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TMC4 is a novel chloride channel involved in high-concentration salt taste sensation.
Kasahara Y, Narukawa M, Ishimaru Y, Kanda S, Umatani C, Takayama Y, Tominaga M, Oka Y, Kondo K, Kondo T, Takeuchi A, Misaka T, Abe K, Asakura T. Kasahara Y, et al. J Physiol Sci. 2021 Aug 25;71(1):23. doi: 10.1186/s12576-021-00807-z. J Physiol Sci. 2021. PMID: 34429071 Free PMC article.
Tmc4-deficient mice showed significantly weaker glossopharyngeal nerve response to high-concentration of NaCl than the wild-type littermates. These results indicated that TMC4 is a novel chloride channel that responds to high-concentration of NaCl....
Tmc4-deficient mice showed significantly weaker glossopharyngeal nerve response to high-concentration of NaCl than the wild-type litt …
MBOAT7-TMC4 rs641738 Is Not Associated With the Risk of Hepatocellular Carcinoma or Persistent Hepatitis B Infection.
Wang P, Li Y, Li L, Zhong R, Shen N. Wang P, et al. Front Oncol. 2021 May 25;11:639438. doi: 10.3389/fonc.2021.639438. eCollection 2021. Front Oncol. 2021. PMID: 34113561 Free PMC article.
OBJECTIVE: A hot genetic variant, rs641738 within the membrane-bound O-acyltransferase domain containing 7(MBOAT7) and transmembrane channel-like 4 (TMC4), was recently reported to be associated with several liver diseases. ...RESULTS: The results suggested no association …
OBJECTIVE: A hot genetic variant, rs641738 within the membrane-bound O-acyltransferase domain containing 7(MBOAT7) and transmembrane channel …
Mouse TMC4 is involved in the detection of chloride taste of salts.
Narukawa M, Masago A, Murata M, Saito Y, Kasahara Y, Abe K, Asakura T. Narukawa M, et al. Biosci Biotechnol Biochem. 2024 Jan 24;88(2):203-205. doi: 10.1093/bbb/zbad155. Biosci Biotechnol Biochem. 2024. PMID: 37947260
Licking behavior with various salts in transmembrane channel-like 4 (Tmc4) knockout (KO) mice was observed. In Tmc4 KO mice, a significant decrease in sensitivity to chloride salts, such as NaCl, KCl, and NH4Cl, was observed, while no significant decrease in sensiti …
Licking behavior with various salts in transmembrane channel-like 4 (Tmc4) knockout (KO) mice was observed. In Tmc4 KO mice, a …
Genome-wide association meta-analysis identifies 17 loci associated with nonalcoholic fatty liver disease.
Chen Y, Du X, Kuppa A, Feitosa MF, Bielak LF, O'Connell JR, Musani SK, Guo X, Kahali B, Chen VL, Smith AV, Ryan KA, Eirksdottir G, Allison MA, Bowden DW, Budoff MJ, Carr JJ, Chen YI, Taylor KD, Oliveri A, Correa A, Crudup BF, Kardia SLR, Mosley TH Jr, Norris JM, Terry JG, Rotter JI, Wagenknecht LE, Halligan BD, Young KA, Hokanson JE, Washko GR, Gudnason V, Province MA, Peyser PA, Palmer ND, Speliotes EK. Chen Y, et al. Nat Genet. 2023 Oct;55(10):1640-1650. doi: 10.1038/s41588-023-01497-6. Epub 2023 Sep 14. Nat Genet. 2023. PMID: 37709864 Free PMC article.
We identified NAFLD-associated variants at torsin family 1 member B (TOR1B), fat mass and obesity associated (FTO), cordon-bleu WH2 repeat protein like 1 (COBLL1)/growth factor receptor-bound protein 14 (GRB14), insulin receptor (INSR), sterol regulatory element-binding transcrip …
We identified NAFLD-associated variants at torsin family 1 member B (TOR1B), fat mass and obesity associated (FTO), cordon-bleu WH2 repeat p …
The MBOAT7-TMC4 Variant rs641738 Increases Risk of Nonalcoholic Fatty Liver Disease in Individuals of European Descent.
Mancina RM, Dongiovanni P, Petta S, Pingitore P, Meroni M, Rametta R, Borén J, Montalcini T, Pujia A, Wiklund O, Hindy G, Spagnuolo R, Motta BM, Pipitone RM, Craxì A, Fargion S, Nobili V, Käkelä P, Kärjä V, Männistö V, Pihlajamäki J, Reilly DF, Castro-Perez J, Kozlitina J, Valenti L, Romeo S. Mancina RM, et al. Gastroenterology. 2016 May;150(5):1219-1230.e6. doi: 10.1053/j.gastro.2016.01.032. Epub 2016 Feb 2. Gastroenterology. 2016. PMID: 26850495 Free PMC article.
A genome-wide association study showed that the rs641738 C>T variant in the locus that contains the membrane bound O-acyltransferase domain-containing 7 gene (MBOAT7, also called LPIAT1) and transmembrane channel-like 4 gene (TMC4) increased the risk for cirrhosis in al …
A genome-wide association study showed that the rs641738 C>T variant in the locus that contains the membrane bound O-acyltransferase doma …
Identification of novel saltiness-enhancing peptides from yeast extract and their mechanism of action for transmembrane channel-like 4 (TMC4) protein through experimental and integrated computational modeling.
Shen DY, Pan F, Yang ZC, Song HL, Zou TT, Xiong J, Li K, Li P, Hu N, Xue DD. Shen DY, et al. Food Chem. 2022 Sep 15;388:132993. doi: 10.1016/j.foodchem.2022.132993. Epub 2022 Apr 16. Food Chem. 2022. PMID: 35447578
Ultrafiltration, gel filtration, preparative high-performance liquid chromatography, and liquid chromatography with tandem mass spectrometry were employed for further purification and identification of the salty enhancing peptides in yeast extracts. Moreover, human transmembrane …
Ultrafiltration, gel filtration, preparative high-performance liquid chromatography, and liquid chromatography with tandem mass spectrometry …
Genetic variants associated with steatohepatitis and liver fibrosis in HIV-infected patients with NAFLD.
Busca C, Arias P, Sánchez-Conde M, Rico M, Montejano R, Martín-Carbonero L, Valencia E, Moreno V, Bernardino JI, Olveira A, Abadía M, González-García J, Montes ML. Busca C, et al. Front Pharmacol. 2022 Aug 30;13:905126. doi: 10.3389/fphar.2022.905126. eCollection 2022. Front Pharmacol. 2022. PMID: 36110512 Free PMC article.
Our objective was to analyze the relationship between PNPLA3, TM6SF2, and MBOAT7-TMC4 and steatosis, steatohepatitis, and liver fibrosis in PLWHIV with NAFLD. ...We recommend routine genotyping for PNPLA3 and MBOAT7-TMC4 in PLWHIV with NAFLD to identify those at hig …
Our objective was to analyze the relationship between PNPLA3, TM6SF2, and MBOAT7-TMC4 and steatosis, steatohepatitis, and liver fibro …
Lack of evidence supporting a role of TMC4-rs641738 missense variant-MBOAT7- intergenic downstream variant-in the Susceptibility to Nonalcoholic Fatty Liver Disease.
Sookoian S, Flichman D, Garaycoechea ME, Gazzi C, Martino JS, Castaño GO, Pirola CJ. Sookoian S, et al. Sci Rep. 2018 Mar 23;8(1):5097. doi: 10.1038/s41598-018-23453-9. Sci Rep. 2018. PMID: 29572551 Free PMC article.
Current knowledge on the genetic basis of nonalcoholic fatty liver disease (NAFLD) suggests that variants contributing not only to the disease predisposition but histological severity as well are located in genes that regulate lipid metabolism. We explored the role of rs641738 C/ …
Current knowledge on the genetic basis of nonalcoholic fatty liver disease (NAFLD) suggests that variants contributing not only to the disea …
Ibuprofen inhibits oral NaCl response through transmembrane channel-like 4.
Kasahara Y, Narukawa M, Nakagita T, Abe K, Misaka T, Asakura T. Kasahara Y, et al. Biochem Biophys Res Commun. 2021 Oct 8;573:76-79. doi: 10.1016/j.bbrc.2021.07.082. Epub 2021 Aug 17. Biochem Biophys Res Commun. 2021. PMID: 34411898
We investigated the inhibitory effect of ibuprofen on the NaCl stimulation of epithelium sodium channel (ENaC) and transmembrane channel-like 4 (TMC4), which are involved in salty taste detection. Although ibuprofen only minimally inhibited the response of the ENaC to NaCl …
We investigated the inhibitory effect of ibuprofen on the NaCl stimulation of epithelium sodium channel (ENaC) and transmembrane channel-lik …
39 results