PubMed

Disodium ascorbyl phytostanol phosphate (FM-VP4), a modified phytostanol, is a highly active hypocholesterolaemic agent that affects the enterohepatic circulation of both cholesterol and bile acids in mice.

Méndez-González J, Süren-Castillo S, Calpe-Berdiel L, Rotllan N, Vázquez-Carrera M, Escolà-Gil JC, Blanco-Vaca F.

Br J Nutr. 2009 Oct 13:1-8. [Epub ahead of print]PMID: 19822032 [PubMed - as supplied by publisher]Related articles

Atorvastatin prevents carbohydrate response element binding protein activation in the fructose-fed rat by activating protein kinase A.

Rodríguez-Calvo R, Barroso E, Serrano L, Coll T, Sánchez RM, Merlos M, Palomer X, Laguna JC, Vázquez-Carrera M.

Hepatology. 2009 Jan;49(1):106-15.PMID: 19053045 [PubMed - indexed for MEDLINE]Related articles

TNF-alpha reduces PGC-1alpha expression through NF-kappaB and p38 MAPK leading to increased glucose oxidation in a human cardiac cell model.

Palomer X, Alvarez-Guardia D, Rodríguez-Calvo R, Coll T, Laguna JC, Davidson MM, Chan TO, Feldman AM, Vázquez-Carrera M.

Cardiovasc Res. 2009 Mar 1;81(4):703-12. Epub 2008 Nov 27.PMID: 19038972 [PubMed - indexed for MEDLINE]Related articles

Hepatic gene expression changes in an experimental model of accelerated senescence: the SAM-P8 mouse.

Vilà L, Roglans N, Alegret M, Camins A, Pallàs M, Sánchez RM, Vázquez-Carrera M, Laguna JC.

J Gerontol A Biol Sci Med Sci. 2008 Oct;63(10):1043-52.PMID: 18948554 [PubMed - indexed for MEDLINE]Related articles

Suppressor of cytokine signaling-3 (SOCS-3) and a deficit of serine/threonine (Ser/Thr) phosphoproteins involved in leptin transduction mediate the effect of fructose on rat liver lipid metabolism.

Vilà L, Roglans N, Alegret M, Sánchez RM, Vázquez-Carrera M, Laguna JC.

Hepatology. 2008 Nov;48(5):1506-16.PMID: 18924245 [PubMed - indexed for MEDLINE]Related articles

Ritonavir increases CD36, ABCA1 and CYP27 expression in THP-1 macrophages.

Pou J, Rebollo A, Roglans N, Sánchez RM, Vázquez-Carrera M, Laguna JC, Pedro-Botet J, Alegret M.

Exp Biol Med (Maywood). 2008 Dec;233(12):1572-82. Epub 2008 Oct 10.PMID: 18849545 [PubMed - indexed for MEDLINE]Related articles

Monocyte gene-expression profile in men with familial combined hyperlipidemia and its modification by atorvastatin treatment.

Llaverias G, Pou J, Ros E, Zambón D, Cofán M, Sánchez A, Vázquez-Carrera M, Sánchez RM, Laguna JC, Alegret M.

Pharmacogenomics. 2008 Aug;9(8):1035-54.PMID: 18681780 [PubMed - indexed for MEDLINE]Related articles

Activation of peroxisome proliferator-activated receptor beta/delta inhibits lipopolysaccharide-induced cytokine production in adipocytes by lowering nuclear factor-kappaB activity via extracellular signal-related kinase 1/2.

Rodríguez-Calvo R, Serrano L, Coll T, Moullan N, Sánchez RM, Merlos M, Palomer X, Laguna JC, Michalik L, Wahli W, Vázquez-Carrera M.

Diabetes. 2008 Aug;57(8):2149-57. Epub 2008 Apr 28.PMID: 18443198 [PubMed - indexed for MEDLINE]Related articlesFree article

Oleate reverses palmitate-induced insulin resistance and inflammation in skeletal muscle cells.

Coll T, Eyre E, Rodríguez-Calvo R, Palomer X, Sánchez RM, Merlos M, Laguna JC, Vázquez-Carrera M.

J Biol Chem. 2008 Apr 25;283(17):11107-16. Epub 2008 Feb 14.PMID: 18281277 [PubMed - indexed for MEDLINE]Related articlesFree article

Peroxisome proliferator-activated receptor alpha down-regulation is associated with enhanced ceramide levels in age-associated cardiac hypertrophy.

Rodríguez-Calvo R, Serrano L, Barroso E, Coll T, Palomer X, Camins A, Sánchez RM, Alegret M, Merlos M, Pallàs M, Laguna JC, Vázquez-Carrera M.

J Gerontol A Biol Sci Med Sci. 2007 Dec;62(12):1326-36.PMID: 18166682 [PubMed - indexed for MEDLINE]Related articles

Atorvastatin inhibits GSK-3beta phosphorylation by cardiac hypertrophic stimuli.

Planavila A, Rodríguez-Calvo R, Palomer X, Coll T, Sánchez RM, Merlos M, Laguna JC, Vázquez-Carrera M.

Biochim Biophys Acta. 2008 Jan-Feb;1781(1-2):26-35. Epub 2007 Nov 12.PMID: 18036354 [PubMed - indexed for MEDLINE]Related articles

Hypertriglyceridemia and hepatic steatosis in senescence-accelerated mouse associate to changes in lipid-related gene expression.

Vilà L, Roglans N, Alegret M, Camins A, Pallàs M, Sánchez RM, Vázquez-Carrera M, Laguna JC.

J Gerontol A Biol Sci Med Sci. 2007 Nov;62(11):1219-27.PMID: 18000141 [PubMed - indexed for MEDLINE]Related articles

Impairment of hepatic Stat-3 activation and reduction of PPARalpha activity in fructose-fed rats.

Roglans N, Vilà L, Farré M, Alegret M, Sánchez RM, Vázquez-Carrera M, Laguna JC.

Hepatology. 2007 Mar;45(3):778-88.PMID: 17326204 [PubMed - indexed for MEDLINE]Related articles

Palmitate-mediated downregulation of peroxisome proliferator-activated receptor-gamma coactivator 1alpha in skeletal muscle cells involves MEK1/2 and nuclear factor-kappaB activation.

Coll T, Jové M, Rodríguez-Calvo R, Eyre E, Palomer X, Sánchez RM, Merlos M, Laguna JC, Vázquez-Carrera M.

Diabetes. 2006 Oct;55(10):2779-87.PMID: 17003343 [PubMed - indexed for MEDLINE]Related articlesFree article

PGC-1beta down-regulation is associated with reduced ERRalpha activity and MCAD expression in skeletal muscle of senescence-accelerated mice.

Rodríguez-Calvo R, Jové M, Coll T, Camins A, Sánchez RM, Alegret M, Merlos M, Pallàs M, Laguna JC, Vázquez-Carrera M.

J Gerontol A Biol Sci Med Sci. 2006 Aug;61(8):773-80.PMID: 16912093 [PubMed - indexed for MEDLINE]Related articles

Ageing introduces a complex pattern of changes in several rat brain transcription factors depending on gender and anatomical localization.

Sanguino E, Roglans N, Rodríguez-Calvo R, Alegret M, Sánchez RM, Vázquez-Carrera M, Laguna JC.

Exp Gerontol. 2006 Apr;41(4):372-9. Epub 2006 Apr 4.PMID: 16600556 [PubMed - indexed for MEDLINE]Related articles

Peroxisome proliferator-activated receptors and the control of fatty acid oxidation in cardiac hypertrophy.

Planavila A, Calvo RR, Vázquez-Carrera M.

Mini Rev Med Chem. 2006 Mar;6(3):357-63. Review.PMID: 16515475 [PubMed - indexed for MEDLINE]Related articles

Inhibition of cardiac hypertrophy by triflusal (4-trifluoromethyl derivative of salicylate) and its active metabolite.

Planavila A, Rodríguez-Calvo R, de Arriba AF, Sánchez RM, Laguna JC, Merlos M, Vazquez-Carrera M.

Mol Pharmacol. 2006 Apr;69(4):1174-81. Epub 2006 Jan 18.PMID: 16421291 [PubMed - indexed for MEDLINE]Related articlesFree article

Effects of rosiglitazone and atorvastatin on the expression of genes that control cholesterol homeostasis in differentiating monocytes.

Llaverias G, Rebollo A, Pou J, Vázquez-Carrera M, Sánchez RM, Laguna JC, Alegret M.

Biochem Pharmacol. 2006 Feb 28;71(5):605-14. Epub 2006 Jan 18.PMID: 16386711 [PubMed - indexed for MEDLINE]Related articles

Leptin down-regulates peroxisome proliferator-activated receptor gamma (PPAR-gamma) mRNA levels in primary human monocyte-derived macrophages.

Cabrero A, Cubero M, Llaverías G, Alegret M, Sánchez R, Laguna JC, Vázquez-Carrera M.

Mol Cell Biochem. 2005 Jul;275(1-2):173-9.PMID: 16335797 [PubMed - indexed for MEDLINE]Related articles

Palmitate induces tumor necrosis factor-alpha expression in C2C12 skeletal muscle cells by a mechanism involving protein kinase C and nuclear factor-kappaB activation.

Jové M, Planavila A, Sánchez RM, Merlos M, Laguna JC, Vázquez-Carrera M.

Endocrinology. 2006 Jan;147(1):552-61. Epub 2005 Oct 13.PMID: 16223857 [PubMed - indexed for MEDLINE]Related articlesFree article

Atorvastatin prevents peroxisome proliferator-activated receptor gamma coactivator-1 (PGC-1) downregulation in lipopolysaccharide-stimulated H9c2 cells.

Planavila A, Sánchez RM, Merlos M, Laguna JC, Vázquez-Carrera M.

Biochim Biophys Acta. 2005 Sep 15;1736(2):120-7.PMID: 16139565 [PubMed - indexed for MEDLINE]Related articles

Cholesterol regulation of genes involved in sterol trafficking in human THP-1 macrophages.

Llaverias G, Lacasa D, Vázquez-Carrera M, Sánchez RM, Laguna JC, Alegret M.

Mol Cell Biochem. 2005 May;273(1-2):185-91.PMID: 16013454 [PubMed - indexed for MEDLINE]Related articles

Different response of senescent female Sprague-Dawley rats to gemfibrozil and rosiglitazone administration.

Sanguino E, Roglans N, Alegret M, Sánchez RM, Vázquez-Carrera M, Laguna JC.

Exp Gerontol. 2005 Jul;40(7):588-98.PMID: 15998575 [PubMed - indexed for MEDLINE]Related articles

Atorvastatin reverses age-related reduction in rat hepatic PPARalpha and HNF-4.

Sanguino E, Roglans N, Alegret M, Sánchez RM, Vázquez-Carrera M, Laguna JC.

Br J Pharmacol. 2005 Aug;145(7):853-61.PMID: 15912134 [PubMed - indexed for MEDLINE]Related articlesFree article

Agonist-induced activation releases peroxisome proliferator-activated receptor beta/delta from its inhibition by palmitate-induced nuclear factor-kappaB in skeletal muscle cells.

Jové M, Laguna JC, Vázquez-Carrera M.

Biochim Biophys Acta. 2005 May 1;1734(1):52-61. Epub 2005 Mar 17.PMID: 15866483 [PubMed - indexed for MEDLINE]Related articles

Palmitate-induced interleukin 6 production is mediated by protein kinase C and nuclear-factor kappaB activation and leads to glucose transporter 4 down-regulation in skeletal muscle cells.

Jové M, Planavila A, Laguna JC, Vázquez-Carrera M.

Endocrinology. 2005 Jul;146(7):3087-95. Epub 2005 Mar 31.PMID: 15802498 [PubMed - indexed for MEDLINE]Related articlesFree article

Increased Akt protein expression is associated with decreased ceramide content in skeletal muscle of troglitazone-treated mice.

Planavila A, Alegret M, Sánchez RM, Rodríguez-Calvo R, Laguna JC, Vázquez-Carrera M.

Biochem Pharmacol. 2005 Apr 15;69(8):1195-204.PMID: 15794940 [PubMed - indexed for MEDLINE]Related articles

Aspirin increases CD36, SR-BI, and ABCA1 expression in human THP-1 macrophages.

Viñals M, Bermúdez I, Llaverias G, Alegret M, Sanchez RM, Vázquez-Carrera M, Laguna JC.

Cardiovasc Res. 2005 Apr 1;66(1):141-9. Epub 2005 Jan 28.PMID: 15769457 [PubMed - indexed for MEDLINE]Related articlesFree article

Nuclear factor-kappaB activation leads to down-regulation of fatty acid oxidation during cardiac hypertrophy.

Planavila A, Laguna JC, Vázquez-Carrera M.

J Biol Chem. 2005 Apr 29;280(17):17464-71. Epub 2005 Feb 22.PMID: 15728586 [PubMed - indexed for MEDLINE]Related articlesFree article

Peroxisome proliferator-activated receptor beta/delta activation inhibits hypertrophy in neonatal rat cardiomyocytes.

Planavila A, Rodríguez-Calvo R, Jové M, Michalik L, Wahli W, Laguna JC, Vázquez-Carrera M.

Cardiovasc Res. 2005 Mar 1;65(4):832-41.PMID: 15721863 [PubMed - indexed for MEDLINE]Related articlesFree article

Atorvastatin improves peroxisome proliferator-activated receptor signaling in cardiac hypertrophy by preventing nuclear factor-kappa B activation.

Planavila A, Laguna JC, Vázquez-Carrera M.

Biochim Biophys Acta. 2005 Feb 21;1687(1-3):76-83.PMID: 15708355 [PubMed - indexed for MEDLINE]Related articles

Sexual dimorphism in lipid metabolic phenotype associated with old age in Sprague-Dawley rats.

Sanguino E, Bejarano R, Alegret M, Sánchez RM, Vázquez-Carrera M, Laguna JC.

Exp Gerontol. 2004 Sep;39(9):1295-306.PMID: 15489052 [PubMed - indexed for MEDLINE]Related articles

Insulin analogues in the management of diabetes.

Vázquez-Carrera M, Silvestre JS.

Methods Find Exp Clin Pharmacol. 2004 Jul-Aug;26(6):445-61. Review.PMID: 15349139 [PubMed - indexed for MEDLINE]Related articles

Prevention of age-related changes in rat cortex transcription factor activator protein-1 by hypolipidemic drugs.

Sanguino E, Roglans N, Alegret M, Sánchez RM, Vázquez-Carrera M, Laguna JC.

Biochem Pharmacol. 2004 Oct 1;68(7):1411-21.PMID: 15345331 [PubMed - indexed for MEDLINE]Related articles

Rosiglitazone upregulates caveolin-1 expression in THP-1 cells through a PPAR-dependent mechanism.

Llaverias G, Vázquez-Carrera M, Sánchez RM, Noé V, Ciudad CJ, Laguna JC, Alegret M.

J Lipid Res. 2004 Nov;45(11):2015-24. Epub 2004 Aug 16.PMID: 15314095 [PubMed - indexed for MEDLINE]Related articlesFree article

[Does the lipidic metabolism of myocardium modulate cardiac hypertrophy?]

Planavila A, Jové M, Cabrero A, Vázquez Carrera M.

Nefrologia. 2004;24 Suppl 4:29-33. Spanish. No abstract available. PMID: 15279383 [PubMed - indexed for MEDLINE]Related articles

Reduction of intracellular cholesterol accumulation in THP-1 macrophages by a combination of rosiglitazone and atorvastatin.

Llaverias G, Lacasa D, Viñals M, Vázquez-Carrera M, Sánchez RM, Laguna JC, Alegret M.

Biochem Pharmacol. 2004 Jul 1;68(1):155-63.PMID: 15183127 [PubMed - indexed for MEDLINE]Related articles

Atorvastatin reduces CD68, FABP4, and HBP expression in oxLDL-treated human macrophages.

Llaverias G, Noé V, Peñuelas S, Vázquez-Carrera M, Sánchez RM, Laguna JC, Ciudad CJ, Alegret M.

Biochem Biophys Res Commun. 2004 May 21;318(1):265-74.PMID: 15110783 [PubMed - indexed for MEDLINE]Related articles

Fibrates modify the expression of key factors involved in bile-acid synthesis and biliary-lipid secretion in gallstone patients.

Roglans N, Vázquez-Carrera M, Alegret M, Novell F, Zambón D, Ros E, Laguna JC, Sánchez RM.

Eur J Clin Pharmacol. 2004 Feb;59(12):855-61. Epub 2003 Dec 18.PMID: 14685799 [PubMed - indexed for MEDLINE]Related articles

Lack of hypotriglyceridemic effect of gemfibrozil as a consequence of age-related changes in rat liver PPARalpha.

Sanguino E, Ramón M, Michalik L, Wahli W, Alegret M, Sánchez RM, Vázquez-Carrera M, Laguna JC.

Biochem Pharmacol. 2004 Jan 1;67(1):157-66.PMID: 14667938 [PubMed - indexed for MEDLINE]Related articles

Impaired expression of NADH dehydrogenase subunit 1 and PPARgamma coactivator-1 in skeletal muscle of ZDF rats: restoration by troglitazone.

Jové M, Salla J, Planavila A, Cabrero A, Michalik L, Wahli W, Laguna JC, Vázquez-Carrera M.

J Lipid Res. 2004 Jan;45(1):113-23. Epub 2003 Oct 16.PMID: 14563825 [PubMed - indexed for MEDLINE]Related articlesFree article

Gemfibrozil increases the specific binding of rat-cortex nuclear extracts to a PPRE probe.

Sanguino E, Ramón M, Roglans N, Alegret M, Sánchez RM, Vázquez-Carrera M, Laguna JC.

Life Sci. 2003 Oct 24;73(23):2927-37.PMID: 14519442 [PubMed - indexed for MEDLINE]Related articles

Down-regulation of acyl-CoA oxidase gene expression in heart of troglitazone-treated mice through a mechanism involving chicken ovalbumin upstream promoter transcription factor II.

Cabrero A, Jové M, Planavila A, Merlos M, Laguna JC, Vázquez-Carrera M.

Mol Pharmacol. 2003 Sep;64(3):764-72.PMID: 12920214 [PubMed - indexed for MEDLINE]Related articlesFree article

Avasimibe and atorvastatin synergistically reduce cholesteryl ester content in THP-1 macrophages.

Llaverías G, Jové M, Vázquez-Carrera M, Sánchez RM, Díaz C, Hernández G, Laguna JC, Alegret M.

Eur J Pharmacol. 2002 Sep 6;451(1):11-7.PMID: 12223223 [PubMed - indexed for MEDLINE]Related articles