PubMed

Pathogenesis of non-alcoholic fatty liver disease.

Dowman JK, Tomlinson JW, Newsome PN.

QJM. 2009 Nov 13. [Epub ahead of print] No abstract available. PMID: 19914930 [PubMed - as supplied by publisher]Related articlesFree article

The Role of 11ss-Hydroxysteroid Dehydrogenase 1 in Adipogenesis in Thyroid-Associated Ophthalmopathy.

Tomlinson JW, Durrani OM, Bujalska IJ, Gathercole LL, Tomlins PJ, Reuser TT, Rose GE, Curnow SJ, Stewart PM, Walker EA, Rauz S.

J Clin Endocrinol Metab. 2009 Oct 30. [Epub ahead of print]PMID: 19880789 [PubMed - as supplied by publisher]Related articles

Nonclassic lipoid congenital adrenal hyperplasia masquerading as familial glucocorticoid deficiency.

Metherell LA, Naville D, Halaby G, Begeot M, Huebner A, Nürnberg G, Nürnberg P, Green J, Tomlinson JW, Krone NP, Lin L, Racine M, Berney DM, Achermann JC, Arlt W, Clark AJ.

J Clin Endocrinol Metab. 2009 Oct;94(10):3865-71. Epub 2009 Sep 22.PMID: 19773404 [PubMed - indexed for MEDLINE]Related articles

11beta-hydroxysteroid dehydrogenase type 1 regulates glucocorticoid-induced insulin resistance in skeletal muscle.

Morgan SA, Sherlock M, Gathercole LL, Lavery GG, Lenaghan C, Bujalska IJ, Laber D, Yu A, Convey G, Mayers R, Hegyi K, Sethi JK, Stewart PM, Smith DM, Tomlinson JW.

Diabetes. 2009 Nov;58(11):2506-15. Epub 2009 Aug 12.PMID: 19675138 [PubMed - in process]Related articles

Increased 5 alpha-reductase activity and adrenocortical drive in women with polycystic ovary syndrome.

Vassiliadi DA, Barber TM, Hughes BA, McCarthy MI, Wass JA, Franks S, Nightingale P, Tomlinson JW, Arlt W, Stewart PM.

J Clin Endocrinol Metab. 2009 Sep;94(9):3558-66. Epub 2009 Jun 30.PMID: 19567518 [PubMed - indexed for MEDLINE]Related articles

Orlistat for overweight subjects with nonalcoholic steatohepatitis.

Dowman JK, Stocken D, Tomlinson JW, Newsome PN.

Hepatology. 2009 Jul;50(1):321; author reply 321-2. No abstract available. Erratum in: Hepatology. 2009 Sep;50(3):995. Newsome, Philip [corrected to Newsome, Philip N]. PMID: 19492425 [PubMed - indexed for MEDLINE]Related articles

Selective inhibitors of 11beta-hydroxysteroid dehydrogenase type 1 for patients with metabolic syndrome: is the target liver, fat, or both?

Stewart PM, Tomlinson JW.

Diabetes. 2009 Jan;58(1):14-5. No abstract available. PMID: 19114723 [PubMed - indexed for MEDLINE]Related articlesFree article

Regulation--the real threat to clinical research.

Stewart PM, Stears A, Tomlinson JW, Brown MJ.

BMJ. 2008 Oct 16;337:a1732. doi: 10.1136/bmj.a1732. No abstract available. PMID: 18927171 [PubMed - indexed for MEDLINE]Related articles

11beta-Hydroxysteroid dehydrogenase type 1 regulates insulin and glucagon secretion in pancreatic islets.

Swali A, Walker EA, Lavery GG, Tomlinson JW, Stewart PM.

Diabetologia. 2008 Nov;51(11):2003-11. Epub 2008 Sep 9.PMID: 18779947 [PubMed - indexed for MEDLINE]Related articles

Elevated cerebrospinal fluid (CSF) leptin in idiopathic intracranial hypertension (IIH): evidence for hypothalamic leptin resistance?

Ball AK, Sinclair AJ, Curnow SJ, Tomlinson JW, Burdon MA, Walker EA, Stewart PM, Nightingale PG, Clarke CE, Rauz S.

Clin Endocrinol (Oxf). 2009 Jun;70(6):863-9. Epub 2008 Sep 2.PMID: 18771566 [PubMed - indexed for MEDLINE]Related articles

Impaired glucose tolerance and insulin resistance are associated with increased adipose 11beta-hydroxysteroid dehydrogenase type 1 expression and elevated hepatic 5alpha-reductase activity.

Tomlinson JW, Finney J, Gay C, Hughes BA, Hughes SV, Stewart PM.

Diabetes. 2008 Oct;57(10):2652-60. Epub 2008 Jul 15.PMID: 18633104 [PubMed - indexed for MEDLINE]Related articlesFree article

Steroid biomarkers and genetic studies reveal inactivating mutations in hexose-6-phosphate dehydrogenase in patients with cortisone reductase deficiency.

Lavery GG, Walker EA, Tiganescu A, Ride JP, Shackleton CH, Tomlinson JW, Connell JM, Ray DW, Biason-Lauber A, Malunowicz EM, Arlt W, Stewart PM.

J Clin Endocrinol Metab. 2008 Oct;93(10):3827-32. Epub 2008 Jul 15.PMID: 18628520 [PubMed - indexed for MEDLINE]Related articlesFree article

Adrenal suppression in bronchiectasis and the impact of inhaled corticosteroids.

Holme J, Tomlinson JW, Stockley RA, Stewart PM, Barlow N, Sullivan AL.

Eur Respir J. 2008 Oct;32(4):1047-52. Epub 2008 May 28.PMID: 18508829 [PubMed - indexed for MEDLINE]Related articles

A novel selective 11beta-hydroxysteroid dehydrogenase type 1 inhibitor prevents human adipogenesis.

Bujalska IJ, Gathercole LL, Tomlinson JW, Darimont C, Ermolieff J, Fanjul AN, Rejto PA, Stewart PM.

J Endocrinol. 2008 May;197(2):297-307.PMID: 18434359 [PubMed - indexed for MEDLINE]Related articlesFree article

Reduced glucocorticoid production rate, decreased 5alpha-reductase activity, and adipose tissue insulin sensitization after weight loss.

Tomlinson JW, Finney J, Hughes BA, Hughes SV, Stewart PM.

Diabetes. 2008 Jun;57(6):1536-43. Epub 2008 Mar 13.PMID: 18340018 [PubMed - indexed for MEDLINE]Related articlesFree article

Lack of hexose-6-phosphate dehydrogenase impairs lipid mobilization from mouse adipose tissue.

Bujalska IJ, Hewitt KN, Hauton D, Lavery GG, Tomlinson JW, Walker EA, Stewart PM.

Endocrinology. 2008 May;149(5):2584-91. Epub 2008 Jan 24.PMID: 18218694 [PubMed - indexed for MEDLINE]Related articlesFree article

Modulation of glucocorticoid action and the treatment of type-2 diabetes.

Tomlinson JW, Stewart PM.

Best Pract Res Clin Endocrinol Metab. 2007 Dec;21(4):607-19. Review.PMID: 18054738 [PubMed - indexed for MEDLINE]Related articles

Reduced 11beta-hydroxysteroid dehydrogenase type 1 activity in obese boys.

Wiegand S, Richardt A, Remer T, Wudy SA, Tomlinson JW, Hughes B, Grüters A, Stewart PM, Strasburger CJ, Quinkler M.

Eur J Endocrinol. 2007 Sep;157(3):319-24.PMID: 17766714 [PubMed - indexed for MEDLINE]Related articlesFree article

Glucocorticoid modulation of insulin signaling in human subcutaneous adipose tissue.

Gathercole LL, Bujalska IJ, Stewart PM, Tomlinson JW.

J Clin Endocrinol Metab. 2007 Nov;92(11):4332-9. Epub 2007 Aug 21.PMID: 17711920 [PubMed - indexed for MEDLINE]Related articlesFree article

Corticosteroids, 11beta-hydroxysteroid dehydrogenase isozymes and the rabbit choroid plexus.

Sinclair AJ, Onyimba CU, Khosla P, Vijapurapu N, Tomlinson JW, Burdon MA, Stewart PM, Murray PI, Walker EA, Rauz S.

J Neuroendocrinol. 2007 Aug;19(8):614-20.PMID: 17620103 [PubMed - indexed for MEDLINE]Related articles

11beta-Hydroxysteroid Dehydrogenase Type 1 Regulation by Intracellular Glucose 6-Phosphate Provides Evidence for a Novel Link between Glucose Metabolism and Hypothalamo-Pituitary-Adrenal Axis Function.

Walker EA, Ahmed A, Lavery GG, Tomlinson JW, Kim SY, Cooper MS, Ride JP, Hughes BA, Shackleton CH, McKiernan P, Elias E, Chou JY, Stewart PM.

J Biol Chem. 2007 Sep 14;282(37):27030-6. Epub 2007 Jun 22.PMID: 17588937 [PubMed - indexed for MEDLINE]Related articlesFree article

Characterisation of 11beta-hydroxysteroid dehydrogenase 1 in human orbital adipose tissue: a comparison with subcutaneous and omental fat.

Bujalska IJ, Durrani OM, Abbott J, Onyimba CU, Khosla P, Moosavi AH, Reuser TT, Stewart PM, Tomlinson JW, Walker EA, Rauz S.

J Endocrinol. 2007 Feb;192(2):279-88.PMID: 17283228 [PubMed - indexed for MEDLINE]Related articlesFree article

Inhibition of 11beta-hydroxysteroid dehydrogenase type 1 activity in vivo limits glucocorticoid exposure to human adipose tissue and decreases lipolysis.

Tomlinson JW, Sherlock M, Hughes B, Hughes SV, Kilvington F, Bartlett W, Courtney R, Rejto P, Carley W, Stewart PM.

J Clin Endocrinol Metab. 2007 Mar;92(3):857-64. Epub 2007 Jan 2.PMID: 17200165 [PubMed - indexed for MEDLINE]Related articlesFree article

Expression profiling of 11beta-hydroxysteroid dehydrogenase type-1 and glucocorticoid-target genes in subcutaneous and omental human preadipocytes.

Bujalska IJ, Quinkler M, Tomlinson JW, Montague CT, Smith DM, Stewart PM.

J Mol Endocrinol. 2006 Oct;37(2):327-40.PMID: 17032748 [PubMed - indexed for MEDLINE]Related articlesFree article

Mechanisms of disease: Selective inhibition of 11beta-hydroxysteroid dehydrogenase type 1 as a novel treatment for the metabolic syndrome.

Tomlinson JW, Stewart PM.

Nat Clin Pract Endocrinol Metab. 2005 Dec;1(2):92-9. Review.PMID: 16929377 [PubMed - indexed for MEDLINE]Related articles

Depot-specific prostaglandin synthesis in human adipose tissue: a novel possible mechanism of adipogenesis.

Quinkler M, Bujalska IJ, Tomlinson JW, Smith DM, Stewart PM.

Gene. 2006 Oct 1;380(2):137-43. Epub 2006 Jun 10.PMID: 16842938 [PubMed - indexed for MEDLINE]Related articles

The long-term predictive accuracy of the short synacthen (corticotropin) stimulation test for assessment of the hypothalamic-pituitary-adrenal axis.

Agha A, Tomlinson JW, Clark PM, Holder G, Stewart PM.

J Clin Endocrinol Metab. 2006 Jan;91(1):43-7. Epub 2005 Oct 25.PMID: 16249286 [PubMed - indexed for MEDLINE]Related articlesFree article

Hexose-6-phosphate dehydrogenase confers oxo-reductase activity upon 11 beta-hydroxysteroid dehydrogenase type 1.

Bujalska IJ, Draper N, Michailidou Z, Tomlinson JW, White PC, Chapman KE, Walker EA, Stewart PM.

J Mol Endocrinol. 2005 Jun;34(3):675-84.PMID: 15956339 [PubMed - indexed for MEDLINE]Related articlesFree article

11Beta-hydroxysteroid dehydrogenase type 1 in human disease: a novel therapeutic target.

Tomlinson JW.

Minerva Endocrinol. 2005 Mar;30(1):37-46. Review.PMID: 15877012 [PubMed - indexed for MEDLINE]Related articlesFree article

Electron interactions and transport between coupled quantum Hall edge states.

Tomlinson JW, Caux JS, Chalker JT.

Phys Rev Lett. 2005 Mar 4;94(8):086804. Epub 2005 Mar 3.PMID: 15783917 [PubMed]Related articles

Androgen generation in adipose tissue in women with simple obesity--a site-specific role for 17beta-hydroxysteroid dehydrogenase type 5.

Quinkler M, Sinha B, Tomlinson JW, Bujalska IJ, Stewart PM, Arlt W.

J Endocrinol. 2004 Nov;183(2):331-42.PMID: 15531721 [PubMed - indexed for MEDLINE]Related articlesFree article

11beta-hydroxysteroid dehydrogenase type 1: a tissue-specific regulator of glucocorticoid response.

Tomlinson JW, Walker EA, Bujalska IJ, Draper N, Lavery GG, Cooper MS, Hewison M, Stewart PM.

Endocr Rev. 2004 Oct;25(5):831-66. Review.PMID: 15466942 [PubMed - indexed for MEDLINE]Related articlesFree article

11beta-hydroxysteroid dehydrogenase type 1 activity in lean and obese males with type 2 diabetes mellitus.

Valsamakis G, Anwar A, Tomlinson JW, Shackleton CH, McTernan PG, Chetty R, Wood PJ, Banerjee AK, Holder G, Barnett AH, Stewart PM, Kumar S.

J Clin Endocrinol Metab. 2004 Sep;89(9):4755-61.PMID: 15356090 [PubMed - indexed for MEDLINE]Related articlesFree article

Weight loss increases 11beta-hydroxysteroid dehydrogenase type 1 expression in human adipose tissue.

Tomlinson JW, Moore JS, Clark PM, Holder G, Shakespeare L, Stewart PM.

J Clin Endocrinol Metab. 2004 Jun;89(6):2711-6.PMID: 15181046 [PubMed - indexed for MEDLINE]Related articlesFree article

"Cushing's disease of the omentum"--fact or fiction?

Tomlinson JW, Stewart PM.

J Endocrinol Invest. 2004 Feb;27(2):171-4. Review. No abstract available. PMID: 15129814 [PubMed - indexed for MEDLINE]Related articles

Mutations in the genes encoding 11beta-hydroxysteroid dehydrogenase type 1 and hexose-6-phosphate dehydrogenase interact to cause cortisone reductase deficiency.

Draper N, Walker EA, Bujalska IJ, Tomlinson JW, Chalder SM, Arlt W, Lavery GG, Bedendo O, Ray DW, Laing I, Malunowicz E, White PC, Hewison M, Mason PJ, Connell JM, Shackleton CH, Stewart PM.

Nat Genet. 2003 Aug;34(4):434-9.PMID: 12858176 [PubMed - indexed for MEDLINE]Related articles

Treating hypertension in diabetic nephropathy.

Tomlinson JW, Owen KR, Close CF.

Diabetes Care. 2003 Jun;26(6):1802-5.PMID: 12766113 [PubMed - indexed for MEDLINE]Related articlesFree article

Low-dose growth hormone inhibits 11 beta-hydroxysteroid dehydrogenase type 1 but has no effect upon fat mass in patients with simple obesity.

Tomlinson JW, Crabtree N, Clark PM, Holder G, Toogood AA, Shackleton CH, Stewart PM.

J Clin Endocrinol Metab. 2003 May;88(5):2113-8.PMID: 12727963 [PubMed - indexed for MEDLINE]Related articlesFree article

The functional consequences of 11beta-hydroxysteroid dehydrogenase expression in adipose tissue.

Tomlinson JW, Stewart PM.

Horm Metab Res. 2002 Nov-Dec;34(11-12):746-51. Review.PMID: 12660893 [PubMed - indexed for MEDLINE]Related articles

11Beta-hydroxysteroid dehydrogenase type 1 in differentiating omental human preadipocytes: from de-activation to generation of cortisol.

Bujalska IJ, Walker EA, Tomlinson JW, Hewison M, Stewart PM.

Endocr Res. 2002 Nov;28(4):449-61.PMID: 12530648 [PubMed - indexed for MEDLINE]Related articles

Expression of 11beta-hydroxysteroid dehydrogenase type 1 in adipose tissue is not increased in human obesity.

Tomlinson JW, Sinha B, Bujalska I, Hewison M, Stewart PM.

J Clin Endocrinol Metab. 2002 Dec;87(12):5630-5.PMID: 12466364 [PubMed - indexed for MEDLINE]Related articlesFree article

Cortisol, 11 beta-hydroxysteroid dehydrogenase type 1 and central obesity.

Stewart PM, Tomlinson JW.

Trends Endocrinol Metab. 2002 Apr;13(3):94-6. No abstract available. PMID: 11893517 [PubMed - indexed for MEDLINE]Related articles

Absence of Cushingoid phenotype in a patient with Cushing's disease due to defective cortisone to cortisol conversion.

Tomlinson JW, Draper N, Mackie J, Johnson AP, Holder G, Wood P, Stewart PM.

J Clin Endocrinol Metab. 2002 Jan;87(1):57-62.PMID: 11788623 [PubMed - indexed for MEDLINE]Related articlesFree article

Growth hormone, insulin-like growth factor-I and the cortisol-cortisone shuttle.

Stewart PM, Toogood AA, Tomlinson JW.

Horm Res. 2001;56 Suppl 1:1-6. Review.PMID: 11786677 [PubMed - indexed for MEDLINE]Related articles

Cortisol metabolism and the role of 11beta-hydroxysteroid dehydrogenase.

Tomlinson JW, Stewart PM.

Best Pract Res Clin Endocrinol Metab. 2001 Mar;15(1):61-78. Review.PMID: 11469811 [PubMed - indexed for MEDLINE]Related articles

Regulation of expression of 11beta-hydroxysteroid dehydrogenase type 1 in adipose tissue: tissue-specific induction by cytokines.

Tomlinson JW, Moore J, Cooper MS, Bujalska I, Shahmanesh M, Burt C, Strain A, Hewison M, Stewart PM.

Endocrinology. 2001 May;142(5):1982-9.PMID: 11316764 [PubMed - indexed for MEDLINE]Related articlesFree article

Association between premature mortality and hypopituitarism. West Midlands Prospective Hypopituitary Study Group.

Tomlinson JW, Holden N, Hills RK, Wheatley K, Clayton RN, Bates AS, Sheppard MC, Stewart PM.

Lancet. 2001 Feb 10;357(9254):425-31.PMID: 11273062 [PubMed - indexed for MEDLINE]Related articles

The role of 11 beta-hydroxysteroid dehydrogenase in central obesity and osteoporosis.

Tomlinson JW, Bujalska I, Stewart PM, Cooper MS.

Endocr Res. 2000 Nov;26(4):711-22.PMID: 11196447 [PubMed - indexed for MEDLINE]Related articles

A vacuum furnace for use in the temperature range 1000-2000 degree C.

TOMLINSON JW, BOCKRIS JO.

Rev Sci Instrum. 1950 Jun;21(6):507-8. No abstract available. PMID: 15430646 [PubMed - indexed for MEDLINE]Related articles