhang JG, Cai W, Li Z, Croitoru A, Thung S, Vlassara H.

Diabetes. 2003 Nov;52(11):2805-13.PMID: 14578300 [PubMed - indexed for MEDLINE]Related articlesFree article

Glycoxidation: the menace of diabetes and aging.

Vlassara H, Palace MR.

Mt Sinai J Med. 2003 Sep;70(4):232-41. Review.PMID: 12968196 [PubMed - indexed for MEDLINE]Related articlesFree article

Dietary glycotoxins correlate with circulating advanced glycation end product levels in renal failure patients.

Uribarri J, Peppa M, Cai W, Goldberg T, Lu M, Baliga S, Vassalotti JA, Vlassara H.

Am J Kidney Dis. 2003 Sep;42(3):532-8.PMID: 12955681 [PubMed - indexed for MEDLINE]Related articles

Diabetes-induced oxidative stress and low-grade inflammation in porcine coronary arteries.

Zhang L, Zalewski A, Liu Y, Mazurek T, Cowan S, Martin JL, Hofmann SM, Vlassara H, Shi Y.

Circulation. 2003 Jul 29;108(4):472-8. Epub 2003 Jul 14.PMID: 12860917 [PubMed - indexed for MEDLINE]Related articlesFree article

Dietary glycotoxins promote diabetic atherosclerosis in apolipoprotein E-deficient mice.

Lin RY, Choudhury RP, Cai W, Lu M, Fallon JT, Fisher EA, Vlassara H.

Atherosclerosis. 2003 Jun;168(2):213-20.PMID: 12801603 [PubMed - indexed for MEDLINE]Related articles

Fetal or neonatal low-glycotoxin environment prevents autoimmune diabetes in NOD mice.

Peppa M, He C, Hattori M, McEvoy R, Zheng F, Vlassara H.

Diabetes. 2003 Jun;52(6):1441-8.PMID: 12765955 [PubMed - indexed for MEDLINE]Related articlesFree article

Advanced glycoxidation. A new risk factor for cardiovascular disease?

Peppa M, Uribarri J, Vlassara H.

Cardiovasc Toxicol. 2002;2(4):275-87. Review.PMID: 12665661 [PubMed - indexed for MEDLINE]Related articles

Restriction of dietary glycotoxins reduces excessive advanced glycation end products in renal failure patients.

Uribarri J, Peppa M, Cai W, Goldberg T, Lu M, He C, Vlassara H.

J Am Soc Nephrol. 2003 Mar;14(3):728-31.PMID: 12595509 [PubMed - indexed for MEDLINE]Related articlesFree article

Inflammatory mediators are induced by dietary glycotoxins, a major risk factor for diabetic angiopathy.

Vlassara H, Cai W, Crandall J, Goldberg T, Oberstein R, Dardaine V, Peppa M, Rayfield EJ.

Proc Natl Acad Sci U S A. 2002 Nov 26;99(24):15596-601. Epub 2002 Nov 12. Erratum in: Proc Natl Acad Sci U S A. 2003 Jan 21;100(2):763.. PMID: 12429856 [PubMed - indexed for MEDLINE]Related articlesFree article

Oxidative stress-inducing carbonyl compounds from common foods: novel mediators of cellular dysfunction.

Cai W, Gao QD, Zhu L, Peppa M, He C, Vlassara H.

Mol Med. 2002 Jul;8(7):337-46.PMID: 12393931 [PubMed - indexed for MEDLINE]Related articlesFree article

Targeted disruption of Slc19a2, the gene encoding the high-affinity thiamin transporter Thtr-1, causes diabetes mellitus, sensorineural deafness and megaloblastosis in mice.

Oishi K, Hofmann S, Diaz GA, Brown T, Manwani D, Ng L, Young R, Vlassara H, Ioannou YA, Forrest D, Gelb BD.

Hum Mol Genet. 2002 Nov 1;11(23):2951-60.PMID: 12393806 [PubMed - indexed for MEDLINE]Related articlesFree article

Glycotoxins: a missing link in the "relationship of dietary fat and meat intake in relation to risk of type 2 diabetes in men".

Peppa M, Goldberg T, Cai W, Rayfield E, Vlassara H.

Diabetes Care. 2002 Oct;25(10):1898-9. No abstract available. PMID: 12351512 [PubMed - indexed for MEDLINE]Related articlesFree article

Prevention of diabetic nephropathy in mice by a diet low in glycoxidation products.

Zheng F, He C, Cai W, Hattori M, Steffes M, Vlassara H.

Diabetes Metab Res Rev. 2002 May-Jun;18(3):224-37. Erratum in: Diabetes Metab Res Rev. 2002 Jul-Aug;18(4):332. PMID: 12112941 [PubMed - indexed for MEDLINE]Related articles

Improved insulin sensitivity is associated with restricted intake of dietary glycoxidation products in the db/db mouse.

Hofmann SM, Dong HJ, Li Z, Cai W, Altomonte J, Thung SN, Zeng F, Fisher EA, Vlassara H.

Diabetes. 2002 Jul;51(7):2082-9.PMID: 12086936 [PubMed - indexed for MEDLINE]Related articlesFree article

Lowering of dietary advanced glycation endproducts (AGE) reduces neointimal formation after arterial injury in genetically hypercholesterolemic mice.

Lin RY, Reis ED, Dore AT, Lu M, Ghodsi N, Fallon JT, Fisher EA, Vlassara H.

Atherosclerosis. 2002 Aug;163(2):303-11.PMID: 12052477 [PubMed - indexed for MEDLINE]Related articles

Prevention Conference VI: Diabetes and Cardiovascular Disease: Writing Group II: pathogenesis of atherosclerosis in diabetes.

Eckel RH, Wassef M, Chait A, Sobel B, Barrett E, King G, Lopes-Virella M, Reusch J, Ruderman N, Steiner G, Vlassara H.

Circulation. 2002 May 7;105(18):e138-43. No abstract available. PMID: 11994264 [PubMed - indexed for MEDLINE]Related articlesFree article