PubMed

Pharmacokinetic and Pharmacodynamic Modeling of a Monoclonal Antibody Antagonist of Glucagon Receptor in Male ob/ob Mice.

Lau YY, Ma P, Gibiansky L, Komorowski R, Wang J, Wang G, Yan H, Véniant MM, Kakkar T.

AAPS J. 2009 Oct 23. [Epub ahead of print]PMID: 19851873 [PubMed - as supplied by publisher]Related articles

Inhibition of lipolysis may contribute to the acute regulation of plasma FFA and glucose by FGF21 in ob/ob mice.

Li X, Ge H, Weiszmann J, Hecht R, Li YS, Véniant MM, Xu J, Wu X, Lindberg R, Li Y.

FEBS Lett. 2009 Oct 6;583(19):3230-4. Epub 2009 Sep 12.PMID: 19751733 [PubMed - indexed for MEDLINE]Related articles

Long-Term Inhibition of the Glucagon Receptor with a Monoclonal Antibody in Mice Causes Sustained Improvement in Glycemic Control, with Reversible {alpha}-Cell Hyperplasia and Hyperglucagonemia.

Gu W, Yan H, Winters KA, Komorowski R, Vonderfecht S, Atangan L, Sivits G, Hill D, Yang J, Bi V, Shen Y, Hu S, Boone T, Lindberg RA, Véniant MM.

J Pharmacol Exp Ther. 2009 Dec;331(3):871-81. Epub 2009 Aug 31.PMID: 19720878 [PubMed - in process]Related articlesFree article

Acute glucose-lowering and insulin-sensitizing action of FGF21 in insulin resistant mouse models----Association with liver and adipose tissue effects.

Xu J, Stanislaus S, Chinookoswong N, Lau YY, Hager T, Patel J, Ge H, Weiszmann J, Lu SC, Graham M, Busby J, Hecht R, Li YS, Li Y, Lindberg RA, Véniant MM.

Am J Physiol Endocrinol Metab. 2009 Aug 25. [Epub ahead of print]PMID: 19706786 [PubMed - as supplied by publisher]Related articles

Antidiabetic effects of 11beta-HSD1 inhibition in a mouse model of combined diabetes, dyslipidaemia and atherosclerosis.

Lloyd DJ, Helmering J, Cordover D, Bowsman M, Chen M, Hale C, Fordstrom P, Zhou M, Wang M, Kaufman SA, Véniant MM.

Diabetes Obes Metab. 2009 Jul;11(7):688-99.PMID: 19527482 [PubMed - in process]Related articles

Pancreatic islet expression profiling in diabetes-prone C57BLKS/J mice reveals transcriptional differences contributed by DBA loci, including Plagl1 and Nnt.

Anderson AA, Helmering J, Juan T, Li CM, McCormick J, Graham M, Baker DM, Damore MA, Véniant MM, Lloyd DJ.

Pathogenetics. 2009 Jan 22;2(1):1.PMID: 19161594 [PubMed - in process]Related articlesFree article

Fully human monoclonal antibodies antagonizing the glucagon receptor improve glucose homeostasis in mice and monkeys.

Yan H, Gu W, Yang J, Bi V, Shen Y, Lee E, Winters KA, Komorowski R, Zhang C, Patel JJ, Caughey D, Elliott GS, Lau YY, Wang J, Li YS, Boone T, Lindberg RA, Hu S, Véniant MM.

J Pharmacol Exp Ther. 2009 Apr;329(1):102-11. Epub 2009 Jan 7.PMID: 19129372 [PubMed - indexed for MEDLINE]Related articles

Identification of three loci affecting HDL-cholesterol levels in a screen for chemically induced recessive mutations in mice.

Juan T, Véniant MM, Helmering J, Babij P, Baker DM, Damore MA, Bass MB, Gyuris T, Chhoa M, Li CM, Ebeling C, Amato J, Carlson GA, Lloyd DJ.

J Lipid Res. 2009 Mar;50(3):534-45. Epub 2008 Oct 29.PMID: 18974039 [PubMed - indexed for MEDLINE]Related articles

Fibroblast growth factor 21 reverses hepatic steatosis, increases energy expenditure, and improves insulin sensitivity in diet-induced obese mice.

Xu J, Lloyd DJ, Hale C, Stanislaus S, Chen M, Sivits G, Vonderfecht S, Hecht R, Li YS, Lindberg RA, Chen JL, Jung DY, Zhang Z, Ko HJ, Kim JK, Véniant MM.

Diabetes. 2009 Jan;58(1):250-9. Epub 2008 Oct 7.PMID: 18840786 [PubMed - indexed for MEDLINE]Related articlesFree article

Time of the day for 11beta-HSD1 inhibition plays a role in improving glucose homeostasis in DIO mice.

Véniant MM, Hale C, Komorowski R, Chen MM, St Jean DJ, Fotsch C, Wang M.

Diabetes Obes Metab. 2009 Feb;11(2):109-17. Epub 2008 May 12.PMID: 18479468 [PubMed - indexed for MEDLINE]Related articles

Design and synthesis of conformationally constrained glucagon-like peptide-1 derivatives with increased plasma stability and prolonged in vivo activity.

Miranda LP, Winters KA, Gegg CV, Patel A, Aral J, Long J, Zhang J, Diamond S, Guido M, Stanislaus S, Ma M, Li H, Rose MJ, Poppe L, Véniant MM.

J Med Chem. 2008 May 8;51(9):2758-65. Epub 2008 Apr 15.PMID: 18412318 [PubMed - indexed for MEDLINE]Related articles

An optimized fast-performance liquid chromatography method for analyzing lipoprotein profiles using microliter volumes of serum.

Kim KW, McCormick J, Helmering J, Véniant MM, Wang M.

Anal Biochem. 2008 May 15;376(2):268-74. Epub 2008 Mar 4.PMID: 18358227 [PubMed - indexed for MEDLINE]Related articles

Lipoprotein size and susceptibility to atherosclerosis--insights from genetically modified mouse models.

Véniant MM, Beigneux AP, Bensadoun A, Fong LG, Young SG.

Curr Drug Targets. 2008 Mar;9(3):174-89. Review.PMID: 18336235 [PubMed - indexed for MEDLINE]Related articles

Generation and characterization of two novel mouse models exhibiting the phenotypes of the metabolic syndrome: Apob48-/-Lepob/ob mice devoid of ApoE or Ldlr.

Lloyd DJ, McCormick J, Helmering J, Kim KW, Wang M, Fordstrom P, Kaufman SA, Lindberg RA, Véniant MM.

Am J Physiol Endocrinol Metab. 2008 Mar;294(3):E496-505. Epub 2007 Dec 26.PMID: 18160459 [PubMed - indexed for MEDLINE]Related articlesFree article

Co-receptor requirements for fibroblast growth factor-19 signaling.

Wu X, Ge H, Gupte J, Weiszmann J, Shimamoto G, Stevens J, Hawkins N, Lemon B, Shen W, Xu J, Veniant MM, Li YS, Lindberg R, Chen JL, Tian H, Li Y.

J Biol Chem. 2007 Oct 5;282(40):29069-72. Epub 2007 Aug 21.PMID: 17711860 [PubMed - indexed for MEDLINE]Related articlesFree article

Targeting foxo1 in mice using antisense oligonucleotide improves hepatic and peripheral insulin action.

Samuel VT, Choi CS, Phillips TG, Romanelli AJ, Geisler JG, Bhanot S, McKay R, Monia B, Shutter JR, Lindberg RA, Shulman GI, Veniant MM.

Diabetes. 2006 Jul;55(7):2042-50.PMID: 16804074 [PubMed - indexed for MEDLINE]Related articlesFree article

Leptin: from animals to humans.

Veniant MM, LeBel CP.

Curr Pharm Des. 2003;9(10):811-8. Review.PMID: 12678880 [PubMed - indexed for MEDLINE]Related articles

Lipoprotein size and atherosclerosis susceptibility in Apoe(-/-) and Ldlr(-/-) mice.

Véniant MM, Withycombe S, Young SG.

Arterioscler Thromb Vasc Biol. 2001 Oct;21(10):1567-70. Review.PMID: 11597927 [PubMed - indexed for MEDLINE]Related articlesFree article

Defining the atherogenicity of large and small lipoproteins containing apolipoprotein B100.

Véniant MM, Sullivan MA, Kim SK, Ambroziak P, Chu A, Wilson MD, Hellerstein MK, Rudel LL, Walzem RL, Young SG.

J Clin Invest. 2000 Dec;106(12):1501-10.PMID: 11120757 [PubMed - indexed for MEDLINE]Related articlesFree article

A deficiency of microsomal triglyceride transfer protein reduces apolipoprotein B secretion.

Leung GK, Véniant MM, Kim SK, Zlot CH, Raabe M, Björkegren J, Neese RA, Hellerstein MK, Young SG.

J Biol Chem. 2000 Mar 17;275(11):7515-20.PMID: 10713055 [PubMed - indexed for MEDLINE]Related articlesFree article

Lipoproteins containing apolipoprotein B-100 are secreted by the heart.

Véniant MM, Nielsen LB, Borén J, Young SG.

Trends Cardiovasc Med. 1999 Apr-May;9(3-4):103-7. Review.PMID: 10578525 [PubMed - indexed for MEDLINE]Related articles

Renal vascular and biochemical responses to systemic renin inhibition in dogs at low renal perfusion pressure.

Clozel JP, Véniant MM, Qiu C, Sprecher U, Wolfgang R, Fischli W.

J Cardiovasc Pharmacol. 1999 Nov;34(5):674-82.PMID: 10547083 [PubMed - indexed for MEDLINE]Related articles

Analysis of the role of microsomal triglyceride transfer protein in the liver of tissue-specific knockout mice.

Raabe M, Véniant MM, Sullivan MA, Zlot CH, Björkegren J, Nielsen LB, Wong JS, Hamilton RL, Young SG.

J Clin Invest. 1999 May;103(9):1287-98.PMID: 10225972 [PubMed - indexed for MEDLINE]Related articlesFree article

Insights into apolipoprotein B biology from transgenic and gene-targeted mice.

Véniant MM, Kim E, McCormick S, Borén J, Nielsen LB, Raabe M, Young SG.

J Nutr. 1999 Feb;129(2S Suppl):451S-455S. Review.PMID: 10064308 [PubMed - indexed for MEDLINE]Related articlesFree article

Generation of monoclonal antibodies specific for mouse apolipoprotein B-100 in apolipoprotein B-48-only mice.

Zlot CH, Flynn LM, Véniant MM, Kim E, Raabe M, McCormick SP, Ambroziak P, McEvoy LM, Young SG.

J Lipid Res. 1999 Jan;40(1):76-84.PMID: 9869652 [PubMed - indexed for MEDLINE]Related articlesFree article

A gene-targeted mouse model for familial hypobetalipoproteinemia. Low levels of apolipoprotein B mRNA in association with a nonsense mutation in exon 26 of the apolipoprotein B gene.

Kim E, Ambroziak P, Véniant MM, Hamilton RL, Young SG.

J Biol Chem. 1998 Dec 18;273(51):33977-84.PMID: 9852051 [PubMed - indexed for MEDLINE]Related articlesFree article

Lipoprotein clearance mechanisms in LDL receptor-deficient "Apo-B48-only" and "Apo-B100-only" mice.

Véniant MM, Zlot CH, Walzem RL, Pierotti V, Driscoll R, Dichek D, Herz J, Young SG.

J Clin Invest. 1998 Oct 15;102(8):1559-68.PMID: 9788969 [PubMed - indexed for MEDLINE]Related articlesFree article

Knockout of the abetalipoproteinemia gene in mice: reduced lipoprotein secretion in heterozygotes and embryonic lethality in homozygotes.

Raabe M, Flynn LM, Zlot CH, Wong JS, Véniant MM, Hamilton RL, Young SG.

Proc Natl Acad Sci U S A. 1998 Jul 21;95(15):8686-91.PMID: 9671739 [PubMed - indexed for MEDLINE]Related articlesFree article

Dual mechanisms for the low plasma levels of truncated apolipoprotein B proteins in familial hypobetalipoproteinemia. Analysis of a new mouse model with a nonsense mutation in the Apob gene.

Kim E, Cham CM, Véniant MM, Ambroziak P, Young SG.

J Clin Invest. 1998 Mar 15;101(6):1468-77.PMID: 9502790 [PubMed - indexed for MEDLINE]Related articlesFree article

Apo B100-containing lipoproteins are secreted by the heart.

Borén J, Véniant MM, Young SG.

J Clin Invest. 1998 Mar 15;101(6):1197-202.PMID: 9502759 [PubMed - indexed for MEDLINE]Related articlesFree article

Susceptibility to atherosclerosis in mice expressing exclusively apolipoprotein B48 or apolipoprotein B100.

Véniant MM, Pierotti V, Newland D, Cham CM, Sanan DA, Walzem RL, Young SG.

J Clin Invest. 1997 Jul 1;100(1):180-8.PMID: 9202070 [PubMed - indexed for MEDLINE]Related articlesFree article

Phenotypic analysis of mice expressing exclusively apolipoprotein B48 or apolipoprotein B100.

Farese RV Jr, Véniant MM, Cham CM, Flynn LM, Pierotti V, Loring JF, Traber M, Ruland S, Stokowski RS, Huszar D, Young SG.

Proc Natl Acad Sci U S A. 1996 Jun 25;93(13):6393-8.PMID: 8692825 [PubMed - indexed for MEDLINE]Related articlesFree article

Endothelin in the kidney in malignant phase hypertension.

Whitworth CE, Veniant MM, Firth JD, Cumming AD, Mullins JJ.

Hypertension. 1995 Dec;26(6 Pt 1):925-31.PMID: 7490150 [PubMed - indexed for MEDLINE]Related articlesFree article