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Serum Amyloid A Regulates Granulomatous Inflammation in Sarcoidosis through Toll-like Receptor-2.

Chen ES, Song Z, Willett MH, Heine S, Yung RC, Liu MC, Groshong SD, Zhang Y, Tuder RM, Moller DR.

Am J Respir Crit Care Med. 2009 Nov 12. [Epub ahead of print]PMID: 19910611 [PubMed - as supplied by publisher]Related articles

CD4+CD25+Foxp3+ Tregs resolve experimental lung injury in mice and are present in humans with acute lung injury.

D'Alessio FR, Tsushima K, Aggarwal NR, West EE, Willett MH, Britos MF, Pipeling MR, Brower RG, Tuder RM, McDyer JF, King LS.

J Clin Invest. 2009 Oct;119(10):2898-913. doi: 10.1172/JCI36498. Epub 2009 Sep 21.PMID: 19770521 [PubMed - in process]Related articlesFree article

New paradigms in the pathogenesis of chronic obstructive pulmonary disease I.

MacNee W, Tuder RM.

Proc Am Thorac Soc. 2009 Sep 15;6(6):527-31.PMID: 19741262 [PubMed - in process]Related articlesFree article

Combinatorial ligand-directed lung targeting.

Giordano RJ, Edwards JK, Tuder RM, Arap W, Pasqualini R.

Proc Am Thorac Soc. 2009 Aug 15;6(5):411-5.PMID: 19687212 [PubMed - in process]Related articlesFree article

Golgi dysfunction is a common feature in idiopathic human pulmonary hypertension and vascular lesions in SHIV-nef-infected macaques.

Sehgal PB, Mukhopadhyay S, Patel K, Xu F, Almodóvar S, Tuder RM, Flores SC.

Am J Physiol Lung Cell Mol Physiol. 2009 Oct;297(4):L729-37. Epub 2009 Jul 31.PMID: 19648286 [PubMed - indexed for MEDLINE]Related articles

Pathology of pulmonary arterial hypertension.

Tuder RM.

Semin Respir Crit Care Med. 2009 Aug;30(4):376-85. Epub 2009 Jul 24. Review.PMID: 19634077 [PubMed - indexed for MEDLINE]Related articles

Development and pathology of pulmonary hypertension.

Tuder RM, Abman SH, Braun T, Capron F, Stevens T, Thistlethwaite PA, Haworth SG.

J Am Coll Cardiol. 2009 Jun 30;54(1 Suppl):S3-9. Review.PMID: 19555856 [PubMed - indexed for MEDLINE]Related articles

Complex integration of matrix, oxidative stress, and apoptosis in genetic emphysema.

Podowski M, Calvi CL, Cheadle C, Tuder RM, Biswals S, Neptune ER.

Am J Pathol. 2009 Jul;175(1):84-96. Epub 2009 Jun 18.PMID: 19541933 [PubMed - indexed for MEDLINE]Related articles

Deletion of Keap1 in the Lung Attenuates Acute Cigarette Smoke-induced Oxidative Stress and Inflammation.

Blake DJ, Singh A, Kombairaju P, Malhotra D, Mariani TJ, Tuder RM, Gabrielson E, Biswal S.

Am J Respir Cell Mol Biol. 2009 Jun 11. [Epub ahead of print]PMID: 19520915 [PubMed - as supplied by publisher]Related articles

Pulmonary epithelial neuropilin-1 deletion enhances development of cigarette smoke-induced emphysema.

Le A, Zielinski R, He C, Crow MT, Biswal S, Tuder RM, Becker PM.

Am J Respir Crit Care Med. 2009 Sep 1;180(5):396-406. Epub 2009 Jun 11.PMID: 19520907 [PubMed - indexed for MEDLINE]Related articles

Kidney ischemia-reperfusion injury induces caspase-dependent pulmonary apoptosis.

Hassoun HT, Lie ML, Grigoryev DN, Liu M, Tuder RM, Rabb H.

Am J Physiol Renal Physiol. 2009 Jul;297(1):F125-37. Epub 2009 Apr 29.PMID: 19403643 [PubMed - indexed for MEDLINE]Related articles

Cigarette smoke-induced emphysema in A/J mice is associated with pulmonary oxidative stress, apoptosis of lung cells, and global alterations in gene expression.

Rangasamy T, Misra V, Zhen L, Tankersley CG, Tuder RM, Biswal S.

Am J Physiol Lung Cell Mol Physiol. 2009 Jun;296(6):L888-900. Epub 2009 Mar 13.PMID: 19286929 [PubMed - indexed for MEDLINE]Related articles

Letter by asosingh et Al regarding article, "circulating endothelial progenitor cells in patients with eisenmenger syndrome and idiopathic pulmonary arterial hypertension".

Asosingh K, Erzurum SC, Yoder MC, Tuder RM.

Circulation. 2009 Mar 10;119(9):e230; author reply e231. No abstract available. PMID: 19273727 [PubMed - indexed for MEDLINE]Related articles

Resistin-like molecule-beta in scleroderma-associated pulmonary hypertension.

Angelini DJ, Su Q, Yamaji-Kegan K, Fan C, Teng X, Hassoun PM, Yang SC, Champion HC, Tuder RM, Johns RA.

Am J Respir Cell Mol Biol. 2009 Nov;41(5):553-61. Epub 2009 Feb 27.PMID: 19251945 [PubMed - in process]Related articles

Targeting Nrf2 with the triterpenoid CDDO-imidazolide attenuates cigarette smoke-induced emphysema and cardiac dysfunction in mice.

Sussan TE, Rangasamy T, Blake DJ, Malhotra D, El-Haddad H, Bedja D, Yates MS, Kombairaju P, Yamamoto M, Liby KT, Sporn MB, Gabrielson KL, Champion HC, Tuder RM, Kensler TW, Biswal S.

Proc Natl Acad Sci U S A. 2009 Jan 6;106(1):250-5. Epub 2008 Dec 22.PMID: 19104057 [PubMed - indexed for MEDLINE]Related articlesFree article

Nrf2-dependent sulfiredoxin-1 expression protects against cigarette smoke-induced oxidative stress in lungs.

Singh A, Ling G, Suhasini AN, Zhang P, Yamamoto M, Navas-Acien A, Cosgrove G, Tuder RM, Kensler TW, Watson WH, Biswal S.

Free Radic Biol Med. 2009 Feb 1;46(3):376-86. Epub 2008 Nov 1.PMID: 19027064 [PubMed - indexed for MEDLINE]Related articles

Resident cellular components of the human lung: current knowledge and goals for research on cell phenotyping and function.

Franks TJ, Colby TV, Travis WD, Tuder RM, Reynolds HY, Brody AR, Cardoso WV, Crystal RG, Drake CJ, Engelhardt J, Frid M, Herzog E, Mason R, Phan SH, Randell SH, Rose MC, Stevens T, Serge J, Sunday ME, Voynow JA, Weinstein BM, Whitsett J, Williams MC.

Proc Am Thorac Soc. 2008 Sep 15;5(7):763-6.PMID: 18757314 [PubMed - indexed for MEDLINE]Related articlesFree article

Short telomeres are a risk factor for idiopathic pulmonary fibrosis.

Alder JK, Chen JJ, Lancaster L, Danoff S, Su SC, Cogan JD, Vulto I, Xie M, Qi X, Tuder RM, Phillips JA 3rd, Lansdorp PM, Loyd JE, Armanios MY.

Proc Natl Acad Sci U S A. 2008 Sep 2;105(35):13051-6. Epub 2008 Aug 27.PMID: 18753630 [PubMed - indexed for MEDLINE]Related articlesFree article

Targeted induction of lung endothelial cell apoptosis causes emphysema-like changes in the mouse.

Giordano RJ, Lahdenranta J, Zhen L, Chukwueke U, Petrache I, Langley RR, Fidler IJ, Pasqualini R, Tuder RM, Arap W.

J Biol Chem. 2008 Oct 24;283(43):29447-60. Epub 2008 Aug 21.PMID: 18718906 [PubMed - indexed for MEDLINE]Related articlesFree article

Alveolar cell apoptosis is dependent on p38 MAP kinase-mediated activation of xanthine oxidoreductase in ventilator-induced lung injury.

Le A, Damico R, Damarla M, Boueiz A, Pae HH, Skirball J, Hasan E, Peng X, Chesley A, Crow MT, Reddy SP, Tuder RM, Hassoun PM.

J Appl Physiol. 2008 Oct;105(4):1282-90. Epub 2008 Jul 31.PMID: 18669934 [PubMed - indexed for MEDLINE]Related articlesFree article

It takes two to tango: cigarette smoke partners with viruses to promote emphysema.

Tuder RM, Yun JH.

J Clin Invest. 2008 Aug;118(8):2689-93.PMID: 18654673 [PubMed - indexed for MEDLINE]Related articlesFree article

Decline in NRF2-regulated antioxidants in chronic obstructive pulmonary disease lungs due to loss of its positive regulator, DJ-1.

Malhotra D, Thimmulappa R, Navas-Acien A, Sandford A, Elliott M, Singh A, Chen L, Zhuang X, Hogg J, Pare P, Tuder RM, Biswal S.

Am J Respir Crit Care Med. 2008 Sep 15;178(6):592-604. Epub 2008 Jun 12. Erratum in: Am J Respir Crit Care Med. 2009 Apr 1;179(7):624. PMID: 18556627 [PubMed - indexed for MEDLINE]Related articlesFree article

Vascular endothelial growth factor of the lung: friend or foe.

Tuder RM, Yun JH.

Curr Opin Pharmacol. 2008 Jun;8(3):255-60. Epub 2008 May 28. Review.PMID: 18468486 [PubMed - indexed for MEDLINE]Related articlesFree article

HIV associated pulmonary emphysema: a review of the literature and inquiry into its mechanism.

Petrache I, Diab K, Knox KS, Twigg HL 3rd, Stephens RS, Flores S, Tuder RM.

Thorax. 2008 May;63(5):463-9. Review.PMID: 18443163 [PubMed - indexed for MEDLINE]Related articles

Cigarette smoke triggers code red: p21CIP1/WAF1/SDI1 switches on danger responses in the lung.

Tuder RM, Yun JH, Graham BB.

Am J Respir Cell Mol Biol. 2008 Jul;39(1):1-6. Epub 2008 Apr 25. Review.PMID: 18441278 [PubMed - indexed for MEDLINE]Related articlesFree article

Superoxide dismutase protects against apoptosis and alveolar enlargement induced by ceramide.

Petrache I, Medler TR, Richter AT, Kamocki K, Chukwueke U, Zhen L, Gu Y, Adamowicz J, Schweitzer KS, Hubbard WC, Berdyshev EV, Lungarella G, Tuder RM.

Am J Physiol Lung Cell Mol Physiol. 2008 Jul;295(1):L44-53. Epub 2008 Apr 25.PMID: 18441093 [PubMed - indexed for MEDLINE]Related articlesFree article

Identification of candidate genes in scleroderma-related pulmonary arterial hypertension.

Grigoryev DN, Mathai SC, Fisher MR, Girgis RE, Zaiman AL, Housten-Harris T, Cheadle C, Gao L, Hummers LK, Champion HC, Garcia JG, Wigley FM, Tuder RM, Barnes KC, Hassoun PM.

Transl Res. 2008 Apr;151(4):197-207. Epub 2008 Feb 1.PMID: 18355767 [PubMed - indexed for MEDLINE]Related articlesFree article

Circulating angiogenic precursors in idiopathic pulmonary arterial hypertension.

Asosingh K, Aldred MA, Vasanji A, Drazba J, Sharp J, Farver C, Comhair SA, Xu W, Licina L, Huang L, Anand-Apte B, Yoder MC, Tuder RM, Erzurum SC.

Am J Pathol. 2008 Mar;172(3):615-27. Epub 2008 Feb 7.PMID: 18258847 [PubMed - indexed for MEDLINE]Related articlesFree article

Effects of acid aspiration-induced acute lung injury on kidney function.

Hoag JB, Liu M, Easley RB, Britos-Bray MF, Kesari P, Hassoun H, Haas M, Tuder RM, Rabb H, Simon BA.

Am J Physiol Renal Physiol. 2008 Apr;294(4):F900-8. Epub 2008 Feb 6.PMID: 18256314 [PubMed - indexed for MEDLINE]Related articlesFree article

Role of the TGF-beta/Alk5 signaling pathway in monocrotaline-induced pulmonary hypertension.

Zaiman AL, Podowski M, Medicherla S, Gordy K, Xu F, Zhen L, Shimoda LA, Neptune E, Higgins L, Murphy A, Chakravarty S, Protter A, Sehgal PB, Champion HC, Tuder RM.

Am J Respir Crit Care Med. 2008 Apr 15;177(8):896-905. Epub 2008 Jan 17.PMID: 18202349 [PubMed - indexed for MEDLINE]Related articlesFree article

Apoptotic sphingolipid signaling by ceramides in lung endothelial cells.

Medler TR, Petrusca DN, Lee PJ, Hubbard WC, Berdyshev EV, Skirball J, Kamocki K, Schuchman E, Tuder RM, Petrache I.

Am J Respir Cell Mol Biol. 2008 Jun;38(6):639-46. Epub 2008 Jan 10.PMID: 18192502 [PubMed - indexed for MEDLINE]Related articlesFree article

Apoptosis in the lung: induction, clearance and detection.

Henson PM, Tuder RM.

Am J Physiol Lung Cell Mol Physiol. 2008 Apr;294(4):L601-11. Epub 2008 Jan 4. Review.PMID: 18178675 [PubMed - indexed for MEDLINE]Related articlesFree article

Cytoplasmic provenance of STAT3 and PY-STAT3 in the endolysosomal compartments in pulmonary arterial endothelial and smooth muscle cells: implications in pulmonary arterial hypertension.

Mukhopadhyay S, Shah M, Xu F, Patel K, Tuder RM, Sehgal PB.

Am J Physiol Lung Cell Mol Physiol. 2008 Mar;294(3):L449-68. Epub 2007 Dec 14.PMID: 18083767 [PubMed - indexed for MEDLINE]Related articlesFree article

Hypoxia and chronic lung disease.

Tuder RM, Yun JH, Bhunia A, Fijalkowska I.

J Mol Med. 2007 Dec;85(12):1317-24. Epub 2007 Nov 27. Review.PMID: 18040654 [PubMed - indexed for MEDLINE]Related articles

Impaired lung homeostasis in neonatal mice exposed to cigarette smoke.

McGrath-Morrow S, Rangasamy T, Cho C, Sussan T, Neptune E, Wise R, Tuder RM, Biswal S.

Am J Respir Cell Mol Biol. 2008 Apr;38(4):393-400. Epub 2007 Nov 1.PMID: 17975176 [PubMed - indexed for MEDLINE]Related articlesFree article

Genetic and pharmacologic evidence links oxidative stress to ventilator-induced lung injury in mice.

Papaiahgari S, Yerrapureddy A, Reddy SR, Reddy NM, Dodd-O JM, Crow MT, Grigoryev DN, Barnes K, Tuder RM, Yamamoto M, Kensler TW, Biswal S, Mitzner W, Hassoun PM, Reddy SP.

Am J Respir Crit Care Med. 2007 Dec 15;176(12):1222-35. Epub 2007 Sep 27.PMID: 17901416 [PubMed - indexed for MEDLINE]Related articlesFree article

Pathobiology of cigarette smoke-induced chronic obstructive pulmonary disease.

Yoshida T, Tuder RM.

Physiol Rev. 2007 Jul;87(3):1047-82.PMID: 17615396 [PubMed - indexed for MEDLINE]Related articlesFree article

Macrophage migration inhibitory factor in acute lung injury: expression, biomarker, and associations.

Gao L, Flores C, Fan-Ma S, Miller EJ, Moitra J, Moreno L, Wadgaonkar R, Simon B, Brower R, Sevransky J, Tuder RM, Maloney JP, Moss M, Shanholtz C, Yates CR, Meduri GU, Ye SQ, Barnes KC, Garcia JG.

Transl Res. 2007 Jul;150(1):18-29. Epub 2007 May 25.PMID: 17585860 [PubMed - indexed for MEDLINE]Related articlesFree article

Molecular multitasking in the airspace: alpha1-antitrypsin takes on thrombin and plasmin.

Tuder RM, Petrache I.

Am J Respir Cell Mol Biol. 2007 Aug;37(2):130-4. Epub 2007 May 31. No abstract available. PMID: 17541009 [PubMed - indexed for MEDLINE]Related articlesFree article

Role of PD-1 and its ligand, B7-H1, in early fate decisions of CD8 T cells.

Goldberg MV, Maris CH, Hipkiss EL, Flies AS, Zhen L, Tuder RM, Grosso JF, Harris TJ, Getnet D, Whartenby KA, Brockstedt DG, Dubensky TW Jr, Chen L, Pardoll DM, Drake CG.

Blood. 2007 Jul 1;110(1):186-92. Epub 2007 Mar 28.PMID: 17392506 [PubMed - indexed for MEDLINE]Related articlesFree article

Pathology of pulmonary hypertension.

Tuder RM, Marecki JC, Richter A, Fijalkowska I, Flores S.

Clin Chest Med. 2007 Mar;28(1):23-42, vii. Review.PMID: 17338926 [PubMed - indexed for MEDLINE]Related articlesFree article

Ischemic acute kidney injury induces a distant organ functional and genomic response distinguishable from bilateral nephrectomy.

Hassoun HT, Grigoryev DN, Lie ML, Liu M, Cheadle C, Tuder RM, Rabb H.

Am J Physiol Renal Physiol. 2007 Jul;293(1):F30-40. Epub 2007 Feb 27.PMID: 17327501 [PubMed - indexed for MEDLINE]Related articlesFree article

Regression of chronic hypoxic pulmonary hypertension by simvastatin.

Girgis RE, Mozammel S, Champion HC, Li D, Peng X, Shimoda L, Tuder RM, Johns RA, Hassoun PM.

Am J Physiol Lung Cell Mol Physiol. 2007 May;292(5):L1105-10. Epub 2007 Feb 2.PMID: 17277047 [PubMed - indexed for MEDLINE]Related articlesFree article

Idiopathic pulmonary fibrosis and pulmonary hypertension: connecting the dots.

Nathan SD, Noble PW, Tuder RM.

Am J Respir Crit Care Med. 2007 May 1;175(9):875-80. Epub 2007 Jan 25. Review.PMID: 17255562 [PubMed - indexed for MEDLINE]Related articlesFree article

Alterations of cellular bioenergetics in pulmonary artery endothelial cells.

Xu W, Koeck T, Lara AR, Neumann D, DiFilippo FP, Koo M, Janocha AJ, Masri FA, Arroliga AC, Jennings C, Dweik RA, Tuder RM, Stuehr DJ, Erzurum SC.

Proc Natl Acad Sci U S A. 2007 Jan 23;104(4):1342-7. Epub 2007 Jan 16.PMID: 17227868 [PubMed - indexed for MEDLINE]Related articlesFree article

WITHDRAWN: The Pathobiological Mechanisms of Emphysema Models: What do They Have in Common?

Tuder RM, McGrath S, Neptune E.

Pulm Pharmacol Ther. 2008 Dec 8. [Epub ahead of print]PMID: 17215152 [PubMed - as supplied by publisher]Related articles

Is alveolar destruction and emphysema in chronic obstructive pulmonary disease an immune disease?

Taraseviciene-Stewart L, Douglas IS, Nana-Sinkam PS, Lee JD, Tuder RM, Nicolls MR, Voelkel NF.

Proc Am Thorac Soc. 2006 Nov;3(8):687-90. Review.PMID: 17065374 [PubMed - indexed for MEDLINE]Related articlesFree article

Role of lung maintenance program in the heterogeneity of lung destruction in emphysema.

Tuder RM, Yoshida T, Fijalkowka I, Biswal S, Petrache I.

Proc Am Thorac Soc. 2006 Nov;3(8):673-9. Review.PMID: 17065372 [PubMed - indexed for MEDLINE]Related articlesFree article

alpha-1 antitrypsin inhibits caspase-3 activity, preventing lung endothelial cell apoptosis.

Petrache I, Fijalkowska I, Medler TR, Skirball J, Cruz P, Zhen L, Petrache HI, Flotte TR, Tuder RM.

Am J Pathol. 2006 Oct;169(4):1155-66.PMID: 17003475 [PubMed - indexed for MEDLINE]Related articlesFree article

N-acetylcysteine treatment protects against VEGF-receptor blockade-related emphysema.

Demura Y, Taraseviciene-Stewart L, Scerbavicius R, Tuder RM, Voelkel NF.

COPD. 2004 Apr;1(1):25-32.PMID: 16997736 [PubMed - indexed for MEDLINE]Related articles