PubMed

The crystal structure of cobra venom factor, a cofactor for C3- and C5-convertase CVFBb.

Krishnan V, Ponnuraj K, Xu Y, Macon K, Volanakis JE, Narayana SV.

Structure. 2009 Apr 15;17(4):611-9.PMID: 19368894 [PubMed - indexed for MEDLINE]Related articles

The structure of C2b, a fragment of complement component C2 produced during C3 convertase formation.

Krishnan V, Xu Y, Macon K, Volanakis JE, Narayana SV.

Acta Crystallogr D Biol Crystallogr. 2009 Mar;65(Pt 3):266-74. Epub 2009 Feb 20.PMID: 19237749 [PubMed - indexed for MEDLINE]Related articles

The crystal structure of C2a, the catalytic fragment of classical pathway C3 and C5 convertase of human complement.

Krishnan V, Xu Y, Macon K, Volanakis JE, Narayana SV.

J Mol Biol. 2007 Mar 16;367(1):224-33. Epub 2006 Dec 19.PMID: 17234210 [PubMed - indexed for MEDLINE]Related articlesFree article

The structure of complement C3b provides insights into complement activation and regulation.

Abdul Ajees A, Gunasekaran K, Volanakis JE, Narayana SV, Kotwal GJ, Murthy HM.

Nature. 2006 Nov 9;444(7116):221-5. Epub 2006 Oct 15.PMID: 17051152 [PubMed - indexed for MEDLINE]Related articles

A novel human complement-related protein, C1r-like protease (C1r-LP), specifically cleaves pro-C1s.

Ligoudistianou C, Xu Y, Garnier G, Circolo A, Volanakis JE.

Biochem J. 2005 Apr 1;387(Pt 1):165-73.PMID: 15527420 [PubMed - indexed for MEDLINE]Related articlesFree article

Structural analysis of engineered Bb fragment of complement factor B: insights into the activation mechanism of the alternative pathway C3-convertase.

Ponnuraj K, Xu Y, Macon K, Moore D, Volanakis JE, Narayana SV.

Mol Cell. 2004 Apr 9;14(1):17-28.PMID: 15068800 [PubMed - indexed for MEDLINE]Related articles

Delayed lupus onset in (NZB x NZW)F1 mice expressing a human C-reactive protein transgene.

Szalai AJ, Weaver CT, McCrory MA, van Ginkel FW, Reiman RM, Kearney JF, Marion TN, Volanakis JE.

Arthritis Rheum. 2003 Jun;48(6):1602-11.PMID: 12794828 [PubMed - indexed for MEDLINE]Related articlesFree article

A novel murine complement-related gene encoding a C1r-like serum protein.

Circolo A, Garnier G, Volanakis JE.

Mol Immunol. 2003 May;39(14):899-906.PMID: 12686506 [PubMed - indexed for MEDLINE]Related articles

Complement C1r and C1s genes are duplicated in the mouse: differential expression generates alternative isomorphs in the liver and in the male reproductive system.

Garnier G, Circolo A, Xu Y, Volanakis JE.

Biochem J. 2003 Apr 15;371(Pt 2):631-40.PMID: 12513694 [PubMed - indexed for MEDLINE]Related articlesFree article

Determining alleles of the C2 gene by Southern Blotting.

Zhu ZB, Volanakis JE.

Methods Mol Biol. 2003;210:259-68. No abstract available. PMID: 12412460 [PubMed - indexed for MEDLINE]Related articles

Structure, function and molecular genetics of human and murine C1r.

Arlaud GJ, Gaboriaud C, Garnier G, Circolo A, Thielens NM, Budayova-Spano M, Fontecilla-Camps JC, Volanakis JE.

Immunobiology. 2002 Sep;205(4-5):365-82. Review.PMID: 12396000 [PubMed - indexed for MEDLINE]Related articles

The three-dimensional structure of calcium-depleted human C-reactive protein from perfectly twinned crystals.

Ramadan MA, Shrive AK, Holden D, Myles DA, Volanakis JE, DeLucas LJ, Greenhough TJ.

Acta Crystallogr D Biol Crystallogr. 2002 Jun;58(Pt 6 Pt 2):992-1001. Epub 2002 May 29.PMID: 12037301 [PubMed - indexed for MEDLINE]Related articles

The role of complement in innate and adaptive immunity.

Volanakis JE.

Curr Top Microbiol Immunol. 2002;266:41-56. Review. No abstract available. PMID: 12014202 [PubMed - indexed for MEDLINE]Related articles

Calnexin is associated with and induced by overexpressed human complement protein C2.

Tsukamoto H, Tousson A, Circolo A, Marchase RB, Volanakis JE.

Anat Rec. 2002 May 1;267(1):7-16.PMID: 11984787 [PubMed - indexed for MEDLINE]Related articlesFree article

Complement activation in factor D-deficient mice.

Xu Y, Ma M, Ippolito GC, Schroeder HW Jr, Carroll MC, Volanakis JE.

Proc Natl Acad Sci U S A. 2001 Dec 4;98(25):14577-82. Epub 2001 Nov 27.PMID: 11724962 [PubMed - indexed for MEDLINE]Related articlesFree article

Human C-reactive protein: expression, structure, and function.

Volanakis JE.

Mol Immunol. 2001 Aug;38(2-3):189-97. Review.PMID: 11532280 [PubMed - indexed for MEDLINE]Related articles

Structural biology of the alternative pathway convertase.

Xu Y, Narayana SV, Volanakis JE.

Immunol Rev. 2001 Apr;180:123-35. Review.PMID: 11414354 [PubMed - indexed for MEDLINE]Related articles

Topology and structure of the C1q-binding site on C-reactive protein.

Agrawal A, Shrive AK, Greenhough TJ, Volanakis JE.

J Immunol. 2001 Mar 15;166(6):3998-4004.PMID: 11238646 [PubMed - indexed for MEDLINE]Related articlesFree article

Human C-reactive protein is protective against fatal Salmonella enterica serovar typhimurium infection in transgenic mice.

Szalai AJ, VanCott JL, McGhee JR, Volanakis JE, Benjamin WH Jr.

Infect Immun. 2000 Oct;68(10):5652-6.PMID: 10992466 [PubMed - indexed for MEDLINE]Related articlesFree article

Complement-dependent acute-phase expression of C-reactive protein and serum amyloid P-component.

Szalai AJ, van Ginkel FW, Wang Y, McGhee JR, Volanakis JE.

J Immunol. 2000 Jul 15;165(2):1030-5.PMID: 10878380 [PubMed - indexed for MEDLINE]Related articlesFree article

New structural motifs on the chymotrypsin fold and their potential roles in complement factor B.

Jing H, Xu Y, Carson M, Moore D, Macon KJ, Volanakis JE, Narayana SV.

EMBO J. 2000 Jan 17;19(2):164-73.PMID: 10637221 [PubMed - indexed for MEDLINE]Related articlesFree article

High prevalence of complement component C6 deficiency among African-Americans in the south-eastern USA.

Zhu Z, Atkinson TP, Hovanky KT, Boppana SB, Dai YL, Densen P, Go RC, Jablecki JS, Volanakis JE.

Clin Exp Immunol. 2000 Feb;119(2):305-10.PMID: 10632667 [PubMed - indexed for MEDLINE]Related articlesFree article

Mutational analysis of the primary substrate specificity pocket of complement factor B. Asp(226) is a major structural determinant for p(1)-Arg binding.

Xu Y, Circolo A, Jing H, Wang Y, Narayana SV, Volanakis JE.

J Biol Chem. 2000 Jan 7;275(1):378-85.PMID: 10617628 [PubMed - indexed for MEDLINE]Related articlesFree article

The Arthus reaction in rodents: species-specific requirement of complement.

Szalai AJ, Digerness SB, Agrawal A, Kearney JF, Bucy RP, Niwas S, Kilpatrick JM, Babu YS, Volanakis JE.

J Immunol. 2000 Jan 1;164(1):463-8.PMID: 10605043 [PubMed - indexed for MEDLINE]Related articlesFree article

Genetic disruption of the murine complement C3 promoter region generates deficient mice with extrahepatic expression of C3 mRNA.

Circolo A, Garnier G, Fukuda W, Wang X, Hidvegi T, Szalai AJ, Briles DE, Volanakis JE, Wetsel RA, Colten HR.

Immunopharmacology. 1999 May;42(1-3):135-49.PMID: 10408374 [PubMed - indexed for MEDLINE]Related articles

C-reactive protein: structural biology and host defense function.

Szalai AJ, Agrawal A, Greenhough TJ, Volanakis JE.

Clin Chem Lab Med. 1999 Mar;37(3):265-70. Review.PMID: 10353470 [PubMed - indexed for MEDLINE]Related articles

The evolution, structure, biology and pathophysiology of complement.

Lambris JD, Reid KB, Volanakis JE.

Immunol Today. 1999 May;20(5):207-11. No abstract available. PMID: 10322298 [PubMed - indexed for MEDLINE]Related articles

Structural basis of profactor D activation: from a highly flexible zymogen to a novel self-inhibited serine protease, complement factor D.

Jing H, Macon KJ, Moore D, DeLucas LJ, Volanakis JE, Narayana SV.

EMBO J. 1999 Feb 15;18(4):804-14.PMID: 10022823 [PubMed - indexed for MEDLINE]Related articlesFree article

Structures of native and complexed complement factor D: implications of the atypical His57 conformation and self-inhibitory loop in the regulation of specific serine protease activity.

Jing H, Babu YS, Moore D, Kilpatrick JM, Liu XY, Volanakis JE, Narayana SV.

J Mol Biol. 1998 Oct 9;282(5):1061-81.PMID: 9753554 [PubMed - indexed for MEDLINE]Related articles

A novel type II complement C2 deficiency allele in an African-American family.

Zhu ZB, Atkinson TP, Volanakis JE.

J Immunol. 1998 Jul 15;161(2):578-84.PMID: 9670930 [PubMed - indexed for MEDLINE]Related articlesFree article

The atypical serine proteases of the complement system.

Arlaud GJ, Volanakis JE, Thielens NM, Narayana SV, Rossi V, Xu Y.

Adv Immunol. 1998;69:249-307. Review. No abstract available. PMID: 9646846 [PubMed - indexed for MEDLINE]Related articles

Testosterone and IL-6 requirements for human C-reactive protein gene expression in transgenic mice.

Szalai AJ, van Ginkel FW, Dalrymple SA, Murray R, McGhee JR, Volanakis JE.

J Immunol. 1998 Jun 1;160(11):5294-9.PMID: 9605127 [PubMed - indexed for MEDLINE]Related articlesFree article

Susceptibility locus for IgA deficiency and common variable immunodeficiency in the HLA-DR3, -B8, -A1 haplotypes.

Schroeder HW Jr, Zhu ZB, March RE, Campbell RD, Berney SM, Nedospasov SA, Turetskaya RL, Atkinson TP, Go RC, Cooper MD, Volanakis JE.

Mol Med. 1998 Feb;4(2):72-86.PMID: 9508785 [PubMed - indexed for MEDLINE]Related articlesFree article

Molecular defects leading to human complement component C6 deficiency in an African-American family.

Zhu ZB, Totemchokchyakarn K, Atkinson TP, Volanakis JE.

Clin Exp Immunol. 1998 Jan;111(1):91-6.PMID: 9472666 [PubMed - indexed for MEDLINE]Related articlesFree article

Evaluation of IgA deficiency in Sardinians indicates a susceptibility gene is encoded within the HLA class III region.

Cucca F, Zhu ZB, Khanna A, Cossu F, Congia M, Badiali M, Lampis R, Frau F, De Virgiliis S, Cao A, Arnone M, Piras P, Campbell RD, Cooper MD, Volanakis JE, Powis SH.

Clin Exp Immunol. 1998 Jan;111(1):76-80.PMID: 9472664 [PubMed - indexed for MEDLINE]Related articlesFree article

Contribution of the complement control protein modules of C2 in C4b binding assessed by analysis of C2/factor B chimeras.

Xu Y, Volanakis JE.

J Immunol. 1997 Jun 15;158(12):5958-65.PMID: 9190950 [PubMed - indexed for MEDLINE]Related articles

Surface loops adjacent to the cation-binding site of the complement factor B von Willebrand factor type A module determine C3b binding specificity.

Tuckwell DS, Xu Y, Newham P, Humphries MJ, Volanakis JE.

Biochemistry. 1997 Jun 3;36(22):6605-13.PMID: 9184140 [PubMed - indexed for MEDLINE]Related articles

Age-related changes in serum immunoglobulins in patients with familial IgA deficiency and common variable immunodeficiency (CVID).

Johnson ML, Keeton LG, Zhu ZB, Volanakis JE, Cooper MD, Schroeder HW Jr.

Clin Exp Immunol. 1997 Jun;108(3):477-83.PMID: 9182895 [PubMed - indexed for MEDLINE]Related articlesFree article

Structure of diisopropyl fluorophosphate-inhibited factor D.

Cole LB, Chu N, Kilpatrick JM, Volanakis JE, Narayana SV, Babu YS.

Acta Crystallogr D Biol Crystallogr. 1997 Mar 1;53(Pt 2):143-50.PMID: 15299948 [PubMed]Related articles

C-reactive protein: structural biology, gene expression, and host defense function.

Szalai AJ, Agrawal A, Greenhough TJ, Volanakis JE.

Immunol Res. 1997;16(2):127-36. Review.PMID: 9212359 [PubMed - indexed for MEDLINE]Related articles

Site-directed mutagenesis of the phosphocholine-binding site of human C-reactive protein: role of Thr76 and Trp67.

Agrawal A, Lee S, Carson M, Narayana SV, Greenhough TJ, Volanakis JE.

J Immunol. 1997 Jan 1;158(1):345-50.PMID: 8977209 [PubMed - indexed for MEDLINE]Related articles

Genetic bases of human complement C7 deficiency.

Nishizaka H, Horiuchi T, Zhu ZB, Fukumori Y, Volanakis JE.

J Immunol. 1996 Nov 1;157(9):4239-43.PMID: 8892662 [PubMed - indexed for MEDLINE]Related articles

Role of complement in C-reactive-protein-mediated protection of mice from Streptococcus pneumoniae.

Szalai AJ, Briles DE, Volanakis JE.

Infect Immun. 1996 Nov;64(11):4850-3.PMID: 8890251 [PubMed - indexed for MEDLINE]Related articlesFree article

Down-regulation of secretion of human complement component C2 by the product of an alternatively spliced C2 messenger RNA.

Tsukamoto H, Tousson A, Marchase RB, Volanakis JE.

J Immunol. 1996 Jun 15;156(12):4901-8.PMID: 8648140 [PubMed - indexed for MEDLINE]Related articles

Complement factor D, a novel serine protease.

Volanakis JE, Narayana SV.

Protein Sci. 1996 Apr;5(4):553-64. Review.PMID: 8845746 [PubMed - indexed for MEDLINE]Related articlesFree article

Three dimensional structure of human C-reactive protein.

Shrive AK, Cheetham GM, Holden D, Myles DA, Turnell WG, Volanakis JE, Pepys MB, Bloomer AC, Greenhough TJ.

Nat Struct Biol. 1996 Apr;3(4):346-54.PMID: 8599761 [PubMed - indexed for MEDLINE]Related articles

Molecular bases for inherited human complement component C6 deficiency in two unrelated individuals.

Nishizaka H, Horiuchi T, Zhu ZB, Fukumori Y, Nagasawa K, Hayashi K, Krumdieck R, Cobbs CG, Higuchi M, Yasunaga S, Niho Y, Volanakis JE.

J Immunol. 1996 Mar 15;156(6):2309-15.PMID: 8690922 [PubMed - indexed for MEDLINE]Related articles

Crystal structure of a complement factor D mutant expressing enhanced catalytic activity.

Kim S, Narayana SV, Volanakis JE.

J Biol Chem. 1995 Oct 13;270(41):24399-405. Erratum in: J Biol Chem 1995 Dec 29;270(52):31414. PMID: 7592653 [PubMed - indexed for MEDLINE]Related articlesFree article

Human C-reactive protein is protective against fatal Streptococcus pneumoniae infection in transgenic mice.

Szalai AJ, Briles DE, Volanakis JE.

J Immunol. 1995 Sep 1;155(5):2557-63.PMID: 7650385 [PubMed - indexed for MEDLINE]Related articles

Catalytic role of a surface loop of the complement serine protease factor D.

Kim S, Narayana SV, Volanakis JE.

J Immunol. 1995 Jun 1;154(11):6073-9.PMID: 7751649 [PubMed - indexed for MEDLINE]Related articles