PubMed

Discovery of a potent, selective, and orally efficacious pyrimidinooxazinyl bicyclooctaneacetic acid diacylglycerol acyltransferase-1 inhibitor.

Birch AM, Birtles S, Buckett LK, Kemmitt PD, Smith GJ, Smith TJ, Turnbull AV, Wang SJ.

J Med Chem. 2009 Mar 26;52(6):1558-68.PMID: 19256504 [PubMed - indexed for MEDLINE]Related articles

Diacylglycerol acyltransferases: Potential roles as pharmacological targets.

Zammit VA, Buckett LK, Turnbull AV, Wure H, Proven A.

Pharmacol Ther. 2008 Jun;118(3):295-302. Epub 2008 Apr 11. Review.PMID: 18508126 [PubMed - indexed for MEDLINE]Related articles

An assessment of the in vivo efficacy of the glycogen phosphorylase inhibitor GPi688 in rat models of hyperglycaemia.

Poucher SM, Freeman S, Loxham SJ, Convey G, Bartlett JB, De Schoolmeester J, Teague J, Walker M, Turnbull AV, Charles AD, Carey F, Berg S.

Br J Pharmacol. 2007 Dec;152(8):1239-47. Epub 2007 Oct 15.PMID: 17934512 [PubMed - indexed for MEDLINE]Related articlesFree article

Glucagon challenge in the rat: a robust method for the in vivo assessment of Glycogen phosphorlyase inhibitor efficacy.

Loxham SJ, Teague J, Poucher SM, De Schoolmeester J, Turnbull AV, Carey F.

J Pharmacol Toxicol Methods. 2007 Jan-Feb;55(1):71-7. Epub 2006 Mar 27.PMID: 16713718 [PubMed - indexed for MEDLINE]Related articles

Inhibition of 11beta-hydroxysteroid dehydrogenase type 1 reduces food intake and weight gain but maintains energy expenditure in diet-induced obese mice.

Wang SJ, Birtles S, de Schoolmeester J, Swales J, Moody G, Hislop D, O'Dowd J, Smith DM, Turnbull AV, Arch JR.

Diabetologia. 2006 Jun;49(6):1333-7. Epub 2006 Apr 13.PMID: 16612591 [PubMed - indexed for MEDLINE]Related articles

Interleukin-6 is an afferent signal to the hypothalamo-pituitary-adrenal axis during local inflammation in mice.

Turnbull AV, Prehar S, Kennedy AR, Little RA, Hopkins SJ.

Endocrinology. 2003 May;144(5):1894-906.PMID: 12697697 [PubMed - indexed for MEDLINE]Related articlesFree article

Proopiomelanocortin-derived peptides in rat cerebrospinal fluid and hypothalamic extracts: evidence that secretion is regulated with respect to energy balance.

Pritchard LE, Oliver RL, McLoughlin JD, Birtles S, Lawrence CB, Turnbull AV, White A.

Endocrinology. 2003 Mar;144(3):760-6.PMID: 12586751 [PubMed - indexed for MEDLINE]Related articlesFree article

Rat anterior pituitary folliculostellate cells are targets of interleukin-1beta and a major source of intrapituitary follistatin.

Bilezikjian LM, Leal AM, Blount AL, Corrigan AZ, Turnbull AV, Vale WW.

Endocrinology. 2003 Feb;144(2):732-40.PMID: 12538636 [PubMed - indexed for MEDLINE]Related articlesFree article

Selective antagonism of the NPY Y5 receptor does not have a major effect on feeding in rats.

Turnbull AV, Ellershaw L, Masters DJ, Birtles S, Boyer S, Carroll D, Clarkson P, Loxham SJ, McAulay P, Teague JL, Foote KM, Pease JE, Block MH.

Diabetes. 2002 Aug;51(8):2441-9.PMID: 12145156 [PubMed - indexed for MEDLINE]Related articlesFree article

Discovery and optimization of a series of carbazole ureas as NPY5 antagonists for the treatment of obesity.

Block MH, Boyer S, Brailsford W, Brittain DR, Carroll D, Chapman S, Clarke DS, Donald CS, Foote KM, Godfrey L, Ladner A, Marsham PR, Masters DJ, Mee CD, O'Donovan MR, Pease JE, Pickup AG, Rayner JW, Roberts A, Schofield P, Suleman A, Turnbull AV.

J Med Chem. 2002 Aug 1;45(16):3509-23.PMID: 12139462 [PubMed - indexed for MEDLINE]Related articles

Pro-opiomelanocortin processing in the hypothalamus: impact on melanocortin signalling and obesity.

Pritchard LE, Turnbull AV, White A.

J Endocrinol. 2002 Mar;172(3):411-21. Review.PMID: 11874690 [PubMed - indexed for MEDLINE]Related articlesFree article

Circulating interleukin-6 mediates the febrile response to localised inflammation in rats.

Cartmell T, Poole S, Turnbull AV, Rothwell NJ, Luheshi GN.

J Physiol. 2000 Aug 1;526 Pt 3:653-61.PMID: 10922015 [PubMed - indexed for MEDLINE]Related articlesFree article

Hypothalamic control of feeding.

Lawrence CB, Turnbull AV, Rothwell NJ.

Curr Opin Neurobiol. 1999 Dec;9(6):778-83. Review.PMID: 10607641 [PubMed - indexed for MEDLINE]Related articles

Sprague-Dawley rats obtained from different vendors exhibit distinct adrenocorticotropin responses to inflammatory stimuli.

Turnbull AV, Rivier CL.

Neuroendocrinology. 1999 Sep;70(3):186-95.PMID: 10516481 [PubMed - indexed for MEDLINE]Related articles

Effects of prenatal exposure to alcohol on the release of adenocorticotropic hormone, corticosterone, and proinflammatory cytokines.

Kim CK, Turnbull AV, Lee SY, Rivier CL.

Alcohol Clin Exp Res. 1999 Jan;23(1):52-9.PMID: 10029203 [PubMed - indexed for MEDLINE]Related articles

CRF type I receptor-deficient mice exhibit a pronounced pituitary-adrenal response to local inflammation.

Turnbull AV, Smith GW, Lee S, Vale WW, Lee KF, Rivier C.

Endocrinology. 1999 Feb;140(2):1013-7.PMID: 9927337 [PubMed - indexed for MEDLINE]Related articlesFree article

Regulation of the hypothalamic-pituitary-adrenal axis by cytokines: actions and mechanisms of action.

Turnbull AV, Rivier CL.

Physiol Rev. 1999 Jan;79(1):1-71. Review.PMID: 9922367 [PubMed - indexed for MEDLINE]Related articlesFree article

Urocortin is not a significant regulator of intermittent electrofootshock-induced adrenocorticotropin secretion in the intact male rat.

Turnbull AV, Vaughan J, Rivier JE, Vale WW, Rivier C.

Endocrinology. 1999 Jan;140(1):71-8.PMID: 9886809 [PubMed - indexed for MEDLINE]Related articlesFree article

Influence of carbon monoxide, and its interaction with nitric oxide, on the adrenocorticotropin hormone response of the normal rat to a physico-emotional stress.

Turnbull AV, Kim CK, Lee S, Rivier CL.

J Neuroendocrinol. 1998 Oct;10(10):793-802.PMID: 9792331 [PubMed - indexed for MEDLINE]Related articles

Interleukin-1beta regulates pituitary follistatin and inhibin/activin betaB mRNA levels and attenuates FSH secretion in response to activin-A.

Bilezikjian LM, Turnbull AV, Corrigan AZ, Blount AL, Rivier CL, Vale WW.

Endocrinology. 1998 Jul;139(7):3361-4.PMID: 9645713 [PubMed - indexed for MEDLINE]Related articlesFree article

Mechanisms of hypothalamic-pituitary-adrenal axis stimulation by immune signals in the adult rat.

Turnbull AV, Lee S, Rivier C.

Ann N Y Acad Sci. 1998 May 1;840:434-43. Review.PMID: 9629270 [PubMed - indexed for MEDLINE]Related articles

Cerebral interleukin-6 is neuroprotective during permanent focal cerebral ischemia in the rat.

Loddick SA, Turnbull AV, Rothwell NJ.

J Cereb Blood Flow Metab. 1998 Feb;18(2):176-9.PMID: 9469160 [PubMed - indexed for MEDLINE]Related articlesFree article

Intracerebroventricular passive immunization. II. Intracerebroventricular infusion of neuropeptide antisera can inhibit neuropeptide signaling in peripheral tissues.

Turnbull AV, Rivier CL.

Endocrinology. 1998 Jan;139(1):128-36.PMID: 9421407 [PubMed - indexed for MEDLINE]Related articlesFree article

Intracerebroventricular passive immunization. I. The effect of intracerebroventricular administration of an antiserum to tumor necrosis factor-alpha on the plasma adrenocorticotropin response to lipopolysaccharide in rats.

Turnbull AV, Rivier CL.

Endocrinology. 1998 Jan;139(1):119-27.PMID: 9421406 [PubMed - indexed for MEDLINE]Related articlesFree article

Corticotropin-releasing factor (CRF) and endocrine responses to stress: CRF receptors, binding protein, and related peptides.

Turnbull AV, Rivier C.

Proc Soc Exp Biol Med. 1997 May;215(1):1-10. Review.PMID: 9142133 [PubMed - indexed for MEDLINE]Related articles

Inhibition of tumor necrosis factor-alpha action within the CNS markedly reduces the plasma adrenocorticotropin response to peripheral local inflammation in rats.

Turnbull AV, Pitossi FJ, Lebrun JJ, Lee S, Meltzer JC, Nance DM, del Rey A, Besedovsky HO, Rivier C.

J Neurosci. 1997 May 1;17(9):3262-73.PMID: 9096159 [PubMed - indexed for MEDLINE]Related articlesFree article

Endotoxin decreases corticotropin-releasing factor receptor 1 messenger ribonucleic acid levels in the rat pituitary.

Aubry JM, Turnbull AV, Pozzoli G, Rivier C, Vale W.

Endocrinology. 1997 Apr;138(4):1621-6.PMID: 9075723 [PubMed - indexed for MEDLINE]Related articlesFree article

Febrile response to tissue inflammation involves both peripheral and brain IL-1 and TNF-alpha in the rat.

Luheshi GN, Stefferl A, Turnbull AV, Dascombe MJ, Brouwer S, Hopkins SJ, Rothwell NJ.

Am J Physiol. 1997 Mar;272(3 Pt 2):R862-8.PMID: 9087648 [PubMed - indexed for MEDLINE]Related articles

Inhibition of gonadotropin-induced testosterone secretion by the intracerebroventricular injection of interleukin-1 beta in the male rat.

Turnbull AV, Rivier C.

Endocrinology. 1997 Mar;138(3):1008-13.PMID: 9048602 [PubMed - indexed for MEDLINE]Related articlesFree article

Urocortin, a corticotropin-releasing factor-related mammalian peptide, inhibits edema due to thermal injury in rats.

Turnbull AV, Vale W, Rivier C.

Eur J Pharmacol. 1996 May 15;303(3):213-6.PMID: 8813571 [PubMed - indexed for MEDLINE]Related articles

Corticotropin-releasing factor, vasopressin, and prostaglandins mediate, and nitric oxide restrains, the hypothalamic-pituitary-adrenal response to acute local inflammation in the rat.

Turnbull AV, Rivier C.

Endocrinology. 1996 Feb;137(2):455-63.PMID: 8593789 [PubMed - indexed for MEDLINE]Related articles

Regulation of the HPA axis by cytokines.

Turnbull AV, Rivier C.

Brain Behav Immun. 1995 Dec;9(4):253-75. Review.PMID: 8903845 [PubMed - indexed for MEDLINE]Related articles

Urocortin, a mammalian neuropeptide related to fish urotensin I and to corticotropin-releasing factor.

Vaughan J, Donaldson C, Bittencourt J, Perrin MH, Lewis K, Sutton S, Chan R, Turnbull AV, Lovejoy D, Rivier C, et al.

Nature. 1995 Nov 16;378(6554):287-92.PMID: 7477349 [PubMed - indexed for MEDLINE]Related articles

Tumor necrosis factor-alpha and fever after peripheral inflammation in the rat.

Cooper AL, Brouwer S, Turnbull AV, Luheshi GN, Hopkins SJ, Kunkel SL, Rothwell NJ.

Am J Physiol. 1994 Dec;267(6 Pt 2):R1431-6.PMID: 7810749 [PubMed - indexed for MEDLINE]Related articles

Dietary n-3 Fatty Acids Inhibit Fever Induced by Inflammation in the Rat.

Cooper AL, Turnbull AV, Hopkins SJ, Rothwell NJ.

Mediators Inflamm. 1994;3(5):353-7.PMID: 18475580 [PubMed - in process]Related articlesFree article

Mechanisms of activation of the pituitary-adrenal axis by tissue injury in the rat.

Turnbull AV, Dow RC, Hopkins SJ, White A, Fink G, Rothwell NJ.

Psychoneuroendocrinology. 1994;19(2):165-78.PMID: 8190836 [PubMed - indexed for MEDLINE]Related articles

The neuropeptide CRF is involved in the modulation of the baroreflex during hindlimb ischaemia in the anaesthetized rat.

Turnbull AV, Kirkman E, Rothwell NJ, Little RA.

J Physiol. 1993 Aug;468:529-41.PMID: 8254521 [PubMed - indexed for MEDLINE]Related articlesFree article