PubMed

Islet allograft rejection is independent of toll-like receptor signaling in mice.

Hutton MJ, Westwell-Roper C, Soukhatcheva G, Plesner A, Dutz JP, Verchere CB.

Transplantation. 2009 Nov 15;88(9):1075-80.PMID: 19898202 [PubMed - in process]Related articles

Impaired proinsulin processing is a characteristic of transplanted islets.

Klimek AM, Soukhatcheva G, Thompson DM, Warnock GL, Salehi M, Rilo H, D'Alessio D, Meneilly GS, Panagiotopoulos C, Verchere CB.

Am J Transplant. 2009 Sep;9(9):2119-25.PMID: 19706025 [PubMed - in process]Related articles

Different effects of FK506, rapamycin, and mycophenolate mofetil on glucose-stimulated insulin release and apoptosis in human islets.

Johnson JD, Ao Z, Ao P, Li H, Dai L, He Z, Tee M, Potter KJ, Klimek AM, Meloche RM, Thompson DM, Verchere CB, Warnock GL.

Cell Transplant. 2009 Apr 10. pii: CT-1977. [Epub ahead of print]PMID: 19500470 [PubMed - as supplied by publisher]Related articles

Local expression of B7-H4 by recombinant adenovirus transduction in mouse islets prolongs allograft survival.

Wang X, Hao J, Metzger DL, Mui A, Ao Z, Verchere CB, Chen L, Ou D, Warnock GL.

Transplantation. 2009 Feb 27;87(4):482-90.PMID: 19307783 [PubMed - indexed for MEDLINE]Related articles

Amyloid inhibitors enhance survival of cultured human islets.

Potter KJ, Scrocchi LA, Warnock GL, Ao Z, Younker MA, Rosenberg L, Lipsett M, Verchere CB, Fraser PE.

Biochim Biophys Acta. 2009 Jun;1790(6):566-74. Epub 2009 Mar 2.PMID: 19264107 [PubMed - indexed for MEDLINE]Related articles

Moderate exercise attenuates caspase-3 activity, oxidative stress, and inhibits progression of diabetic renal disease in db/db mice.

Ghosh S, Khazaei M, Moien-Afshari F, Ang LS, Granville DJ, Verchere CB, Dunn SR, McCue P, Mizisin A, Sharma K, Laher I.

Am J Physiol Renal Physiol. 2009 Apr;296(4):F700-8. Epub 2009 Jan 14.PMID: 19144689 [PubMed - indexed for MEDLINE]Related articles

A multi-year analysis of islet transplantation compared with intensive medical therapy on progression of complications in type 1 diabetes.

Warnock GL, Thompson DM, Meloche RM, Shapiro RJ, Ao Z, Keown P, Johnson JD, Verchere CB, Partovi N, Begg IS, Fung M, Kozak SE, Tong SO, Alghofaili KM, Harris C.

Transplantation. 2008 Dec 27;86(12):1762-6.PMID: 19104418 [PubMed - indexed for MEDLINE]Related articles

Small interfering RNA-mediated suppression of proislet amyloid polypeptide expression inhibits islet amyloid formation and enhances survival of human islets in culture.

Marzban L, Tomas A, Becker TC, Rosenberg L, Oberholzer J, Fraser PE, Halban PA, Verchere CB.

Diabetes. 2008 Nov;57(11):3045-55. Epub 2008 Aug 11.PMID: 18694973 [PubMed - indexed for MEDLINE]Related articlesFree article

Rifampicin does not prevent amyloid fibril formation by human islet amyloid polypeptide but does inhibit fibril thioflavin-T interactions: implications for mechanistic studies of beta-cell death.

Meng F, Marek P, Potter KJ, Verchere CB, Raleigh DP.

Biochemistry. 2008 Jun 3;47(22):6016-24. Epub 2008 May 6.PMID: 18457428 [PubMed - indexed for MEDLINE]Related articles

Cholesterol in islet dysfunction and type 2 diabetes.

Brunham LR, Kruit JK, Verchere CB, Hayden MR.

J Clin Invest. 2008 Feb;118(2):403-8. Review.PMID: 18246189 [PubMed - indexed for MEDLINE]Related articlesFree article

An odyssey of islet transplantation for therapy of type 1 diabetes.

Warnock GL, Liao YH, Wang X, Ou D, Ao Z, Johnson JD, Verchere CB, Thompson D.

World J Surg. 2007 Aug;31(8):1569-76. Epub 2007 Jun 12. Review.PMID: 17562107 [PubMed - indexed for MEDLINE]Related articles

Adult stem or progenitor cells in treatment for type 1 diabetes: current progress.

Liao YH, Verchere CB, Warnock GL.

Can J Surg. 2007 Apr;50(2):137-42. Review.PMID: 17550719 [PubMed - indexed for MEDLINE]Related articlesFree article

Prospective prediction of spontaneous but not recurrent autoimmune diabetes in the non-obese diabetic mouse.

Trudeau JD, Chandler T, Soukhatcheva G, Verchere CB, Tan R.

Diabetologia. 2007 May;50(5):1015-23. Epub 2007 Mar 2.PMID: 17334749 [PubMed - indexed for MEDLINE]Related articles

Beta-cell ABCA1 influences insulin secretion, glucose homeostasis and response to thiazolidinedione treatment.

Brunham LR, Kruit JK, Pape TD, Timmins JM, Reuwer AQ, Vasanji Z, Marsh BJ, Rodrigues B, Johnson JD, Parks JS, Verchere CB, Hayden MR.

Nat Med. 2007 Mar;13(3):340-7. Epub 2007 Feb 18.PMID: 17322896 [PubMed - indexed for MEDLINE]Related articles

Pten (phosphatase and tensin homologue gene) haploinsufficiency promotes insulin hypersensitivity.

Wong JT, Kim PT, Peacock JW, Yau TY, Mui AL, Chung SW, Sossi V, Doudet D, Green D, Ruth TJ, Parsons R, Verchere CB, Ong CJ.

Diabetologia. 2007 Feb;50(2):395-403. Epub 2006 Dec 29.PMID: 17195063 [PubMed - indexed for MEDLINE]Related articlesFree article

Recognition of HLA class I-restricted beta-cell epitopes in type 1 diabetes.

Ouyang Q, Standifer NE, Qin H, Gottlieb P, Verchere CB, Nepom GT, Tan R, Panagiotopoulos C.

Diabetes. 2006 Nov;55(11):3068-74.PMID: 17065344 [PubMed - indexed for MEDLINE]Related articlesFree article

Identification of Novel HLA-A*0201-restricted epitopes in recent-onset type 1 diabetic subjects and antibody-positive relatives.

Standifer NE, Ouyang Q, Panagiotopoulos C, Verchere CB, Tan R, Greenbaum CJ, Pihoker C, Nepom GT.

Diabetes. 2006 Nov;55(11):3061-7.PMID: 17065343 [PubMed - indexed for MEDLINE]Related articlesFree article

Improving function and survival of pancreatic islets by endogenous production of glucagon-like peptide 1 (GLP-1).

Wideman RD, Yu IL, Webber TD, Verchere CB, Johnson JD, Cheung AT, Kieffer TJ.

Proc Natl Acad Sci U S A. 2006 Sep 5;103(36):13468-73. Epub 2006 Aug 28.PMID: 16938896 [PubMed - indexed for MEDLINE]Related articlesFree article

Impaired NH2-terminal processing of human proislet amyloid polypeptide by the prohormone convertase PC2 leads to amyloid formation and cell death.

Marzban L, Rhodes CJ, Steiner DF, Haataja L, Halban PA, Verchere CB.

Diabetes. 2006 Aug;55(8):2192-201.PMID: 16873681 [PubMed - indexed for MEDLINE]Related articlesFree article

Application of in situ ductal perfusion to facilitate isolation of high-quality RNA from mouse pancreas.

Mullin AE, Soukatcheva G, Verchere CB, Chantler JK.

Biotechniques. 2006 May;40(5):617-21.PMID: 16708761 [PubMed - indexed for MEDLINE]Related articlesFree article

The X-linked inhibitor of apoptosis protein enhances survival of murine islet allografts.

Plesner A, Liston P, Tan R, Korneluk RG, Verchere CB.

Diabetes. 2005 Sep;54(9):2533-40.PMID: 16123340 [PubMed - indexed for MEDLINE]Related articlesFree article

Improved human pancreatic islet isolation for a prospective cohort study of islet transplantation vs best medical therapy in type 1 diabetes mellitus.

Warnock GL, Meloche RM, Thompson D, Shapiro RJ, Fung M, Ao Z, Ho S, He Z, Dai LJ, Young L, Blackburn L, Kozak S, Kim PT, Al-Adra D, Johnson JD, Liao YH, Elliott T, Verchere CB.

Arch Surg. 2005 Aug;140(8):735-44.PMID: 16103282 [PubMed - indexed for MEDLINE]Related articlesFree article

Processing of pro-islet amyloid polypeptide in the constitutive and regulated secretory pathways of beta cells.

Marzban L, Trigo-Gonzalez G, Verchere CB.

Mol Endocrinol. 2005 Aug;19(8):2154-63. Epub 2005 Mar 31.PMID: 15802374 [PubMed - indexed for MEDLINE]Related articlesFree article

Synergistic inhibition of tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis in human pancreatic beta cells by Bcl-2 and X-linked inhibitor of apoptosis.

Ou D, Wang X, Metzger DL, James RF, Pozzilli P, Plesner A, Korneluk RG, Verchere CB, Tingle AJ.

Hum Immunol. 2005 Mar;66(3):274-84.PMID: 15784465 [PubMed - indexed for MEDLINE]Related articles

Role of carboxypeptidase E in processing of pro-islet amyloid polypeptide in {beta}-cells.

Marzban L, Soukhatcheva G, Verchere CB.

Endocrinology. 2005 Apr;146(4):1808-17. Epub 2004 Dec 23.PMID: 15618358 [PubMed - indexed for MEDLINE]Related articlesFree article

Progression of spontaneous autoimmune diabetes is associated with a switch in the killing mechanism used by autoreactive CTL.

Qin H, Trudeau JD, Reid GS, Lee IF, Dutz JP, Santamaria P, Verchere CB, Tan R.

Int Immunol. 2004 Nov;16(11):1657-62. Epub 2004 Oct 5.PMID: 15466911 [PubMed - indexed for MEDLINE]Related articlesFree article

Glycosylphosphatidylinositol-specific phospholipase D immunoreactivity is present in islet amyloid in type 2 diabetes.

Larson DM, Kennedy MA, Bowen RF, Verchere CB, Deeg MA.

J Pathol. 2004 Aug;203(4):961-7.PMID: 15259000 [PubMed - indexed for MEDLINE]Related articles

Role of beta-cell prohormone convertase (PC)1/3 in processing of pro-islet amyloid polypeptide.

Marzban L, Trigo-Gonzalez G, Zhu X, Rhodes CJ, Halban PA, Steiner DF, Verchere CB.

Diabetes. 2004 Jan;53(1):141-8.PMID: 14693708 [PubMed - indexed for MEDLINE]Related articlesFree article

Extended life span is associated with insulin resistance in a transgenic mouse model of insulinoma secreting human islet amyloid polypeptide.

Andrikopoulos S, Hull RL, Verchere CB, Wang F, Wilbur SM, Wight TN, Marzban L, Kahn SE.

Am J Physiol Endocrinol Metab. 2004 Mar;286(3):E418-24. Epub 2003 Nov 12. Erratum in: Am J Physiol Endocrinol Metab. 2004 May;286(5):E862. PMID: 14613923 [PubMed - indexed for MEDLINE]Related articlesFree article

Identification of a beta-cell-specific HLA class I restricted epitope in type 1 diabetes.

Panagiotopoulos C, Qin H, Tan R, Verchere CB.

Diabetes. 2003 Nov;52(11):2647-51.PMID: 14578281 [PubMed - indexed for MEDLINE]Related articlesFree article

Islet amyloid polypeptide and type 2 diabetes.

Marzban L, Park K, Verchere CB.

Exp Gerontol. 2003 Apr;38(4):347-51. Review.PMID: 12670620 [PubMed - indexed for MEDLINE]Related articles

The effect of apolipoprotein E deficiency on islet amyloid deposition in human islet amyloid polypeptide transgenic mice.

Vidal J, Verchere CB, Andrikopoulos S, Wang F, Hull RL, Cnop M, Olin KL, LeBoeuf RC, O'Brien KD, Chait A, Kahn SE.

Diabetologia. 2003 Jan;46(1):71-9. Epub 2003 Jan 9.PMID: 12637985 [PubMed - indexed for MEDLINE]Related articles

Increased dietary fat promotes islet amyloid formation and beta-cell secretory dysfunction in a transgenic mouse model of islet amyloid.

Hull RL, Andrikopoulos S, Verchere CB, Vidal J, Wang F, Cnop M, Prigeon RL, Kahn SE.

Diabetes. 2003 Feb;52(2):372-9.PMID: 12540610 [PubMed - indexed for MEDLINE]Related articlesFree article

Prediction of spontaneous autoimmune diabetes in NOD mice by quantification of autoreactive T cells in peripheral blood.

Trudeau JD, Kelly-Smith C, Verchere CB, Elliott JF, Dutz JP, Finegood DT, Santamaria P, Tan R.

J Clin Invest. 2003 Jan;111(2):217-23.PMID: 12531877 [PubMed - indexed for MEDLINE]Related articlesFree article

Oophorectomy promotes islet amyloid formation in human islet amyloid polypeptide transgenic mice.

Hull RL, Verchere CB, Andrikopoulos S, Wang F, Vidal J, Kahn SE.

Diabetes. 2001 Feb;50 Suppl 1:S184-5. No abstract available. PMID: 11272188 [PubMed - indexed for MEDLINE]Related articles

The prohormone convertase enzyme 2 (PC2) is essential for processing pro-islet amyloid polypeptide at the NH2-terminal cleavage site.

Wang J, Xu J, Finnerty J, Furuta M, Steiner DF, Verchere CB.

Diabetes. 2001 Mar;50(3):534-9.PMID: 11246872 [PubMed - indexed for MEDLINE]Related articlesFree article

Identification of a heparin binding domain in the N-terminal cleavage site of pro-islet amyloid polypeptide. Implications for islet amyloid formation.

Park K, Verchere CB.

J Biol Chem. 2001 May 18;276(20):16611-6. Epub 2001 Jan 5.PMID: 11145957 [PubMed - indexed for MEDLINE]Related articlesFree article

beta-cell glucokinase deficiency and hyperglycemia are associated with reduced islet amyloid deposition in a mouse model of type 2 diabetes.

Andrikopoulos S, Verchere CB, Terauchi Y, Kadowaki T, Kahn SE.

Diabetes. 2000 Dec;49(12):2056-62.PMID: 11118007 [PubMed - indexed for MEDLINE]Related articlesFree article

Oophorectomy promotes islet amyloid formation in a transgenic mouse model of Type II diabetes.

Kahn SE, Andrikopoulos S, Verchere CB, Wang F, Hull RL, Vidal J.

Diabetologia. 2000 Oct;43(10):1309-12.PMID: 11079750 [PubMed - indexed for MEDLINE]Related articles

The constitutive secretory pathway is a major route for islet amyloid polypeptide secretion in neonatal but not adult rat islet cells.

Verchere CB, D'Alessio DA, Prigeon RL, Hull RL, Kahn SE.

Diabetes. 2000 Sep;49(9):1477-84.PMID: 10969831 [PubMed - indexed for MEDLINE]Related articlesFree article

Two novel immortal pancreatic beta-cell lines expressing and secreting human islet amyloid polypeptide do not spontaneously develop islet amyloid.

Andrikopoulos S, Verchere CB, Teague JC, Howell WM, Fujimoto WY, Wight TN, Kahn SE.

Diabetes. 1999 Oct;48(10):1962-70. Erratum in: Diabetes 2000 Jan;49(1):135. PMID: 10512360 [PubMed - indexed for MEDLINE]Related articlesFree article

The canine sympathetic neuropeptide galanin: a neurotransmitter in pancreas, a neuromodulator in liver.

Taborsky GJ Jr, Dunning BE, Havel PJ, Ahren B, Kowalyk S, Boyle MR, Verchere CB, Baskin DG, Mundinger TO.

Horm Metab Res. 1999 May;31(5):351-4. Review.PMID: 10422734 [PubMed - indexed for MEDLINE]Related articles

Islet amyloid: a long-recognized but underappreciated pathological feature of type 2 diabetes.

Kahn SE, Andrikopoulos S, Verchere CB.

Diabetes. 1999 Feb;48(2):241-53. Review.PMID: 10334297 [PubMed - indexed for MEDLINE]Related articlesFree article

Human aging is associated with parallel reductions in insulin and amylin release.

Dechenes CJ, Verchere CB, Andrikopoulos S, Kahn SE.

Am J Physiol. 1998 Nov;275(5 Pt 1):E785-91.PMID: 9814997 [PubMed - indexed for MEDLINE]Related articlesFree article

Reduced amylin release is a characteristic of impaired glucose tolerance and type 2 diabetes in Japanese Americans.

Kahn SE, Verchere CB, Andrikopoulos S, Asberry PJ, Leonetti DL, Wahl PW, Boyko EJ, Schwartz RS, Newell-Morris L, Fujimoto WY.

Diabetes. 1998 Apr;47(4):640-5.PMID: 9568698 [PubMed - indexed for MEDLINE]Related articlesFree article

Galanin is localized in sympathetic neurons of the dog liver.

Mundinger TO, Verchere CB, Baskin DG, Boyle MR, Kowalyk S, Taborsky GJ Jr.

Am J Physiol. 1997 Dec;273(6 Pt 1):E1194-202.PMID: 9435536 [PubMed - indexed for MEDLINE]Related articlesFree article

Proinsulin targeting to the regulated pathway is not impaired in carboxypeptidase E-deficient Cpefat/Cpefat mice.

Irminger JC, Verchere CB, Meyer K, Halban PA.

J Biol Chem. 1997 Oct 31;272(44):27532-4.PMID: 9346885 [PubMed - indexed for MEDLINE]Related articlesFree article

Insulin production: from gene to granule.

Regazzi R, Verchere CB, Halban PA, Polonsky KS.

Diabetologia. 1997 Oct;40 Suppl 3:B33-8. No abstract available. PMID: 9345643 [PubMed - indexed for MEDLINE]Related articles

Evidence that vasoactive intestinal polypeptide is a parasympathetic neurotransmitter in the endocrine pancreas in dogs.

Havel PJ, Dunning BE, Verchere CB, Baskin DG, O'Dorisio T, Taborsky GJ Jr.

Regul Pept. 1997 Aug 29;71(3):163-70.PMID: 9350974 [PubMed - indexed for MEDLINE]Related articles

Transgenic overproduction of islet amyloid polypeptide (amylin) is not sufficient for islet amyloid formation.

Verchere CB, D'Alessio DA, Wang S, Andrikopoulos S, Kahn SE.

Horm Metab Res. 1997 Jun;29(6):311-6. Review.PMID: 9230354 [PubMed - indexed for MEDLINE]Related articles