PubMed

Drug-induced lipotoxicity: Lipodystrophy associated with HIV-1 infection and antiretroviral treatment.

Villarroya F, Domingo P, Giralt M.

Biochim Biophys Acta. 2009 Sep 30. [Epub ahead of print]PMID: 19800025 [PubMed - as supplied by publisher]Related articles

Genetic and functional mitochondrial assessment of HIV-infected patients developing HAART-related hyperlactatemia.

Garrabou G, Morén C, Gallego-Escuredo JM, Milinkovic A, Villarroya F, Negredo E, Giralt M, Vidal F, Pedrol E, Martínez E, Cardellach F, Gatell JM, Miró O.

J Acquir Immune Defic Syndr. 2009 Dec 1;52(4):443-51.PMID: 19779356 [PubMed - in process]Related articles

UCP3 expression in liver modulates gene expression and oxidative metabolism in response to fatty acids, and sensitizes mitochondria to permeability transition.

Camara Y, Mampel T, Armengol J, Villarroya F, Dejean L.

Cell Physiol Biochem. 2009;24(3-4):243-52. Epub 2009 Aug 3.PMID: 19710539 [PubMed - indexed for MEDLINE]Related articles

The importance of brown adipose tissue.

Villarroya F, Domingo P, Giralt M.

N Engl J Med. 2009 Jul 23;361(4):417; author reply 418-21. No abstract available. PMID: 19630143 [PubMed - indexed for MEDLINE]Related articles

SIRT1 controls the transcription of the peroxisome proliferator-activated receptor-gamma Co-activator-1alpha (PGC-1alpha) gene in skeletal muscle through the PGC-1alpha autoregulatory loop and interaction with MyoD.

Amat R, Planavila A, Chen SL, Iglesias R, Giralt M, Villarroya F.

J Biol Chem. 2009 Aug 14;284(33):21872-80. Epub 2009 Jun 24.PMID: 19553684 [PubMed - indexed for MEDLINE]Related articles

Pharmacological and gene modification-based models for studying the impact of perinatal metabolic disturbances in adult life.

Villarroya F, Bocos C, Giralt M, Pilar Ramos M, Herrera E, Sevillano J, Gual M, Rosell M, Iglesias R.

Adv Exp Med Biol. 2009;646:141-8. Review.PMID: 19536673 [PubMed - indexed for MEDLINE]Related articles

Transcription of the human uncoupling protein 3 gene is governed by a complex interplay between the promoter and intronic sequences.

Girousse A, Tavernier G, Tiraby C, Lichtenstein L, Iacovoni JS, Mairal A, Villarroya F, Langin D.

Diabetologia. 2009 Aug;52(8):1638-46. Epub 2009 May 26.PMID: 19468707 [PubMed - indexed for MEDLINE]Related articles

Mitochondrial DNA: an up-and-coming actor in white adipose tissue pathophysiology.

Villarroya J, Giralt M, Villarroya F.

Obesity (Silver Spring). 2009 Oct;17(10):1814-20. Epub 2009 May 21. No abstract available. PMID: 19461585 [PubMed - in process]Related articles

HIV-1 Infection and the PPARgamma-Dependent Control of Adipose Tissue Physiology.

Giralt M, Domingo P, Villarroya F.

PPAR Res. 2009;2009:607902. Epub 2008 Dec 1.PMID: 19081837 [PubMed - in process]Related articlesFree article

Impaired expression of mitochondrial and adipogenic genes in adipose tissue from a patient with acquired partial lipodystrophy (Barraquer-Simons syndrome): a case report.

Guallar JP, Rojas-Garcia R, Garcia-Arumi E, Domingo JC, Gallardo E, Andreu AL, Domingo P, Illa I, Giralt M, Villarroya F.

J Med Case Reports. 2008 Aug 27;2:284.PMID: 18752661 [PubMed - in process]Related articlesFree article

Human dendritic cell activities are modulated by the omega-3 fatty acid, docosahexaenoic acid, mainly through PPAR(gamma):RXR heterodimers: comparison with other polyunsaturated fatty acids.

Zapata-Gonzalez F, Rueda F, Petriz J, Domingo P, Villarroya F, Diaz-Delfin J, de Madariaga MA, Domingo JC.

J Leukoc Biol. 2008 Oct;84(4):1172-82. Epub 2008 Jul 16.PMID: 18632990 [PubMed - indexed for MEDLINE]Related articlesFree article

Early oxidative damage underlying neurodegeneration in X-adrenoleukodystrophy.

Fourcade S, López-Erauskin J, Galino J, Duval C, Naudi A, Jove M, Kemp S, Villarroya F, Ferrer I, Pamplona R, Portero-Otin M, Pujol A.

Hum Mol Genet. 2008 Jun 15;17(12):1762-73. Epub 2008 Mar 14.PMID: 18344354 [PubMed - indexed for MEDLINE]Related articlesFree article

Differential gene expression indicates that 'buffalo hump' is a distinct adipose tissue disturbance in HIV-1-associated lipodystrophy.

Guallar JP, Gallego-Escuredo JM, Domingo JC, Alegre M, Fontdevila J, Martínez E, Hammond EL, Domingo P, Giralt M, Villarroya F.

AIDS. 2008 Mar 12;22(5):575-84.PMID: 18316998 [PubMed - indexed for MEDLINE]Related articles

Altered expression of nucleoside transporter genes (SLC28 and SLC29) in adipose tissue from HIV-1-infected patients.

Guallar JP, Cano-Soldado P, Aymerich I, Domingo JC, Alegre M, Domingo P, Villarroya F, Javier Casado F, Giralt M, Pastor-Anglada M.

Antivir Ther. 2007;12(6):853-63.PMID: 17926640 [PubMed - indexed for MEDLINE]Related articles

HIV-1-infected long-term non-progressors have milder mitochondrial impairment and lower mitochondrially-driven apoptosis in peripheral blood mononuclear cells than typical progressors.

Peraire J, Miró O, Saumoy M, Domingo P, Pedrol E, Villarroya F, Martínez E, López-Dupla M, Garrabou G, Sambeat MA, Deig E, Villarroya J, Chacón MR, López S, Fontanet A, Holmstrom M, Giralt M, Gatell JM, Vidal F.

Curr HIV Res. 2007 Sep;5(5):467-73.PMID: 17896966 [PubMed - indexed for MEDLINE]Related articles

SIRT1 is involved in glucocorticoid-mediated control of uncoupling protein-3 gene transcription.

Amat R, Solanes G, Giralt M, Villarroya F.

J Biol Chem. 2007 Nov 23;282(47):34066-76. Epub 2007 Sep 20.PMID: 17884810 [PubMed - indexed for MEDLINE]Related articlesFree article

Lipodystrophy in HIV 1-infected patients: lessons for obesity research.

Villarroya F, Domingo P, Giralt M.

Int J Obes (Lond). 2007 Dec;31(12):1763-76. Epub 2007 Jul 24. Review.PMID: 17653062 [PubMed - indexed for MEDLINE]Related articles

Mechanisms of antiretroviral-induced mitochondrial dysfunction in adipocytes and adipose tissue: in-vitro, animal and human adipose tissue studies.

Villarroya F, Domingo P, Giralt M.

Curr Opin HIV AIDS. 2007 Jul;2(4):261-267.PMID: 19372897 [PubMed - as supplied by publisher]Related articles

Differential 3,5,3'-triiodothyronine-mediated regulation of uncoupling protein 3 transcription: role of Fatty acids.

de Lange P, Feola A, Ragni M, Senese R, Moreno M, Lombardi A, Silvestri E, Amat R, Villarroya F, Goglia F, Lanni A.

Endocrinology. 2007 Aug;148(8):4064-72. Epub 2007 May 3.PMID: 17478558 [PubMed - indexed for MEDLINE]Related articlesFree article

9-cis-Retinoic acid (9cRA), a retinoid X receptor (RXR) ligand, exerts immunosuppressive effects on dendritic cells by RXR-dependent activation: inhibition of peroxisome proliferator-activated receptor gamma blocks some of the 9cRA activities, and precludes them to mature phenotype development.

Zapata-Gonzalez F, Rueda F, Petriz J, Domingo P, Villarroya F, de Madariaga A, Domingo JC.

J Immunol. 2007 May 15;178(10):6130-9.PMID: 17475839 [PubMed - indexed for MEDLINE]Related articlesFree article

Uncoupling protein-2 controls adiponectin gene expression in adipose tissue through the modulation of reactive oxygen species production.

Chevillotte E, Giralt M, Miroux B, Ricquier D, Villarroya F.

Diabetes. 2007 Apr;56(4):1042-50.PMID: 17395745 [PubMed - indexed for MEDLINE]Related articlesFree article

PPARs in the Control of Uncoupling Proteins Gene Expression.

Villarroya F, Iglesias R, Giralt M.

PPAR Res. 2007;2007:74364.PMID: 17389766 [PubMed - in process]Related articlesFree article

HIV-1 infection alters gene expression in adipose tissue, which contributes to HIV- 1/HAART-associated lipodystrophy.

Giralt M, Domingo P, Guallar JP, Rodriguez de la Concepción ML, Alegre M, Domingo JC, Villarroya F.

Antivir Ther. 2006;11(6):729-40.PMID: 17310817 [PubMed - indexed for MEDLINE]Related articles

Overexpression of mitochondrial uncoupling protein-3 does not decrease production of the reactive oxygen species, elevated by palmitate in skeletal muscle cells.

Duval C, Cámara Y, Hondares E, Sibille B, Villarroya F.

FEBS Lett. 2007 Mar 6;581(5):955-61. Epub 2007 Feb 8.PMID: 17303124 [PubMed - indexed for MEDLINE]Related articles

PPARdelta, but not PPARalpha, activates PGC-1alpha gene transcription in muscle.

Hondares E, Pineda-Torra I, Iglesias R, Staels B, Villarroya F, Giralt M.

Biochem Biophys Res Commun. 2007 Mar 23;354(4):1021-7. Epub 2007 Jan 25.PMID: 17275789 [PubMed - indexed for MEDLINE]Related articles

Reversible inhibition of mitochondrial protein synthesis during linezolid-related hyperlactatemia.

Garrabou G, Soriano A, López S, Guallar JP, Giralt M, Villarroya F, Martínez JA, Casademont J, Cardellach F, Mensa J, Miró O.

Antimicrob Agents Chemother. 2007 Mar;51(3):962-7. Epub 2006 Dec 28.PMID: 17194826 [PubMed - indexed for MEDLINE]Related articlesFree article

Activation of mitochondrial-driven apoptosis in skeletal muscle cells is not mediated by reactive oxygen species production.

Cámara Y, Duval C, Sibille B, Villarroya F.

Int J Biochem Cell Biol. 2007;39(1):146-60. Epub 2006 Aug 17.PMID: 16968671 [PubMed - indexed for MEDLINE]Related articles

In vitro cytotoxicity and mitochondrial toxicity of tenofovir alone and in combination with other antiretrovirals in human renal proximal tubule cells.

Vidal F, Domingo JC, Guallar J, Saumoy M, Cordobilla B, Sánchez de la Rosa R, Giralt M, Alvarez ML, López-Dupla M, Torres F, Villarroya F, Cihlar T, Domingo P.

Antimicrob Agents Chemother. 2006 Nov;50(11):3824-32. Epub 2006 Aug 28.PMID: 16940060 [PubMed - indexed for MEDLINE]Related articlesFree article

Developmental and tissue-specific involvement of peroxisome proliferator-activated receptor-alpha in the control of mouse uncoupling protein-3 gene expression.

Pedraza N, Rosell M, Villarroya J, Iglesias R, Gonzalez FJ, Solanes G, Villarroya F.

Endocrinology. 2006 Oct;147(10):4695-704. Epub 2006 Jul 20.PMID: 16857752 [PubMed - indexed for MEDLINE]Related articlesFree article

Altered expression of master regulatory genes of adipogenesis in lipomas from patients bearing tRNA(Lys) point mutations in mitochondrial DNA.

Guallar JP, Vilà MR, López-Gallardo E, Solano A, Domingo JC, Gámez J, Pineda M, Capablo JL, Domingo P, Andreu AL, Montoya J, Giralt M, Villarroya F.

Mol Genet Metab. 2006 Nov;89(3):283-5. Epub 2006 Apr 17.PMID: 16603396 [PubMed - indexed for MEDLINE]Related articles

Thiazolidinediones and rexinoids induce peroxisome proliferator-activated receptor-coactivator (PGC)-1alpha gene transcription: an autoregulatory loop controls PGC-1alpha expression in adipocytes via peroxisome proliferator-activated receptor-gamma coactivation.

Hondares E, Mora O, Yubero P, Rodriguez de la Concepción M, Iglesias R, Giralt M, Villarroya F.

Endocrinology. 2006 Jun;147(6):2829-38. Epub 2006 Mar 2.PMID: 16513826 [PubMed - indexed for MEDLINE]Related articlesFree article

In vivo effects of highly active antiretroviral therapies containing the protease inhibitor nelfinavir on mitochondrially driven apoptosis.

Miró O, Villarroya J, Garrabou G, López S, Rodríguez de la Concepción M, Pedrol E, Martínez E, Giralt M, Gatell JM, Cardellach F, Casademont J, Villarroya F.

Antivir Ther. 2005;10(8):945-51.PMID: 16430200 [PubMed - indexed for MEDLINE]Related articles

Reverse transcriptase inhibitors alter uncoupling protein-1 and mitochondrial biogenesis in brown adipocytes.

Rodríguez de la Concepción ML, Yubero P, Domingo JC, Iglesias R, Domingo P, Villarroya F, Giralt M.

Antivir Ther. 2005;10(4):515-26.PMID: 16038477 [PubMed - indexed for MEDLINE]Related articles

Defective thermoregulation, impaired lipid metabolism, but preserved adrenergic induction of gene expression in brown fat of mice lacking C/EBPbeta.

Carmona MC, Hondares E, Rodríguez de la Concepción ML, Rodríguez-Sureda V, Peinado-Onsurbe J, Poli V, Iglesias R, Villarroya F, Giralt M.

Biochem J. 2005 Jul 1;389(Pt 1):47-56.PMID: 15762841 [PubMed - indexed for MEDLINE]Related articlesFree article

Lithium inhibits brown adipocyte differentiation.

Rodríguez de la Concepción ML, Yubero P, Iglesias R, Giralt M, Villarroya F.

FEBS Lett. 2005 Mar 14;579(7):1670-4.PMID: 15757659 [PubMed - indexed for MEDLINE]Related articles

Lipodystrophy associated with highly active anti-retroviral therapy for HIV infection: the adipocyte as a target of anti-retroviral-induced mitochondrial toxicity.

Villarroya F, Domingo P, Giralt M.

Trends Pharmacol Sci. 2005 Feb;26(2):88-93. Review.PMID: 15681026 [PubMed - indexed for MEDLINE]Related articles

Thyroid hormones directly activate the expression of the human and mouse uncoupling protein-3 genes through a thyroid response element in the proximal promoter region.

Solanes G, Pedraza N, Calvo V, Vidal-Puig A, Lowell BB, Villarroya F.

Biochem J. 2005 Mar 15;386(Pt 3):505-13.PMID: 15496137 [PubMed - indexed for MEDLINE]Related articlesFree article

Uncoupling protein-3 sensitizes cells to mitochondrial-dependent stimulus of apoptosis.

Dejean L, Cámara Y, Sibille B, Solanes G, Villarroya F.

J Cell Physiol. 2004 Nov;201(2):294-304.PMID: 15334664 [PubMed - indexed for MEDLINE]Related articles

The developmental regulation of peroxisome proliferator-activated receptor-gamma coactivator-1alpha expression in the liver is partially dissociated from the control of gluconeogenesis and lipid catabolism.

Yubero P, Hondares E, Carmona MC, Rossell M, Gonzalez FJ, Iglesias R, Giralt M, Villarroya F.

Endocrinology. 2004 Sep;145(9):4268-77. Epub 2004 Jun 3.PMID: 15178647 [PubMed - indexed for MEDLINE]Related articlesFree article

Uncoupling protein 1 gene expression implicates brown adipocytes in highly active antiretroviral therapy-associated lipomatosis.

Rodríguez de la Concepción ML, Domingo JC, Domingo P, Giralt M, Villarroya F.

AIDS. 2004 Apr 9;18(6):959-60. No abstract available. PMID: 15060448 [PubMed - indexed for MEDLINE]Related articles

Retinoids and retinoid receptors in the control of energy balance: novel pharmacological strategies in obesity and diabetes.

Villarroya F, Iglesias R, Giralt M.

Curr Med Chem. 2004 Mar;11(6):795-805. Review.PMID: 15032732 [PubMed - indexed for MEDLINE]Related articles

Functional relationship between MyoD and peroxisome proliferator-activated receptor-dependent regulatory pathways in the control of the human uncoupling protein-3 gene transcription.

Solanes G, Pedraza N, Iglesias R, Giralt M, Villarroya F.

Mol Endocrinol. 2003 Oct;17(10):1944-58. Epub 2003 Jul 3.PMID: 12843208 [PubMed - indexed for MEDLINE]Related articlesFree article

Mitochondrial biogenesis in brown adipose tissue is associated with differential expression of transcription regulatory factors.

Villena JA, Carmona MC, Rodriguez de la Concepción M, Rossmeisl M, Viñas O, Mampel T, Iglesias R, Giralt M, Villarroya F.

Cell Mol Life Sci. 2002 Nov;59(11):1934-44.PMID: 12530524 [PubMed - indexed for MEDLINE]Related articles

The chlorophyll-derived metabolite phytanic acid induces white adipocyte differentiation.

Schlüter A, Yubero P, Iglesias R, Giralt M, Villarroya F.

Int J Obes Relat Metab Disord. 2002 Sep;26(9):1277-80.PMID: 12187408 [PubMed - indexed for MEDLINE]Related articlesFree article

Phytanic acid, but not pristanic acid, mediates the positive effects of phytol derivatives on brown adipocyte differentiation.

Schluter A, Giralt M, Iglesias R, Villarroya F.

FEBS Lett. 2002 Apr 24;517(1-3):83-6.PMID: 12062414 [PubMed - indexed for MEDLINE]Related articles

Epitope mapping of mitochondrial adenine nucleotide translocase-1 in idiopathic dilated cardiomyopathy.

Manchado C, Orús J, Villarroya F, Roig E, Heras M, Giralt M, Iglesias R, Sanz G, Mampel T, Viñas O.

J Mol Cell Cardiol. 2002 May;34(5):571-82.PMID: 12056860 [PubMed - indexed for MEDLINE]Related articles

Mitochondrial biogenesis and thyroid status maturation in brown fat require CCAAT/enhancer-binding protein alpha.

Carmona MC, Iglesias R, Obregón MJ, Darlington GJ, Villarroya F, Giralt M.

J Biol Chem. 2002 Jun 14;277(24):21489-98. Epub 2002 Apr 8.PMID: 11940593 [PubMed - indexed for MEDLINE]Related articlesFree article

Phytanic acid, a novel activator of uncoupling protein-1 gene transcription and brown adipocyte differentiation.

Schlüter A, Barberá MJ, Iglesias R, Giralt M, Villarroya F.

Biochem J. 2002 Feb 15;362(Pt 1):61-9.PMID: 11829740 [PubMed - indexed for MEDLINE]Related articlesFree article

Overexpression of UCP3 in cultured human muscle lowers mitochondrial membrane potential, raises ATP/ADP ratio, and favors fatty acid vs. glucose oxidation.

García-Martinez C, Sibille B, Solanes G, Darimont C, Macé K, Villarroya F, Gómez-Foix AM.

FASEB J. 2001 Sep;15(11):2033-5. Epub 2001 Jul 24.PMID: 11511517 [PubMed - indexed for MEDLINE]Related articlesFree article

Gene expression of leptin and uncoupling proteins: molecular end-points of fetal development.

Villarroya F, Brun S, Giralt M, Cámara Y, Solanes G, Iglesias R.

Biochem Soc Trans. 2001 May;29(Pt 2):76-80.PMID: 11356131 [PubMed - indexed for MEDLINE]Related articles