PubMed

Prevention of Cardiac Dysfunction in Acute Coxsackievirus B3 Cardiomyopathy by Inducible Expression of a Soluble Coxsackievirus-Adenovirus Receptor.

Pinkert S, Westermann D, Wang X, Klingel K, Dörner A, Savvatis K, Größl T, Krohn S, Tschöpe C, Zeichhardt H, Kotsch K, Weitmann K, Hoffmann W, Schultheiss HP, Spiller OB, Poller W, Fechner H.

Circulation. 2009 Nov 23. [Epub ahead of print]PMID: 19933937 [PubMed - as supplied by publisher]

Immunosuppression with an interleukin-2 fusion protein leads to improved LV function in experimental ischemic cardiomyopathy.

Koch M, Savvatis K, Scheeler M, Dhayat S, Bonaventura K, Pohl T, Riad A, Bulfone-Paus S, Schultheiss HP, Tschöpe C.

Int Immunopharmacol. 2009 Nov 6. [Epub ahead of print]PMID: 19897056 [PubMed - as supplied by publisher]Related articles

Single-beat estimation of the left ventricular end-diastolic pressure-volume relationship in heart failure patients.

Ten Brinke EA, Burkhoff D, Klautz RJ, Tschöpe C, Schalij MJ, Bax JJ, van der Wall EE, Dion RA, Steendijk P.

Heart. 2009 Oct 28. [Epub ahead of print]PMID: 19875367 [PubMed - as supplied by publisher]Related articles

Immunomodulation and matrix metalloproteinases in viral myocarditis.

Westermann D, Savvatis K, Schultheiss HP, Tschöpe C.

J Mol Cell Cardiol. 2009 Sep 1. [Epub ahead of print]PMID: 19729021 [PubMed - as supplied by publisher]Related articles

Is echocardiographic evaluation of diastolic function useful in determining clinical care? Doppler echocardiography yields dubious estimates of left ventricular diastolic pressures.

Tschöpe C, Paulus WJ.

Circulation. 2009 Sep 1;120(9):810-20; discussion 820. No abstract available. PMID: 19720947 [PubMed - indexed for MEDLINE]Related articles

Blunted frequency-dependent upregulation of cardiac output is related to impaired relaxation in diastolic heart failure.

Wachter R, Schmidt-Schweda S, Westermann D, Post H, Edelmann F, Kasner M, Lüers C, Steendijk P, Hasenfuß G, Tschöpe C, Pieske B.

Eur Heart J. 2009 Aug 30. [Epub ahead of print]PMID: 19720638 [PubMed - as supplied by publisher]Related articles

Truncation of titin's elastic PEVK region leads to cardiomyopathy with diastolic dysfunction.

Granzier HL, Radke MH, Peng J, Westermann D, Nelson OL, Rost K, King NM, Yu Q, Tschöpe C, McNabb M, Larson DF, Labeit S, Gotthardt M.

Circ Res. 2009 Sep 11;105(6):557-64. Epub 2009 Aug 13.PMID: 19679835 [PubMed - indexed for MEDLINE]Related articles

The role of placental-derived adherent stromal cell (PLX-PAD) in the treatment of critical limb ischemia.

Prather WR, Toren A, Meiron M, Ofir R, Tschope C, Horwitz EM.

Cytotherapy. 2009;11(4):427-34.PMID: 19526389 [PubMed - indexed for MEDLINE]Related articles

Heart failure with normal ejection fraction. Pathophysiology, diagnosis, and treatment.

Tschöpe C, Westermann D.

Herz. 2009 Mar;34(2):89-96. Review.PMID: 19370324 [PubMed - indexed for MEDLINE]Related articles

Cardiac deletion of the Coxsackievirus-adenovirus receptor abolishes Coxsackievirus B3 infection and prevents myocarditis in vivo.

Shi Y, Chen C, Lisewski U, Wrackmeyer U, Radke M, Westermann D, Sauter M, Tschöpe C, Poller W, Klingel K, Gotthardt M.

J Am Coll Cardiol. 2009 Apr 7;53(14):1219-26.PMID: 19341864 [PubMed - indexed for MEDLINE]Related articles

Gene deletion of the kinin receptor B1 attenuates cardiac inflammation and fibrosis during the development of experimental diabetic cardiomyopathy.

Westermann D, Walther T, Savvatis K, Escher F, Sobirey M, Riad A, Bader M, Schultheiss HP, Tschöpe C.

Diabetes. 2009 Jun;58(6):1373-81. Epub 2009 Mar 10.PMID: 19276445 [PubMed - indexed for MEDLINE]Related articlesFree article

Vascular-protective effects of high-density lipoprotein include the downregulation of the angiotensin II type 1 receptor.

Van Linthout S, Spillmann F, Lorenz M, Meloni M, Jacobs F, Egorova M, Stangl V, De Geest B, Schultheiss HP, Tschöpe C.

Hypertension. 2009 Apr;53(4):682-7. Epub 2009 Mar 9.PMID: 19273745 [PubMed - indexed for MEDLINE]Related articles

Enhancement of the endothelial NO synthase attenuates experimental diastolic heart failure.

Westermann D, Riad A, Richter U, Jäger S, Savvatis K, Schuchardt M, Bergmann N, Tölle M, Nagorsen D, Gotthardt M, Schultheiss HP, Tschöpe C.

Basic Res Cardiol. 2009 Sep;104(5):499-509. Epub 2009 Mar 3.PMID: 19255799 [PubMed - in process]Related articles

Long-term cardiac-targeted RNA interference for the treatment of heart failure restores cardiac function and reduces pathological hypertrophy.

Suckau L, Fechner H, Chemaly E, Krohn S, Hadri L, Kockskämper J, Westermann D, Bisping E, Ly H, Wang X, Kawase Y, Chen J, Liang L, Sipo I, Vetter R, Weger S, Kurreck J, Erdmann V, Tschope C, Pieske B, Lebeche D, Schultheiss HP, Hajjar RJ, Poller WC.

Circulation. 2009 Mar 10;119(9):1241-52. Epub 2009 Feb 23.PMID: 19237664 [PubMed - indexed for MEDLINE]Related articles

Inflammation as a therapeutic target in heart failure? A scientific statement from the Translational Research Committee of the Heart Failure Association of the European Society of Cardiology.

Heymans S, Hirsch E, Anker SD, Aukrust P, Balligand JL, Cohen-Tervaert JW, Drexler H, Filippatos G, Felix SB, Gullestad L, Hilfiker-Kleiner D, Janssens S, Latini R, Neubauer G, Paulus WJ, Pieske B, Ponikowski P, Schroen B, Schultheiss HP, Tschöpe C, Van Bilsen M, Zannad F, McMurray J, Shah AM.

Eur J Heart Fail. 2009 Feb;11(2):119-29. Review.PMID: 19168509 [PubMed - indexed for MEDLINE]Related articles

Pretreatment with statin attenuates the cardiotoxicity of Doxorubicin in mice.

Riad A, Bien S, Westermann D, Becher PM, Loya K, Landmesser U, Kroemer HK, Schultheiss HP, Tschöpe C.

Cancer Res. 2009 Jan 15;69(2):695-9.PMID: 19147586 [PubMed - indexed for MEDLINE]Related articles

Angiotensin II type 2 receptor stimulation: a novel option of therapeutic interference with the renin-angiotensin system in myocardial infarction?

Kaschina E, Grzesiak A, Li J, Foryst-Ludwig A, Timm M, Rompe F, Sommerfeld M, Kemnitz UR, Curato C, Namsolleck P, Tschöpe C, Hallberg A, Alterman M, Hucko T, Paetsch I, Dietrich T, Schnackenburg B, Graf K, Dahlöf B, Kintscher U, Unger T, Steckelings UM.

Circulation. 2008 Dec 9;118(24):2523-32. Epub 2008 Nov 24.PMID: 19029468 [PubMed - indexed for MEDLINE]Related articles

Renin inhibition improves cardiac function and remodeling after myocardial infarction independent of blood pressure.

Westermann D, Riad A, Lettau O, Roks A, Savvatis K, Becher PM, Escher F, Jan Danser AH, Schultheiss HP, Tschöpe C.

Hypertension. 2008 Dec;52(6):1068-75. Epub 2008 Oct 27.PMID: 18955663 [PubMed - indexed for MEDLINE]Related articles

Complication rate of right ventricular endomyocardial biopsy via the femoral approach: a retrospective and prospective study analyzing 3048 diagnostic procedures over an 11-year period.

Holzmann M, Nicko A, Kühl U, Noutsias M, Poller W, Hoffmann W, Morguet A, Witzenbichler B, Tschöpe C, Schultheiss HP, Pauschinger M.

Circulation. 2008 Oct 21;118(17):1722-8. Epub 2008 Oct 6.PMID: 18838566 [PubMed - indexed for MEDLINE]Related articlesFree article

Enhancement of endothelial nitric oxide synthase production reverses vascular dysfunction and inflammation in the hindlimbs of a rat model of diabetes.

Riad A, Westermann D, Van Linthout S, Mohr Z, Uyulmaz S, Becher PM, Rütten H, Wohlfart P, Peters H, Schultheiss HP, Tschöpe C.

Diabetologia. 2008 Dec;51(12):2325-32. Epub 2008 Sep 30.PMID: 18825362 [PubMed - indexed for MEDLINE]Related articles

Doxorubicin cardiomyopathy-induced inflammation and apoptosis are attenuated by gene deletion of the kinin B1 receptor.

Westermann D, Lettau O, Sobirey M, Riad A, Bader M, Schultheiss HP, Tschöpe C.

Biol Chem. 2008 Jun;389(6):713-8.PMID: 18627295 [PubMed - indexed for MEDLINE]Related articles

Attenuation of left ventricular dysfunction by an ACE inhibitor after myocardial infarction in a kininogen-deficient rat model.

Koch M, Bonaventura K, Spillmann F, Dendorfer A, Schultheiss HP, Tschöpe C.

Biol Chem. 2008 Jun;389(6):719-23.PMID: 18627293 [PubMed - indexed for MEDLINE]Related articles

Development of diabetic cardiomyopathy and the kallikrein-kinin system--new insights from B1 and B2 receptor signaling.

Tschöpe C, Westermann D.

Biol Chem. 2008 Jun;389(6):707-11. Review.PMID: 18627288 [PubMed - indexed for MEDLINE]Related articles

The angiotensin-(1-7) receptor agonist AVE0991 is cardioprotective in diabetic rats.

Ebermann L, Spillmann F, Sidiropoulos M, Escher F, Heringer-Walther S, Schultheiss HP, Tschöpe C, Walther T.

Eur J Pharmacol. 2008 Aug 20;590(1-3):276-80. Epub 2008 May 24.PMID: 18571157 [PubMed - indexed for MEDLINE]Related articles

Human parvovirus B19 NS1 protein modulates inflammatory signaling by activation of STAT3/PIAS3 in human endothelial cells.

Duechting A, Tschöpe C, Kaiser H, Lamkemeyer T, Tanaka N, Aberle S, Lang F, Torresi J, Kandolf R, Bock CT.

J Virol. 2008 Aug;82(16):7942-52. Epub 2008 Jun 11.PMID: 18550668 [PubMed - indexed for MEDLINE]Related articlesFree article

Cardiac-targeted RNA interference mediated by an AAV9 vector improves cardiac function in coxsackievirus B3 cardiomyopathy.

Fechner H, Sipo I, Westermann D, Pinkert S, Wang X, Suckau L, Kurreck J, Zeichhardt H, Müller O, Vetter R, Erdmann V, Tschope C, Poller W.

J Mol Med. 2008 Sep;86(9):987-97. Epub 2008 Jun 12.PMID: 18548221 [PubMed - indexed for MEDLINE]Related articles

Additional lack of iNOS attenuates diastolic dysfunction in aged ET-1 transgenic mice.

Kalk P, Westermann D, Herzfeld S, Relle K, Pfab T, Bauer C, Tschöpe C, Stasch JP, Hocher B.

Can J Physiol Pharmacol. 2008 Jun;86(6):353-7.PMID: 18516098 [PubMed - indexed for MEDLINE]Related articles

Viral myocarditis and coagulopathy: increased tissue factor expression and plasma thrombogenicity.

Antoniak S, Boltzen U, Riad A, Kallwellis-Opara A, Rohde M, Dörner A, Tschöpe C, Noutsias M, Pauschinger M, Schultheiss HP, Rauch U.

J Mol Cell Cardiol. 2008 Jul;45(1):118-26. Epub 2008 Mar 29.PMID: 18495150 [PubMed - indexed for MEDLINE]Related articles

Toll-like receptor-4 modulates survival by induction of left ventricular remodeling after myocardial infarction in mice.

Riad A, Jäger S, Sobirey M, Escher F, Yaulema-Riss A, Westermann D, Karatas A, Heimesaat MM, Bereswill S, Dragun D, Pauschinger M, Schultheiss HP, Tschöpe C.

J Immunol. 2008 May 15;180(10):6954-61.PMID: 18453617 [PubMed - indexed for MEDLINE]Related articlesFree article

Renin inhibitors, clinical experience.

Westermann D, Schmieder R, Schultheiss HP, Tschöpe C.

J Mol Med. 2008 Jun;86(6):691-5. Epub 2008 Apr 25. Review.PMID: 18437334 [PubMed - indexed for MEDLINE]Related articles

Left ventricular function in the post-infarct failing mouse heart by magnetic resonance imaging and conductance catheter: a comparative analysis.

Winter EM, Grauss RW, Atsma DE, Hogers B, Poelmann RE, van der Geest RJ, Tschöpe C, Schalij MJ, Gittenberger-de Groot AC, Steendijk P.

Acta Physiol (Oxf). 2008 Oct;194(2):111-22. Epub 2008 Apr 17.PMID: 18419776 [PubMed - indexed for MEDLINE]Related articles

Role of left ventricular stiffness in heart failure with normal ejection fraction.

Westermann D, Kasner M, Steendijk P, Spillmann F, Riad A, Weitmann K, Hoffmann W, Poller W, Pauschinger M, Schultheiss HP, Tschöpe C.

Circulation. 2008 Apr 22;117(16):2051-60. Epub 2008 Apr 14.PMID: 18413502 [PubMed - indexed for MEDLINE]Related articlesFree article

Reduced MMP-2 activity contributes to cardiac fibrosis in experimental diabetic cardiomyopathy.

Van Linthout S, Seeland U, Riad A, Eckhardt O, Hohl M, Dhayat N, Richter U, Fischer JW, Böhm M, Pauschinger M, Schultheiss HP, Tschöpe C.

Basic Res Cardiol. 2008 Jul;103(4):319-27. Epub 2008 Mar 17.PMID: 18347835 [PubMed - indexed for MEDLINE]Related articles

Human apolipoprotein A-I gene transfer reduces the development of experimental diabetic cardiomyopathy.

Van Linthout S, Spillmann F, Riad A, Trimpert C, Lievens J, Meloni M, Escher F, Filenberg E, Demir O, Li J, Shakibaei M, Schimke I, Staudt A, Felix SB, Schultheiss HP, De Geest B, Tschöpe C.

Circulation. 2008 Mar 25;117(12):1563-73. Epub 2008 Mar 10.PMID: 18332268 [PubMed - indexed for MEDLINE]Related articlesFree article

Toll-like receptor-4 deficiency attenuates doxorubicin-induced cardiomyopathy in mice.

Riad A, Bien S, Gratz M, Escher F, Westermann D, Heimesaat MM, Bereswill S, Krieg T, Felix SB, Schultheiss HP, Kroemer HK, Tschöpe C.

Eur J Heart Fail. 2008 Mar;10(3):233-43. Epub 2008 Mar 5.PMID: 18321777 [PubMed - indexed for MEDLINE]Related articles

Biglycan is required for adaptive remodeling after myocardial infarction.

Westermann D, Mersmann J, Melchior A, Freudenberger T, Petrik C, Schaefer L, Lüllmann-Rauch R, Lettau O, Jacoby C, Schrader J, Brand-Herrmann SM, Young MF, Schultheiss HP, Levkau B, Baba HA, Unger T, Zacharowski K, Tschöpe C, Fischer JW.

Circulation. 2008 Mar 11;117(10):1269-76. Epub 2008 Feb 25.PMID: 18299507 [PubMed - indexed for MEDLINE]Related articlesFree article

The cardiovascular influence of interleukin-1 beta on the expression of bradykinin B1 and B2 receptors.

Riad A, Walther T, Yang J, Altmann C, Escher F, Westermann D, Spillmann F, Schultheiss HP, Tschöpe C.

Int Immunopharmacol. 2008 Feb;8(2):222-30. Epub 2007 Aug 21.PMID: 18182231 [PubMed - indexed for MEDLINE]Related articles

New perspective on the tissue kallikrein-kinin system in myocardial infarction: role of angiogenesis and cardiac regeneration.

Westermann D, Schultheiss HP, Tschöpe C.

Int Immunopharmacol. 2008 Feb;8(2):148-54. Epub 2007 Aug 17. Review.PMID: 18182218 [PubMed - indexed for MEDLINE]Related articles

Cardiac overexpression of human VEGF(165) by recombinant Semliki Forest virus leads to adverse effects in pressure-induced heart failure.

Loot AE, Roks AJ, Westermann D, Orzechowski HD, Tschöpe C, Wilschut JC, Tio RA, van Gilst WH, Henning RH.

Neth Heart J. 2007;15(10):335-41.PMID: 18167566 [PubMed - in process]Related articlesFree article

Up-regulation of PPARgamma in myocardial infarction.

Fliegner D, Westermann D, Riad A, Schubert C, Becher E, Fielitz J, Tschöpe C, Regitz-Zagrosek V.

Eur J Heart Fail. 2008 Jan;10(1):30-8. Epub 2007 Dec 27.PMID: 18162196 [PubMed - indexed for MEDLINE]Related articles

The endothelin receptor blocker bosentan inhibits doxorubicin-induced cardiomyopathy.

Bien S, Riad A, Ritter CA, Gratz M, Olshausen F, Westermann D, Grube M, Krieg T, Ciecholewski S, Felix SB, Staudt A, Schultheiss HP, Ewert R, Völker U, Tschöpe C, Kroemer HK.

Cancer Res. 2007 Nov 1;67(21):10428-35.PMID: 17974986 [PubMed - indexed for MEDLINE]Related articlesFree article

Tumor necrosis factor-alpha antagonism protects from myocardial inflammation and fibrosis in experimental diabetic cardiomyopathy.

Westermann D, Van Linthout S, Dhayat S, Dhayat N, Schmidt A, Noutsias M, Song XY, Spillmann F, Riad A, Schultheiss HP, Tschöpe C.

Basic Res Cardiol. 2007 Nov;102(6):500-7. Epub 2007 Oct 5.PMID: 17909696 [PubMed - indexed for MEDLINE]Related articles

Low-dose treatment with atorvastatin leads to anti-oxidative and anti-inflammatory effects in diabetes mellitus.

Riad A, Du J, Stiehl S, Westermann D, Mohr Z, Sobirey M, Doehner W, Adams V, Pauschinger M, Schultheiss HP, Tschöpe C.

Eur J Pharmacol. 2007 Aug 27;569(3):204-11. Epub 2007 May 24.PMID: 17669395 [PubMed - indexed for MEDLINE]Related articles

Utility of Doppler echocardiography and tissue Doppler imaging in the estimation of diastolic function in heart failure with normal ejection fraction: a comparative Doppler-conductance catheterization study.

Kasner M, Westermann D, Steendijk P, Gaub R, Wilkenshoff U, Weitmann K, Hoffmann W, Poller W, Schultheiss HP, Pauschinger M, Tschöpe C.

Circulation. 2007 Aug 7;116(6):637-47. Epub 2007 Jul 23.PMID: 17646587 [PubMed - indexed for MEDLINE]Related articlesFree article

Anti-inflammatory effects of atorvastatin improve left ventricular function in experimental diabetic cardiomyopathy.

Van Linthout S, Riad A, Dhayat N, Spillmann F, Du J, Dhayat S, Westermann D, Hilfiker-Kleiner D, Noutsias M, Laufs U, Schultheiss HP, Tschöpe C.

Diabetologia. 2007 Sep;50(9):1977-86. Epub 2007 Jun 23.PMID: 17589825 [PubMed - indexed for MEDLINE]Related articles

Cardioprotective and anti-inflammatory effects of interleukin converting enzyme inhibition in experimental diabetic cardiomyopathy.

Westermann D, Van Linthout S, Dhayat S, Dhayat N, Escher F, Bücker-Gärtner C, Spillmann F, Noutsias M, Riad A, Schultheiss HP, Tschöpe C.

Diabetes. 2007 Jul;56(7):1834-41. Epub 2007 May 1.PMID: 17473225 [PubMed - indexed for MEDLINE]Related articlesFree article

Regional and global protective effects of tissue kallikrein gene delivery to the peri-infarct myocardium.

Spillmann F, Graiani G, Van Linthout S, Meloni M, Campesi I, Lagrasta C, Westermann D, Tschöpe C, Quaini F, Emanueli C, Madeddu P.

Regen Med. 2006 Mar;1(2):235-54.PMID: 17465807 [PubMed - indexed for MEDLINE]Related articles

How to diagnose diastolic heart failure: a consensus statement on the diagnosis of heart failure with normal left ventricular ejection fraction by the Heart Failure and Echocardiography Associations of the European Society of Cardiology.

Paulus WJ, Tschöpe C, Sanderson JE, Rusconi C, Flachskampf FA, Rademakers FE, Marino P, Smiseth OA, De Keulenaer G, Leite-Moreira AF, Borbély A, Edes I, Handoko ML, Heymans S, Pezzali N, Pieske B, Dickstein K, Fraser AG, Brutsaert DL.

Eur Heart J. 2007 Oct;28(20):2539-50. Epub 2007 Apr 11.PMID: 17428822 [PubMed - indexed for MEDLINE]Related articlesFree article

Secretory sphingomyelinase is upregulated in chronic heart failure: a second messenger system of immune activation relates to body composition, muscular functional capacity, and peripheral blood flow.

Doehner W, Bunck AC, Rauchhaus M, von Haehling S, Brunkhorst FM, Cicoira M, Tschope C, Ponikowski P, Claus RA, Anker SD.

Eur Heart J. 2007 Apr;28(7):821-8. Epub 2007 Mar 12.PMID: 17353227 [PubMed - indexed for MEDLINE]Related articlesFree article

Contributions of inflammation and cardiac matrix metalloproteinase activity to cardiac failure in diabetic cardiomyopathy: the role of angiotensin type 1 receptor antagonism.

Westermann D, Rutschow S, Jäger S, Linderer A, Anker S, Riad A, Unger T, Schultheiss HP, Pauschinger M, Tschöpe C.

Diabetes. 2007 Mar;56(3):641-6.PMID: 17327431 [PubMed - indexed for MEDLINE]Related articlesFree article