PubMed

Engineered zinc finger protein mediated VEGF-A activation restores deficient VEGF-A in sensory neurons in experimental diabetes.

Pawson EJ, Duran-Jimenez B, Surosky R, Brooke HE, Spratt SK, Tomlinson DR, Gardiner NJ.

Diabetes. 2009 Nov 23. [Epub ahead of print]PMID: 19934008 [PubMed - as supplied by publisher]

Advanced glycation end products in extracellular matrix proteins contribute to the failure of sensory nerve regeneration in diabetes.

Duran-Jimenez B, Dobler D, Moffatt S, Rabbani N, Streuli CH, Thornalley PJ, Tomlinson DR, Gardiner NJ.

Diabetes. 2009 Dec;58(12):2893-903. Epub 2009 Aug 31.PMID: 19720799 [PubMed - in process]Related articles

Accuracy of manual QRS duration assessment: its importance in patient selection for cardiac resynchronization and implantable cardioverter defibrillator therapy.

Tomlinson DR, Bashir Y, Betts TR, Rajappan K.

Europace. 2009 May;11(5):638-42. Epub 2009 Jan 26.PMID: 19174376 [PubMed - indexed for MEDLINE]Related articles

Interatrial septum thickness and difficulty with transseptal puncture during redo catheter ablation of atrial fibrillation.

Tomlinson DR, Sabharwal N, Bashir Y, Betts TR.

Pacing Clin Electrophysiol. 2008 Dec;31(12):1606-11.PMID: 19067814 [PubMed - indexed for MEDLINE]Related articles

Diabetic neuropathies: components of etiology.

Tomlinson DR, Gardiner NJ.

J Peripher Nerv Syst. 2008 Jun;13(2):112-21. Review.PMID: 18601656 [PubMed - indexed for MEDLINE]Related articles

Assessment of myocardial viability: comparison of echocardiography versus cardiac magnetic resonance imaging in the current era.

Tomlinson DR, Becher H, Selvanayagam JB.

Heart Lung Circ. 2008 Jun;17(3):173-85. Epub 2008 Jan 28. Review.PMID: 18222726 [PubMed - indexed for MEDLINE]Related articles

Intravenous amiodarone for the pharmacological termination of haemodynamically-tolerated sustained ventricular tachycardia: is bolus dose amiodarone an appropriate first-line treatment?

Tomlinson DR, Cherian P, Betts TR, Bashir Y.

Emerg Med J. 2008 Jan;25(1):15-8.PMID: 18156531 [PubMed - indexed for MEDLINE]Related articles

Glucose neurotoxicity.

Tomlinson DR, Gardiner NJ.

Nat Rev Neurosci. 2008 Jan;9(1):36-45. Review.PMID: 18094705 [PubMed - indexed for MEDLINE]Related articles

Neuritin mediates nerve growth factor-induced axonal regeneration and is deficient in experimental diabetic neuropathy.

Karamoysoyli E, Burnand RC, Tomlinson DR, Gardiner NJ.

Diabetes. 2008 Jan;57(1):181-9. Epub 2007 Oct 1.PMID: 17909094 [PubMed - indexed for MEDLINE]Related articlesFree article

Preconditioning injury-induced neurite outgrowth of adult rat sensory neurons on fibronectin is mediated by mobilisation of axonal alpha5 integrin.

Gardiner NJ, Moffatt S, Fernyhough P, Humphries MJ, Streuli CH, Tomlinson DR.

Mol Cell Neurosci. 2007 Jun;35(2):249-60. Epub 2007 Mar 6.PMID: 17433878 [PubMed - indexed for MEDLINE]Related articles

Thioredoxin interacting protein is increased in sensory neurons in experimental diabetes.

Price SA, Gardiner NJ, Duran-Jimenez B, Zeef LA, Obrosova IG, Tomlinson DR.

Brain Res. 2006 Oct 20;1116(1):206-14. Epub 2006 Aug 30.PMID: 16938273 [PubMed - indexed for MEDLINE]Related articles

Homocysteine, B vitamins, and cardiovascular disease.

Tomlinson DR, Lang D, Lewis MJ.

N Engl J Med. 2006 Jul 13;355(2):209; author reply 209-11. No abstract available. PMID: 16838444 [PubMed - indexed for MEDLINE]Related articles

Identification of changes in gene expression in dorsal root ganglia in diabetic neuropathy: correlation with functional deficits.

Price SA, Zeef LA, Wardleworth L, Hayes A, Tomlinson DR.

J Neuropathol Exp Neurol. 2006 Jul;65(7):722-32.PMID: 16825959 [PubMed - indexed for MEDLINE]Related articles

Gene transfer of an engineered transcription factor promoting expression of VEGF-A protects against experimental diabetic neuropathy.

Price SA, Dent C, Duran-Jimenez B, Liang Y, Zhang L, Rebar EJ, Case CC, Gregory PD, Martin TJ, Spratt SK, Tomlinson DR.

Diabetes. 2006 Jun;55(6):1847-54.PMID: 16731852 [PubMed - indexed for MEDLINE]Related articlesFree article

Phosphorylation of c-Jun N-terminal kinase (JNK) in sensory neurones of diabetic rats, with possible effects on nerve conduction and neuropathic pain: prevention with an aldose reductase inhibitor.

Middlemas AB, Agthong S, Tomlinson DR.

Diabetologia. 2006 Mar;49(3):580-7. Epub 2006 Feb 3.PMID: 16456679 [PubMed - indexed for MEDLINE]Related articles

Altered expression of iron transport proteins in streptozotocin-induced diabetic rat kidney.

Ward DT, Hamilton K, Burnand R, Smith CP, Tomlinson DR, Riccardi D.

Biochim Biophys Acta. 2005 Apr 15;1740(1):79-84. Epub 2005 Feb 23.PMID: 15878745 [PubMed - indexed for MEDLINE]Related articles

Alpha7 integrin mediates neurite outgrowth of distinct populations of adult sensory neurons.

Gardiner NJ, Fernyhough P, Tomlinson DR, Mayer U, von der Mark H, Streuli CH.

Mol Cell Neurosci. 2005 Feb;28(2):229-40.PMID: 15691705 [PubMed - indexed for MEDLINE]Related articles

Expression of axotomy-inducible and apoptosis-related genes in sensory nerves of rats with experimental diabetes.

Burnand RC, Price SA, McElhaney M, Barker D, Tomlinson DR.

Brain Res Mol Brain Res. 2004 Dec 20;132(2):235-40.PMID: 15582161 [PubMed - indexed for MEDLINE]Related articles

The p75 neurotrophin receptor appears in plasma in diabetic rats-characterisation of a potential early test for neuropathy.

Chilton L, Middlemas A, Gardiner N, Tomlinson DR.

Diabetologia. 2004 Nov;47(11):1924-30. Epub 2004 Nov 19.PMID: 15558233 [PubMed - indexed for MEDLINE]Related articles

Mitogen-activated protein kinase p38 mediates reduced nerve conduction velocity in experimental diabetic neuropathy: interactions with aldose reductase.

Price SA, Agthong S, Middlemas AB, Tomlinson DR.

Diabetes. 2004 Jul;53(7):1851-6.PMID: 15220210 [PubMed - indexed for MEDLINE]Related articlesFree article

Activation of JNK in sensory neurons protects against sensory neuron cell death in diabetes and on exposure to glucose/oxidative stress in vitro.

Price SA, Hounsom L, Purves-Tyson TD, Fernyhough P, Tomlinson DR.

Ann N Y Acad Sci. 2003 Dec;1010:95-9.PMID: 15033701 [PubMed - indexed for MEDLINE]Related articles

Peripheral axon crush elevates transport of p75NTR in the central projection of sensory neurones of rats.

Delcroix JD, Patel J, Averill S, Tomlinson DR, Priestley JV, Fernyhough P.

Neurosci Lett. 2003 Nov 20;351(3):181-5.PMID: 14623136 [PubMed - indexed for MEDLINE]Related articles

Neurotrophin-3 prevents the proximal accumulation of neurofilament proteins in sensory neurons of streptozocin-induced diabetic rats.

Sayers NM, Beswick LJ, Middlemas A, Calcutt NA, Mizisin AP, Tomlinson DR, Fernyhough P.

Diabetes. 2003 Sep;52(9):2372-80.PMID: 12941778 [PubMed - indexed for MEDLINE]Related articlesFree article

Insulin prevents depolarization of the mitochondrial inner membrane in sensory neurons of type 1 diabetic rats in the presence of sustained hyperglycemia.

Huang TJ, Price SA, Chilton L, Calcutt NA, Tomlinson DR, Verkhratsky A, Fernyhough P.

Diabetes. 2003 Aug;52(8):2129-36.PMID: 12882932 [PubMed - indexed for MEDLINE]Related articlesFree article

Enhanced activation of axonally transported stress-activated protein kinases in peripheral nerve in diabetic neuropathy is prevented by neurotrophin-3.

Middlemas A, Delcroix JD, Sayers NM, Tomlinson DR, Fernyhough P.

Brain. 2003 Jul;126(Pt 7):1671-82. Epub 2003 Apr 22.PMID: 12805110 [PubMed - indexed for MEDLINE]Related articlesFree article

Therapeutic efficacy of sonic hedgehog protein in experimental diabetic neuropathy.

Calcutt NA, Allendoerfer KL, Mizisin AP, Middlemas A, Freshwater JD, Burgers M, Ranciato R, Delcroix JD, Taylor FR, Shapiro R, Strauch K, Dudek H, Engber TM, Galdes A, Rubin LL, Tomlinson DR.

J Clin Invest. 2003 Feb;111(4):507-14.PMID: 12588889 [PubMed - indexed for MEDLINE]Related articlesFree article

Diminished transcription factor survival signals in dorsal root ganglia in rats with streptozotocin-induced diabetes.

Purves TD, Tomlinson DR.

Ann N Y Acad Sci. 2002 Nov;973:472-6.PMID: 12485914 [PubMed - indexed for MEDLINE]Related articles

Inhibition of p38 MAP kinase corrects biochemical and neurological deficits in experimental diabetic neuropathy.

Agthong S, Tomlinson DR.

Ann N Y Acad Sci. 2002 Nov;973:359-62.PMID: 12485893 [PubMed - indexed for MEDLINE]Related articles

Are mitogen-activated protein kinases glucose transducers for diabetic neuropathies?

Purves TD, Tomlinson DR.

Int Rev Neurobiol. 2002;50:83-114. Review. No abstract available. PMID: 12198822 [PubMed - indexed for MEDLINE]Related articles

Angiotensin-converting enzyme inhibitors: are there credible mechanisms for beneficial effects in diabetic neuropathy?

Malik RA, Tomlinson DR.

Int Rev Neurobiol. 2002;50:415-30. Review. No abstract available. PMID: 12198819 [PubMed - indexed for MEDLINE]Related articles

Effects of nerve growth factor on expression of GAP-43 in right atria after sympathectomy in diabetic rats.

Vo PA, Tomlinson DR.

Diabetes Obes Metab. 2001 Oct;3(5):350-9.PMID: 11703425 [PubMed - indexed for MEDLINE]Related articles

A role for mitogen-activated protein kinases in the etiology of diabetic neuropathy.

Purves T, Middlemas A, Agthong S, Jude EB, Boulton AJ, Fernyhough P, Tomlinson DR.

FASEB J. 2001 Nov;15(13):2508-14.PMID: 11689477 [PubMed - indexed for MEDLINE]Related articlesFree article

Nerve growth factor modulates the activation status and fast axonal transport of ERK 1/2 in adult nociceptive neurones.

Averill S, Delcroix JD, Michael GJ, Tomlinson DR, Fernyhough P, Priestley JV.

Mol Cell Neurosci. 2001 Aug;18(2):183-96.PMID: 11520179 [PubMed - indexed for MEDLINE]Related articles

Effects of experimental diabetes on axonal and Schwann cell changes in sciatic nerve isografts.

Eckersley L, Ansselin AD, Tomlinson DR.

Brain Res Mol Brain Res. 2001 Aug 15;92(1-2):128-37.PMID: 11483249 [PubMed - indexed for MEDLINE]Related articles

Oxidative stress participates in the breakdown of neuronal phenotype in experimental diabetic neuropathy.

Hounsom L, Corder R, Patel J, Tomlinson DR.

Diabetologia. 2001 Apr;44(4):424-8.PMID: 11357471 [PubMed - indexed for MEDLINE]Related articles

Clenbuterol stimulates neurotrophic support in streptozotocin-diabetic rats.

Riaz SS, Tomlinson DR.

Diabetes Obes Metab. 1999 Jan;1(1):43-51.PMID: 11221812 [PubMed - indexed for MEDLINE]Related articles

STI prevention and the male sex industry in London: evaluating a pilot peer education programme.

Ziersch A, Gaffney J, Tomlinson DR.

Sex Transm Infect. 2000 Dec;76(6):447-53.PMID: 11221127 [PubMed - indexed for MEDLINE]Related articlesFree article

Pharmacological modulation of nerve growth factor synthesis: a mechanistic comparison of vitamin D receptor and beta(2)-adrenoceptor agonists.

Samina Riaz S, Tomlinson DR.

Brain Res Mol Brain Res. 2000 Dec 28;85(1-2):179-88.PMID: 11146120 [PubMed - indexed for MEDLINE]Related articles

Primary care involvement in human immune deficiency virus infection-a pan-European view. The Eurosupport Study Group.

Tomlinson DR, Colebunders R, Coppieters Y, Dreezen C, Andraghetti R, Fleerackers Y, Liess H, Kosmidis J.

Fam Pract. 2000 Aug;17(4):288-92.PMID: 10934174 [PubMed - indexed for MEDLINE]Related articlesFree article

Alternative splicing of the neurotrophin-3 gene gives rise to different transcripts in a number of human and rat tissues.

Kendall S, Yeo M, Henttu P, Tomlinson DR.

J Neurochem. 2000 Jul;75(1):41-7.PMID: 10854245 [PubMed - indexed for MEDLINE]Related articles

Effect of streptozotocin-induced diabetes on NGF, P75(NTR) and TrkA content of prevertebral and paravertebral rat sympathetic ganglia.

Schmidt RE, Dorsey DA, Roth KA, Parvin CA, Hounsom L, Tomlinson DR.

Brain Res. 2000 Jun 9;867(1-2):149-56.PMID: 10837808 [PubMed - indexed for MEDLINE]Related articles

Neurotrophin-3 reverses nerve conduction velocity deficits in streptozotocin-diabetic rats.

Mizisin AP, Calcutt NA, Tomlinson DR, Gallagher A, Fernyhough P.

J Peripher Nerv Syst. 1999;4(3-4):211-21.PMID: 10642089 [PubMed - indexed for MEDLINE]Related articles

A vitamin D(3) derivative (CB1093) induces nerve growth factor and prevents neurotrophic deficits in streptozotocin-diabetic rats.

Riaz S, Malcangio M, Miller M, Tomlinson DR.

Diabetologia. 1999 Nov;42(11):1308-13.PMID: 10550414 [PubMed - indexed for MEDLINE]Related articles

Mitogen-activated protein kinases as glucose transducers for diabetic complications.

Tomlinson DR.

Diabetologia. 1999 Nov;42(11):1271-81. Review.PMID: 10550410 [PubMed - indexed for MEDLINE]Related articles

Transforming growth factor-beta1 and glial growth factor 2 reduce neurotrophin-3 mRNA expression in cultured Schwann cells via a cAMP-dependent pathway.

Cai F, Campana WM, Tomlinson DR, Fernyhough P.

Brain Res Mol Brain Res. 1999 Aug 25;71(2):256-64.PMID: 10521580 [PubMed - indexed for MEDLINE]Related articles

Nerve conduction impairment in experimental diabetes-proximodistal gradient of severity.

Patel J, Tomlinson DR.

Muscle Nerve. 1999 Oct;22(10):1403-11.PMID: 10487907 [PubMed - indexed for MEDLINE]Related articles

Axonal transport of activating transcription factor-2 is modulated by nerve growth factor in nociceptive neurons.

Delcroix JD, Averill S, Fernandes K, Tomlinson DR, Priestley JV, Fernyhough P.

J Neurosci. 1999 Sep 15;19(18):RC24.PMID: 10479717 [PubMed - indexed for MEDLINE]Related articlesFree article

The structural effect of systemic NGF treatment on permanently axotomised dorsal root ganglion cells in adult rats.

Tandrup T, Vestergaard S, Tomlinson DR, Diemel LT, Jakobsen J.

J Anat. 1999 Apr;194 ( Pt 3):373-9.PMID: 10386775 [PubMed - indexed for MEDLINE]Related articlesFree article

Focally administered nerve growth factor suppresses molecular regenerative responses of axotomized peripheral afferents in rats.

Mohiuddin L, Delcroix JD, Fernyhough P, Tomlinson DR.

Neuroscience. 1999;91(1):265-71.PMID: 10336076 [PubMed - indexed for MEDLINE]Related articles

Increased nerve growth factor mRNA in lateral calf skin biopsies from diabetic patients.

Diemel LT, Cai F, Anand P, Warner G, Kopelman PG, Fernyhough P, Tomlinson DR.

Diabet Med. 1999 Feb;16(2):113-8.PMID: 10229303 [PubMed - indexed for MEDLINE]Related articles