PubMed

A loss-of-function polymorphism in the propeptide domain of the LOX gene and breast cancer.

Min C, Yu Z, Kirsch KH, Zhao Y, Vora SR, Trackman PC, Spicer DB, Rosenberg L, Palmer JR, Sonenshein GE.

Cancer Res. 2009 Aug 15;69(16):6685-93. Epub 2009 Aug 4.PMID: 19654310 [PubMed - indexed for MEDLINE]Related articles

Lysyl oxidase propeptide inhibits prostate cancer cell growth by mechanisms that target FGF-2-cell binding and signaling.

Palamakumbura AH, Vora SR, Nugent MA, Kirsch KH, Sonenshein GE, Trackman PC.

Oncogene. 2009 Sep 24;28(38):3390-400. Epub 2009 Jul 13.PMID: 19597471 [PubMed - indexed for MEDLINE]Related articles

Lysyl oxidase (lox) gene deficiency affects osteoblastic phenotype.

Pischon N, Mäki JM, Weisshaupt P, Heng N, Palamakumbura AH, N'Guessan P, Ding A, Radlanski R, Renz H, Bronckers TA, Myllyharju J, Kielbassa AM, Kleber BM, Bernimoulin JP, Trackman PC.

Calcif Tissue Int. 2009 Aug;85(2):119-26. Epub 2009 May 21.PMID: 19458888 [PubMed - indexed for MEDLINE]Related articles

The lysyl oxidase pro-peptide attenuates fibronectin-mediated activation of focal adhesion kinase and p130Cas in breast cancer cells.

Zhao Y, Min C, Vora SR, Trackman PC, Sonenshein GE, Kirsch KH.

J Biol Chem. 2009 Jan 16;284(3):1385-93. Epub 2008 Nov 21.PMID: 19029090 [PubMed - indexed for MEDLINE]Related articles

Expression of metalloproteinases and their tissue inhibitors in inflamed gingival biopsies.

Gonçalves LD, Oliveira G, Hurtado PA, Feitosa A, Takiya CM, Granjeiro JM, Trackman PC, Otazú I, Feres-Filho EJ.

J Periodontal Res. 2008 Oct;43(5):570-7. Epub 2008 Jul 4.PMID: 18624953 [PubMed - indexed for MEDLINE]Related articles

Transforming growth factor-beta1 (TGFbeta1) stimulates connective tissue growth factor (CCN2/CTGF) expression in human gingival fibroblasts through a RhoA-independent, Rac1/Cdc42-dependent mechanism: statins with forskolin block TGFbeta1-induced CCN2/CTGF expression.

Black SA Jr, Trackman PC.

J Biol Chem. 2008 Apr 18;283(16):10835-47. Epub 2008 Feb 20.PMID: 18287089 [PubMed - indexed for MEDLINE]Related articlesFree article

Lysyl oxidase propeptide inhibits smooth muscle cell signaling and proliferation.

Hurtado PA, Vora S, Sume SS, Yang D, St Hilaire C, Guo Y, Palamakumbura AH, Schreiber BM, Ravid K, Trackman PC.

Biochem Biophys Res Commun. 2008 Feb 1;366(1):156-61. Epub 2007 Dec 3.PMID: 18060869 [PubMed - indexed for MEDLINE]Related articlesFree article

Apoptosis in gingival overgrowth tissues.

Kantarci A, Augustin P, Firatli E, Sheff MC, Hasturk H, Graves DT, Trackman PC.

J Dent Res. 2007 Sep;86(9):888-92.PMID: 17720861 [PubMed - indexed for MEDLINE]Related articles

Enhanced chondrogenesis and Wnt signaling in PTH-treated fractures.

Kakar S, Einhorn TA, Vora S, Miara LJ, Hon G, Wigner NA, Toben D, Jacobsen KA, Al-Sebaei MO, Song M, Trackman PC, Morgan EF, Gerstenfeld LC, Barnes GL.

J Bone Miner Res. 2007 Dec;22(12):1903-12.PMID: 17680724 [PubMed - indexed for MEDLINE]Related articles

Repression of BCL2 by the tumor suppressor activity of the lysyl oxidase propeptide inhibits transformed phenotype of lung and pancreatic cancer cells.

Wu M, Min C, Wang X, Yu Z, Kirsch KH, Trackman PC, Sonenshein GE.

Cancer Res. 2007 Jul 1;67(13):6278-85.PMID: 17616686 [PubMed - indexed for MEDLINE]Related articlesFree article

Tissue-specific mechanisms for CCN2/CTGF persistence in fibrotic gingiva: interactions between cAMP and MAPK signaling pathways, and prostaglandin E2-EP3 receptor mediated activation of the c-JUN N-terminal kinase.

Black SA Jr, Palamakumbura AH, Stan M, Trackman PC.

J Biol Chem. 2007 May 25;282(21):15416-29. Epub 2007 Apr 10.PMID: 17428796 [PubMed - indexed for MEDLINE]Related articlesFree article

Intracellular distribution of the lysyl oxidase propeptide in osteoblastic cells.

Guo Y, Pischon N, Palamakumbura AH, Trackman PC.

Am J Physiol Cell Physiol. 2007 Jun;292(6):C2095-102. Epub 2007 Feb 7.PMID: 17287363 [PubMed - indexed for MEDLINE]Related articlesFree article

The tumor suppressor activity of the lysyl oxidase propeptide reverses the invasive phenotype of Her-2/neu-driven breast cancer.

Min C, Kirsch KH, Zhao Y, Jeay S, Palamakumbura AH, Trackman PC, Sonenshein GE.

Cancer Res. 2007 Feb 1;67(3):1105-12.PMID: 17283144 [PubMed - indexed for MEDLINE]Related articlesFree article

Activation of RAGE induces elevated O2- generation by mononuclear phagocytes in diabetes.

Ding Y, Kantarci A, Hasturk H, Trackman PC, Malabanan A, Van Dyke TE.

J Leukoc Biol. 2007 Feb;81(2):520-7. Epub 2006 Nov 9.PMID: 17095613 [PubMed - indexed for MEDLINE]Related articlesFree article

Controlled release of fibroblast growth factor 2 stimulates bone healing in an animal model of diabetes mellitus.

Santana RB, Trackman PC.

Int J Oral Maxillofac Implants. 2006 Sep-Oct;21(5):711-8.PMID: 17066631 [PubMed - indexed for MEDLINE]Related articles

Advanced glycation end products stimulate osteoblast apoptosis via the MAP kinase and cytosolic apoptotic pathways.

Alikhani M, Alikhani Z, Boyd C, MacLellan CM, Raptis M, Liu R, Pischon N, Trackman PC, Gerstenfeld L, Graves DT.

Bone. 2007 Feb;40(2):345-53. Epub 2006 Oct 24.PMID: 17064973 [PubMed - indexed for MEDLINE]Related articlesFree article

Advanced glycation end products induce apoptosis in fibroblasts through activation of ROS, MAP kinases, and the FOXO1 transcription factor.

Alikhani M, Maclellan CM, Raptis M, Vora S, Trackman PC, Graves DT.

Am J Physiol Cell Physiol. 2007 Feb;292(2):C850-6. Epub 2006 Sep 27.PMID: 17005604 [PubMed - indexed for MEDLINE]Related articlesFree article

Epithelial and connective tissue cell CTGF/CCN2 expression in gingival fibrosis.

Kantarci A, Black SA, Xydas CE, Murawel P, Uchida Y, Yucekal-Tuncer B, Atilla G, Emingil G, Uzel MI, Lee A, Firatli E, Sheff M, Hasturk H, Van Dyke TE, Trackman PC.

J Pathol. 2006 Sep;210(1):59-66.PMID: 16841303 [PubMed - indexed for MEDLINE]Related articlesFree article

CCN2, connective tissue growth factor, stimulates collagen deposition by gingival fibroblasts via module 3 and alpha6- and beta1 integrins.

Heng EC, Huang Y, Black SA Jr, Trackman PC.

J Cell Biochem. 2006 May 15;98(2):409-20.PMID: 16440322 [PubMed - indexed for MEDLINE]Related articlesFree article

Diabetes-enhanced inflammation and apoptosis--impact on periodontal pathology.

Graves DT, Liu R, Alikhani M, Al-Mashat H, Trackman PC.

J Dent Res. 2006 Jan;85(1):15-21. Review.PMID: 16373675 [PubMed - indexed for MEDLINE]Related articles

Diverse biological functions of extracellular collagen processing enzymes.

Trackman PC.

J Cell Biochem. 2005 Dec 1;96(5):927-37. Review.PMID: 16167328 [PubMed - indexed for MEDLINE]Related articlesFree article

Enhanced superoxide release and elevated protein kinase C activity in neutrophils from diabetic patients: association with periodontitis.

Karima M, Kantarci A, Ohira T, Hasturk H, Jones VL, Nam BH, Malabanan A, Trackman PC, Badwey JA, Van Dyke TE.

J Leukoc Biol. 2005 Oct;78(4):862-70. Epub 2005 Aug 4.PMID: 16081595 [PubMed - indexed for MEDLINE]Related articlesFree article

Advanced glycation end products enhance expression of pro-apoptotic genes and stimulate fibroblast apoptosis through cytoplasmic and mitochondrial pathways.

Alikhani Z, Alikhani M, Boyd CM, Nagao K, Trackman PC, Graves DT.

J Biol Chem. 2005 Apr 1;280(13):12087-95. Epub 2004 Dec 6.PMID: 15590648 [PubMed - indexed for MEDLINE]Related articlesFree article

A procollagen C-proteinase inhibitor diminishes collagen and lysyl oxidase processing but not collagen cross-linking in osteoblastic cultures.

Pischon N, Babakhanlou-Chase H, Darbois L, Ho WB, Brenner MC, Kessler E, Palamakumbura AH, Trackman PC.

J Cell Physiol. 2005 Apr;203(1):111-7.PMID: 15368541 [PubMed - indexed for MEDLINE]Related articles

The propeptide domain of lysyl oxidase induces phenotypic reversion of ras-transformed cells.

Palamakumbura AH, Jeay S, Guo Y, Pischon N, Sommer P, Sonenshein GE, Trackman PC.

J Biol Chem. 2004 Sep 24;279(39):40593-600. Epub 2004 Jul 23.PMID: 15277520 [PubMed - indexed for MEDLINE]Related articlesFree article

Hereditary gingival fibromatosis associated with generalized aggressive periodontitis: a case report.

Casavecchia P, Uzel MI, Kantarci A, Hasturk H, Dibart S, Hart TC, Trackman PC, Van Dyke TE.

J Periodontol. 2004 May;75(5):770-8.PMID: 15212361 [PubMed - indexed for MEDLINE]Related articles

Connective tissue metabolism and gingival overgrowth.

Trackman PC, Kantarci A.

Crit Rev Oral Biol Med. 2004 Jun 4;15(3):165-75. Review.PMID: 15187034 [PubMed - indexed for MEDLINE]Related articlesFree article

Regulation of collagen deposition and lysyl oxidase by tumor necrosis factor-alpha in osteoblasts.

Pischon N, Darbois LM, Palamakumbura AH, Kessler E, Trackman PC.

J Biol Chem. 2004 Jul 16;279(29):30060-5. Epub 2004 May 10.PMID: 15138266 [PubMed - indexed for MEDLINE]Related articlesFree article

A role for lysyl oxidase regulation in the control of normal collagen deposition in differentiating osteoblast cultures.

Hong HH, Pischon N, Santana RB, Palamakumbura AH, Chase HB, Gantz D, Guo Y, Uzel MI, Ma D, Trackman PC.

J Cell Physiol. 2004 Jul;200(1):53-62.PMID: 15137057 [PubMed - indexed for MEDLINE]Related articles

Autocrine growth factor regulation of lysyl oxidase expression in transformed fibroblasts.

Palamakumbura AH, Sommer P, Trackman PC.

J Biol Chem. 2003 Aug 15;278(33):30781-7. Epub 2003 Jun 4.PMID: 12788924 [PubMed - indexed for MEDLINE]Related articlesFree article

A role for advanced glycation end products in diminished bone healing in type 1 diabetes.

Santana RB, Xu L, Chase HB, Amar S, Graves DT, Trackman PC.

Diabetes. 2003 Jun;52(6):1502-10.PMID: 12765963 [PubMed - indexed for MEDLINE]Related articlesFree article

Lysyl oxidase gene expression and enzyme activity in the rat ovary: regulation by follicle-stimulating hormone, androgen, and transforming growth factor-beta superfamily members in vitro.

Harlow CR, Rae M, Davidson L, Trackman PC, Hillier SG.

Endocrinology. 2003 Jan;144(1):154-62.PMID: 12488341 [PubMed - indexed for MEDLINE]Related articlesFree article

Cytokine regulation of gingival fibroblast lysyl oxidase, collagen, and elastin.

Hong HH, Trackman PC.

J Periodontol. 2002 Feb;73(2):145-52.PMID: 11895278 [PubMed - indexed for MEDLINE]Related articles

A fluorometric assay for detection of lysyl oxidase enzyme activity in biological samples.

Palamakumbura AH, Trackman PC.

Anal Biochem. 2002 Jan 15;300(2):245-51.PMID: 11779117 [PubMed - indexed for MEDLINE]Related articles

Connective tissue growth factor in drug-induced gingival overgrowth.

Uzel MI, Kantarci A, Hong HH, Uygur C, Sheff MC, Firatli E, Trackman PC.

J Periodontol. 2001 Jul;72(7):921-31.PMID: 11495141 [PubMed - indexed for MEDLINE]Related articles

Multiple bone morphogenetic protein 1-related mammalian metalloproteinases process pro-lysyl oxidase at the correct physiological site and control lysyl oxidase activation in mouse embryo fibroblast cultures.

Uzel MI, Scott IC, Babakhanlou-Chase H, Palamakumbura AH, Pappano WN, Hong HH, Greenspan DS, Trackman PC.

J Biol Chem. 2001 Jun 22;276(25):22537-43. Epub 2001 Apr 19.PMID: 11313359 [PubMed - indexed for MEDLINE]Related articlesFree article

Molecular events that contribute to lysyl oxidase enzyme activity and insoluble collagen accumulation in osteosarcoma cell clones.

Uzel MI, Shih SD, Gross H, Kessler E, Gerstenfeld LC, Trackman PC.

J Bone Miner Res. 2000 Jun;15(6):1189-97.PMID: 10841188 [PubMed - indexed for MEDLINE]Related articles

Regulation of lysyl oxidase, collagen, and connective tissue growth factor by TGF-beta1 and detection in human gingiva.

Hong HH, Uzel MI, Duan C, Sheff MC, Trackman PC.

Lab Invest. 1999 Dec;79(12):1655-67.PMID: 10616214 [PubMed - indexed for MEDLINE]Related articles

Increased mRNAs for procollagens and key regulating enzymes in rat skeletal muscle following downhill running.

Han XY, Wang W, Komulainen J, Koskinen SO, Kovanen V, Vihko V, Trackman PC, Takala TE.

Pflugers Arch. 1999 May;437(6):857-64.PMID: 10370063 [PubMed - indexed for MEDLINE]Related articles

Inflammation-associated lysyl oxidase protein expression in vivo, and modulation by FGF-2 plus IGF-1.

Trackman PC, Graham RJ, Bittner HK, Carnes DL, Gilles JA, Graves DT.

Histochem Cell Biol. 1998 Jul;110(1):9-14.PMID: 9681684 [PubMed - indexed for MEDLINE]Related articles

Regulation of lysyl oxidase by basic fibroblast growth factor in osteoblastic MC3T3-E1 cells.

Feres-Filho EJ, Menassa GB, Trackman PC.

J Biol Chem. 1996 Mar 15;271(11):6411-6.PMID: 8626440 [PubMed - indexed for MEDLINE]Related articlesFree article

Functional analysis of the promoter and first intron of the human lysyl oxidase gene.

Csiszar K, Entersz I, Trackman PC, Samid D, Boyd CD.

Mol Biol Rep. 1996;23(2):97-108.PMID: 8983023 [PubMed - indexed for MEDLINE]Related articles

Pre- and post-translational regulation of lysyl oxidase by transforming growth factor-beta 1 in osteoblastic MC3T3-E1 cells.

Feres-Filho EJ, Choi YJ, Han X, Takala TE, Trackman PC.

J Biol Chem. 1995 Dec 22;270(51):30797-803.PMID: 8530522 [PubMed - indexed for MEDLINE]Related articlesFree article

The 3'-untranslated region of rat lysyl oxidase cDNA.

Trackman PC, Feres-Filho EJ, Choi YJ.

Biochim Biophys Acta. 1995 Feb 21;1260(3):355-60.PMID: 7873615 [PubMed - indexed for MEDLINE]Related articles

Transient expression of lysyl oxidase by liver myofibroblasts in murine schistosomiasis.

Sommer P, Gleyzal C, Raccurt M, Delbourg M, Serrar M, Joazeiro P, Peyrol S, Kagan H, Trackman PC, Grimaud JA.

Lab Invest. 1993 Oct;69(4):460-70.PMID: 7901452 [PubMed - indexed for MEDLINE]Related articles

Reaction of lysyl oxidase with trans-2-phenylcyclopropylamine.

Shah MA, Trackman PC, Gallop PM, Kagan HM.

J Biol Chem. 1993 Jun 5;268(16):11580-5.PMID: 8099355 [PubMed - indexed for MEDLINE]Related articlesFree article

Characterization and developmental expression of chick aortic lysyl oxidase.

Wu Y, Rich CB, Lincecum J, Trackman PC, Kagan HM, Foster JA.

J Biol Chem. 1992 Dec 5;267(34):24199-206.PMID: 1360009 [PubMed - indexed for MEDLINE]Related articlesFree article

The complete derived amino acid sequence of human lysyl oxidase and assignment of the gene to chromosome 5 (extensive sequence homology with the murine ras recision gene).

Mariani TJ, Trackman PC, Kagan HM, Eddy RL, Shows TB, Boyd CD, Deak SB.

Matrix. 1992 Jun;12(3):242-8.PMID: 1357535 [PubMed - indexed for MEDLINE]Related articles

Post-translational glycosylation and proteolytic processing of a lysyl oxidase precursor.

Trackman PC, Bedell-Hogan D, Tang J, Kagan HM.

J Biol Chem. 1992 Apr 25;267(12):8666-71.PMID: 1349020 [PubMed - indexed for MEDLINE]Related articlesFree article

Properties and function of lysyl oxidase.

Kagan HM, Trackman PC.

Am J Respir Cell Mol Biol. 1991 Sep;5(3):206-10. Review.PMID: 1680355 [PubMed - indexed for MEDLINE]Related articles