PubMed

Moderate Exercise Decreases Inflammation and Oxidative Stress in Hypertension: But What Are the Mechanisms?

Briones AM, Touyz RM.

Hypertension. 2009 Dec;54(6):1206-1208. Epub 2009 Oct 19. No abstract available. PMID: 19841287 [PubMed - as supplied by publisher]Related articles

Loss of Lkb1 in adult beta cells increases beta cell mass and enhances glucose tolerance in mice.

Fu A, Ng AC, Depatie C, Wijesekara N, He Y, Wang GS, Bardeesy N, Scott FW, Touyz RM, Wheeler MB, Screaton RA.

Cell Metab. 2009 Oct;10(4):285-95.PMID: 19808021 [PubMed - in process]Related articles

Endothelial cells negatively modulate reactive oxygen species generation in vascular smooth muscle cells: role of thioredoxin.

Xu S, He Y, Vokurkova M, Touyz RM.

Hypertension. 2009 Aug;54(2):427-33. Epub 2009 Jun 29.PMID: 19564543 [PubMed - indexed for MEDLINE]Related articles

Molecular mechanisms of hypertension: role of Nox family NADPH oxidases.

Sedeek M, Hébert RL, Kennedy CR, Burns KD, Touyz RM.

Curr Opin Nephrol Hypertens. 2009 Mar;18(2):122-7. Review.PMID: 19430333 [PubMed - indexed for MEDLINE]Related articles

The 2009 Canadian Hypertension Education Program recommendations for the management of hypertension: Part 2--therapy.

Khan NA, Hemmelgarn B, Herman RJ, Bell CM, Mahon JL, Leiter LA, Rabkin SW, Hill MD, Padwal R, Touyz RM, Larochelle P, Feldman RD, Schiffrin EL, Campbell NR, Moe G, Prasad R, Arnold MO, Campbell TS, Milot A, Stone JA, Jones C, Ogilvie RI, Hamet P, Fodor G, Carruthers G, Burns KD, Ruzicka M, DeChamplain J, Pylypchuk G, Petrella R, Boulanger JM, Trudeau L, Hegele RA, Woo V, McFarlane P, Vallée M, Howlett J, Bacon SL, Lindsay P, Gilbert RE, Lewanczuk RZ, Tobe S; Canadian Hypertension Education Program.

Can J Cardiol. 2009 May;25(5):287-98. Review.PMID: 19417859 [PubMed - indexed for MEDLINE]Related articles

The 2009 Canadian Hypertension Education Program recommendations for the management of hypertension: Part 1--blood pressure measurement, diagnosis and assessment of risk.

Padwal RS, Hemmelgarn BR, Khan NA, Grover S, McKay DW, Wilson T, Penner B, Burgess E, McAlister FA, Bolli P, Hill MD, Mahon J, Myers MG, Abbott C, Schiffrin EL, Honos G, Mann K, Tremblay G, Milot A, Cloutier L, Chockalingam A, Rabkin SW, Dawes M, Touyz RM, Bell C, Burns KD, Ruzicka M, Campbell NR, Vallée M, Prasad R, Lebel M, Tobe SW; Canadian Hypertension Education Program.

Can J Cardiol. 2009 May;25(5):279-86. Review.PMID: 19417858 [PubMed - indexed for MEDLINE]Related articles

Regulation of the novel Mg2+ transporter transient receptor potential melastatin 7 (TRPM7) cation channel by bradykinin in vascular smooth muscle cells.

Callera GE, He Y, Yogi A, Montezano AC, Paravicini T, Yao G, Touyz RM.

J Hypertens. 2009 Jan;27(1):155-66.PMID: 19145781 [PubMed - indexed for MEDLINE]Related articles

Angiotensin-(1-7) activates a tyrosine phosphatase and inhibits glucose-induced signalling in proximal tubular cells.

Gava E, Samad-Zadeh A, Zimpelmann J, Bahramifarid N, Kitten GT, Santos RA, Touyz RM, Burns KD.

Nephrol Dial Transplant. 2009 Jun;24(6):1766-73. Epub 2009 Jan 14.PMID: 19144997 [PubMed - indexed for MEDLINE]Related articlesFree article

Expression of NAD(P)H oxidase subunits and their contribution to cardiovascular damage in aldosterone/salt-induced hypertensive rat.

Park YM, Lim BH, Touyz RM, Park JB.

J Korean Med Sci. 2008 Dec;23(6):1039-45. Epub 2008 Dec 24.PMID: 19119450 [PubMed - indexed for MEDLINE]Related articlesFree article

A new look at the eye: aldosterone and mineralocorticoid receptors as novel targets in retinal vasculopathy.

Touyz RM, Callera GE.

Circ Res. 2009 Jan 2;104(1):9-11. No abstract available. PMID: 19118282 [PubMed - indexed for MEDLINE]Related articles

Dysregulation of vascular TRPM7 and annexin-1 is associated with endothelial dysfunction in inherited hypomagnesemia.

Paravicini TM, Yogi A, Mazur A, Touyz RM.

Hypertension. 2009 Feb;53(2):423-9. Epub 2008 Dec 22.PMID: 19103997 [PubMed - indexed for MEDLINE]Related articles

Vascular smooth muscle cells sense calcium: a new paradigm in vascular calcification.

Touyz RM, Montezano AC.

Cardiovasc Res. 2009 Feb 1;81(2):237-9. Epub 2008 Dec 16. No abstract available. PMID: 19088081 [PubMed - indexed for MEDLINE]Related articles

Networking between systemic angiotensin II and cardiac mineralocorticoid receptors.

Montezano AC, Touyz RM.

Hypertension. 2008 Dec;52(6):1016-8. Epub 2008 Nov 3. No abstract available. PMID: 18981322 [PubMed - indexed for MEDLINE]Related articles

Neonatal oxygen exposure in rats leads to cardiovascular and renal alterations in adulthood.

Yzydorczyk C, Comte B, Cambonie G, Lavoie JC, Germain N, Ting Shun Y, Wolff J, Deschepper C, Touyz RM, Lelièvre-Pegorier M, Nuyt AM.

Hypertension. 2008 Nov;52(5):889-95. Epub 2008 Oct 13.PMID: 18852387 [PubMed - indexed for MEDLINE]Related articlesFree article

Angiotensin(1-7) blunts hypertensive cardiac remodeling by a direct effect on the heart.

Mercure C, Yogi A, Callera GE, Aranha AB, Bader M, Ferreira AJ, Santos RA, Walther T, Touyz RM, Reudelhuber TL.

Circ Res. 2008 Nov 21;103(11):1319-26. Epub 2008 Oct 9.PMID: 18845809 [PubMed - indexed for MEDLINE]Related articles

Bradykinin regulates calpain and proinflammatory signaling through TRPM7-sensitive pathways in vascular smooth muscle cells.

Yogi A, Callera GE, Tostes R, Touyz RM.

Am J Physiol Regul Integr Comp Physiol. 2009 Feb;296(2):R201-7. Epub 2008 Sep 17.PMID: 18799634 [PubMed - indexed for MEDLINE]Related articles

Cardiac hypertrophy is associated with altered thioredoxin and ASK-1 signaling in a mouse model of menopause.

Ebrahimian T, Sairam MR, Schiffrin EL, Touyz RM.

Am J Physiol Heart Circ Physiol. 2008 Oct;295(4):H1481-8. Epub 2008 Aug 1.PMID: 18676690 [PubMed - indexed for MEDLINE]Related articlesFree article

Effects of AGTR1 A1166C gene polymorphism in patients with heart failure treated with candesartan.

de Denus S, Zakrzewski-Jakubiak M, Dubé MP, Bélanger F, Lepage S, Leblanc MH, Gossard D, Ducharme A, Racine N, Whittom L, Lavoie J, Touyz RM, Turgeon J, White M.

Ann Pharmacother. 2008 Jul;42(7):925-32. Epub 2008 Jul 1.PMID: 18594050 [PubMed - indexed for MEDLINE]Related articles

Redox-sensitive signaling by angiotensin II involves oxidative inactivation and blunted phosphorylation of protein tyrosine phosphatase SHP-2 in vascular smooth muscle cells from SHR.

Tabet F, Schiffrin EL, Callera GE, He Y, Yao G, Ostman A, Kappert K, Tonks NK, Touyz RM.

Circ Res. 2008 Jul 18;103(2):149-58. Epub 2008 Jun 19.PMID: 18566342 [PubMed - indexed for MEDLINE]Related articlesFree article

The 2008 Canadian Hypertension Education Program recommendations for the management of hypertension: part 2 - therapy.

Khan NA, Hemmelgarn B, Herman RJ, Rabkin SW, McAlister FA, Bell CM, Touyz RM, Padwal R, Leiter LA, Mahon JL, Hill MD, Larochelle P, Feldman RD, Schiffrin EL, Campbell NR, Arnold MO, Moe G, Campbell TS, Milot A, Stone JA, Jones C, Ogilvie RI, Hamet P, Fodor G, Carruthers G, Burns KD, Ruzicka M, dechamplain J, Pylypchuk G, Petrella R, Boulanger JM, Trudeau L, Hegele RA, Woo V, McFarlane P, Vallée M, Howlett J, Katzmarzyk P, Tobe S, Lewanczuk RZ; Canadian Hypertension Education Program.

Can J Cardiol. 2008 Jun;24(6):465-75. Review.PMID: 18548143 [PubMed - indexed for MEDLINE]Related articlesFree article

The 2008 Canadian Hypertension Education Program recommendations for the management of hypertension: Part 1 - blood pressure measurement, diagnosis and assessment of risk.

Padwal RJ, Hemmelgarn BR, Khan NA, Grover S, McAlister FA, McKay DW, Wilson T, Penner B, Burgess E, Bolli P, Hill MD, Mahon J, Myers MG, Abbott C, Schiffrin EL, Honos G, Mann K, Tremblay G, Milot A, Cloutier L, Chockalingam A, Rabkin SW, Dawes MD, Touyz RM, Bell C, Burns KD, Ruzicka M, Campbell NR, Lebel M, Tobe SW; Canadian Hypertension Education Program.

Can J Cardiol. 2008 Jun;24(6):455-63. Review.PMID: 18548142 [PubMed - indexed for MEDLINE]Related articlesFree article

Xanthine oxidase and mitochondria contribute to vascular superoxide anion generation in DOCA-salt hypertensive rats.

Viel EC, Benkirane K, Javeshghani D, Touyz RM, Schiffrin EL.

Am J Physiol Heart Circ Physiol. 2008 Jul;295(1):H281-8. Epub 2008 May 16.PMID: 18487445 [PubMed - indexed for MEDLINE]Related articlesFree article

Aldosterone and angiotensin II synergistically stimulate migration in vascular smooth muscle cells through c-Src-regulated redox-sensitive RhoA pathways.

Montezano AC, Callera GE, Yogi A, He Y, Tostes RC, He G, Schiffrin EL, Touyz RM.

Arterioscler Thromb Vasc Biol. 2008 Aug;28(8):1511-8. Epub 2008 May 8.PMID: 18467645 [PubMed - indexed for MEDLINE]Related articlesFree article

Reactive oxygen species and hypertension: a complex association.

Touyz RM, Schiffrin EL.

Antioxid Redox Signal. 2008 Jun;10(6):1041-4. No abstract available. PMID: 18315497 [PubMed - indexed for MEDLINE]Related articles

Thioredoxin in vascular biology: role in hypertension.

Ebrahimian T, Touyz RM.

Antioxid Redox Signal. 2008 Jun;10(6):1127-36. Review.PMID: 18315495 [PubMed - indexed for MEDLINE]Related articles

NADPH oxidases, reactive oxygen species, and hypertension: clinical implications and therapeutic possibilities.

Paravicini TM, Touyz RM.

Diabetes Care. 2008 Feb;31 Suppl 2:S170-80. Review.PMID: 18227481 [PubMed - indexed for MEDLINE]Related articlesFree article

Downregulation of renal TRPM7 and increased inflammation and fibrosis in aldosterone-infused mice: effects of magnesium.

Sontia B, Montezano AC, Paravicini T, Tabet F, Touyz RM.

Hypertension. 2008 Apr;51(4):915-21. Epub 2008 Feb 11.PMID: 18268139 [PubMed - indexed for MEDLINE]Related articlesFree article

Pseudohyperaldosteronism, liquorice, and hypertension.

Sontia B, Mooney J, Gaudet L, Touyz RM.

J Clin Hypertens (Greenwich). 2008 Feb;10(2):153-7.PMID: 18256580 [PubMed - indexed for MEDLINE]Related articles

Renal redox-sensitive signaling, but not blood pressure, is attenuated by Nox1 knockout in angiotensin II-dependent chronic hypertension.

Yogi A, Mercure C, Touyz J, Callera GE, Montezano AC, Aranha AB, Tostes RC, Reudelhuber T, Touyz RM.

Hypertension. 2008 Feb;51(2):500-6. Epub 2008 Jan 14.PMID: 18195161 [PubMed - indexed for MEDLINE]Related articlesFree article

Selective mineralocorticoid receptor blocker eplerenone reduces resistance artery stiffness in hypertensive patients.

Savoia C, Touyz RM, Amiri F, Schiffrin EL.

Hypertension. 2008 Feb;51(2):432-9. Epub 2008 Jan 14.PMID: 18195160 [PubMed - indexed for MEDLINE]Related articlesFree article

Transient receptor potential melastatin 6 and 7 channels, magnesium transport, and vascular biology: implications in hypertension.

Touyz RM.

Am J Physiol Heart Circ Physiol. 2008 Mar;294(3):H1103-18. Epub 2008 Jan 11. Review.PMID: 18192217 [PubMed - indexed for MEDLINE]Related articlesFree article

Apocynin, NADPH oxidase, and vascular cells: a complex matter.

Touyz RM.

Hypertension. 2008 Feb;51(2):172-4. Epub 2007 Dec 17. No abstract available. PMID: 18086948 [PubMed - indexed for MEDLINE]Related articlesFree article

Endothelin, sex and hypertension.

Tostes RC, Fortes ZB, Callera GE, Montezano AC, Touyz RM, Webb RC, Carvalho MH.

Clin Sci (Lond). 2008 Jan;114(2):85-97. Review.PMID: 18062774 [PubMed - indexed for MEDLINE]Related articles

Magnesium transport in hypertension.

Sontia B, Touyz RM.

Pathophysiology. 2007 Dec;14(3-4):205-11. Epub 2007 Oct 29.PMID: 18029156 [PubMed - in process]Related articles

Angiotensin-(1-7) counterregulates angiotensin II signaling in human endothelial cells.

Sampaio WO, Henrique de Castro C, Santos RA, Schiffrin EL, Touyz RM.

Hypertension. 2007 Dec;50(6):1093-8. Epub 2007 Nov 5.PMID: 17984366 [PubMed - indexed for MEDLINE]Related articlesFree article

A method for measuring intracellular free magnesium concentration in platelets using flow cytometry.

Fox CH, Timm EA Jr, Smith SJ, Touyz RM, Bush EG, Wallace PK.

Magnes Res. 2007 Sep;20(3):200-7.PMID: 17972463 [PubMed - indexed for MEDLINE]Related articles

Candidate genes that determine response to salt in the stroke-prone spontaneously hypertensive rat: congenic analysis.

Graham D, McBride MW, Gaasenbeek M, Gilday K, Beattie E, Miller WH, McClure JD, Polke JM, Montezano A, Touyz RM, Dominiczak AF.

Hypertension. 2007 Dec;50(6):1134-41. Epub 2007 Oct 15.PMID: 17938382 [PubMed - indexed for MEDLINE]Related articlesFree article

Vascular remodeling, retinal arteries, and hypertension.

Touyz RM.

Hypertension. 2007 Oct;50(4):603-4. Epub 2007 Aug 13. No abstract available. PMID: 17698718 [PubMed - indexed for MEDLINE]Related articlesFree article

Evidence that the vasodilator angiotensin-(1-7)-Mas axis plays an important role in erectile function.

da Costa Gonçalves AC, Leite R, Fraga-Silva RA, Pinheiro SV, Reis AB, Reis FM, Touyz RM, Webb RC, Alenina N, Bader M, Santos RA.

Am J Physiol Heart Circ Physiol. 2007 Oct;293(4):H2588-96. Epub 2007 Jul 6.PMID: 17616753 [PubMed - indexed for MEDLINE]Related articlesFree article

Endothelin-1, but not Ang II, activates MAP kinases through c-Src independent Ras-Raf dependent pathways in vascular smooth muscle cells.

Yogi A, Callera GE, Montezano AC, Aranha AB, Tostes RC, Schiffrin EL, Touyz RM.

Arterioscler Thromb Vasc Biol. 2007 Sep;27(9):1960-7. Epub 2007 Jun 14.PMID: 17569879 [PubMed - indexed for MEDLINE]Related articlesFree article

Differential regulation of thioredoxin and NAD(P)H oxidase by angiotensin II in male and female mice.

Ebrahimian T, He Y, Schiffrin EL, Touyz RM.

J Hypertens. 2007 Jun;25(6):1263-71.PMID: 17563540 [PubMed - indexed for MEDLINE]Related articles

The Canadian Hypertension Education Program - a unique Canadian knowledge translation program.

Tobe SW, Touyz RM, Campbell NR; Canadian Hypertension Education Program.

Can J Cardiol. 2007 May 15;23(7):551-5.PMID: 17534461 [PubMed - indexed for MEDLINE]Related articlesFree article

The 2007 Canadian Hypertension Education Program recommendations for the management of hypertension: part 2 - therapy.

Khan NA, Hemmelgarn B, Padwal R, Larochelle P, Mahon JL, Lewanczuk RZ, McAlister FA, Rabkin SW, Hill MD, Feldman RD, Schiffrin EL, Campbell NR, Logan AG, Arnold M, Moe G, Campbell TS, Milot A, Stone JA, Jones C, Leiter LA, Ogilvie RI, Herman RJ, Hamet P, Fodor G, Carruthers G, Culleton B, Burns KD, Ruzicka M, deChamplain J, Pylypchuk G, Gledhill N, Petrella R, Boulanger JM, Trudeau L, Hegele RA, Woo V, McFarlane P, Touyz RM, Tobe SW; Canadian Hypertension Education Program.

Can J Cardiol. 2007 May 15;23(7):539-50.PMID: 17534460 [PubMed - indexed for MEDLINE]Related articlesFree article

The 2007 Canadian Hypertension Education Program recommendations for the management of hypertension: part 1- blood pressure measurement, diagnosis and assessment of risk.

Padwal RS, Hemmelgarn BR, McAlister FA, McKay DW, Grover S, Wilson T, Penner B, Burgess E, Bolli P, Hill M, Mahon J, Myers MG, Abbott C, Schiffrin EL, Honos G, Mann K, Tremblay G, Milot A, Cloutier L, Chockalingam A, Khan NA, Rabkin SW, Dawes M, Touyz RM, Tobe SW; Canadian Hypertension Education Program.

Can J Cardiol. 2007 May 15;23(7):529-38.PMID: 17534459 [PubMed - indexed for MEDLINE]Related articlesFree article

Vasoactive peptides in cardiovascular (patho)physiology.

Callera G, Tostes R, Savoia C, Muscara MN, Touyz RM.

Expert Rev Cardiovasc Ther. 2007 May;5(3):531-52. Review.PMID: 17489676 [PubMed - indexed for MEDLINE]Related articles

Synergistic vascular protective effects of combined low doses of PPARalpha and PPARgamma activators in angiotensin II-induced hypertension in rats.

De Ciuceis C, Amiri F, Iglarz M, Cohn JS, Touyz RM, Schiffrin EL.

Br J Pharmacol. 2007 May;151(1):45-53. Epub 2007 Mar 12.PMID: 17351653 [PubMed - indexed for MEDLINE]Related articlesFree article

Vascular signaling through cholesterol-rich domains: implications in hypertension.

Callera GE, Montezano AC, Yogi A, Tostes RC, Touyz RM.

Curr Opin Nephrol Hypertens. 2007 Mar;16(2):90-104. Review.PMID: 17293683 [PubMed - indexed for MEDLINE]Related articles

alpha 8 Integrin overexpression in de-differentiated vascular smooth muscle cells attenuates migratory activity and restores the characteristics of the differentiated phenotype.

Zargham R, Touyz RM, Thibault G.

Atherosclerosis. 2007 Dec;195(2):303-12. Epub 2007 Feb 1.PMID: 17275006 [PubMed - indexed for MEDLINE]Related articles

Regulation of endothelial nitric oxide synthase by thrombin.

Touyz RM.

Hypertension. 2007 Mar;49(3):429-31. Epub 2007 Jan 8. No abstract available. PMID: 17210837 [PubMed - indexed for MEDLINE]Related articlesFree article

Reactive oxygen species, cell growth, cell cycle progression and vascular remodeling in hypertension.

Vokurkova M, Xu S, Touyz RM.

Future Cardiol. 2007 Jan;3(1):53-63.PMID: 19804207 [PubMed - in process]