PubMed

Interplay between PTPN22 C1858T polymorphism and cow's milk formula exposure in type 1 diabetes.

Lempainen J, Vaarala O, Mäkelä M, Veijola R, Simell O, Knip M, Hermann R, Ilonen J.

J Autoimmun. 2009 Sep;33(2):155-64. Epub 2009 May 26.PMID: 19473815 [PubMed - indexed for MEDLINE]Related articles

Activation of T cells in preterm infants with respiratory distress syndrome.

Turunen R, Vaarala O, Nupponen I, Kajantie E, Siitonen S, Lano A, Repo H, Andersson S.

Neonatology. 2009;96(4):248-58. Epub 2009 May 26.PMID: 19468239 [PubMed - in process]Related articles

Breastfeeding stimulates total and cow's milk-specific salivary IgA in infants.

Piirainen L, Pesola J, Pesola I, Komulainen J, Vaarala O.

Pediatr Allergy Immunol. 2009 May;20(3):295-8.PMID: 19438984 [PubMed - indexed for MEDLINE]Related articles

Scientific rationale for the Finnish Allergy Programme 2008-2018: emphasis on prevention and endorsing tolerance.

von Hertzen LC, Savolainen J, Hannuksela M, Klaukka T, Lauerma A, Mäkelä MJ, Pekkanen J, Pietinalho A, Vaarala O, Valovirta E, Vartiainen E, Haahtela T.

Allergy. 2009 May;64(5):678-701. Review.PMID: 19383025 [PubMed - indexed for MEDLINE]Related articles

Leaking gut in type 1 diabetes.

Vaarala O.

Curr Opin Gastroenterol. 2008 Nov;24(6):701-6. Review.PMID: 19122519 [PubMed - indexed for MEDLINE]Related articles

Increased FOXP3 expression in small-bowel mucosa of children with coeliac disease and type I diabetes mellitus.

Vorobjova T, Uibo O, Heilman K, Rägo T, Honkanen J, Vaarala O, Tillmann V, Ojakivi I, Uibo R.

Scand J Gastroenterol. 2009;44(4):422-30.PMID: 19096978 [PubMed - indexed for MEDLINE]Related articles

Poor in vitro induction of FOXP3 and ICOS in type 1 cytokine environment activated T-cells from children with type 1 diabetes.

Honkanen J, Skarsvik S, Knip M, Vaarala O.

Diabetes Metab Res Rev. 2008 Nov-Dec;24(8):635-41.PMID: 18973208 [PubMed - indexed for MEDLINE]Related articles

Lipopolysaccharide-induced immune responses in relation to the TLR4(Asp299Gly) gene polymorphism.

Lundberg A, Wikberg LA, Ilonen J, Vaarala O, Böttcher MF.

Clin Vaccine Immunol. 2008 Dec;15(12):1878-83. Epub 2008 Oct 15.PMID: 18927069 [PubMed - indexed for MEDLINE]Related articlesFree article

GAD treatment and insulin secretion in recent-onset type 1 diabetes.

Ludvigsson J, Faresjö M, Hjorth M, Axelsson S, Chéramy M, Pihl M, Vaarala O, Forsander G, Ivarsson S, Johansson C, Lindh A, Nilsson NO, Aman J, Ortqvist E, Zerhouni P, Casas R.

N Engl J Med. 2008 Oct 30;359(18):1909-20. Epub 2008 Oct 8.PMID: 18843118 [PubMed - indexed for MEDLINE]Related articlesFree article

The "perfect storm" for type 1 diabetes: the complex interplay between intestinal microbiota, gut permeability, and mucosal immunity.

Vaarala O, Atkinson MA, Neu J.

Diabetes. 2008 Oct;57(10):2555-62. Review.PMID: 18820210 [PubMed - indexed for MEDLINE]Related articlesFree article

Effect of HLA genotype or CTLA-4 polymorphism on cytokine response in healthy children.

Walldén J, Ilonen J, Roivainen M, Ludvigsson J, Vaarala O; ABIS Study Group.

Scand J Immunol. 2008 Sep;68(3):345-50.PMID: 18782261 [PubMed - indexed for MEDLINE]Related articles

T-cell reactivity to insulin peptide A1-12 in children with recently diagnosed type 1 diabetes or multiple beta-cell autoantibodies.

Marttila J, Huttunen S, Vaarala O, Suzuki K, Elliott JF, Närvänen A, Knip M, Simell O, Ilonen J.

J Autoimmun. 2008 Sep;31(2):142-8. Epub 2008 Jun 18.PMID: 18565729 [PubMed - indexed for MEDLINE]Related articles

Pre and probiotics in the prevention and treatment of food allergy.

Savilahti E, Kuitunen M, Vaarala O.

Curr Opin Allergy Clin Immunol. 2008 Jun;8(3):243-8. Review.PMID: 18560300 [PubMed - indexed for MEDLINE]Related articles

IL-23/IL-17 immunity as a hallmark of Crohn's disease.

Hölttä V, Klemetti P, Sipponen T, Westerholm-Ormio M, Kociubinski G, Salo H, Räsänen L, Kolho KL, Färkkilä M, Savilahti E, Vaarala O.

Inflamm Bowel Dis. 2008 Sep;14(9):1175-84.PMID: 18512248 [PubMed - indexed for MEDLINE]Related articlesFree article

Enhanced levels of cow's milk antibodies in infancy in children who develop type 1 diabetes later in childhood.

Luopajärvi K, Savilahti E, Virtanen SM, Ilonen J, Knip M, Akerblom HK, Vaarala O.

Pediatr Diabetes. 2008 Oct;9(5):434-41. Epub 2008 May 21.PMID: 18503496 [PubMed - indexed for MEDLINE]Related articles

Effect of Lactobacillus rhamnosus GG on rBet v1 and rMal d1 specific IgA in the saliva of patients with birch pollen allergy.

Piirainen L, Haahtela S, Helin T, Korpela R, Haahtela T, Vaarala O.

Ann Allergy Asthma Immunol. 2008 Apr;100(4):338-42.PMID: 18450119 [PubMed - indexed for MEDLINE]Related articles

Infiltration of forkhead box P3-expressing cells in small intestinal mucosa in coeliac disease but not in type 1 diabetes.

Tiittanen M, Westerholm-Ormio M, Verkasalo M, Savilahti E, Vaarala O.

Clin Exp Immunol. 2008 Jun;152(3):498-507. Epub 2008 Apr 24.PMID: 18435801 [PubMed - indexed for MEDLINE]Related articlesFree article

Relation among mannose-binding lectin 2 genotype, beta-cell autoantibodies, and risk for type 1 diabetes in Finnish children.

Aittoniemi J, Turpeinen H, Tiittanen M, Knip M, Simell O, Ilonen J, Vaarala O.

Hum Immunol. 2008 Feb;69(2):108-11. Epub 2008 Feb 20.PMID: 18361935 [PubMed - indexed for MEDLINE]Related articles

Progression to type 1 diabetes and autoantibody positivity in relation to HLA-risk genotypes in children participating in the ABIS study.

Gullstrand C, Wahlberg J, Ilonen J, Vaarala O, Ludvigsson J.

Pediatr Diabetes. 2008 Jun;9(3 Pt 1):182-90. Epub 2008 Mar 5.PMID: 18331414 [PubMed - indexed for MEDLINE]Related articles

Probiotics in infancy induce protective immune profiles that are characteristic for chronic low-grade inflammation.

Marschan E, Kuitunen M, Kukkonen K, Poussa T, Sarnesto A, Haahtela T, Korpela R, Savilahti E, Vaarala O.

Clin Exp Allergy. 2008 Apr;38(4):611-8. Epub 2008 Feb 11.PMID: 18266878 [PubMed - indexed for MEDLINE]Related articles

Increased activation of GATA-3, IL-2 and IL-5 of cord blood mononuclear cells in infants with IgE sensitization.

Marschan E, Honkanen J, Kukkonen K, Kuitunen M, Savilahti E, Vaarala O.

Pediatr Allergy Immunol. 2008 Mar;19(2):132-9. Epub 2007 Jul 25.PMID: 17651376 [PubMed - indexed for MEDLINE]Related articles

Simvastatin protects against multiple low-dose streptozotocin-induced type 1 diabetes in CD-1 mice and recurrence of disease in nonobese diabetic mice.

Rydgren T, Vaarala O, Sandler S.

J Pharmacol Exp Ther. 2007 Oct;323(1):180-5. Epub 2007 Jul 17.PMID: 17636011 [PubMed - indexed for MEDLINE]Related articlesFree article

Genetic and phenotypic diversity of echovirus 30 strains and pathogenesis of type 1 diabetes.

Paananen A, Savolainen-Kopra C, Kaijalainen S, Vaarala O, Hovi T, Roivainen M.

J Med Virol. 2007 Jul;79(7):945-55.PMID: 17516516 [PubMed - indexed for MEDLINE]Related articles

Two insulin gene single nucleotide polymorphisms associated with type 1 diabetes risk in the Finnish and Swedish populations.

Laine AP, Holmberg H, Nilsson A, Ortqvist E, Kiviniemi M, Vaarala O, Akerblom HK, Simell O, Knip M, Ludvigsson J, Ivarsson SA, Larsson K, Lernmark A, Ilonen J; Finnish Paediatric Diabetes Registry.

Dis Markers. 2007;23(3):139-45.PMID: 17473382 [PubMed - indexed for MEDLINE]Related articlesFree article

Reduced CCR4, interleukin-13 and GATA-3 up-regulation in response to type 2 cytokines of cord blood T lymphocytes in infants at genetic risk of type 1 diabetes.

Luopajärvi K, Skarsvik S, Ilonen J, Akerblom HK, Vaarala O.

Immunology. 2007 Jun;121(2):189-96. Epub 2007 Jan 18.PMID: 17244154 [PubMed - indexed for MEDLINE]Related articlesFree article

Short duration of breast-feeding as a risk-factor for beta-cell autoantibodies in 5-year-old children from the general population.

Holmberg H, Wahlberg J, Vaarala O, Ludvigsson J; ABIS Study Group.

Br J Nutr. 2007 Jan;97(1):111-6.PMID: 17217566 [PubMed - indexed for MEDLINE]Related articles

Probiotics for the prevention of beta cell autoimmunity in children at genetic risk of type 1 diabetes--the PRODIA study.

Ljungberg M, Korpela R, Ilonen J, Ludvigsson J, Vaarala O.

Ann N Y Acad Sci. 2006 Oct;1079:360-4.PMID: 17130579 [PubMed - indexed for MEDLINE]Related articles

Is it dietary insulin?

Vaarala O.

Ann N Y Acad Sci. 2006 Oct;1079:350-9. Review.PMID: 17130578 [PubMed - indexed for MEDLINE]Related articles

Insulin treatment in patients with type 1 diabetes induces upregulation of regulatory T-cell markers in peripheral blood mononuclear cells stimulated with insulin in vitro.

Tiittanen M, Huupponen JT, Knip M, Vaarala O.

Diabetes. 2006 Dec;55(12):3446-54.PMID: 17130491 [PubMed - indexed for MEDLINE]Related articlesFree article

Intestinal cytokine mRNA expression in delayed-type cow's milk allergy.

Paajanen L, Kokkonen J, Karttunen TJ, Tuure T, Korpela R, Vaarala O.

J Pediatr Gastroenterol Nutr. 2006 Oct;43(4):470-6.PMID: 17033521 [PubMed - indexed for MEDLINE]Related articles

Dietary insulin as an immunogen and tolerogen.

Tiittanen M, Paronen J, Savilahti E, Virtanen SM, Ilonen J, Knip M, Akerblom HK, Vaarala O; Finnish TRIGR Study Group.

Pediatr Allergy Immunol. 2006 Nov;17(7):538-43.PMID: 17014631 [PubMed - indexed for MEDLINE]Related articles

Aire deficient mice do not develop the same profile of tissue-specific autoantibodies as APECED patients.

Pöntynen N, Miettinen A, Arstila TP, Kämpe O, Alimohammadi M, Vaarala O, Peltonen L, Ulmanen I.

J Autoimmun. 2006 Sep;27(2):96-104. Epub 2006 Jul 3.PMID: 16820279 [PubMed - indexed for MEDLINE]Related articles

Effect of HLA DQ2, dietary exposure and coeliac disease on the development of antibody response to gliadin in children.

Ludvigsson JF, Eylert M, Ilonen J, Ludvigson J, Vaarala O.

Scand J Gastroenterol. 2006 Aug;41(8):919-28.PMID: 16803690 [PubMed - indexed for MEDLINE]Related articles

The association of CTLA-4 and HLA class II autoimmune risk genotype with regulatory T cell marker expression in 5-year-old children.

Jonson CO, Hedman M, Karlsson Faresjö M, Casas R, Ilonen J, Ludvigsson J, Vaarala O; ABIS Study Group.

Clin Exp Immunol. 2006 Jul;145(1):48-55.PMID: 16792673 [PubMed - indexed for MEDLINE]Related articlesFree article

Enteral virus infections in early childhood and an enhanced type 1 diabetes-associated antibody response to dietary insulin.

Mäkelä M, Vaarala O, Hermann R, Salminen K, Vahlberg T, Veijola R, Hyöty H, Knip M, Simell O, Ilonen J.

J Autoimmun. 2006 Aug;27(1):54-61. Epub 2006 Jun 6.PMID: 16757149 [PubMed - indexed for MEDLINE]Related articles

Long-term effects of weaning habits: type-1 diabetes.

Vaarala O.

Nestle Nutr Workshop Ser Pediatr Program. 2005;56:175-82; discussion 182-4. Review. No abstract available. PMID: 16632952 [PubMed - indexed for MEDLINE]Related articles

Dietary risk factors for the emergence of type 1 diabetes-related autoantibodies in 21/2 year-old Swedish children.

Wahlberg J, Vaarala O, Ludvigsson J; ABIS-study group.

Br J Nutr. 2006 Mar;95(3):603-8.PMID: 16578935 [PubMed - indexed for MEDLINE]Related articles

Diminished IFN-gamma response to diabetes-associated autoantigens in children at diagnosis and during follow up of type 1 diabetes.

Faresjö MK, Vaarala O, Thuswaldner S, Ilonen J, Hinkkanen A, Ludvigsson J.

Diabetes Metab Res Rev. 2006 Nov-Dec;22(6):462-70.PMID: 16572494 [PubMed - indexed for MEDLINE]Related articles

Decreased in vitro type 1 immune response against coxsackie virus B4 in children with type 1 diabetes.

Skarsvik S, Puranen J, Honkanen J, Roivainen M, Ilonen J, Holmberg H, Ludvigsson J, Vaarala O.

Diabetes. 2006 Apr;55(4):996-1003.PMID: 16567521 [PubMed - indexed for MEDLINE]Related articlesFree article

Higher prevalence of autoantibodies to insulin and GAD65 in Swedish compared to Lithuanian children with type 1 diabetes.

Holmberg H, Vaarala O, Sadauskaite-Kuehne V, Ilonen J, Padaiga Z, Ludvigsson J.

Diabetes Res Clin Pract. 2006 Jun;72(3):308-14. Epub 2006 Jan 26.PMID: 16442659 [PubMed - indexed for MEDLINE]Related articles

Environmental factors related to the induction of beta-cell autoantibodies in 1-yr-old healthy children.

Wahlberg J, Fredriksson J, Nikolic E, Vaarala O, Ludvigsson J; ABIS-Study Group.

Pediatr Diabetes. 2005 Dec;6(4):199-205.PMID: 16390388 [PubMed - indexed for MEDLINE]Related articles

Cow milk is not responsible for most gastrointestinal immune-like syndromes--evidence from a population-based study.

Paajanen L, Korpela R, Tuure T, Honkanen J, Järvelä I, Ilonen J, Knip M, Vaarala O, Kokkonen J.

Am J Clin Nutr. 2005 Dec;82(6):1327-35.PMID: 16332667 [PubMed - indexed for MEDLINE]Related articlesFree article

Environmental triggers and determinants of type 1 diabetes.

Knip M, Veijola R, Virtanen SM, Hyöty H, Vaarala O, Akerblom HK.

Diabetes. 2005 Dec;54 Suppl 2:S125-36. Review.PMID: 16306330 [PubMed - indexed for MEDLINE]Related articlesFree article

IgA antibodies, TGF-beta1 and -beta2, and soluble CD14 in the colostrum and development of atopy by age 4.

Savilahti E, Siltanen M, Kajosaari M, Vaarala O, Saarinen KM.

Pediatr Res. 2005 Dec;58(6):1300-5.PMID: 16306212 [PubMed - indexed for MEDLINE]Related articles

Is type 1 diabetes a disease of the gut immune system triggered by cow's milk insulin?

Vaarala O.

Adv Exp Med Biol. 2005;569:151-6. Review.PMID: 16137120 [PubMed - indexed for MEDLINE]Related articles

Increased IFN-gamma secretion from duodenal biopsy samples in delayed-type cow's milk allergy.

Paajanen L, Vaarala O, Karttunen R, Tuure T, Korpela R, Kokkonen J.

Pediatr Allergy Immunol. 2005 Aug;16(5):439-44.PMID: 16101938 [PubMed - indexed for MEDLINE]Related articles

Innate immune responses in Lyme borreliosis: enhanced tumour necrosis factor-alpha and interleukin-12 in asymptomatic individuals in response to live spirochetes.

Sjöwall J, Carlsson A, Vaarala O, Bergström S, Ernerudh J, Forsberg P, Ekerfelt C.

Clin Exp Immunol. 2005 Jul;141(1):89-98.PMID: 15958074 [PubMed - indexed for MEDLINE]Related articlesFree article

Induction of inflammation as a possible mechanism of probiotic effect in atopic eczema-dermatitis syndrome.

Viljanen M, Pohjavuori E, Haahtela T, Korpela R, Kuitunen M, Sarnesto A, Vaarala O, Savilahti E.

J Allergy Clin Immunol. 2005 Jun;115(6):1254-9.PMID: 15940143 [PubMed - indexed for MEDLINE]Related articles

Dietary manipulation of beta cell autoimmunity in infants at increased risk of type 1 diabetes: a pilot study.

Akerblom HK, Virtanen SM, Ilonen J, Savilahti E, Vaarala O, Reunanen A, Teramo K, Hämäläinen AM, Paronen J, Riikjärv MA, Ormisson A, Ludvigsson J, Dosch HM, Hakulinen T, Knip M; National TRIGR Study Groups.

Diabetologia. 2005 May;48(5):829-37. Epub 2005 Apr 19. Erratum in: Diabetologia. 2005 Aug;48(8):1676. Riikjärv, MA [added]; Ormisson, A [added]; Ludvigsson, J [added]; Dosch, HM [added]; Hakulinen, T [added]; Knip, M [added]. PMID: 15838685 [PubMed - indexed for MEDLINE]Related articles

Psychological stress may induce diabetes-related autoimmunity in infancy.

Sepa A, Wahlberg J, Vaarala O, Frodi A, Ludvigsson J.

Diabetes Care. 2005 Feb;28(2):290-5.PMID: 15677781 [PubMed - indexed for MEDLINE]Related articlesFree article