PubMed

{kappa}-Opioid receptors control the metabolic response to a high-energy diet in mice.

Czyzyk TA, Nogueiras R, Lockwood JF, McKinzie JH, Coskun T, Pintar JE, Hammond C, Tschöp MH, Statnick MA.

FASEB J. 2009 Nov 16. [Epub ahead of print]PMID: 19917675 [PubMed - as supplied by publisher]Related articles

Ghrelin in the regulation of body weight and metabolism.

Castañeda TR, Tong J, Datta R, Culler M, Tschöp MH.

Front Neuroendocrinol. 2009 Nov 5. [Epub ahead of print]PMID: 19896496 [PubMed - as supplied by publisher]Related articles

KSR2 is an essential regulator of AMP kinase, energy expenditure, and insulin sensitivity.

Costanzo-Garvey DL, Pfluger PT, Dougherty MK, Stock JL, Boehm M, Chaika O, Fernandez MR, Fisher K, Kortum RL, Hong EG, Jun JY, Ko HJ, Schreiner A, Volle DJ, Treece T, Swift AL, Winer M, Chen D, Wu M, Leon LR, Shaw AS, McNeish J, Kim JK, Morrison DK, Tschöp MH, Lewis RE.

Cell Metab. 2009 Nov;10(5):366-78.PMID: 19883615 [PubMed - in process]Related articles

Central nervous system melanocortin-3 receptors are required for synchronizing metabolism during entrainment to restricted feeding during the light cycle.

Sutton GM, Begriche K, Kumar KG, Gimble JM, Perez-Tilve D, Nogueiras R, McMillan RP, Hulver MW, Tschöp MH, Butler AA.

FASEB J. 2009 Oct 16. [Epub ahead of print]PMID: 19837866 [PubMed - as supplied by publisher]Related articles

Metabolic effects of diets differing in glycaemic index depend on age and endogenous glucose-dependent insulinotrophic polypeptide in mice.

Isken F, Weickert MO, Tschöp MH, Nogueiras R, Möhlig M, Abdelrahman A, Klaus S, Thorens B, Pfeiffer AF.

Diabetologia. 2009 Oct;52(10):2159-68. Epub 2009 Jul 31.PMID: 19644669 [PubMed - in process]Related articles

An anatomic basis for the communication of hypothalamic, cortical and mesolimbic circuitry in the regulation of energy balance.

Kampe J, Tschöp MH, Hollis JH, Oldfield BJ.

Eur J Neurosci. 2009 Aug;30(3):415-30. Epub 2009 Jul 15.PMID: 19614751 [PubMed - indexed for MEDLINE]Related articles

A new glucagon and GLP-1 co-agonist eliminates obesity in rodents.

Day JW, Ottaway N, Patterson JT, Gelfanov V, Smiley D, Gidda J, Findeisen H, Bruemmer D, Drucker DJ, Chaudhary N, Holland J, Hembree J, Abplanalp W, Grant E, Ruehl J, Wilson H, Kirchner H, Lockie SH, Hofmann S, Woods SC, Nogueiras R, Pfluger PT, Perez-Tilve D, DiMarchi R, Tschöp MH.

Nat Chem Biol. 2009 Oct;5(10):749-57. Epub 2009 Jul 13.PMID: 19597507 [PubMed - indexed for MEDLINE]Related articles

The endocannabinoid system: role in glucose and energy metabolism.

Nogueiras R, Diaz-Arteaga A, Lockie SH, Velásquez DA, Tschop J, López M, Cadwell CC, Diéguez C, Tschöp MH.

Pharmacol Res. 2009 Aug;60(2):93-8. Epub 2009 Apr 14. Review.PMID: 19559361 [PubMed - indexed for MEDLINE]Related articles

The cannabinoid receptor 2 is critical for the host response to sepsis.

Tschöp J, Kasten KR, Nogueiras R, Goetzman HS, Cave CM, England LG, Dattilo J, Lentsch AB, Tschöp MH, Caldwell CC.

J Immunol. 2009 Jul 1;183(1):499-505. Epub 2009 Jun 12.PMID: 19525393 [PubMed - indexed for MEDLINE]Related articles

GOAT links dietary lipids with the endocrine control of energy balance.

Kirchner H, Gutierrez JA, Solenberg PJ, Pfluger PT, Czyzyk TA, Willency JA, Schürmann A, Joost HG, Jandacek RJ, Hale JE, Heiman ML, Tschöp MH.

Nat Med. 2009 Jul;15(7):741-5. Epub 2009 Jun 5. Erratum in: Nat Med. 2009 Sep;15(9):1093. PMID: 19503064 [PubMed - indexed for MEDLINE]Related articles

Dietary sugars: a fat difference.

Hofmann SM, Tschöp MH.

J Clin Invest. 2009 May;119(5):1089-92.PMID: 19422101 [PubMed - indexed for MEDLINE]Related articles

Direct control of peripheral lipid deposition by CNS GLP-1 receptor signaling is mediated by the sympathetic nervous system and blunted in diet-induced obesity.

Nogueiras R, Pérez-Tilve D, Veyrat-Durebex C, Morgan DA, Varela L, Haynes WG, Patterson JT, Disse E, Pfluger PT, López M, Woods SC, DiMarchi R, Diéguez C, Rahmouni K, Rohner-Jeanrenaud F, Tschöp MH.

J Neurosci. 2009 May 6;29(18):5916-25.PMID: 19420258 [PubMed - indexed for MEDLINE]Related articlesFree article

Getting to the core of the gut microbiome.

Tschöp MH, Hugenholtz P, Karp CL.

Nat Biotechnol. 2009 Apr;27(4):344-6. No abstract available. PMID: 19352371 [PubMed - indexed for MEDLINE]Related articles

Coupled with uncouplers: the curious case of lifespan.

Lockie SH, Müller TD, Tschöp MH.

Am J Physiol Endocrinol Metab. 2009 Apr;296(4):E619-20. Epub 2009 Feb 10. No abstract available. PMID: 19208859 [PubMed - indexed for MEDLINE]Related articles

Exposure to elevated levels of dietary fat attenuates psychostimulant reward and mesolimbic dopamine turnover in the rat.

Davis JF, Tracy AL, Schurdak JD, Tschöp MH, Lipton JW, Clegg DJ, Benoit SC.

Behav Neurosci. 2008 Dec;122(6):1257-63.PMID: 19045945 [PubMed - indexed for MEDLINE]Related articles

Low-carbohydrate high-fat diets: regulation of energy balance and body weight regain in rats.

Caton SJ, Yinglong B, Burget L, Spangler LJ, Tschöp MH, Bidlingmaier M.

Obesity (Silver Spring). 2009 Feb;17(2):283-9. Epub 2008 Nov 27.PMID: 19039316 [PubMed - indexed for MEDLINE]Related articles

The melanocortin-3 receptor is required for entrainment to meal intake.

Sutton GM, Perez-Tilve D, Nogueiras R, Fang J, Kim JK, Cone RD, Gimble JM, Tschöp MH, Butler AA.

J Neurosci. 2008 Nov 26;28(48):12946-55.PMID: 19036988 [PubMed - indexed for MEDLINE]Related articlesFree article

A sweet spot for the bariatric surgeon.

Perez-Tilve D, D'Alessio DA, Tschöp MH.

Cell Metab. 2008 Sep;8(3):177-9.PMID: 18762016 [PubMed - indexed for MEDLINE]Related articles

Peripheral, but not central, CB1 antagonism provides food intake-independent metabolic benefits in diet-induced obese rats.

Nogueiras R, Veyrat-Durebex C, Suchanek PM, Klein M, Tschöp J, Caldwell C, Woods SC, Wittmann G, Watanabe M, Liposits Z, Fekete C, Reizes O, Rohner-Jeanrenaud F, Tschöp MH.

Diabetes. 2008 Nov;57(11):2977-91. Epub 2008 Aug 20.PMID: 18716045 [PubMed - indexed for MEDLINE]Related articlesFree article

UCP2 mediates ghrelin's action on NPY/AgRP neurons by lowering free radicals.

Andrews ZB, Liu ZW, Walllingford N, Erion DM, Borok E, Friedman JM, Tschöp MH, Shanabrough M, Cline G, Shulman GI, Coppola A, Gao XB, Horvath TL, Diano S.

Nature. 2008 Aug 14;454(7206):846-51. Epub 2008 Jul 30.PMID: 18668043 [PubMed - indexed for MEDLINE]Related articles

Sirt1 protects against high-fat diet-induced metabolic damage.

Pfluger PT, Herranz D, Velasco-Miguel S, Serrano M, Tschöp MH.

Proc Natl Acad Sci U S A. 2008 Jul 15;105(28):9793-8. Epub 2008 Jul 3.PMID: 18599449 [PubMed - indexed for MEDLINE]Related articlesFree article

Deficiency of glucose-dependent insulinotropic polypeptide receptor prevents ovariectomy-induced obesity in mice.

Isken F, Pfeiffer AF, Nogueiras R, Osterhoff MA, Ristow M, Thorens B, Tschöp MH, Weickert MO.

Am J Physiol Endocrinol Metab. 2008 Aug;295(2):E350-5. Epub 2008 May 27.PMID: 18505834 [PubMed - indexed for MEDLINE]Related articlesFree article

The endocannabinoid system and the control of glucose homeostasis.

Nogueiras R, Rohner-Jeanrenaud F, Woods SC, Tschöp MH.

J Neuroendocrinol. 2008 May;20 Suppl 1:147-51. Review.PMID: 18426514 [PubMed - indexed for MEDLINE]Related articles

Long-term effects of ghrelin and ghrelin receptor agonists on energy balance in rats.

Strassburg S, Anker SD, Castaneda TR, Burget L, Perez-Tilve D, Pfluger PT, Nogueiras R, Halem H, Dong JZ, Culler MD, Datta R, Tschöp MH.

Am J Physiol Endocrinol Metab. 2008 Jul;295(1):E78-84. Epub 2008 May 6.PMID: 18460598 [PubMed - indexed for MEDLINE]Related articlesFree article

Hypothalamic fatty acid metabolism mediates the orexigenic action of ghrelin.

López M, Lage R, Saha AK, Pérez-Tilve D, Vázquez MJ, Varela L, Sangiao-Alvarellos S, Tovar S, Raghay K, Rodríguez-Cuenca S, Deoliveira RM, Castañeda T, Datta R, Dong JZ, Culler M, Sleeman MW, Alvarez CV, Gallego R, Lelliott CJ, Carling D, Tschöp MH, Diéguez C, Vidal-Puig A.

Cell Metab. 2008 May;7(5):389-99.PMID: 18460330 [PubMed - indexed for MEDLINE]Related articles

Central nervous system regulation of adipocyte metabolism.

Nogueiras R, Wilson H, Rohner-Jeanrenaud F, Tschöp MH.

Regul Pept. 2008 Aug 7;149(1-3):26-31. Epub 2008 Apr 1. Review.PMID: 18453013 [PubMed - indexed for MEDLINE]Related articles

Central nervous system regulation of energy metabolism: ghrelin versus leptin.

Nogueiras R, Tschöp MH, Zigman JM.

Ann N Y Acad Sci. 2008 Apr;1126:14-9. Review.PMID: 18448790 [PubMed - indexed for MEDLINE]Related articles

Gastric O-acyl transferase activates hunger signal to the brain.

Tong J, Pfluger PT, Tschöp MH.

Proc Natl Acad Sci U S A. 2008 Apr 29;105(17):6213-4. Epub 2008 Apr 28. No abstract available. PMID: 18443299 [PubMed - indexed for MEDLINE]Related articlesFree article

Bsx, a novel hypothalamic factor linking feeding with locomotor activity, is regulated by energy availability.

Nogueiras R, López M, Lage R, Perez-Tilve D, Pfluger P, Mendieta-Zerón H, Sakkou M, Wiedmer P, Benoit SC, Datta R, Dong JZ, Culler M, Sleeman M, Vidal-Puig A, Horvath T, Treier M, Diéguez C, Tschöp MH.

Endocrinology. 2008 Jun;149(6):3009-15. Epub 2008 Feb 28.PMID: 18308842 [PubMed - indexed for MEDLINE]Related articlesFree article

Mice with chronically increased circulating ghrelin develop age-related glucose intolerance.

Reed JA, Benoit SC, Pfluger PT, Tschöp MH, D'Alessio DA, Seeley RJ.

Am J Physiol Endocrinol Metab. 2008 Apr;294(4):E752-60. Epub 2008 Feb 12.PMID: 18270302 [PubMed - indexed for MEDLINE]Related articlesFree article

The triple uptake inhibitor (1R,5S)-(+)-1-(3,4-dichlorophenyl)-3-azabicyclo[3.1.0] hexane hydrochloride (DOV 21947) reduces body weight and plasma triglycerides in rodent models of diet-induced obesity.

Tizzano JP, Stribling DS, Perez-Tilve D, Strack A, Frassetto A, Chen RZ, Fong TM, Shearman L, Krieter PA, Tschöp MH, Skolnick P, Basile AS.

J Pharmacol Exp Ther. 2008 Mar;324(3):1111-26. Epub 2007 Dec 18.PMID: 18089843 [PubMed - indexed for MEDLINE]Related articlesFree article

Simultaneous deletion of ghrelin and its receptor increases motor activity and energy expenditure.

Pfluger PT, Kirchner H, Günnel S, Schrott B, Perez-Tilve D, Fu S, Benoit SC, Horvath T, Joost HG, Wortley KE, Sleeman MW, Tschöp MH.

Am J Physiol Gastrointest Liver Physiol. 2008 Mar;294(3):G610-8. Epub 2007 Nov 29.PMID: 18048479 [PubMed - indexed for MEDLINE]Related articlesFree article

Adipocyte LDL receptor-related protein-1 expression modulates postprandial lipid transport and glucose homeostasis in mice.

Hofmann SM, Zhou L, Perez-Tilve D, Greer T, Grant E, Wancata L, Thomas A, Pfluger PT, Basford JE, Gilham D, Herz J, Tschöp MH, Hui DY.

J Clin Invest. 2007 Nov;117(11):3271-82.PMID: 17948131 [PubMed - indexed for MEDLINE]Related articlesFree article

Peptide YY regulates bone turnover in rodents.

Wortley KE, Garcia K, Okamoto H, Thabet K, Anderson KD, Shen V, Herman JP, Valenzuela D, Yancopoulos GD, Tschöp MH, Murphy A, Sleeman MW.

Gastroenterology. 2007 Nov;133(5):1534-43. Epub 2007 Aug 15.PMID: 17920065 [PubMed - indexed for MEDLINE]Related articles

Defective lipid delivery modulates glucose tolerance and metabolic response to diet in apolipoprotein E-deficient mice.

Hofmann SM, Perez-Tilve D, Greer TM, Coburn BA, Grant E, Basford JE, Tschöp MH, Hui DY.

Diabetes. 2008 Jan;57(1):5-12. Epub 2007 Oct 3.PMID: 17914034 [PubMed - indexed for MEDLINE]Related articlesFree article

Ghrelin, obesity and diabetes.

Wiedmer P, Nogueiras R, Broglio F, D'Alessio D, Tschöp MH.

Nat Clin Pract Endocrinol Metab. 2007 Oct;3(10):705-12. Review.PMID: 17893689 [PubMed - indexed for MEDLINE]Related articles

The central melanocortin system directly controls peripheral lipid metabolism.

Nogueiras R, Wiedmer P, Perez-Tilve D, Veyrat-Durebex C, Keogh JM, Sutton GM, Pfluger PT, Castaneda TR, Neschen S, Hofmann SM, Howles PN, Morgan DA, Benoit SC, Szanto I, Schrott B, Schürmann A, Joost HG, Hammond C, Hui DY, Woods SC, Rahmouni K, Butler AA, Farooqi IS, O'Rahilly S, Rohner-Jeanrenaud F, Tschöp MH.

J Clin Invest. 2007 Nov;117(11):3475-88.PMID: 17885689 [PubMed - indexed for MEDLINE]Related articlesFree article

NO to obesity: does nitric oxide regulate fat oxidation and insulin sensitivity?

Joost HG, Tschöp MH.

Endocrinology. 2007 Oct;148(10):4545-7. Review. No abstract available. PMID: 17876034 [PubMed - indexed for MEDLINE]Related articlesFree article

Peptide YY: obesity's cause and cure?

Tschöp MH, Ravussin E.

Am J Physiol Endocrinol Metab. 2007 Nov;293(5):E1131-3. Epub 2007 Sep 11. No abstract available. PMID: 17848627 [PubMed - indexed for MEDLINE]Related articlesFree article

Osteopontin mediates obesity-induced adipose tissue macrophage infiltration and insulin resistance in mice.

Nomiyama T, Perez-Tilve D, Ogawa D, Gizard F, Zhao Y, Heywood EB, Jones KL, Kawamori R, Cassis LA, Tschöp MH, Bruemmer D.

J Clin Invest. 2007 Oct;117(10):2877-88.PMID: 17823662 [PubMed - indexed for MEDLINE]Related articlesFree article

Comparison of hydrogenated vegetable shortening and nutritionally complete high-fat diet on limited access-binge behavior in rats.

Davis JF, Melhorn SJ, Shurdak JD, Heiman JU, Tschöp MH, Clegg DJ, Benoit SC.

Physiol Behav. 2007 Dec 5;92(5):924-30. Epub 2007 Jul 5.PMID: 17689576 [PubMed - indexed for MEDLINE]Related articlesFree article

Gastric bypass surgery for treatment of hypothalamic obesity after craniopharyngioma therapy.

Inge TH, Pfluger P, Zeller M, Rose SR, Burget L, Sundararajan S, Daniels SR, Tschöp MH.

Nat Clin Pract Endocrinol Metab. 2007 Aug;3(8):606-9.PMID: 17643131 [PubMed - indexed for MEDLINE]Related articles

A role for brain-specific homeobox factor Bsx in the control of hyperphagia and locomotory behavior.

Sakkou M, Wiedmer P, Anlag K, Hamm A, Seuntjens E, Ettwiller L, Tschöp MH, Treier M.

Cell Metab. 2007 Jun;5(6):450-63.PMID: 17550780 [PubMed - indexed for MEDLINE]Related articles

Development of diabetes in obese, insulin-resistant mice: essential role of dietary carbohydrate in beta cell destruction.

Jürgens HS, Neschen S, Ortmann S, Scherneck S, Schmolz K, Schüler G, Schmidt S, Blüher M, Klaus S, Perez-Tilve D, Tschöp MH, Schürmann A, Joost HG.

Diabetologia. 2007 Jul;50(7):1481-9. Epub 2007 Apr 17.PMID: 17437079 [PubMed - indexed for MEDLINE]Related articles

Diet-induced leptin resistance: the heart of the matter.

Tschöp MH, Hui DY, Horvath TL.

Endocrinology. 2007 Mar;148(3):921-3. No abstract available. PMID: 17303671 [PubMed - indexed for MEDLINE]Related articlesFree article

Peptide YY release in anorectic patients after liquid meal.

Otto B, Cuntz U, Otto C, Heldwein W, Riepl RL, Tschöp MH.

Appetite. 2007 May;48(3):301-4. Epub 2006 Dec 8.PMID: 17157959 [PubMed - indexed for MEDLINE]Related articles

Effect of human body weight changes on circulating levels of peptide YY and peptide YY3-36.

Pfluger PT, Kampe J, Castaneda TR, Vahl T, D'Alessio DA, Kruthaupt T, Benoit SC, Cuntz U, Rochlitz HJ, Moehlig M, Pfeiffer AF, Koebnick C, Weickert MO, Otto B, Spranger J, Tschöp MH.

J Clin Endocrinol Metab. 2007 Feb;92(2):583-8. Epub 2006 Nov 21.PMID: 17119001 [PubMed - indexed for MEDLINE]Related articlesFree article

Ghrelin modulates the activity and synaptic input organization of midbrain dopamine neurons while promoting appetite.

Abizaid A, Liu ZW, Andrews ZB, Shanabrough M, Borok E, Elsworth JD, Roth RH, Sleeman MW, Picciotto MR, Tschöp MH, Gao XB, Horvath TL.

J Clin Invest. 2006 Dec;116(12):3229-39. Epub 2006 Oct 19.PMID: 17060947 [PubMed - indexed for MEDLINE]Related articlesFree article

The brain is getting ready for dinner.

Tschöp MH, Castaneda TR, Woods SC.

Cell Metab. 2006 Oct;4(4):257-8.PMID: 17011496 [PubMed - indexed for MEDLINE]Related articles

Effect of central administration of QRFP(26) peptide on energy balance and characterization of a second QRFP receptor in rat.

Kampe J, Wiedmer P, Pfluger PT, Castaneda TR, Burget L, Mondala H, Kerr J, Liaw C, Oldfield BJ, Tschöp MH, Bagnol D.

Brain Res. 2006 Nov 13;1119(1):133-49. Epub 2006 Sep 22.PMID: 16996040 [PubMed - indexed for MEDLINE]Related articles