PubMed

Lipid Homeostasis, Lipotoxicity and the Metabolic Syndrome.

Unger RH, Clark GO, Scherer PE, Orci L.

Biochim Biophys Acta. 2009 Nov 27. [Epub ahead of print]PMID: 19948243 [PubMed - as supplied by publisher]Related articles

Noninvasive quantification of pancreatic fat in humans.

Lingvay I, Esser V, Legendre JL, Price AL, Wertz KM, Adams-Huet B, Zhang S, Unger RH, Szczepaniak LS.

J Clin Endocrinol Metab. 2009 Oct;94(10):4070-6. Epub 2009 Sep 22.PMID: 19773401 [PubMed - indexed for MEDLINE]Related articles

Diabetes and apoptosis: lipotoxicity.

Kusminski CM, Shetty S, Orci L, Unger RH, Scherer PE.

Apoptosis. 2009 Dec;14(12):1484-95.PMID: 19421860 [PubMed - in process]Related articles

Making insulin-deficient type 1 diabetic rodents thrive without insulin.

Yu X, Park BH, Wang MY, Wang ZV, Unger RH.

Proc Natl Acad Sci U S A. 2008 Sep 16;105(37):14070-5. Epub 2008 Sep 8.PMID: 18779578 [PubMed - indexed for MEDLINE]Related articlesFree article

Noninvasive tracking of gene expression by reporter transgene imaging.

Unger RH.

Proc Natl Acad Sci U S A. 2008 Sep 2;105(35):12641-2. No abstract available. PMID: 18765815 [PubMed - indexed for MEDLINE]Related articlesFree article

Adipogenic capacity and the susceptibility to type 2 diabetes and metabolic syndrome.

Wang MY, Grayburn P, Chen S, Ravazzola M, Orci L, Unger RH.

Proc Natl Acad Sci U S A. 2008 Apr 22;105(16):6139-44. Epub 2008 Apr 14.PMID: 18413598 [PubMed - indexed for MEDLINE]Related articlesFree article

How obesity causes diabetes in Zucker diabetic fatty rats.

Unger RH.

Trends Endocrinol Metab. 1997 Sep;8(7):276-82.PMID: 18406816 [PubMed - in process]Related articles

Reinventing type 2 diabetes: pathogenesis, treatment, and prevention.

Unger RH.

JAMA. 2008 Mar 12;299(10):1185-7. No abstract available. PMID: 18334695 [PubMed - indexed for MEDLINE]Related articles

Forgotten but not gone: the rediscovery of fatty heart, the most common unrecognized disease in America.

Szczepaniak LS, Victor RG, Orci L, Unger RH.

Circ Res. 2007 Oct 12;101(8):759-67. Review.PMID: 17932333 [PubMed - indexed for MEDLINE]Related articlesFree article

Metabolic mechanisms of failure of intraportally transplanted pancreatic beta-cells in rats: role of lipotoxicity and prevention by leptin.

Lee Y, Ravazzola M, Park BH, Bashmakov YK, Orci L, Unger RH.

Diabetes. 2007 Sep;56(9):2295-301. Epub 2007 Jun 11.PMID: 17563069 [PubMed - indexed for MEDLINE]Related articlesFree article

Combined leptin actions on adipose tissue and hypothalamus are required to deplete adipocyte fat in lean rats: implications for obesity treatment.

Park BH, Wang MY, Lee Y, Yu X, Ravazzola M, Orci L, Unger RH.

J Biol Chem. 2006 Dec 29;281(52):40283-91. Epub 2006 Oct 12.PMID: 17038325 [PubMed - indexed for MEDLINE]Related articlesFree article

Alpha-lipoic acid prevents lipotoxic cardiomyopathy in acyl CoA-synthase transgenic mice.

Lee Y, Naseem RH, Park BH, Garry DJ, Richardson JA, Schaffer JE, Unger RH.

Biochem Biophys Res Commun. 2006 May 26;344(1):446-52. Epub 2006 Mar 20.PMID: 16603124 [PubMed - indexed for MEDLINE]Related articles

Adiposity of the heart, revisited.

McGavock JM, Victor RG, Unger RH, Szczepaniak LS; American College of Physicians and the American Physiological Society.

Ann Intern Med. 2006 Apr 4;144(7):517-24. Review.PMID: 16585666 [PubMed - indexed for MEDLINE]Related articlesFree article

Movin' on up: adipocytes become regulators of nutrient homeostasis.

Unger RH, Elmquist JK.

Cell Metab. 2006 Mar;3(3):147-8.PMID: 16517400 [PubMed - indexed for MEDLINE]Related articles

Klotho-induced insulin resistance: a blessing in disguise?

Unger RH.

Nat Med. 2006 Jan;12(1):56-7. No abstract available. PMID: 16397569 [PubMed - indexed for MEDLINE]Related articles

Fat storage in adipocytes requires inactivation of leptin's paracrine activity: implications for treatment of human obesity.

Wang MY, Orci L, Ravazzola M, Unger RH.

Proc Natl Acad Sci U S A. 2005 Dec 13;102(50):18011-6. Epub 2005 Dec 2.PMID: 16326804 [PubMed - indexed for MEDLINE]Related articlesFree article

Hyperleptinemia: protecting the heart from lipid overload.

Unger RH.

Hypertension. 2005 Jun;45(6):1031-4. Epub 2005 May 16. Review.PMID: 15897372 [PubMed - indexed for MEDLINE]Related articlesFree article

Longevity, lipotoxicity and leptin: the adipocyte defense against feasting and famine.

Unger RH.

Biochimie. 2005 Jan;87(1):57-64. Review.PMID: 15733738 [PubMed - indexed for MEDLINE]Related articles

Leptinomimetic effects of the AMP kinase activator AICAR in leptin-resistant rats: prevention of diabetes and ectopic lipid deposition.

Yu X, McCorkle S, Wang M, Lee Y, Li J, Saha AK, Unger RH, Ruderman NB.

Diabetologia. 2004 Nov;47(11):2012-21. Epub 2004 Dec 2.PMID: 15578153 [PubMed - indexed for MEDLINE]Related articles

Role of PP2C in cardiac lipid accumulation in obese rodents and its prevention by troglitazone.

Wang MY, Unger RH.

Am J Physiol Endocrinol Metab. 2005 Jan;288(1):E216-21. Epub 2004 Sep 14.PMID: 15367397 [PubMed - indexed for MEDLINE]Related articlesFree article

Independence of hyperleptinemia-induced fat disappearance from thyroid hormone.

Duplomb L, Takaishi K, Park BH, Visser TJ, Unger RH.

Biochem Biophys Res Commun. 2004 Oct 8;323(1):49-51.PMID: 15351699 [PubMed - indexed for MEDLINE]Related articles

Hyperleptinemia prevents lipotoxic cardiomyopathy in acyl CoA synthase transgenic mice.

Lee Y, Naseem RH, Duplomb L, Park BH, Garry DJ, Richardson JA, Schaffer JE, Unger RH.

Proc Natl Acad Sci U S A. 2004 Sep 14;101(37):13624-9. Epub 2004 Sep 3.PMID: 15347805 [PubMed - indexed for MEDLINE]Related articlesFree article

Demonstration of reverse fatty acid transport from rat cardiomyocytes.

Park BH, Lee Y, Walton M, Duplomb L, Unger RH.

J Lipid Res. 2004 Nov;45(11):1992-9. Epub 2004 Sep 1.PMID: 15342682 [PubMed - indexed for MEDLINE]Related articlesFree article

Hepatic insig-1 or -2 overexpression reduces lipogenesis in obese Zucker diabetic fatty rats and in fasted/refed normal rats.

Takaishi K, Duplomb L, Wang MY, Li J, Unger RH.

Proc Natl Acad Sci U S A. 2004 May 4;101(18):7106-11. Epub 2004 Apr 19.PMID: 15096598 [PubMed - indexed for MEDLINE]Related articlesFree article

The hyperleptinemia of obesity-regulator of caloric surpluses.

Unger RH.

Cell. 2004 Apr 16;117(2):145-6. Review.PMID: 15084251 [PubMed - indexed for MEDLINE]Related articles

Biochemical mechanism of lipid-induced impairment of glucose-stimulated insulin secretion and reversal with a malate analogue.

Boucher A, Lu D, Burgess SC, Telemaque-Potts S, Jensen MV, Mulder H, Wang MY, Unger RH, Sherry AD, Newgard CB.

J Biol Chem. 2004 Jun 25;279(26):27263-71. Epub 2004 Apr 7.PMID: 15073188 [PubMed - indexed for MEDLINE]Related articlesFree article

Rapid transformation of white adipocytes into fat-oxidizing machines.

Orci L, Cook WS, Ravazzola M, Wang MY, Park BH, Montesano R, Unger RH.

Proc Natl Acad Sci U S A. 2004 Feb 17;101(7):2058-63. Epub 2004 Feb 9.PMID: 14769942 [PubMed - indexed for MEDLINE]Related articlesFree article

Increased expression and activity of 11beta-HSD-1 in diabetic islets and prevention with troglitazone.

Duplomb L, Lee Y, Wang MY, Park BH, Takaishi K, Agarwal AK, Unger RH.

Biochem Biophys Res Commun. 2004 Jan 16;313(3):594-9.PMID: 14697232 [PubMed - indexed for MEDLINE]Related articles

Lipid overload and overflow: metabolic trauma and the metabolic syndrome.

Unger RH.

Trends Endocrinol Metab. 2003 Nov;14(9):398-403. Review.PMID: 14580758 [PubMed - indexed for MEDLINE]Related articles

Hair transplanting: an important but often forgotten treatment for female pattern hair loss.

Unger WP, Unger RH.

J Am Acad Dermatol. 2003 Nov;49(5):853-60.PMID: 14576664 [PubMed - indexed for MEDLINE]Related articles

Minireview: weapons of lean body mass destruction: the role of ectopic lipids in the metabolic syndrome.

Unger RH.

Endocrinology. 2003 Dec;144(12):5159-65. Epub 2003 Sep 4. Review.PMID: 12960011 [PubMed - indexed for MEDLINE]Related articlesFree article

Effects of leptin on endothelial function with OB-Rb gene transfer in Zucker fatty rats.

Jin X, Fukuda N, Su J, Takagi H, Lai Y, Lin Z, Kanmatsuse K, Wang ZW, Unger RH.

Atherosclerosis. 2003 Aug;169(2):225-33.PMID: 12921973 [PubMed - indexed for MEDLINE]Related articles

Insig-1 "brakes" lipogenesis in adipocytes and inhibits differentiation of preadipocytes.

Li J, Takaishi K, Cook W, McCorkle SK, Unger RH.

Proc Natl Acad Sci U S A. 2003 Aug 5;100(16):9476-81. Epub 2003 Jul 17.PMID: 12869692 [PubMed - indexed for MEDLINE]Related articlesFree article

What s new in hair transplants?

Unger RH, Unger WP.

Skin Therapy Lett. 2003 Jan;8(1):5-7. Review.PMID: 12728285 [PubMed - indexed for MEDLINE]Related articlesFree article

Lipoapoptosis: its mechanism and its diseases.

Unger RH, Orci L.

Biochim Biophys Acta. 2002 Dec 30;1585(2-3):202-12. Review.PMID: 12531555 [PubMed - indexed for MEDLINE]Related articles

The physiology of cellular liporegulation.

Unger RH.

Annu Rev Physiol. 2003;65:333-47. Epub 2002 May 1. Review.PMID: 12471167 [PubMed - indexed for MEDLINE]Related articles

Effects of leptin, troglitazone, and dietary fat on stearoyl CoA desaturase.

Kakuma T, Lee Y, Unger RH.

Biochem Biophys Res Commun. 2002 Oct 11;297(5):1259-63.PMID: 12372423 [PubMed - indexed for MEDLINE]Related articles

PPAR alpha is necessary for the lipopenic action of hyperleptinemia on white adipose and liver tissue.

Lee Y, Yu X, Gonzales F, Mangelsdorf DJ, Wang MY, Richardson C, Witters LA, Unger RH.

Proc Natl Acad Sci U S A. 2002 Sep 3;99(18):11848-53. Epub 2002 Aug 23.PMID: 12195019 [PubMed - indexed for MEDLINE]Related articlesFree article

Gene expression profile of rat adipose tissue at the onset of high-fat-diet obesity.

Li J, Yu X, Pan W, Unger RH.

Am J Physiol Endocrinol Metab. 2002 Jun;282(6):E1334-41.PMID: 12006364 [PubMed - indexed for MEDLINE]Related articlesFree article

Protein tyrosine phosphatase 1B: a potential leptin resistance factor of obesity.

Cook WS, Unger RH.

Dev Cell. 2002 Apr;2(4):385-7. Review.PMID: 11970889 [PubMed - indexed for MEDLINE]Related articles

Lipotoxic diseases.

Unger RH.

Annu Rev Med. 2002;53:319-36. Review.PMID: 11818477 [PubMed - indexed for MEDLINE]Related articles

[Maurice Dérot Prize 2001. The liporegulator system and disease]

Unger RH.

Journ Annu Diabetol Hotel Dieu. 2001:129-43. Review. French. No abstract available. PMID: 11565455 [PubMed - indexed for MEDLINE]Related articles

Lipotoxicity of beta-cells in obesity and in other causes of fatty acid spillover.

Unger RH, Zhou YT.

Diabetes. 2001 Feb;50 Suppl 1:S118-21.PMID: 11272168 [PubMed - indexed for MEDLINE]Related articles

Diseases of liporegulation: new perspective on obesity and related disorders.

Unger RH, Orci L.

FASEB J. 2001 Feb;15(2):312-21. Review.PMID: 11156947 [PubMed - indexed for MEDLINE]Related articlesFree article

The role of leptin resistance in the lipid abnormalities of aging.

Wang ZW, Pan WT, Lee Y, Kakuma T, Zhou YT, Unger RH.

FASEB J. 2001 Jan;15(1):108-114.PMID: 11149898 [PubMed - indexed for MEDLINE]Related articlesFree article

Lipotoxic diseases of nonadipose tissues in obesity.

Unger RH, Orci L.

Int J Obes Relat Metab Disord. 2000 Nov;24 Suppl 4:S28-32. Review.PMID: 11126236 [PubMed - indexed for MEDLINE]Related articles

Role of leptin in peroxisome proliferator-activated receptor gamma coactivator-1 expression.

Kakuma T, Wang ZW, Pan W, Unger RH, Zhou YT.

Endocrinology. 2000 Dec;141(12):4576-82.PMID: 11108270 [PubMed - indexed for MEDLINE]Related articlesFree article

Liporegulation in diet-induced obesity. The antisteatotic role of hyperleptinemia.

Lee Y, Wang MY, Kakuma T, Wang ZW, Babcock E, McCorkle K, Higa M, Zhou YT, Unger RH.

J Biol Chem. 2001 Feb 23;276(8):5629-35. Epub 2000 Nov 28.PMID: 11096093 [PubMed - indexed for MEDLINE]Related articlesFree article

Leptin resistance of adipocytes in obesity: role of suppressors of cytokine signaling.

Wang Z, Zhou YT, Kakuma T, Lee Y, Kalra SP, Kalra PS, Pan W, Unger RH.

Biochem Biophys Res Commun. 2000 Oct 14;277(1):20-6.PMID: 11027633 [PubMed - indexed for MEDLINE]Related articles

Leptin physiology: a second look.

Unger RH.

Regul Pept. 2000 Aug 25;92(1-3):87-95. Review.PMID: 11024570 [PubMed - indexed for MEDLINE]Related articles