PubMed

S6K1 deficiency protects against apoptosis in hepatocytes.

González-Rodriguez A, Alba J, Zimmerman V, Kozma SC, Valverde AM.

Hepatology. 2009 Jul;50(1):216-29.PMID: 19437488 [PubMed - indexed for MEDLINE]Related articles

Fueling innovation in medical devices (and beyond): venture capital in health care.

Ackerly DC, Valverde AM, Diener LW, Dossary KL, Schulman KA.

Health Aff (Millwood). 2009 Jan-Feb;28(1):w68-75. Epub 2008 Dec 2.PMID: 19049999 [PubMed - indexed for MEDLINE]Related articles

PTP1B deficiency increases glucose uptake in neonatal hepatocytes: involvement of IRA/GLUT2 complexes.

González-Rodriguez A, Nevado C, Escrivá F, Sesti G, Rondinone CM, Benito M, Valverde AM.

Am J Physiol Gastrointest Liver Physiol. 2008 Aug;295(2):G338-47. Epub 2008 Jun 5.PMID: 18535291 [PubMed - indexed for MEDLINE]Related articlesFree article

Role of insulin receptor and balance in insulin receptor isoforms A and B in regulation of apoptosis in simian virus 40-immortalized neonatal hepatocytes.

Nevado C, Benito M, Valverde AM.

Mol Biol Cell. 2008 Mar;19(3):1185-98. Epub 2008 Jan 2.PMID: 18172021 [PubMed - indexed for MEDLINE]Related articlesFree article

Levels of protein tyrosine phosphatase 1B determine susceptibility to apoptosis in serum-deprived hepatocytes.

González-Rodriguez A, Escribano O, Alba J, Rondinone CM, Benito M, Valverde AM.

J Cell Physiol. 2007 Jul;212(1):76-88.PMID: 17323378 [PubMed - indexed for MEDLINE]Related articles

IRS-3 mediates insulin-induced glucose uptake in differentiated IRS-2(-/-) brown adipocytes.

Escribano O, Arribas M, Valverde AM, Benito M.

Mol Cell Endocrinol. 2007 Mar 30;268(1-2):1-9. Epub 2006 Dec 23.PMID: 17316975 [PubMed - indexed for MEDLINE]Related articles

Nuclear forkhead box O1 controls and integrates key signaling pathways in hepatocytes.

Naïmi M, Gautier N, Chaussade C, Valverde AM, Accili D, Van Obberghen E.

Endocrinology. 2007 May;148(5):2424-34. Epub 2007 Feb 15. Erratum in: Endocrinology. 2007 Jul;148(7):3517. PMID: 17303659 [PubMed - indexed for MEDLINE]Related articlesFree article

Protein-tyrosine phosphatase 1B-deficient myocytes show increased insulin sensitivity and protection against tumor necrosis factor-alpha-induced insulin resistance.

Nieto-Vazquez I, Fernández-Veledo S, de Alvaro C, Rondinone CM, Valverde AM, Lorenzo M.

Diabetes. 2007 Feb;56(2):404-13.PMID: 17259385 [PubMed - indexed for MEDLINE]Related articlesFree article

Developmental switch from prolonged insulin action to increased insulin sensitivity in protein tyrosine phosphatase 1B-deficient hepatocytes.

Gonzalez-Rodriguez A, Clampit JE, Escribano O, Benito M, Rondinone CM, Valverde AM.

Endocrinology. 2007 Feb;148(2):594-608. Epub 2006 Oct 26.PMID: 17068137 [PubMed - indexed for MEDLINE]Related articlesFree article

Brief sympathetic activation precedes the development of ventricular tachycardia and ventricular fibrillation in hibernating myocardium.

Pizzuto MF, Valverde AM, Heavey BM, Banas MD, Michelakis N, Suzuki G, Fallavollita JA, Canty JM Jr.

J Electrocardiol. 2006 Oct;39(4 Suppl):S140-5. Epub 2006 Aug 21.PMID: 16919670 [PubMed - indexed for MEDLINE]Related articles

Prediction of arrhythmic events with positron emission tomography: PAREPET study design and methods.

Fallavollita JA, Luisi AJ Jr, Michalek SM, Valverde AM, deKemp RA, Haka MS, Hutson AD, Canty JM Jr.

Contemp Clin Trials. 2006 Aug;27(4):374-88. Epub 2006 May 2.PMID: 16647885 [PubMed - indexed for MEDLINE]Related articles

Role of insulin receptor in the regulation of glucose uptake in neonatal hepatocytes.

Nevado C, Valverde AM, Benito M.

Endocrinology. 2006 Aug;147(8):3709-18. Epub 2006 Apr 27.PMID: 16644916 [PubMed - indexed for MEDLINE]Related articlesFree article

Differential mitogenic signaling in insulin receptor-deficient fetal pancreatic beta-cells.

Guillen C, Navarro P, Robledo M, Valverde AM, Benito M.

Endocrinology. 2006 Apr;147(4):1959-68. Epub 2006 Jan 5.PMID: 16396989 [PubMed - indexed for MEDLINE]Related articlesFree article

The brown adipose cell: a unique model for understanding the molecular mechanism of insulin resistance.

Valverde AM, Benito M.

Mini Rev Med Chem. 2005 Mar;5(3):269-78. Review.PMID: 15777261 [PubMed - indexed for MEDLINE]Related articles

The brown adipose cell: a model for understanding the molecular mechanisms of insulin resistance.

Valverde AM, Benito M, Lorenzo M.

Acta Physiol Scand. 2005 Jan;183(1):59-73. Review.PMID: 15654920 [PubMed - indexed for MEDLINE]Related articles

IRS-2 mediates the antiapoptotic effect of insulin in neonatal hepatocytes.

Valverde AM, Fabregat I, Burks DJ, White MF, Benito M.

Hepatology. 2004 Dec;40(6):1285-94.PMID: 15565601 [PubMed - indexed for MEDLINE]Related articles

Susceptibility to apoptosis in insulin-like growth factor-I receptor-deficient brown adipocytes.

Valverde AM, Mur C, Brownlee M, Benito M.

Mol Biol Cell. 2004 Nov;15(11):5101-17. Epub 2004 Sep 8.PMID: 15356271 [PubMed - indexed for MEDLINE]Related articlesFree article

Transforming growth factor-beta activates both pro-apoptotic and survival signals in fetal rat hepatocytes.

Valdés F, Murillo MM, Valverde AM, Herrera B, Sánchez A, Benito M, Fernández M, Fabregat I.

Exp Cell Res. 2004 Jan 1;292(1):209-18.PMID: 14720520 [PubMed - indexed for MEDLINE]Related articles

Role of IRS-3 in the insulin signaling of IRS-1-deficient brown adipocytes.

Arribas M, Valverde AM, Benito M.

J Biol Chem. 2003 Nov 14;278(46):45189-99. Epub 2003 Aug 27.PMID: 12944402 [PubMed - indexed for MEDLINE]Related articlesFree article

Molecular mechanisms of insulin resistance in IRS-2-deficient hepatocytes.

Valverde AM, Burks DJ, Fabregat I, Fisher TL, Carretero J, White MF, Benito M.

Diabetes. 2003 Sep;52(9):2239-48.PMID: 12941762 [PubMed - indexed for MEDLINE]Related articlesFree article

Essential role of protein kinase C zeta in the impairment of insulin-induced glucose transport in IRS-2-deficient brown adipocytes.

Arribas M, Valverde AM, Burks D, Klein J, Farese RV, White MF, Benito M.

FEBS Lett. 2003 Feb 11;536(1-3):161-6.PMID: 12586357 [PubMed - indexed for MEDLINE]Related articles

Essential role of insulin-like growth factor I receptor in insulin-induced fetal brown adipocyte differentiation.

Mur C, Arribas M, Benito M, Valverde AM.

Endocrinology. 2003 Feb;144(2):581-93.PMID: 12538620 [PubMed - indexed for MEDLINE]Related articlesFree article

Insulin-induced up-regulated uncoupling protein-1 expression is mediated by insulin receptor substrate 1 through the phosphatidylinositol 3-kinase/Akt signaling pathway in fetal brown adipocytes.

Valverde AM, Arribas M, Mur C, Navarro P, Pons S, Cassard-Doulcier AM, Kahn CR, Benito M.

J Biol Chem. 2003 Mar 21;278(12):10221-31. Epub 2003 Jan 13.PMID: 12525499 [PubMed - indexed for MEDLINE]Related articlesFree article

Increased insulin sensitivity in IGF-I receptor--deficient brown adipocytes.

Mur C, Valverde AM, Kahn CR, Benito M.

Diabetes. 2002 Mar;51(3):743-54.PMID: 11872675 [PubMed - indexed for MEDLINE]Related articlesFree article

Brown adipose tissue-specific insulin receptor knockout shows diabetic phenotype without insulin resistance.

Guerra C, Navarro P, Valverde AM, Arribas M, Brüning J, Kozak LP, Kahn CR, Benito M.

J Clin Invest. 2001 Oct;108(8):1205-13.PMID: 11602628 [PubMed - indexed for MEDLINE]Related articlesFree article

Association of insulin receptor substrate 1 (IRS-1) y895 with Grb-2 mediates the insulin signaling involved in IRS-1-deficient brown adipocyte mitogenesis.

Valverde AM, Mur C, Pons S, Alvarez AM, White MF, Kahn CR, Benito M.

Mol Cell Biol. 2001 Apr;21(7):2269-80.PMID: 11259577 [PubMed - indexed for MEDLINE]Related articlesFree article

Insulin produces myogenesis in C2C12 myoblasts by induction of NF-kappaB and downregulation of AP-1 activities.

Conejo R, Valverde AM, Benito M, Lorenzo M.

J Cell Physiol. 2001 Jan;186(1):82-94.PMID: 11147817 [PubMed - indexed for MEDLINE]Related articles

Akt mediates insulin rescue from apoptosis in brown adipocytes: effect of ceramide.

Navarro P, Valverde AM, Rohn JL, Benito M, Lorenzo M.

Growth Horm IGF Res. 2000 Oct;10(5):256-66.PMID: 11042022 [PubMed - indexed for MEDLINE]Related articles

Epidermal growth factor impairs the cytochrome C/caspase-3 apoptotic pathway induced by transforming growth factor beta in rat fetal hepatocytes via a phosphoinositide 3-kinase-dependent pathway.

Fabregat I, Herrera B, Fernández M, Alvarez AM, Sánchez A, Roncero C, Ventura JJ, Valverde AM, Benito M.

Hepatology. 2000 Sep;32(3):528-35.PMID: 10960445 [PubMed - indexed for MEDLINE]Related articles

Okadaic acid inhibits insulin-induced glucose transport in fetal brown adipocytes in an Akt-independent and protein kinase C zeta-dependent manner.

Valverde AM, Lorenzo M, Navarro P, Mur C, Benito M.

FEBS Lett. 2000 Apr 21;472(1):153-8.PMID: 10781824 [PubMed - indexed for MEDLINE]Related articles

Insulin signaling in insulin receptor substrate (IRS)-1-deficient brown adipocytes: requirement of IRS-1 for lipid synthesis.

Valverde AM, Kahn CR, Benito M.

Diabetes. 1999 Nov;48(11):2122-31.PMID: 10535444 [PubMed - indexed for MEDLINE]Related articlesFree article

Activated Ha-ras induces apoptosis by association with phosphorylated Bcl-2 in a mitogen-activated protein kinase-independent manner.

Navarro P, Valverde AM, Benito M, Lorenzo M.

J Biol Chem. 1999 Jul 2;274(27):18857-63.PMID: 10383381 [PubMed - indexed for MEDLINE]Related articlesFree article

Inhibition of caspases rescues brown adipocytes from apoptosis downregulating BCL-XS and upregulating BCL-2 gene expression.

Navarro P, Valverde AM, Conejo R, Benito M, Lorenzo M.

Exp Cell Res. 1999 Feb 1;246(2):301-7.PMID: 9925744 [PubMed - indexed for MEDLINE]Related articles

Insulin and insulin-like growth factor I up-regulate GLUT4 gene expression in fetal brown adipocytes, in a phosphoinositide 3-kinase-dependent manner.

Valverde AM, Navarro P, Teruel T, Conejo R, Benito M, Lorenzo M.

Biochem J. 1999 Feb 1;337 ( Pt 3):397-405.PMID: 9895282 [PubMed - indexed for MEDLINE]Related articlesFree article

H-ras induces glucose uptake in brown adipocytes in an insulin- and phosphatidylinositol 3-kinase-independent manner.

Valverde AM, Navarro P, Benito M, Lorenzo M.

Exp Cell Res. 1998 Sep 15;243(2):274-81.PMID: 9743587 [PubMed - indexed for MEDLINE]Related articles

Insulin/IGF-I rescues immortalized brown adipocytes from apoptosis down-regulating Bcl-xS expression, in a PI 3-kinase- and map kinase-dependent manner.

Navarro P, Valverde AM, Benito M, Lorenzo M.

Exp Cell Res. 1998 Sep 15;243(2):213-21.PMID: 9743581 [PubMed - indexed for MEDLINE]Related articles

Inhibition of PI 3-kinase and RAS blocks IGF-I and insulin-induced uncoupling protein 1 gene expression in brown adipocytes.

Teruel T, Valverde AM, Navarro P, Benito M, Lorenzo M.

J Cell Physiol. 1998 Jul;176(1):99-109.PMID: 9618150 [PubMed - indexed for MEDLINE]Related articles

Insulin receptor substrate (IRS) proteins IRS-1 and IRS-2 differential signaling in the insulin/insulin-like growth factor-I pathways in fetal brown adipocytes.

Valverde AM, Lorenzo M, Pons S, White MF, Benito M.

Mol Endocrinol. 1998 May;12(5):688-97.PMID: 9605931 [PubMed - indexed for MEDLINE]Related articlesFree article

Tumor necrosis factor-alpha causes insulin receptor substrate-2-mediated insulin resistance and inhibits insulin-induced adipogenesis in fetal brown adipocytes.

Valverde AM, Teruel T, Navarro P, Benito M, Lorenzo M.

Endocrinology. 1998 Mar;139(3):1229-38.PMID: 9492058 [PubMed - indexed for MEDLINE]Related articlesFree article

Alterations in the insulin signaling pathway induced by immortalization and H-ras transformation of brown adipocytes.

Valverde AM, Lorenzo M, Teruel T, Benito M.

Endocrinology. 1997 Aug;138(8):3195-206.PMID: 9231768 [PubMed - indexed for MEDLINE]Related articlesFree article

Phosphatidylinositol 3-kinase is a requirement for insulin-like growth factor I-induced differentiation, but not for mitogenesis, in fetal brown adipocytes.

Valverde AM, Lorenzo M, Navarro P, Benito M.

Mol Endocrinol. 1997 May;11(5):595-607.PMID: 9139803 [PubMed - indexed for MEDLINE]Related articlesFree article

Malic enzyme and glucose 6-phosphate dehydrogenase gene expression increases in rat liver cirrhogenesis.

Sanz N, Díez-Fernández C, Valverde AM, Lorenzo M, Benito M, Cascales M.

Br J Cancer. 1997;75(4):487-92.PMID: 9052398 [PubMed - indexed for MEDLINE]Related articlesFree article

Insulin-like growth factor I and insulin induce adipogenic-related gene expression in fetal brown adipocyte primary cultures.

Teruel T, Valverde AM, Benito M, Lorenzo M.

Biochem J. 1996 Oct 15;319 ( Pt 2):627-32.PMID: 8912704 [PubMed - indexed for MEDLINE]Related articlesFree article

Initial expression of phosphoenolpyruvate carboxykinase gene in fetal hepatocytes: role of transcription factors.

Molero C, Valverde AM, Teruel T, Benito M, Lorenzo M.

J Hepatol. 1996 Oct;25(4):510-7.PMID: 8912151 [PubMed - indexed for MEDLINE]Related articles

p21ras induced differentiation-related gene expression in fetal brown adipocyte primary cells and cell lines.

Lorenzo M, Valverde AM, Teruel T, Alvarez A, Benito M.

Cell Growth Differ. 1996 Sep;7(9):1251-9.PMID: 8877105 [PubMed - indexed for MEDLINE]Related articlesFree article

Involvement of Raf-1 kinase and protein kinase C zeta in insulin-like growth factor I-induced brown adipocyte mitogenic signaling cascades: inhibition by cyclic adenosine 3',5'-monophosphate.

Valverde AM, Teruel T, Lorenzo M, Benito M.

Endocrinology. 1996 Sep;137(9):3832-41.PMID: 8756554 [PubMed - indexed for MEDLINE]Related articles

IGF-I: a mitogen also involved in differentiation processes in mammalian cells.

Benito M, Valverde AM, Lorenzo M.

Int J Biochem Cell Biol. 1996 May;28(5):499-510. Review.PMID: 8697095 [PubMed - indexed for MEDLINE]Related articles

Transforming growth factor beta 1 induces mitogenesis in fetal rat brown adipocytes.

Teruel T, Valverde AM, Benito M, Lorenzo M.

J Cell Physiol. 1996 Mar;166(3):577-84.PMID: 8600161 [PubMed - indexed for MEDLINE]Related articles

Protein kinase D (PKD): a novel target for diacylglycerol and phorbol esters.

Rozengurt E, Sinnett-Smith J, Van Lint J, Valverde AM.

Mutat Res. 1995 Dec;333(1-2):153-60. Review.PMID: 8538623 [PubMed - indexed for MEDLINE]Related articles

Differentiation of rat brown adipocytes during late foetal development: role of insulin-like growth factor I.

Teruel T, Valverde AM, Alvarez A, Benito M, Lorenzo M.

Biochem J. 1995 Sep 15;310 ( Pt 3):771-6.PMID: 7575409 [PubMed - indexed for MEDLINE]Related articlesFree article