PubMed

The relative efficacy and safety of clopidogrel in women and men a sex-specific collaborative meta-analysis.

Berger JS, Bhatt DL, Cannon CP, Chen Z, Jiang L, Jones JB, Mehta SR, Sabatine MS, Steinhubl SR, Topol EJ, Berger PB.

J Am Coll Cardiol. 2009 Nov 17;54(21):1935-45.PMID: 19909874 [PubMed - in process]Related articles

Microdroplet-based PCR enrichment for large-scale targeted sequencing.

Tewhey R, Warner JB, Nakano M, Libby B, Medkova M, David PH, Kotsopoulos SK, Samuels ML, Hutchison JB, Larson JW, Topol EJ, Weiner MP, Harismendy O, Olson J, Link DR, Frazer KA.

Nat Biotechnol. 2009 Nov;27(11):1025-31. Epub 2009 Nov 1.PMID: 19881494 [PubMed - in process]Related articles

Benefit of facilitated percutaneous coronary intervention in high-risk ST-segment elevation myocardial infarction patients presenting to nonpercutaneous coronary intervention hospitals.

Herrmann HC, Lu J, Brodie BR, Armstrong PW, Montalescot G, Betriu A, Neuman FJ, Effron MB, Barnathan ES, Topol EJ, Ellis SG; FINESSE Investigators.

JACC Cardiovasc Interv. 2009 Oct;2(10):917-24.PMID: 19850249 [PubMed - in process]Related articles

1-year survival in a randomized trial of facilitated reperfusion: results from the FINESSE (Facilitated Intervention with Enhanced Reperfusion Speed to Stop Events) trial.

Ellis SG, Tendera M, de Belder MA, van Boven AJ, Widimsky P, Andersen HR, Betriu A, Savonitto S, Adamus J, Peruga JZ, Hamankiewicz M, Pluta W, Oldroyd K, Ecollan P, Janssens L, Armstrong P, Brodie BR, Herrmann HC, Montalescot G, Neumann FJ, Effron MB, Barnathan ES, Topol EJ; FINESSE Investigators.

JACC Cardiovasc Interv. 2009 Oct;2(10):909-16.PMID: 19850248 [PubMed - in process]Related articles

Enrichment of sequencing targets from the human genome by solution hybridization.

Tewhey R, Nakano M, Wang X, Pabón-Peña C, Novak B, Giuffre A, Lin E, Happe S, Roberts DN, Leproust EM, Topol EJ, Harismendy O, Frazer KA.

Genome Biol. 2009 Oct 16;10(10):R116. [Epub ahead of print]PMID: 19835619 [PubMed - as supplied by publisher]Related articles

Tirofiban as adjunctive therapy for acute coronary syndromes and percutaneous coronary intervention: a meta-analysis of randomized trials.

Valgimigli M, Biondi-Zoccai G, Tebaldi M, van 't Hof AW, Campo G, Hamm C, Ten Berg J, Bolognese L, Saia F, Danzi GB, Briguori C, Okmen E, King SB, Moliterno DJ, Topol EJ.

Eur Heart J. 2009 Sep 14. [Epub ahead of print]PMID: 19755402 [PubMed - as supplied by publisher]Related articles

A common MECP2 haplotype associates with reduced cortical surface area in humans in two independent populations.

Joyner AH, J CR, Bloss CS, Bakken TE, Rimol LM, Melle I, Agartz I, Djurovic S, Topol EJ, Schork NJ, Andreassen OA, Dale AM.

Proc Natl Acad Sci U S A. 2009 Sep 8;106(36):15483-8. Epub 2009 Aug 26.PMID: 19717458 [PubMed - in process]Related articles

Sex differences in mortality following acute coronary syndromes.

Berger JS, Elliott L, Gallup D, Roe M, Granger CB, Armstrong PW, Simes RJ, White HD, Van de Werf F, Topol EJ, Hochman JS, Newby LK, Harrington RA, Califf RM, Becker RC, Douglas PS.

JAMA. 2009 Aug 26;302(8):874-82.PMID: 19706861 [PubMed - indexed for MEDLINE]Related articles

Clinical outcomes according to permanent discontinuation of clopidogrel or placebo in the CHARISMA trial.

Collet JP, Montalescot G, Steg PG, Steinhubl SR, Fox KA, Hu TF, Johnston SC, Hamm CW, Bhatt DL, Topol EJ.

Arch Cardiovasc Dis. 2009 Jun-Jul;102(6-7):485-96. Epub 2009 Jun 11.PMID: 19664568 [PubMed - in process]Related articles

Molecular genetics of atrial fibrillation.

Damani SB, Topol EJ.

Genome Med. 2009 May 22;1(5):54.PMID: 19490585 [PubMed - in process]Related articlesFree article

Cost-effectiveness of clopidogrel plus aspirin versus aspirin alone for secondary prevention of cardiovascular events: results from the CHARISMA trial.

Chen J, Bhatt DL, Dunn ES, Shi C, Caro JJ, Mahoney EM, Gabriel S, Jackson JD, Topol EJ, Cohen DJ.

Value Health. 2009 Sep;12(6):872-9. Epub 2009 Mar 11.PMID: 19490556 [PubMed - indexed for MEDLINE]Related articles

Common vs. rare allele hypotheses for complex diseases.

Schork NJ, Murray SS, Frazer KA, Topol EJ.

Curr Opin Genet Dev. 2009 Jun;19(3):212-9. Epub 2009 May 28. Review.PMID: 19481926 [PubMed - indexed for MEDLINE]Related articles

Impact of blood transfusion on short- and long-term mortality in patients with ST-segment elevation myocardial infarction.

Shishehbor MH, Madhwal S, Rajagopal V, Hsu A, Kelly P, Gurm HS, Kapadia SR, Lauer MS, Topol EJ.

JACC Cardiovasc Interv. 2009 Jan;2(1):46-53.PMID: 19463397 [PubMed - in process]Related articles

Clinical outcomes of patients with diabetic nephropathy randomized to clopidogrel plus aspirin versus aspirin alone (a post hoc analysis of the clopidogrel for high atherothrombotic risk and ischemic stabilization, management, and avoidance [CHARISMA] trial).

Dasgupta A, Steinhubl SR, Bhatt DL, Berger PB, Shao M, Mak KH, Fox KA, Montalescot G, Weber MA, Haffner SM, Dimas AP, Steg PG, Topol EJ; CHARISMA Investigators.

Am J Cardiol. 2009 May 15;103(10):1359-63. Epub 2009 Apr 1.PMID: 19427428 [PubMed - indexed for MEDLINE]Related articles

Evaluation of individualized clopidogrel therapy after drug-eluting stent implantation in patients with high residual platelet reactivity: design and rationale of the GRAVITAS trial.

Price MJ, Berger PB, Angiolillo DJ, Teirstein PS, Tanguay JF, Kandzari DE, Cannon CP, Topol EJ.

Am Heart J. 2009 May;157(5):818-24, 824.e1.PMID: 19376306 [PubMed - indexed for MEDLINE]Related articles

Past the wall in cardiovascular R&D.

Topol EJ.

Nat Rev Drug Discov. 2009 Apr;8(4):259. No abstract available. PMID: 19348004 [PubMed - indexed for MEDLINE]Related articles

Ethnic variation in adverse cardiovascular outcomes and bleeding complications in the Clopidogrel for High Atherothrombotic Risk and Ischemic Stabilization, Management, and Avoidance (CHARISMA) study.

Mak KH, Bhatt DL, Shao M, Hankey GJ, Easton JD, Fox KA, Topol EJ.

Am Heart J. 2009 Apr;157(4):658-65. Epub 2008 Nov 6.PMID: 19332192 [PubMed - indexed for MEDLINE]Related articles

Evaluation of next generation sequencing platforms for population targeted sequencing studies.

Harismendy O, Ng PC, Strausberg RL, Wang X, Stockwell TB, Beeson KY, Schork NJ, Murray SS, Topol EJ, Levy S, Frazer KA.

Genome Biol. 2009;10(3):R32. Epub 2009 Mar 27.PMID: 19327155 [PubMed - indexed for MEDLINE]Related articlesFree article

Human genetic variation and its contribution to complex traits.

Frazer KA, Murray SS, Schork NJ, Topol EJ.

Nat Rev Genet. 2009 Apr;10(4):241-51. Review.PMID: 19293820 [PubMed - indexed for MEDLINE]Related articles

Aspirin to prevent cardiovascular disease: the association of aspirin dose and clopidogrel with thrombosis and bleeding.

Steinhubl SR, Bhatt DL, Brennan DM, Montalescot G, Hankey GJ, Eikelboom JW, Berger PB, Topol EJ; CHARISMA Investigators.

Ann Intern Med. 2009 Mar 17;150(6):379-86.PMID: 19293071 [PubMed - indexed for MEDLINE]Related articlesFree article

The influence of body mass index on mortality and bleeding among patients with or at high-risk of atherothrombotic disease.

Mak KH, Bhatt DL, Shao M, Haffner SM, Hamm CW, Hankey GJ, Johnston SC, Montalescot G, Steg PG, Steinhubl SR, Fox KA, Topol EJ.

Eur Heart J. 2009 Apr;30(7):857-65. Epub 2009 Feb 20.PMID: 19233855 [PubMed - indexed for MEDLINE]Related articles

Bleeding risk associated with 1 year of dual antiplatelet therapy after percutaneous coronary intervention: Insights from the Clopidogrel for the Reduction of Events During Observation (CREDO) trial.

Aronow HD, Steinhubl SR, Brennan DM, Berger PB, Topol EJ; CREDO Investigators.

Am Heart J. 2009 Feb;157(2):369-74. Epub 2008 Nov 1.PMID: 19185647 [PubMed - indexed for MEDLINE]Related articles

Patients with peripheral arterial disease in the CHARISMA trial.

Cacoub PP, Bhatt DL, Steg PG, Topol EJ, Creager MA; CHARISMA Investigators.

Eur Heart J. 2009 Jan;30(2):192-201. Epub 2009 Jan 9.PMID: 19136484 [PubMed - indexed for MEDLINE]Related articles

The impact of fibrinolytic therapy for ST-segment-elevation acute myocardial infarction.

Van de Werf FJ, Topol EJ, Sobel BE.

J Thromb Haemost. 2009 Jan;7(1):14-20. Review.PMID: 19090814 [PubMed - indexed for MEDLINE]Related articles

Relation between aspirin dose, all-cause mortality, and bleeding in patients with recent cerebrovascular or coronary ischemic events (from the BRAVO Trial).

Aronow HD, Califf RM, Harrington RA, Vallee M, Graffagnino C, Shuaib A, Fitzgerald DJ, Easton JD, Van de Werf F, Diener HC, Ferguson J, Koudstaal PJ, Amarenco P, Theroux P, Davis S, Topol EJ.

Am J Cardiol. 2008 Nov 15;102(10):1285-90. Epub 2008 Sep 15.PMID: 18993142 [PubMed - indexed for MEDLINE]Related articles

Relation between previous lipid-lowering therapy and infarct size (creatine kinase-MB level) in patients presenting with acute myocardial infarction.

Aronow HD, Lincoff AM, Quinn MJ, McRae AT, Gurm HS, Houghtaling PL, Granger CB, Harrington RA, Van de Werf F, Topol EJ, Lauer MS; GUSTO IIb and PURSUIT Trial Investigators.

Am J Cardiol. 2008 Nov 1;102(9):1119-24. Epub 2008 Aug 27.PMID: 18940276 [PubMed - indexed for MEDLINE]Related articles

Incomplete inhibition of thromboxane biosynthesis by acetylsalicylic acid: determinants and effect on cardiovascular risk.

Eikelboom JW, Hankey GJ, Thom J, Bhatt DL, Steg PG, Montalescot G, Johnston SC, Steinhubl SR, Mak KH, Easton JD, Hamm C, Hu T, Fox KA, Topol EJ; Clopidogrel for High Atherothrombotic Risk and Ischemic Stabilization, Management and Avoidance (CHARISMA) Investigators.

Circulation. 2008 Oct 21;118(17):1705-12. Epub 2008 Oct 6.PMID: 18838564 [PubMed - indexed for MEDLINE]Related articlesFree article

Pathway analysis of seven common diseases assessed by genome-wide association.

Torkamani A, Topol EJ, Schork NJ.

Genomics. 2008 Nov;92(5):265-72. Epub 2008 Sep 16.PMID: 18722519 [PubMed - indexed for MEDLINE]Related articlesFree article

The use of high-sensitivity assays for C-reactive protein in clinical practice.

Musunuru K, Kral BG, Blumenthal RS, Fuster V, Campbell CY, Gluckman TJ, Lange RA, Topol EJ, Willerson JT, Desai MY, Davidson MH, Mora S.

Nat Clin Pract Cardiovasc Med. 2008 Oct;5(10):621-35. Epub 2008 Aug 19. Review.PMID: 18711404 [PubMed - indexed for MEDLINE]Related articlesFree article

Deficiency of LRP8 in mice is associated with altered platelet function and prolonged time for in vivo thrombosis.

Robertson JO, Li W, Silverstein RL, Topol EJ, Smith JD.

Thromb Res. 2009 Feb;123(4):644-52. Epub 2008 Aug 15.PMID: 18706682 [PubMed - indexed for MEDLINE]Related articles

Genome scanning and cardiovascular disease.

Topol EJ.

Heart. 2008 Nov;94(11):1361-3. Epub 2008 Jul 31. No abstract available. PMID: 18669549 [PubMed - indexed for MEDLINE]Related articles

Gaining insights in coronary disease genomics.

Murray SS, Topol EJ.

J Am Coll Cardiol. 2008 Jul 29;52(5):385-6. No abstract available. PMID: 18652947 [PubMed - indexed for MEDLINE]Related articles

Four SNPS on chromosome 9p21 confer risk to premature, familial CAD and MI in an American Caucasian population (GeneQuest).

Abdullah KG, Li L, Shen GQ, Hu Y, Yang Y, MacKinlay KG, Topol EJ, Wang QK.

Ann Hum Genet. 2008 Sep;72(Pt 5):654-7. Epub 2008 May 26.PMID: 18505420 [PubMed - indexed for MEDLINE]Related articlesFree article

Facilitated PCI in patients with ST-elevation myocardial infarction.

Ellis SG, Tendera M, de Belder MA, van Boven AJ, Widimsky P, Janssens L, Andersen HR, Betriu A, Savonitto S, Adamus J, Peruga JZ, Kosmider M, Katz O, Neunteufl T, Jorgova J, Dorobantu M, Grinfeld L, Armstrong P, Brodie BR, Herrmann HC, Montalescot G, Neumann FJ, Effron MB, Barnathan ES, Topol EJ; FINESSE Investigators.

N Engl J Med. 2008 May 22;358(21):2205-17.PMID: 18499565 [PubMed - indexed for MEDLINE]Related articlesFree article

Efficacy and safety of clopidogrel pretreatment before percutaneous coronary intervention with and without glycoprotein IIb/IIIa inhibitor use.

Sabatine MS, Hamdalla HN, Mehta SR, Fox KA, Topol EJ, Steinhubl SR, Cannon CP.

Am Heart J. 2008 May;155(5):910-7. Epub 2008 Feb 21.PMID: 18440341 [PubMed - indexed for MEDLINE]Related articles

Genetic determinants of phenotypic diversity in humans.

Rahim NG, Harismendy O, Topol EJ, Frazer KA.

Genome Biol. 2008 Apr 24;9(4):215. [Epub ahead of print]PMID: 18439327 [PubMed - as supplied by publisher]Related articlesFree article

Is computed tomographic angiography prognostic in patients with cardiac symptoms?

Suhar CJ, Hitchcock TM, Russo RJ, Topol EJ.

J Am Coll Cardiol. 2008 Apr 15;51(15):1510; author reply 1510-1. No abstract available. PMID: 18402911 [PubMed - indexed for MEDLINE]Related articles

The efficacy and safety of short- and long-term dual antiplatelet therapy in patients with mild or moderate chronic kidney disease: results from the Clopidogrel for the Reduction of Events During Observation (CREDO) trial.

Best PJ, Steinhubl SR, Berger PB, Dasgupta A, Brennan DM, Szczech LA, Califf RM, Topol EJ; CREDO Investigators.

Am Heart J. 2008 Apr;155(4):687-93. Epub 2008 Feb 21.PMID: 18371477 [PubMed - indexed for MEDLINE]Related articles

Relationship of paraoxonase 1 (PON1) gene polymorphisms and functional activity with systemic oxidative stress and cardiovascular risk.

Bhattacharyya T, Nicholls SJ, Topol EJ, Zhang R, Yang X, Schmitt D, Fu X, Shao M, Brennan DM, Ellis SG, Brennan ML, Allayee H, Lusis AJ, Hazen SL.

JAMA. 2008 Mar 19;299(11):1265-76.PMID: 18349088 [PubMed - indexed for MEDLINE]Related articlesFree article

Clopidogrel and aspirin versus aspirin alone for the prevention of stroke in patients with a history of atrial fibrillation: subgroup analysis of the CHARISMA randomized trial.

Hart RG, Bhatt DL, Hacke W, Fox KA, Hankey GJ, Berger PB, Hu T, Topol EJ; CHARISMA Investigators.

Cerebrovasc Dis. 2008;25(4):344-7. Epub 2008 Feb 27.PMID: 18303254 [PubMed - indexed for MEDLINE]Related articles

Warfarin pharmacogenomics: a big step forward for individualized medicine: enlightened dosing of warfarin.

Elias DJ, Topol EJ.

Eur J Hum Genet. 2008 May;16(5):532-4. Epub 2008 Feb 27. No abstract available. PMID: 18301451 [PubMed - indexed for MEDLINE]Related articlesFree article

Identification of a novel locus for triglyceride on chromosome 1p31-32 in families with premature CAD and MI.

Seidelmann SB, Li L, Shen GQ, Topol EJ, Wang QK.

J Lipid Res. 2008 May;49(5):1034-8. Epub 2008 Jan 31.PMID: 18245017 [PubMed - indexed for MEDLINE]Related articlesFree article

Future use of genomics in coronary artery disease.

Damani SB, Topol EJ.

J Am Coll Cardiol. 2007 Nov 13;50(20):1933-40. Epub 2007 Oct 29. Review.PMID: 17996556 [PubMed - indexed for MEDLINE]Related articles

Mortality, kidney disease and cardiac procedures following acute coronary syndrome.

Inrig JK, Patel UD, Briley LP, She L, Gillespie BS, Easton JD, Topol EJ, Szczech LA.

Nephrol Dial Transplant. 2008 Mar;23(3):934-40. Epub 2007 Nov 4.PMID: 17984102 [PubMed - indexed for MEDLINE]Related articles

Long-term outcome and its predictors among patients with ST-segment elevation myocardial infarction complicated by shock: insights from the GUSTO-I trial.

Singh M, White J, Hasdai D, Hodgson PK, Berger PB, Topol EJ, Califf RM, Holmes DR Jr.

J Am Coll Cardiol. 2007 Oct 30;50(18):1752-8.PMID: 17964038 [PubMed - indexed for MEDLINE]Related articles

Impact of female sex on death and bleeding after fibrinolytic treatment of myocardial infarction in GUSTO V.

Reynolds HR, Farkouh ME, Lincoff AM, Hsu A, Swahn E, Sadowski ZP, White JA, Topol EJ, Hochman JS; GUSTO V Investigators.

Arch Intern Med. 2007 Oct 22;167(19):2054-60.PMID: 17954798 [PubMed - indexed for MEDLINE]Related articlesFree article

Predictors and impact of major hemorrhage on mortality following percutaneous coronary intervention from the REPLACE-2 Trial.

Feit F, Voeltz MD, Attubato MJ, Lincoff AM, Chew DP, Bittl JA, Topol EJ, Manoukian SV.

Am J Cardiol. 2007 Nov 1;100(9):1364-9. Epub 2007 Aug 16.PMID: 17950791 [PubMed - indexed for MEDLINE]Related articles

Validity of reported genetic risk factors for acute coronary syndrome.

McCarthy JJ, Topol EJ.

JAMA. 2007 Oct 17;298(15):1758; author reply 1759. No abstract available. PMID: 17940228 [PubMed - indexed for MEDLINE]Related articles

Is there a genetic basis for acute coronary syndrome?

Patay BA, Topol EJ.

Nat Clin Pract Cardiovasc Med. 2007 Nov;4(11):596-7. Epub 2007 Sep 18. No abstract available. PMID: 17876345 [PubMed]Related articles

An LRP8 variant is associated with familial and premature coronary artery disease and myocardial infarction.

Shen GQ, Li L, Girelli D, Seidelmann SB, Rao S, Fan C, Park JE, Xi Q, Li J, Hu Y, Olivieri O, Marchant K, Barnard J, Corrocher R, Elston R, Cassano J, Henderson S, Hazen SL, Plow EF, Topol EJ, Wang QK.

Am J Hum Genet. 2007 Oct;81(4):780-91. Epub 2007 Aug 31.PMID: 17847002 [PubMed - indexed for MEDLINE]Related articlesFree article