PubMed

Organization of proximal signal initiation at the TCR:CD3 complex.

Guy CS, Vignali DA.

Immunol Rev. 2009 Nov;232(1):7-21.PMID: 19909352 [PubMed - in process]Related articles

Different modes of ubiquitination of the adaptor TRAF3 selectively activate the expression of type I interferons and proinflammatory cytokines.

Tseng PH, Matsuzawa A, Zhang W, Mino T, Vignali DA, Karin M.

Nat Immunol. 2009 Nov 8. [Epub ahead of print]PMID: 19898473 [PubMed - as supplied by publisher]Related articles

Regulatory T cells and inhibitory cytokines in autoimmunity.

Bettini M, Vignali DA.

Curr Opin Immunol. 2009 Dec;21(6):612-8. Epub 2009 Oct 23.PMID: 19854631 [PubMed - in process]Related articles

T cell islet accumulation in type 1 diabetes is a tightly regulated, cell-autonomous event.

Lennon GP, Bettini M, Burton AR, Vincent E, Arnold PY, Santamaria P, Vignali DA.

Immunity. 2009 Oct 16;31(4):643-53. Epub 2009 Oct 8.PMID: 19818656 [PubMed - indexed for MEDLINE]Related articles

Functionally distinct LAG-3 and PD-1 subsets on activated and chronically stimulated CD8 T cells.

Grosso JF, Goldberg MV, Getnet D, Bruno TC, Yen HR, Pyle KJ, Hipkiss E, Vignali DA, Pardoll DM, Drake CG.

J Immunol. 2009 Jun 1;182(11):6659-69.PMID: 19454660 [PubMed - indexed for MEDLINE]Related articles

Regulatory T cell suppression is potentiated by target T cells in a cell contact, IL-35- and IL-10-dependent manner.

Collison LW, Pillai MR, Chaturvedi V, Vignali DA.

J Immunol. 2009 May 15;182(10):6121-8.PMID: 19414764 [PubMed - indexed for MEDLINE]Related articles

The development and function of regulatory T cells.

Workman CJ, Szymczak-Workman AL, Collison LW, Pillai MR, Vignali DA.

Cell Mol Life Sci. 2009 Aug;66(16):2603-22. Epub 2009 Apr 24. Review.PMID: 19390784 [PubMed - indexed for MEDLINE]Related articles

Cutting edge: regulatory T cells do not require stimulation through their TCR to suppress.

Szymczak-Workman AL, Workman CJ, Vignali DA.

J Immunol. 2009 May 1;182(9):5188-92.PMID: 19380762 [PubMed - indexed for MEDLINE]Related articles

LAG-3 regulates plasmacytoid dendritic cell homeostasis.

Workman CJ, Wang Y, El Kasmi KC, Pardoll DM, Murray PJ, Drake CG, Vignali DA.

J Immunol. 2009 Feb 15;182(4):1885-91.PMID: 19201841 [PubMed - indexed for MEDLINE]Related articles

Interleukin-35: odd one out or part of the family?

Collison LW, Vignali DA.

Immunol Rev. 2008 Dec;226:248-62. Review.PMID: 19161429 [PubMed - indexed for MEDLINE]Related articlesFree article

Analysis of nondegradative protein ubiquitylation with a monoclonal antibody specific for lysine-63-linked polyubiquitin.

Wang H, Matsuzawa A, Brown SA, Zhou J, Guy CS, Tseng PH, Forbes K, Nicholson TP, Sheppard PW, Häcker H, Karin M, Vignali DA.

Proc Natl Acad Sci U S A. 2008 Dec 23;105(51):20197-202. Epub 2008 Dec 17.PMID: 19091944 [PubMed - indexed for MEDLINE]Related articlesFree article

Outgrowth of CD4low/negCD25+ T cells with suppressor function in CD4+CD25+ T cell cultures upon polyclonal stimulation ex vivo.

Vogtenhuber C, O'Shaughnessy MJ, Vignali DA, Blazar BR.

J Immunol. 2008 Dec 15;181(12):8767-75.PMID: 19050298 [PubMed - indexed for MEDLINE]Related articles

Coregulation of CD8+ T cell exhaustion by multiple inhibitory receptors during chronic viral infection.

Blackburn SD, Shin H, Haining WN, Zou T, Workman CJ, Polley A, Betts MR, Freeman GJ, Vignali DA, Wherry EJ.

Nat Immunol. 2009 Jan;10(1):29-37. Epub 2008 Nov 30.PMID: 19043418 [PubMed - indexed for MEDLINE]Related articlesFree article

Nonredundant and complementary functions of TRAF2 and TRAF3 in a ubiquitination cascade that activates NIK-dependent alternative NF-kappaB signaling.

Vallabhapurapu S, Matsuzawa A, Zhang W, Tseng PH, Keats JJ, Wang H, Vignali DA, Bergsagel PL, Karin M.

Nat Immunol. 2008 Dec;9(12):1364-70. Epub 2008 Nov 9.PMID: 18997792 [PubMed - indexed for MEDLINE]Related articlesFree article

Essential cytoplasmic translocation of a cytokine receptor-assembled signaling complex.

Matsuzawa A, Tseng PH, Vallabhapurapu S, Luo JL, Zhang W, Wang H, Vignali DA, Gallagher E, Karin M.

Science. 2008 Aug 1;321(5889):663-8. Epub 2008 Jul 17.PMID: 18635759 [PubMed - indexed for MEDLINE]Related articlesFree article

How regulatory T cells work.

Vignali DA, Collison LW, Workman CJ.

Nat Rev Immunol. 2008 Jul;8(7):523-32. Review.PMID: 18566595 [PubMed - indexed for MEDLINE]Related articlesFree article

The proline-rich sequence of CD3epsilon as an amplifier of low-avidity TCR signaling.

Tailor P, Tsai S, Shameli A, Serra P, Wang J, Robbins S, Nagata M, Szymczak-Workman AL, Vignali DA, Santamaria P.

J Immunol. 2008 Jul 1;181(1):243-55.PMID: 18566390 [PubMed - indexed for MEDLINE]Related articlesFree article

Scalable signaling mediated by T cell antigen receptor-CD3 ITAMs ensures effective negative selection and prevents autoimmunity.

Holst J, Wang H, Eder KD, Workman CJ, Boyd KL, Baquet Z, Singh H, Forbes K, Chruscinski A, Smeyne R, van Oers NS, Utz PJ, Vignali DA.

Nat Immunol. 2008 Jun;9(6):658-66. Epub 2008 May 11.PMID: 18469818 [PubMed - indexed for MEDLINE]Related articles

Rapid identification of MHC class I-restricted antigens relevant to autoimmune diabetes using retrogenic T cells.

Chaparro RJ, Burton AR, Serreze DV, Vignali DA, DiLorenzo TP.

J Immunol Methods. 2008 Jun 1;335(1-2):106-15. Epub 2008 Apr 8.PMID: 18439618 [PubMed - indexed for MEDLINE]Related articlesFree article

On the pathogenicity of autoantigen-specific T-cell receptors.

Burton AR, Vincent E, Arnold PY, Lennon GP, Smeltzer M, Li CS, Haskins K, Hutton J, Tisch RM, Sercarz EE, Santamaria P, Workman CJ, Vignali DA.

Diabetes. 2008 May;57(5):1321-30. Epub 2008 Feb 25.PMID: 18299317 [PubMed - indexed for MEDLINE]Related articlesFree article

Lentiviral vectors encoding human immunodeficiency virus type 1 (HIV-1)-specific T-cell receptor genes efficiently convert peripheral blood CD8 T lymphocytes into cytotoxic T lymphocytes with potent in vitro and in vivo HIV-1-specific inhibitory activity.

Joseph A, Zheng JH, Follenzi A, Dilorenzo T, Sango K, Hyman J, Chen K, Piechocka-Trocha A, Brander C, Hooijberg E, Vignali DA, Walker BD, Goldstein H.

J Virol. 2008 Mar;82(6):3078-89. Epub 2008 Jan 9.PMID: 18184707 [PubMed - indexed for MEDLINE]Related articlesFree article

The inhibitory cytokine IL-35 contributes to regulatory T-cell function.

Collison LW, Workman CJ, Kuo TT, Boyd K, Wang Y, Vignali KM, Cross R, Sehy D, Blumberg RS, Vignali DA.

Nature. 2007 Nov 22;450(7169):566-9.PMID: 18033300 [PubMed - indexed for MEDLINE]Related articles

Generation of T-cell receptor retrogenic mice.

Holst J, Szymczak-Workman AL, Vignali KM, Burton AR, Workman CJ, Vignali DA.

Nat Protoc. 2006;1(1):406-17.PMID: 17406263 [PubMed - indexed for MEDLINE]Related articles

Non-cell autonomous expression of TNF-alpha-converting enzyme ADAM17 is required for normal lymphocyte development.

Li N, Boyd K, Dempsey PJ, Vignali DA.

J Immunol. 2007 Apr 1;178(7):4214-21.PMID: 17371977 [PubMed - indexed for MEDLINE]Related articlesFree article

Metalloproteases regulate T-cell proliferation and effector function via LAG-3.

Li N, Wang Y, Forbes K, Vignali KM, Heale BS, Saftig P, Hartmann D, Black RA, Rossi JJ, Blobel CP, Dempsey PJ, Workman CJ, Vignali DA.

EMBO J. 2007 Jan 24;26(2):494-504.PMID: 17245433 [PubMed - indexed for MEDLINE]Related articlesFree article

A natural structural variant of the mouse TCR beta-chain displays intrinsic receptor function and antigen specificity.

Aublin A, Ciofani M, Willkomm N, Hamrouni A, Szymczak-Workman AL, Takahashi T, Sandjeu Y, Guillaume P, Vignali DA, Michielin O, Zúñiga-Pflücker JC, Maryanski JL.

J Immunol. 2006 Dec 15;177(12):8587-94.PMID: 17142757 [PubMed - indexed for MEDLINE]Related articlesFree article

General nature of the STAT3-activated anti-inflammatory response.

El Kasmi KC, Holst J, Coffre M, Mielke L, de Pauw A, Lhocine N, Smith AM, Rutschman R, Kaushal D, Shen Y, Suda T, Donnelly RP, Myers MG Jr, Alexander W, Vignali DA, Watowich SS, Ernst M, Hilton DJ, Murray PJ.

J Immunol. 2006 Dec 1;177(11):7880-8.PMID: 17114459 [PubMed - indexed for MEDLINE]Related articlesFree article

Rapid analysis of T-cell selection in vivo using T cell-receptor retrogenic mice.

Holst J, Vignali KM, Burton AR, Vignali DA.

Nat Methods. 2006 Mar;3(3):191-7. Erratum in: Nat Methods. 2006 Apr;3(4):327. PMID: 16489336 [PubMed - indexed for MEDLINE]Related articles

The CD3epsilon proline-rich sequence, and its interaction with Nck, is not required for T cell development and function.

Szymczak AL, Workman CJ, Gil D, Dilioglou S, Vignali KM, Palmer E, Vignali DA.

J Immunol. 2005 Jul 1;175(1):270-5.PMID: 15972658 [PubMed - indexed for MEDLINE]Related articlesFree article

A picornaviral 2A-like sequence-based tricistronic vector allowing for high-level therapeutic gene expression coupled to a dual-reporter system.

Osborn MJ, Panoskaltsis-Mortari A, McElmurry RT, Bell SK, Vignali DA, Ryan MD, Wilber AC, McIvor RS, Tolar J, Blazar BR.

Mol Ther. 2005 Sep;12(3):569-74.PMID: 15964244 [PubMed - indexed for MEDLINE]Related articles

Development of 2A peptide-based strategies in the design of multicistronic vectors.

Szymczak AL, Vignali DA.

Expert Opin Biol Ther. 2005 May;5(5):627-38. Review.PMID: 15934839 [PubMed - indexed for MEDLINE]Related articles

TNFR1-induced sphingomyelinase activation modulates TCR signaling by impairing store-operated Ca2+ influx.

Church LD, Hessler G, Goodall JE, Rider DA, Workman CJ, Vignali DA, Bacon PA, Gulbins E, Young SP.

J Leukoc Biol. 2005 Jul;78(1):266-78. Epub 2005 Apr 7.PMID: 15817701 [PubMed - indexed for MEDLINE]Related articlesFree article

Plasticity and rigidity in adaptor protein-2-mediated internalization of the TCR:CD3 complex.

Szymczak AL, Vignali DA.

J Immunol. 2005 Apr 1;174(7):4153-60.PMID: 15778375 [PubMed - indexed for MEDLINE]Related articlesFree article

Negative regulation of T cell homeostasis by lymphocyte activation gene-3 (CD223).

Workman CJ, Vignali DA.

J Immunol. 2005 Jan 15;174(2):688-95.PMID: 15634887 [PubMed - indexed for MEDLINE]Related articlesFree article

Biochemical analysis of the regulatory T cell protein lymphocyte activation gene-3 (LAG-3; CD223).

Li N, Workman CJ, Martin SM, Vignali DA.

J Immunol. 2004 Dec 1;173(11):6806-12.PMID: 15557174 [PubMed - indexed for MEDLINE]Related articlesFree article

Role of LAG-3 in regulatory T cells.

Huang CT, Workman CJ, Flies D, Pan X, Marson AL, Zhou G, Hipkiss EL, Ravi S, Kowalski J, Levitsky HI, Powell JD, Pardoll DM, Drake CG, Vignali DA.

Immunity. 2004 Oct;21(4):503-13.PMID: 15485628 [PubMed - indexed for MEDLINE]Related articles

Diabetes incidence is unaltered in glutamate decarboxylase 65-specific TCR retrogenic nonobese diabetic mice: generation by retroviral-mediated stem cell gene transfer.

Arnold PY, Burton AR, Vignali DA.

J Immunol. 2004 Sep 1;173(5):3103-11.PMID: 15322170 [PubMed - indexed for MEDLINE]Related articlesFree article

Lymphocyte activation gene-3 (CD223) regulates the size of the expanding T cell population following antigen activation in vivo.

Workman CJ, Cauley LS, Kim IJ, Blackman MA, Woodland DL, Vignali DA.

J Immunol. 2004 May 1;172(9):5450-5.PMID: 15100286 [PubMed - indexed for MEDLINE]Related articlesFree article

Correction of multi-gene deficiency in vivo using a single 'self-cleaving' 2A peptide-based retroviral vector.

Szymczak AL, Workman CJ, Wang Y, Vignali KM, Dilioglou S, Vanin EF, Vignali DA.

Nat Biotechnol. 2004 May;22(5):589-94. Epub 2004 Apr 4. Erratum in: Nat Biotechnol. 2004 Dec;22(12):1590. Nat Biotechnol. 2004 Jun;22(6):760. PMID: 15064769 [PubMed - indexed for MEDLINE]Related articles

Architectural changes in the TCR:CD3 complex induced by MHC:peptide ligation.

La Gruta NL, Liu H, Dilioglou S, Rhodes M, Wiest DL, Vignali DA.

J Immunol. 2004 Mar 15;172(6):3662-9.PMID: 15004169 [PubMed - indexed for MEDLINE]Related articlesFree article

CD40-induced aggregation of MHC class II and CD80 on the cell surface leads to an early enhancement in antigen presentation.

Clatza A, Bonifaz LC, Vignali DA, Moreno J.

J Immunol. 2003 Dec 15;171(12):6478-87.PMID: 14662847 [PubMed - indexed for MEDLINE]Related articlesFree article

The CD4-related molecule, LAG-3 (CD223), regulates the expansion of activated T cells.

Workman CJ, Vignali DA.

Eur J Immunol. 2003 Apr;33(4):970-9.PMID: 12672063 [PubMed - indexed for MEDLINE]Related articles

Cutting edge: virus-specific CD4+ memory T cells in nonlymphoid tissues express a highly activated phenotype.

Cauley LS, Cookenham T, Miller TB, Adams PS, Vignali KM, Vignali DA, Woodland DL.

J Immunol. 2002 Dec 15;169(12):6655-8.PMID: 12471092 [PubMed - indexed for MEDLINE]Related articlesFree article

Reliable generation and use of MHC class II:gamma2aFc multimers for the identification of antigen-specific CD4(+) T cells.

Arnold PY, Vignali KM, Miller TB, La Gruta NL, Cauley LS, Haynes L, Scott Adams P, Swain SL, Woodland DL, Vignali DA.

J Immunol Methods. 2002 Dec 20;271(1-2):137-51.PMID: 12445737 [PubMed - indexed for MEDLINE]Related articles

Cutting edge: molecular analysis of the negative regulatory function of lymphocyte activation gene-3.

Workman CJ, Dugger KJ, Vignali DA.

J Immunol. 2002 Nov 15;169(10):5392-5.PMID: 12421911 [PubMed - indexed for MEDLINE]Related articlesFree article

Phenotypic analysis of the murine CD4-related glycoprotein, CD223 (LAG-3).

Workman CJ, Rice DS, Dugger KJ, Kurschner C, Vignali DA.

Eur J Immunol. 2002 Aug;32(8):2255-63.PMID: 12209638 [PubMed - indexed for MEDLINE]Related articles

The majority of immunogenic epitopes generate CD4+ T cells that are dependent on MHC class II-bound peptide-flanking residues.

Arnold PY, La Gruta NL, Miller T, Vignali KM, Adams PS, Woodland DL, Vignali DA.

J Immunol. 2002 Jul 15;169(2):739-49. Erratum in: J Immunol 2002 Oct 15;169(8):4674. PMID: 12097376 [PubMed - indexed for MEDLINE]Related articlesFree article

On the dynamics of TCR:CD3 complex cell surface expression and downmodulation.

Liu H, Rhodes M, Wiest DL, Vignali DA.

Immunity. 2000 Nov;13(5):665-75.PMID: 11114379 [PubMed - indexed for MEDLINE]Related articles

Multiplexed particle-based flow cytometric assays.

Vignali DA.

J Immunol Methods. 2000 Sep 21;243(1-2):243-55. Review.PMID: 10986418 [PubMed - indexed for MEDLINE]Related articles

Simultaneous quantitation of 15 cytokines using a multiplexed flow cytometric assay.

Carson RT, Vignali DA.

J Immunol Methods. 1999 Jul 30;227(1-2):41-52.PMID: 10485253 [PubMed - indexed for MEDLINE]Related articles