PubMed

PKA phosphorylates and inactivates AMPKalpha to promote efficient lipolysis.

Djouder N, Tuerk RD, Suter M, Salvioni P, Thali RF, Scholz R, Vaahtomeri K, Auchli Y, Rechsteiner H, Brunisholz RA, Viollet B, Mäkelä TP, Wallimann T, Neumann D, Krek W.

EMBO J. 2009 Nov 26. [Epub ahead of print]PMID: 19942859 [PubMed - as supplied by publisher]

AMPK-deficient mice are resistant to the metabolic effects of resveratrol.

Um JH, Park SJ, Kang H, Yang S, Foretz M, McBurney MW, Kim MK, Viollet B, Chung JH.

Diabetes. 2009 Nov 23. [Epub ahead of print]PMID: 19934007 [PubMed - as supplied by publisher]

The development of hepatic fibrosis occurs normally in AMPK deficient mice.

da Silva Morais A, Abarca-Quinones J, Guigas B, Viollet B, Stärkel P, Horsmans Y, Leclercq IA.

Clin Sci (Lond). 2009 Oct 26. [Epub ahead of print]PMID: 19852755 [PubMed - as supplied by publisher]Related articles

Ion channel regulation by AMPK: the route of hypoxia-response coupling in thecarotid body and pulmonary artery.

Evans AM, Hardie DG, Peers C, Wyatt CN, Viollet B, Kumar P, Dallas ML, Ross F, Ikematsu N, Jordan HL, Barr BL, Rafferty JN, Ogunbayo O.

Ann N Y Acad Sci. 2009 Oct;1177:89-100.PMID: 19845611 [PubMed - indexed for MEDLINE]Related articles

Basal autophagy induction without AMP-activated protein kinase under low glucose conditions.

Williams T, Forsberg LJ, Viollet B, Brenman JE.

Autophagy. 2009 Nov 16;5(8). [Epub ahead of print]PMID: 19844161 [PubMed - as supplied by publisher]Related articles

AMP-activated protein kinase activator A-769662 is an inhibitor of the Na+,K+-ATPase.

Benziane B, Bjornholm M, Lantier L, Viollet B, Zierath JR, Chibalin AV.

Am J Physiol Cell Physiol. 2009 Oct 14. [Epub ahead of print]PMID: 19828836 [PubMed - as supplied by publisher]Related articles

Homo-oligomerization and activation of AMP-activated protein kinase are mediated by the kinase domain alphaG-helix.

Scholz R, Suter M, Weimann T, Polge C, Konarev PV, Thali RF, Tuerk RD, Viollet B, Wallimann T, Schlattner U, Neumann D.

J Biol Chem. 2009 Oct 2;284(40):27425-37. Epub 2009 Aug 3.PMID: 19651772 [PubMed - indexed for MEDLINE]Related articles

In vivo activation of AMP-activated protein kinase attenuates diabetes-enhanced degradation of GTP cyclohydrolase I.

Wang S, Xu J, Song P, Viollet B, Zou MH.

Diabetes. 2009 Aug;58(8):1893-901. Epub 2009 Jun 15.PMID: 19528375 [PubMed - indexed for MEDLINE]Related articlesFree article

Loss of AMPK exacerbates experimental autoimmune encephalomyelitis disease severity.

Nath N, Khan M, Rattan R, Mangalam A, Makkar RS, de Meester C, Bertrand L, Singh I, Chen Y, Viollet B, Giri S.

Biochem Biophys Res Commun. 2009 Aug 14;386(1):16-20. Epub 2009 May 30.PMID: 19486896 [PubMed - indexed for MEDLINE]Related articles

AMPK controls epithelial Na(+) channels through Nedd4-2 and causes an epithelial phenotype when mutated.

Almaça J, Kongsuphol P, Hieke B, Ousingsawat J, Viollet B, Schreiber R, Amaral MD, Kunzelmann K.

Pflugers Arch. 2009 Aug;458(4):713-21. Epub 2009 Mar 31.PMID: 19333618 [PubMed - indexed for MEDLINE]Related articles

Targeting the AMPK pathway for the treatment of Type 2 diabetes.

Viollet B, Lantier L, Devin-Leclerc J, Hebrard S, Amouyal C, Mounier R, Foretz M, Andreelli F.

Front Biosci. 2009 Jan 1;14:3380-400. Review.PMID: 19273282 [PubMed - indexed for MEDLINE]Related articlesFree article

AMPK: Lessons from transgenic and knockout animals.

Viollet B, Athea Y, Mounier R, Guigas B, Zarrinpashneh E, Horman S, Lantier L, Hebrard S, Devin-Leclerc J, Beauloye C, Foretz M, Andreelli F, Ventura-Clapier R, Bertrand L.

Front Biosci. 2009 Jan 1;14:19-44. Review.PMID: 19273052 [PubMed - indexed for MEDLINE]Related articlesFree article

Hypoxic activation of AMPK is dependent on mitochondrial ROS but independent of an increase in AMP/ATP ratio.

Emerling BM, Weinberg F, Snyder C, Burgess Z, Mutlu GM, Viollet B, Budinger GR, Chandel NS.

Free Radic Biol Med. 2009 May 15;46(10):1386-91. Epub 2009 Mar 3.PMID: 19268526 [PubMed - indexed for MEDLINE]Related articles

AMP-activated protein kinase in the regulation of hepatic energy metabolism: from physiology to therapeutic perspectives.

Viollet B, Guigas B, Leclerc J, Hébrard S, Lantier L, Mounier R, Andreelli F, Foretz M.

Acta Physiol (Oxf). 2009 May;196(1):81-98. Epub 2009 Feb 19.PMID: 19245656 [PubMed - in process]Related articles

Important role for AMPKalpha1 in limiting skeletal muscle cell hypertrophy.

Mounier R, Lantier L, Leclerc J, Sotiropoulos A, Pende M, Daegelen D, Sakamoto K, Foretz M, Viollet B.

FASEB J. 2009 Jul;23(7):2264-73. Epub 2009 Feb 23.PMID: 19237506 [PubMed - indexed for MEDLINE]Related articles

Crucial role for LKB1 to AMPKalpha2 axis in the regulation of CD36-mediated long-chain fatty acid uptake into cardiomyocytes.

Habets DD, Coumans WA, El Hasnaoui M, Zarrinpashneh E, Bertrand L, Viollet B, Kiens B, Jensen TE, Richter EA, Bonen A, Glatz JF, Luiken JJ.

Biochim Biophys Acta. 2009 Mar;1791(3):212-9. Epub 2008 Dec 30.PMID: 19159696 [PubMed - indexed for MEDLINE]Related articles

Prevention of steatohepatitis by pioglitazone: implication of adiponectin-dependent inhibition of SREBP-1c and inflammation.

Da Silva Morais A, Lebrun V, Abarca-Quinones J, Brichard S, Hue L, Guigas B, Viollet B, Leclercq IA.

J Hepatol. 2009 Mar;50(3):489-500. Epub 2008 Dec 26.PMID: 19155087 [PubMed - indexed for MEDLINE]Related articles

AMP activated protein kinase-alpha2 deficiency exacerbates pressure-overload-induced left ventricular hypertrophy and dysfunction in mice.

Zhang P, Hu X, Xu X, Fassett J, Zhu G, Viollet B, Xu W, Wiczer B, Bernlohr DA, Bache RJ, Chen Y.

Hypertension. 2008 Nov;52(5):918-24. Epub 2008 Oct 6.PMID: 18838626 [PubMed - indexed for MEDLINE]Related articlesFree article

Upregulation of mitochondrial uncoupling protein-2 by the AMP-activated protein kinase in endothelial cells attenuates oxidative stress in diabetes.

Xie Z, Zhang J, Wu J, Viollet B, Zou MH.

Diabetes. 2008 Dec;57(12):3222-30. Epub 2008 Oct 3.PMID: 18835932 [PubMed - indexed for MEDLINE]Related articlesFree article

Role of adenosine 5'-monophosphate-activated protein kinase in interleukin-6 release from isolated mouse skeletal muscle.

Glund S, Treebak JT, Long YC, Barres R, Viollet B, Wojtaszewski JF, Zierath JR.

Endocrinology. 2009 Feb;150(2):600-6. Epub 2008 Sep 25.PMID: 18818284 [PubMed - indexed for MEDLINE]Related articles

AMPKalpha2 counteracts the development of cardiac hypertrophy induced by isoproterenol.

Zarrinpashneh E, Beauloye C, Ginion A, Pouleur AC, Havaux X, Hue L, Viollet B, Vanoverschelde JL, Bertrand L.

Biochem Biophys Res Commun. 2008 Nov 28;376(4):677-81. Epub 2008 Sep 21.PMID: 18812163 [PubMed - indexed for MEDLINE]Related articles

Beyond AICA riboside: in search of new specific AMP-activated protein kinase activators.

Guigas B, Sakamoto K, Taleux N, Reyna SM, Musi N, Viollet B, Hue L.

IUBMB Life. 2009 Jan;61(1):18-26. Review.PMID: 18798311 [PubMed - indexed for MEDLINE]Related articles

Intestinal gluconeogenesis is a key factor for early metabolic changes after gastric bypass but not after gastric lap-band in mice.

Troy S, Soty M, Ribeiro L, Laval L, Migrenne S, Fioramonti X, Pillot B, Fauveau V, Aubert R, Viollet B, Foretz M, Leclerc J, Duchampt A, Zitoun C, Thorens B, Magnan C, Mithieux G, Andreelli F.

Cell Metab. 2008 Sep;8(3):201-11.PMID: 18762021 [PubMed - indexed for MEDLINE]Related articles

Regulation of Cl(-) secretion by AMPK in vivo.

Kongsuphol P, Hieke B, Ousingsawat J, Almaca J, Viollet B, Schreiber R, Kunzelmann K.

Pflugers Arch. 2009 Mar;457(5):1071-8. Epub 2008 Aug 28.PMID: 18752001 [PubMed - indexed for MEDLINE]Related articles

A769662, a novel activator of AMP-activated protein kinase, inhibits non-proteolytic components of the 26S proteasome by an AMPK-independent mechanism.

Moreno D, Knecht E, Viollet B, Sanz P.

FEBS Lett. 2008 Jul 23;582(17):2650-4. Epub 2008 Jun 30.PMID: 18593584 [PubMed - indexed for MEDLINE]Related articles

Resveratrol inhibits cardiac hypertrophy via AMP-activated protein kinase and Akt.

Chan AY, Dolinsky VW, Soltys CL, Viollet B, Baksh S, Light PE, Dyck JR.

J Biol Chem. 2008 Aug 29;283(35):24194-201. Epub 2008 Jun 18.PMID: 18562309 [PubMed - indexed for MEDLINE]Related articlesFree article

AMPK alpha1 activation is required for stimulation of glucose uptake by twitch contraction, but not by H2O2, in mouse skeletal muscle.

Jensen TE, Schjerling P, Viollet B, Wojtaszewski JF, Richter EA.

PLoS One. 2008 May 7;3(5):e2102.PMID: 18461163 [PubMed - indexed for MEDLINE]Related articlesFree article

AMP-activated protein kinase phosphorylates and desensitizes smooth muscle myosin light chain kinase.

Horman S, Morel N, Vertommen D, Hussain N, Neumann D, Beauloye C, El Najjar N, Forcet C, Viollet B, Walsh MP, Hue L, Rider MH.

J Biol Chem. 2008 Jul 4;283(27):18505-12. Epub 2008 Apr 21.PMID: 18426792 [PubMed - indexed for MEDLINE]Related articlesFree article

AMP-activated protein kinase regulates lymphocyte responses to metabolic stress but is largely dispensable for immune cell development and function.

Mayer A, Denanglaire S, Viollet B, Leo O, Andris F.

Eur J Immunol. 2008 Apr;38(4):948-56.PMID: 18350549 [PubMed - indexed for MEDLINE]Related articles

Role of AMP-activated protein kinase in autophagy and proteasome function.

Viana R, Aguado C, Esteban I, Moreno D, Viollet B, Knecht E, Sanz P.

Biochem Biophys Res Commun. 2008 May 9;369(3):964-8. Epub 2008 Mar 6.PMID: 18328803 [PubMed - indexed for MEDLINE]Related articles

Role of adenosine 5'-monophosphate-activated protein kinase subunits in skeletal muscle mammalian target of rapamycin signaling.

Deshmukh AS, Treebak JT, Long YC, Viollet B, Wojtaszewski JF, Zierath JR.

Mol Endocrinol. 2008 May;22(5):1105-12. Epub 2008 Feb 14.PMID: 18276828 [PubMed - indexed for MEDLINE]Related articlesFree article

AMP-activated protein kinase inhibits transforming growth factor-beta-induced Smad3-dependent transcription and myofibroblast transdifferentiation.

Mishra R, Cool BL, Laderoute KR, Foretz M, Viollet B, Simonson MS.

J Biol Chem. 2008 Apr 18;283(16):10461-9. Epub 2008 Feb 4.PMID: 18250161 [PubMed - indexed for MEDLINE]Related articlesFree article

Identification of protein kinase D as a novel contraction-activated kinase linked to GLUT4-mediated glucose uptake, independent of AMPK.

Luiken JJ, Vertommen D, Coort SL, Habets DD, El Hasnaoui M, Pelsers MM, Viollet B, Bonen A, Hue L, Rider MH, Glatz JF.

Cell Signal. 2008 Mar;20(3):543-56. Epub 2007 Nov 26.PMID: 18164589 [PubMed - indexed for MEDLINE]Related articles

Compound C inhibits hypoxic activation of HIF-1 independent of AMPK.

Emerling BM, Viollet B, Tormos KV, Chandel NS.

FEBS Lett. 2007 Dec 11;581(29):5727-31. Epub 2007 Nov 26.PMID: 18036344 [PubMed - indexed for MEDLINE]Related articlesFree article

Targeting AMP-activated protein kinase as a novel therapeutic approach for the treatment of metabolic disorders.

Viollet B, Mounier R, Leclerc J, Yazigi A, Foretz M, Andreelli F.

Diabetes Metab. 2007 Dec;33(6):395-402. Epub 2007 Nov 7. Review.PMID: 17997341 [PubMed - indexed for MEDLINE]Related articlesFree article

Protein kinase CK2 acts as a signal molecule switching between the NDPK-A/AMPK 1 complex and NDPK-B.

Crawford RM, Treharne KJ, Arnaud-Dabernat S, Daniel JY, Foretz M, Viollet B, Mehta A.

FASEB J. 2007 Oct;21(12):3398. No abstract available. PMID: 17905730 [PubMed - indexed for MEDLINE]Related articlesFree article

Neuroprotective effects of adenosine monophosphate-activated protein kinase inhibition and gene deletion in stroke.

Li J, Zeng Z, Viollet B, Ronnett GV, McCullough LD.

Stroke. 2007 Nov;38(11):2992-9. Epub 2007 Sep 27.PMID: 17901380 [PubMed - indexed for MEDLINE]Related articlesFree article

Mechanism of action of A-769662, a valuable tool for activation of AMP-activated protein kinase.

Göransson O, McBride A, Hawley SA, Ross FA, Shpiro N, Foretz M, Viollet B, Hardie DG, Sakamoto K.

J Biol Chem. 2007 Nov 9;282(45):32549-60. Epub 2007 Sep 12.PMID: 17855357 [PubMed - indexed for MEDLINE]Related articlesFree article

The relationship between p38 mitogen-activated protein kinase and AMP-activated protein kinase during myocardial ischemia.

Jacquet S, Zarrinpashneh E, Chavey A, Ginion A, Leclerc I, Viollet B, Rutter GA, Bertrand L, Marber MS.

Cardiovasc Res. 2007 Dec 1;76(3):465-72. Epub 2007 Aug 8.PMID: 17765884 [PubMed - indexed for MEDLINE]Related articlesFree article

Lack of AMPKalpha2 enhances pyruvate dehydrogenase activity during exercise.

Klein DK, Pilegaard H, Treebak JT, Jensen TE, Viollet B, Schjerling P, Wojtaszewski JF.

Am J Physiol Endocrinol Metab. 2007 Nov;293(5):E1242-9. Epub 2007 Aug 21.PMID: 17711995 [PubMed - indexed for MEDLINE]Related articlesFree article

AMPK is essential for energy homeostasis regulation and glucose sensing by POMC and AgRP neurons.

Claret M, Smith MA, Batterham RL, Selman C, Choudhury AI, Fryer LG, Clements M, Al-Qassab H, Heffron H, Xu AW, Speakman JR, Barsh GS, Viollet B, Vaulont S, Ashford ML, Carling D, Withers DJ.

J Clin Invest. 2007 Aug;117(8):2325-36.PMID: 17671657 [PubMed - indexed for MEDLINE]Related articlesFree article

Systemic treatment with the antidiabetic drug metformin selectively impairs p53-deficient tumor cell growth.

Buzzai M, Jones RG, Amaravadi RK, Lum JJ, DeBerardinis RJ, Zhao F, Viollet B, Thompson CB.

Cancer Res. 2007 Jul 15;67(14):6745-52.PMID: 17638885 [PubMed - indexed for MEDLINE]Related articlesFree article

S6 kinase deletion suppresses muscle growth adaptations to nutrient availability by activating AMP kinase.

Aguilar V, Alliouachene S, Sotiropoulos A, Sobering A, Athea Y, Djouadi F, Miraux S, Thiaudière E, Foretz M, Viollet B, Diolez P, Bastin J, Benit P, Rustin P, Carling D, Sandri M, Ventura-Clapier R, Pende M.

Cell Metab. 2007 Jun;5(6):476-87.PMID: 17550782 [PubMed - indexed for MEDLINE]Related articles

Activation of 5'-AMP-activated kinase with diabetes drug metformin induces casein kinase Iepsilon (CKIepsilon)-dependent degradation of clock protein mPer2.

Um JH, Yang S, Yamazaki S, Kang H, Viollet B, Foretz M, Chung JH.

J Biol Chem. 2007 Jul 20;282(29):20794-8. Epub 2007 May 24.PMID: 17525164 [PubMed - indexed for MEDLINE]Related articlesFree article

Activation of AMP kinase alpha1 subunit induces aortic vasorelaxation in mice.

Goirand F, Solar M, Athea Y, Viollet B, Mateo P, Fortin D, Leclerc J, Hoerter J, Ventura-Clapier R, Garnier A.

J Physiol. 2007 Jun 15;581(Pt 3):1163-71. Epub 2007 Apr 19.PMID: 17446219 [PubMed - indexed for MEDLINE]Related articlesFree article

A conserved sequence immediately N-terminal to the Bateman domains in AMP-activated protein kinase gamma subunits is required for the interaction with the beta subunits.

Viana R, Towler MC, Pan DA, Carling D, Viollet B, Hardie DG, Sanz P.

J Biol Chem. 2007 Jun 1;282(22):16117-25. Epub 2007 Apr 2.PMID: 17403675 [PubMed - indexed for MEDLINE]Related articlesFree article

Dual cardiac contractile effects of the alpha2-AMPK deletion in low-flow ischemia and reperfusion.

Carvajal K, Zarrinpashneh E, Szarszoi O, Joubert F, Athea Y, Mateo P, Gillet B, Vaulont S, Viollet B, Bigard X, Bertrand L, Ventura-Clapier R, Hoerter JA.

Am J Physiol Heart Circ Physiol. 2007 Jun;292(6):H3136-47. Epub 2007 Mar 2.PMID: 17337600 [PubMed - indexed for MEDLINE]Related articlesFree article

AMP-activated protein kinase alpha2 deficiency affects cardiac cardiolipin homeostasis and mitochondrial function.

Athéa Y, Viollet B, Mateo P, Rousseau D, Novotova M, Garnier A, Vaulont S, Wilding JR, Grynberg A, Veksler V, Hoerter J, Ventura-Clapier R.

Diabetes. 2007 Mar;56(3):786-94.PMID: 17327449 [PubMed - indexed for MEDLINE]Related articlesFree article

AMP-activated protein kinase-independent inhibition of hepatic mitochondrial oxidative phosphorylation by AICA riboside.

Guigas B, Taleux N, Foretz M, Detaille D, Andreelli F, Viollet B, Hue L.

Biochem J. 2007 Jun 15;404(3):499-507.PMID: 17324122 [PubMed - indexed for MEDLINE]Related articlesFree article

Iron overload in Hepc1(-/-) mice is not impairing glucose homeostasis.

Ramey G, Faye A, Durel B, Viollet B, Vaulont S.

FEBS Lett. 2007 Mar 6;581(5):1053-7. Epub 2007 Feb 12.PMID: 17316628 [PubMed - indexed for MEDLINE]Related articles