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Genetic analysis of potential biomarkers and therapeutic targets in ferroptosis from psoriasis.
Wu MN, Zhou DM, Jiang CY, Chen WW, Chen JC, Zou YM, Han T, Zhou LJ. Wu MN, et al. Front Immunol. 2023 Jan 4;13:1104462. doi: 10.3389/fimmu.2022.1104462. eCollection 2022. Front Immunol. 2023. PMID: 36685512 Free PMC article.
Thereafter, the present study utilized SVM-RFE and LASSO algorithms to identify NR5A2, CISD1, GCLC, PRKAA2, TRIB2, ABCC5, ACSF2, TIMM9, DCAF7, PEBP1, and MDM2 from those 199 DE-FRGs to be marker genes. ...
Thereafter, the present study utilized SVM-RFE and LASSO algorithms to identify NR5A2, CISD1, GCLC, PRKAA2, TRIB2, ABCC5, ACSF2, TIMM9 …
High expression of mitochondrial intermembrane chaperone TIMM9 represents a negative prognostic marker in gastric cancer.
Lin CC, Fang CL, Sun DP, Hseu YC, Uen YH, Lin KY, Lin YC. Lin CC, et al. J Formos Med Assoc. 2017 Jun;116(6):476-483. doi: 10.1016/j.jfma.2016.08.007. Epub 2016 Oct 6. J Formos Med Assoc. 2017. PMID: 27720672 Free article.
Cox proportional hazard model was used for multivariate analysis to determine the independence of prognostic effects of TIMM9 expression. RESULTS: A borderline association was found between overexpression of TIMM9 and vascular invasion (p = 0.0887). ...Multivariate …
Cox proportional hazard model was used for multivariate analysis to determine the independence of prognostic effects of TIMM9 express …
Heart failure in patients is associated with downregulation of mitochondrial quality control genes.
Svagusa T, Sikiric S, Milavic M, Sepac A, Seiwerth S, Milicic D, Gasparovic H, Biocina B, Rudez I, Sutlic Z, Manola S, Varvodic J, Udovicic M, Urlic M, Ivankovic S, Plestina S, Paic F, Kulic A, Bakovic P, Sedlic F. Svagusa T, et al. Eur J Clin Invest. 2023 Nov;53(11):e14054. doi: 10.1111/eci.14054. Epub 2023 Jul 4. Eur J Clin Invest. 2023. PMID: 37403271
RESULTS: The following genes were downregulated in ischemic and dilated cardiomyopathy: COX1, NRF1, TFAM, SIRT1, MTOR, MFF, DNM1L, DDIT3, UBL5, HSPA9, HSPE1, YME1L, LONP1, SPG7, HTRA2, OMA1, TIMM23, TIMM17A, TIMM17B, TIMM44, PAM16, TIMM22, TIMM9, TIMM10, PINK1, PARK2, ROTH …
RESULTS: The following genes were downregulated in ischemic and dilated cardiomyopathy: COX1, NRF1, TFAM, SIRT1, MTOR, MFF, DNM1L, DDIT3, UB …
Identifification and validation of ferroptosis signatures and immune infifiltration characteristics associated with intervertebral disc degeneration.
Zhang F, Cui D, Wang K, Cheng H, Zhai Y, Jiao W, Wang Z, Cui X, Yu H. Zhang F, et al. Front Genet. 2023 Feb 22;14:1133615. doi: 10.3389/fgene.2023.1133615. eCollection 2023. Front Genet. 2023. PMID: 36911415 Free PMC article.
Seven key DE-FRGs were screened, including the upregulated genes NOX4 and PIR, and the downregulated genes TIMM9, ATF3, ENPP2, FADS2 and TFAP2A. Single gene GSEA analysis further elucidates the role of DE-FRGs in IDD associated with ferroptosis. ...
Seven key DE-FRGs were screened, including the upregulated genes NOX4 and PIR, and the downregulated genes TIMM9, ATF3, ENPP2, FADS2 …
Omentin-1 promotes mitochondrial biogenesis via PGC1α-AMPK pathway in chondrocytes.
Li Z, Zhang Y, Tian F, Wang Z, Song H, Chen H, Wu B. Li Z, et al. Arch Physiol Biochem. 2023 Apr;129(2):291-297. doi: 10.1080/13813455.2020.1819337. Epub 2020 Sep 15. Arch Physiol Biochem. 2023. PMID: 32930026
Omentin-1 promoted mtDNA/nDNA and four mitochondrial genes (Tomm20, Tomm40, Timm9 and Atp5c1), mRNA transcripts as well as two mitochondrial protein expressions (SDHB and MTCO1). ...
Omentin-1 promoted mtDNA/nDNA and four mitochondrial genes (Tomm20, Tomm40, Timm9 and Atp5c1), mRNA transcripts as well as two mitoch …
Sitagliptin promotes mitochondrial biogenesis in human SH-SY5Y cells by increasing the expression of PGC-1α/NRF1/TFAM.
Weng G, Zhou B, Liu T, Huang Z, Yang H. Weng G, et al. IUBMB Life. 2019 Oct;71(10):1515-1521. doi: 10.1002/iub.2076. Epub 2019 Jul 10. IUBMB Life. 2019. PMID: 31290617 Free article.
Notably, our data indicate that sitagliptin promoted mitochondrial biogenesis by increasing the amount of mtDNA, the levels of mitochondria-related genes such as TOMM20, TOMM40, TIMM9, NDUFS3, ATP5C1, and the expression of oxidative phosphorylation subunits complex I and c …
Notably, our data indicate that sitagliptin promoted mitochondrial biogenesis by increasing the amount of mtDNA, the levels of mitochondria- …
Proteomics identifies differentially expressed proteins in glioblastoma U87 cells treated with hederagenin.
Zhang Y, Han Y, Shang Y, Wang X, Sun J. Zhang Y, et al. Proteome Sci. 2023 Apr 29;21(1):7. doi: 10.1186/s12953-023-00208-7. Proteome Sci. 2023. PMID: 37120556 Free PMC article.
KIF7 and ATAD2B expression were significantly down-regulated and PHEX and TIMM9 expression were significantly upregulated, according to WB analysis, supporting the TMT findings. ...
KIF7 and ATAD2B expression were significantly down-regulated and PHEX and TIMM9 expression were significantly upregulated, according …
A Novel Oxidative Phosphorylation-Associated Gene Signature for Prognosis Prediction in Patients with Hepatocellular Carcinoma.
Chen W, Yang Z, Chen Y. Chen W, et al. Dis Markers. 2022 Sep 5;2022:3594901. doi: 10.1155/2022/3594901. eCollection 2022. Dis Markers. 2022. PMID: 36105252 Free PMC article.
A five-gene signature including ATP6V0B, ATP6V1C1, ATP6V1E1, TIMM9, and UQCRH was identified by LASSO Cox regression to classify patients into low- and high-risk groups. ...
A five-gene signature including ATP6V0B, ATP6V1C1, ATP6V1E1, TIMM9, and UQCRH was identified by LASSO Cox regression to classify pati …
Construction of HBV gene-related prognostic and diagnostic models for hepatocellular carcinoma.
Ma K, Wu H, Ji L. Ma K, et al. Front Genet. 2023 Jan 4;13:1065644. doi: 10.3389/fgene.2022.1065644. eCollection 2022. Front Genet. 2023. PMID: 36685852 Free PMC article.
Conclusion: In conclusion, the prognostic and diagnostic models of hepatitis B virus gene-related Hepatocellular carcinoma were constructed. ABCB6, IPO7, TIMM9, FZD7, and ACAT1, the five HBV-related genes that affect the prognosis, can work as reliable biomarkers for the d …
Conclusion: In conclusion, the prognostic and diagnostic models of hepatitis B virus gene-related Hepatocellular carcinoma were constructed. …
Identification of candidate genomic regions for thermogelled egg yolk traits based on a genome-wide association study.
Zhang R, Li X, Ma Y, Liu Y, Zhang Y, Cheng X, Ning Z. Zhang R, et al. Poult Sci. 2023 Mar;102(3):102402. doi: 10.1016/j.psj.2022.102402. Epub 2022 Dec 9. Poult Sci. 2023. PMID: 36610105 Free PMC article.
Five traits, including hardness, cohesiveness, gumminess, chewiness, and resilience, had low heritability (0.044-0.078). Ten genes, including U6, FSHR, PKDCC, SLC7A11, TIMM9, ARID4A, PSMA3, ACTR10, EML4, and SLC35F4 may control the hardness of the thermogelled egg yolks. . …
Five traits, including hardness, cohesiveness, gumminess, chewiness, and resilience, had low heritability (0.044-0.078). Ten genes, includin …
13 results