PubMed

Human colon tissue in organ culture: preservation of normal and neoplastic characteristics.

Dame MK, Bhagavathula N, Mankey C, Dasilva M, Paruchuri T, Aslam MN, Varani J.

In Vitro Cell Dev Biol Anim. 2009 Nov 14. [Epub ahead of print]PMID: 19915935 [PubMed - as supplied by publisher]Related articles

A combination of curcumin and ginger extract improves abrasion wound healing in corticosteroid-impaired hairless rat skin.

Bhagavathula N, Warner RL, DaSilva M, McClintock SD, Barron A, Aslam MN, Johnson KJ, Varani J.

Wound Repair Regen. 2009 May-Jun;17(3):360-6.PMID: 19660044 [PubMed - indexed for MEDLINE]Related articles

Regulation of collagen turnover in human skin fibroblasts exposed to a gadolinium-based contrast agent.

Bhagavathula N, DaSilva M, Aslam MN, Dame MK, Warner RL, Xu Y, Fisher GJ, Johnson KJ, Swartz R, Varani J.

Invest Radiol. 2009 Aug;44(8):433-9.PMID: 19561517 [PubMed - indexed for MEDLINE]Related articles

The Göttingen minipig for assessment of retinoid efficacy in the skin: comparison of results from topically treated animals with results from organ-cultured skin.

Dame MK, Paruchuri T, DaSilva M, Bhagavathula N, Ridder W, Varani J.

In Vitro Cell Dev Biol Anim. 2009 Oct;45(9):551-7. Epub 2009 Jun 18.PMID: 19536603 [PubMed - in process]Related articles

Growth-inhibitory effects of a mineralized extract from the red marine algae, Lithothamnion calcareum, on Ca(2+)-sensitive and Ca(2+)-resistant human colon carcinoma cells.

Aslam MN, Bhagavathula N, Paruchuri T, Hu X, Chakrabarty S, Varani J.

Cancer Lett. 2009 Oct 8;283(2):186-92. Epub 2009 Apr 24.PMID: 19394137 [PubMed - indexed for MEDLINE]Related articles

Impaired keratinocyte function on matrix metalloproteinase-1 (MMP-1) damaged collagen.

Varani J, Perone P, Deming MO, Warner RL, Aslam MN, Bhagavathula N, Dame MK, Voorhees JJ.

Arch Dermatol Res. 2009 Aug;301(7):497-506. Epub 2009 Apr 8.PMID: 19352688 [PubMed - in process]Related articles

Collagen fragmentation promotes oxidative stress and elevates matrix metalloproteinase-1 in fibroblasts in aged human skin.

Fisher GJ, Quan T, Purohit T, Shao Y, Cho MK, He T, Varani J, Kang S, Voorhees JJ.

Am J Pathol. 2009 Jan;174(1):101-14. Epub 2008 Dec 30.PMID: 19116368 [PubMed - indexed for MEDLINE]Related articlesFree article

Effects of gadolinium-based magnetic resonance imaging contrast agents on human skin in organ culture and human skin fibroblasts.

Varani J, DaSilva M, Warner RL, Deming MO, Barron AG, Johnson KJ, Swartz RD.

Invest Radiol. 2009 Feb;44(2):74-81.PMID: 19077912 [PubMed - indexed for MEDLINE]Related articles

Attachment and growth of anchorage-dependent cells on a novel, charged-surface microcarrier under serum-free conditions.

Varani J, Piel F, Josephs S, Beals TF, Hillegas WJ.

Cytotechnology. 1998 Nov;28(1-3):101-9.PMID: 19003412 [PubMed - in process]Related articles

Recombinant collagen for animal product-free dextran microcarriers.

Dame MK, Varani J.

In Vitro Cell Dev Biol Anim. 2008 Nov-Dec;44(10):407-14. Epub 2008 Sep 25.PMID: 18815845 [PubMed - indexed for MEDLINE]Related articles

Calcium and calcium sensing receptor modulates the expression of thymidylate synthase, NAD(P)H:quinone oxidoreductase 1 and survivin in human colon carcinoma cells: promotion of cytotoxic response to mitomycin C and fluorouracil.

Liu G, Hu X, Varani J, Chakrabarty S.

Mol Carcinog. 2009 Mar;48(3):202-11.PMID: 18618519 [PubMed - indexed for MEDLINE]Related articles

Establishment and characteristics of Gottingen minipig skin in organ culture and monolayer cell culture: relevance to drug safety testing.

Dame MK, Spahlinger DM, DaSilva M, Perone P, Dunstan R, Varani J.

In Vitro Cell Dev Biol Anim. 2008 Jul-Aug;44(7):245-52. Epub 2008 Jun 21.PMID: 18568375 [PubMed - indexed for MEDLINE]Related articles

Looking older: fibroblast collapse and therapeutic implications.

Fisher GJ, Varani J, Voorhees JJ.

Arch Dermatol. 2008 May;144(5):666-72. Review.PMID: 18490597 [PubMed - indexed for MEDLINE]Related articlesFree article

Vascular tube formation on matrix metalloproteinase-1-damaged collagen.

Varani J, Perone P, Warner RL, Dame MK, Kang S, Fisher GJ, Voorhees JJ.

Br J Cancer. 2008 May 20;98(10):1646-52. Epub 2008 Apr 29.PMID: 18443597 [PubMed - indexed for MEDLINE]Related articlesFree article

MDI 301, a nonirritating retinoid, improves abrasion wound healing in damaged/atrophic skin.

Warner RL, Bhagavathula N, Nerusu K, Hanosh A, McClintock SD, Naik MK, Johnson KJ, Ginsburg I, Varani J.

Wound Repair Regen. 2008 Jan-Feb;16(1):117-24.PMID: 18211583 [PubMed - indexed for MEDLINE]Related articles

7-Chloro-5-(4-hydroxyphenyl)-1-methyl-3-(naphthalen-2-ylmethyl)-4,5-dihydro-1H-benzo[b][1,4]diazepin-2(3H)-one (Bz-423), a benzodiazepine, suppresses keratinocyte proliferation and has antipsoriatic activity in the human skin-severe, combined immunodeficient mouse transplant model.

Bhagavathula N, Nerusu KC, Hanosh A, Aslam MN, Sundberg TB, Opipari AW Jr, Johnson K, Kang S, Glick GD, Varani J.

J Pharmacol Exp Ther. 2008 Mar;324(3):938-47. Epub 2007 Nov 30.PMID: 18055879 [PubMed - indexed for MEDLINE]Related articlesFree article

Inhibition of retinoic acid-induced skin irritation in calorie-restricted mice.

Varani J, Bhagavathula N, Aslam MN, Fay K, Warner RL, Hanosh A, Barron AG, Miller RA.

Arch Dermatol Res. 2008 Jan;300(1):27-35. Epub 2007 Oct 30.PMID: 17968574 [PubMed - indexed for MEDLINE]Related articles

Human skin in organ culture and human skin cells (keratinocytes and fibroblasts) in monolayer culture for assessment of chemically induced skin damage.

Varani J, Perone P, Spahlinger DM, Singer LM, Diegel KL, Bobrowski WF, Dunstan R.

Toxicol Pathol. 2007;35(5):693-701.PMID: 17763283 [PubMed - indexed for MEDLINE]Related articles

PADMA-28, a traditional tibetan herbal preparation inhibits the respiratory burst in human neutrophils, the killing of epithelial cells by mixtures of oxidants and pro-inflammatory agonists and peroxidation of lipids.

Ginsburg I, Sadovnik M, Sallon S, Milo-Goldzweig I, Mechoulam R, Breuer A, Gibbs D, Varani J, Roberts S, Cleator E, Singh N.

Inflammopharmacology. 1999;7(1):47-62.PMID: 17657446 [PubMed - in process]Related articles

Regulation of E-cadherin and beta-catenin by Ca2+ in colon carcinoma is dependent on calcium-sensing receptor expression and function.

Bhagavathula N, Hanosh AW, Nerusu KC, Appelman H, Chakrabarty S, Varani J.

Int J Cancer. 2007 Oct 1;121(7):1455-62.PMID: 17557293 [PubMed - indexed for MEDLINE]Related articles

Matrix metalloproteinase-3 (stromelysin-1) in acute inflammatory tissue injury.

Nerusu KC, Warner RL, Bhagavathula N, McClintock SD, Johnson KJ, Varani J.

Exp Mol Pathol. 2007 Oct;83(2):169-76. Epub 2007 May 4.PMID: 17540368 [PubMed - indexed for MEDLINE]Related articlesFree article

Improvement of naturally aged skin with vitamin A (retinol).

Kafi R, Kwak HS, Schumacher WE, Cho S, Hanft VN, Hamilton TA, King AL, Neal JD, Varani J, Fisher GJ, Voorhees JJ, Kang S.

Arch Dermatol. 2007 May;143(5):606-12.PMID: 17515510 [PubMed - indexed for MEDLINE]Related articlesFree article

Vitamins as hormones.

Reichrath J, Lehmann B, Carlberg C, Varani J, Zouboulis CC.

Horm Metab Res. 2007 Feb;39(2):71-84. Review.PMID: 17326003 [PubMed - indexed for MEDLINE]Related articles

In vivo stimulation of de novo collagen production caused by cross-linked hyaluronic acid dermal filler injections in photodamaged human skin.

Wang F, Garza LA, Kang S, Varani J, Orringer JS, Fisher GJ, Voorhees JJ.

Arch Dermatol. 2007 Feb;143(2):155-63.PMID: 17309996 [PubMed - indexed for MEDLINE]Related articlesFree article

MDI 301, a non-irritating retinoid, induces changes in human skin that underlie repair.

Varani J, Fay K, Perone P.

Arch Dermatol Res. 2007 Feb;298(9):439-48. Epub 2006 Dec 5.PMID: 17146625 [PubMed - indexed for MEDLINE]Related articles

Thiazolidinediones: potential as therapeutics for psoriasis and perhaps other hyperproliferative skin disease.

Varani J, Bhagavathula N, Ellis CN, Pershadsingh HA.

Expert Opin Investig Drugs. 2006 Nov;15(11):1453-68. Review.PMID: 17040203 [PubMed - indexed for MEDLINE]Related articles

Decreased collagen production in chronologically aged skin: roles of age-dependent alteration in fibroblast function and defective mechanical stimulation.

Varani J, Dame MK, Rittie L, Fligiel SE, Kang S, Fisher GJ, Voorhees JJ.

Am J Pathol. 2006 Jun;168(6):1861-8.PMID: 16723701 [PubMed - indexed for MEDLINE]Related articlesFree article

Matrix metalloproteinases and matrix metalloproteinase inhibitors in acute lung injury.

Fligiel SE, Standiford T, Fligiel HM, Tashkin D, Strieter RM, Warner RL, Johnson KJ, Varani J.

Hum Pathol. 2006 Apr;37(4):422-30.PMID: 16564916 [PubMed - indexed for MEDLINE]Related articles

Retinoid-induced epidermal hyperplasia is mediated by epidermal growth factor receptor activation via specific induction of its ligands heparin-binding EGF and amphiregulin in human skin in vivo.

Rittié L, Varani J, Kang S, Voorhees JJ, Fisher GJ.

J Invest Dermatol. 2006 Apr;126(4):732-9.PMID: 16470170 [PubMed - indexed for MEDLINE]Related articlesFree article

Upregulation of calcium-sensing receptor and mitogen-activated protein kinase signalling in the regulation of growth and differentiation in colon carcinoma.

Bhagavathula N, Kelley EA, Reddy M, Nerusu KC, Leonard C, Fay K, Chakrabarty S, Varani J.

Br J Cancer. 2005 Dec 12;93(12):1364-71.PMID: 16278666 [PubMed - indexed for MEDLINE]Related articlesFree article

Pomegranate as a cosmeceutical source: pomegranate fractions promote proliferation and procollagen synthesis and inhibit matrix metalloproteinase-1 production in human skin cells.

Aslam MN, Lansky EP, Varani J.

J Ethnopharmacol. 2006 Feb 20;103(3):311-8. Epub 2005 Oct 10.PMID: 16221534 [PubMed - indexed for MEDLINE]Related articles

BP-1107 [{2-[4-(2,4-dioxo-thiazolidin-5-ylmethyl)-phenoxy]-ethyl}-methyl-amide]: a novel synthetic thiazolidinedione that inhibits epidermal hyperplasia in psoriatic skin-severe-combined immunodeficient mouse transplants after topical application.

Bhagavathula N, Nerusu KC, Reddy M, Ellis CN, Chittiboyina A, Avery M, Pershadsingh HA, Kurtz TW, Varani J.

J Pharmacol Exp Ther. 2005 Dec;315(3):996-1004. Epub 2005 Aug 18.PMID: 16109743 [PubMed - indexed for MEDLINE]Related articlesFree article

Matrix metalloproteinase expression in normal skin associated with basal cell carcinoma and in distal skin from the same patients.

Monhian N, Jewett BS, Baker SR, Varani J.

Arch Facial Plast Surg. 2005 Jul-Aug;7(4):238-43.PMID: 16027344 [PubMed - indexed for MEDLINE]Related articlesFree article

Matrix metalloproteinase expression in basal cell carcinoma: relationship between enzyme profile and collagen fragmentation pattern.

Yucel T, Mutnal A, Fay K, Fligiel SE, Wang T, Johnson T, Baker SR, Varani J.

Exp Mol Pathol. 2005 Oct;79(2):151-60.PMID: 16004981 [PubMed - indexed for MEDLINE]Related articles

Pretreatment of diabetic rats with lipoic acid improves healing of subsequently-induced abrasion wounds.

Lateef H, Aslam MN, Stevens MJ, Varani J.

Arch Dermatol Res. 2005 Aug;297(2):75-83. Epub 2005 Oct 8.PMID: 15986218 [PubMed - indexed for MEDLINE]Related articles

Antagonism of epidermal growth factor receptor tyrosine kinase ameliorates the psoriatic phenotype in organ-cultured skin.

Varani J, Lateef H, Fay K, Elder JT.

Skin Pharmacol Physiol. 2005 May-Jun;18(3):123-31.PMID: 15897684 [PubMed - indexed for MEDLINE]Related articles

Amphiregulin and epidermal hyperplasia: amphiregulin is required to maintain the psoriatic phenotype of human skin grafts on severe combined immunodeficient mice.

Bhagavathula N, Nerusu KC, Fisher GJ, Liu G, Thakur AB, Gemmell L, Kumar S, Xu ZH, Hinton P, Tsurushita N, Landolfi NF, Voorhees JJ, Varani J.

Am J Pathol. 2005 Apr;166(4):1009-16.PMID: 15793282 [PubMed - indexed for MEDLINE]Related articlesFree article

PADMA 28: a multi-component herbal preparation with retinoid-like dermal activity but without epidermal effects.

Aslam MN, Fligiel H, Lateef H, Fisher GJ, Ginsburg I, Varani J.

J Invest Dermatol. 2005 Mar;124(3):524-9.PMID: 15737192 [PubMed - indexed for MEDLINE]Related articlesFree article

Topical pretreatment of diabetic rats with all-trans retinoic acid improves healing of subsequently induced abrasion wounds.

Lateef H, Abatan OI, Aslam MN, Stevens MJ, Varani J.

Diabetes. 2005 Mar;54(3):855-61.PMID: 15734865 [PubMed - indexed for MEDLINE]Related articlesFree article

Calcium sensing receptor in human colon carcinoma: interaction with Ca(2+) and 1,25-dihydroxyvitamin D(3).

Chakrabarty S, Wang H, Canaff L, Hendy GN, Appelman H, Varani J.

Cancer Res. 2005 Jan 15;65(2):493-8.PMID: 15695391 [PubMed - indexed for MEDLINE]Related articlesFree article

Role of metalloelastase in a model of allergic lung responses induced by cockroach allergen.

Warner RL, Lukacs NW, Shapiro SD, Bhagarvathula N, Nerusu KC, Varani J, Johnson KJ.

Am J Pathol. 2004 Dec;165(6):1921-30.PMID: 15579436 [PubMed - indexed for MEDLINE]Related articlesFree article

A novel benzodiazepine selectively inhibits keratinocyte proliferation and reduces retinoid-induced epidermal hyperplasia in organ-cultured human skin.

Varani J, Bhagavathula N, Nerusu KC, Sherzer H, Fay K, Boitano AE, Glick GD, Johnson K, Kang S, Opipari AW Jr.

J Pharmacol Exp Ther. 2005 Apr;313(1):56-63. Epub 2004 Dec 2.PMID: 15576471 [PubMed - indexed for MEDLINE]Related articlesFree article

Activity of MDI-301, a novel synthetic retinoid, in xenografts.

Appleyard VC, O'Neill MA, Murray KE, Bray SE, Thomson G, Kernohan NM, Varani J, Zhang J, Thompson AM.

Anticancer Drugs. 2004 Nov;15(10):991-6.PMID: 15514569 [PubMed - indexed for MEDLINE]Related articles

Retinoid-induced epidermal hyperplasia in human skin organ culture: inhibition with soy extract and soy isoflavones.

Varani J, Kelley EA, Perone P, Lateef H.

Exp Mol Pathol. 2004 Dec;77(3):176-83.PMID: 15507233 [PubMed - indexed for MEDLINE]Related articles

Epithelial cell invasion of the stroma in human skin organ culture.

Varani J.

Front Biosci. 2004 Sep 1;9:2989-95. Review.PMID: 15353331 [PubMed - indexed for MEDLINE]Related articles

Marasmius oreades lectin induces renal thrombotic microangiopathic lesions.

Warner RL, Winter HC, Speyer CL, Varani J, Oldstein IJ, Murphy HS, Johnson KJ.

Exp Mol Pathol. 2004 Oct;77(2):77-84.PMID: 15351229 [PubMed - indexed for MEDLINE]Related articles

Alpha-Lipoic acid-based PPARgamma agonists for treating inflammatory skin diseases.

Venkatraman MS, Chittiboyina A, Meingassner J, Ho CI, Varani J, Ellis CN, Avery MA, Pershadsingh HA, Kurtz TW, Benson SC.

Arch Dermatol Res. 2004 Aug;296(3):97-104. Epub 2004 Jun 24.PMID: 15221328 [PubMed - indexed for MEDLINE]Related articles

All-trans-retinoic acid suppresses matrix metalloproteinase activity and increases collagen synthesis in diabetic human skin in organ culture.

Lateef H, Stevens MJ, Varani J.

Am J Pathol. 2004 Jul;165(1):167-74.PMID: 15215172 [PubMed - indexed for MEDLINE]Related articlesFree article

Reduced fibroblast interaction with intact collagen as a mechanism for depressed collagen synthesis in photodamaged skin.

Varani J, Schuger L, Dame MK, Leonard C, Fligiel SE, Kang S, Fisher GJ, Voorhees JJ.

J Invest Dermatol. 2004 Jun;122(6):1471-9.PMID: 15175039 [PubMed - indexed for MEDLINE]Related articlesFree article

Matrix metalloproteinases in acute inflammation: induction of MMP-3 and MMP-9 in fibroblasts and epithelial cells following exposure to pro-inflammatory mediators in vitro.

Warner RL, Bhagavathula N, Nerusu KC, Lateef H, Younkin E, Johnson KJ, Varani J.

Exp Mol Pathol. 2004 Jun;76(3):189-95.PMID: 15126100 [PubMed - indexed for MEDLINE]Related articles