PubMed

An adventitial IL-6/MCP1 amplification loop accelerates macrophage-mediated vascular inflammation leading to aortic dissection in mice.

Tieu BC, Lee C, Sun H, Lejeune W, Recinos A 3rd, Ju X, Spratt H, Guo DC, Milewicz D, Tilton RG, Brasier AR.

J Clin Invest. 2009 Nov 16. pii: 38308. doi: 10.1172/JCI38308. [Epub ahead of print]PMID: 19920349 [PubMed - as supplied by publisher]Related articlesFree article

Early Neural and Vascular Dysfunction in Diabetic Rats are Largely Sequelae of Increased Sorbitol Oxidation.

Ido Y, Nyengaard JR, Chang K, Tilton RG, Kilo C, Mylari BL, Oates PJ, Williamson JR.

Antioxid Redox Signal. 2009 Jul 22. [Epub ahead of print]PMID: 19624259 [PubMed - as supplied by publisher]Related articles

Production of scFv antibody fragments from a hybridoma with functional activity against human vascular endothelial growth factor.

Irani Y, Brereton HM, Tilton RG, Coster DJ, Williams KA.

Hybridoma (Larchmt). 2009 Jun;28(3):205-9.PMID: 19445630 [PubMed - indexed for MEDLINE]Related articles

Oct-4A isoform is expressed in human cord blood-derived CD133 stem cells and differentiated progeny.

Howe M, Zhao J, Bodenburg Y, McGuckin CP, Forraz N, Tilton RG, Urban RJ, Denner L.

Cell Prolif. 2009 Jun;42(3):265-75. Epub 2009 Mar 25.PMID: 19438894 [PubMed - indexed for MEDLINE]Related articles

Roles of IL-6-gp130 Signaling in Vascular Inflammation.

Hou T, Tieu BC, Ray S, Recinos Iii A, Cui R, Tilton RG, Brasier AR.

Curr Cardiol Rev. 2008 Aug;4(3):179-92.PMID: 19936194 [PubMed - in process]

PCR amplification of the functional immunoglobulin heavy chain variable gene from a hybridoma in the presence of two aberrant transcripts.

Irani Y, Tea M, Tilton RG, Coster DJ, Williams KA, Brereton HM.

J Immunol Methods. 2008 Jul 31;336(2):246-50. Epub 2008 May 16.PMID: 18538340 [PubMed - indexed for MEDLINE]Related articles

Comprehensive analysis of the mouse renal cortex using two-dimensional HPLC - tandem mass spectrometry.

Zhao Y, Denner L, Haidacher SJ, Lejeune WS, Tilton RG.

Proteome Sci. 2008 May 23;6:15.PMID: 18501002 [PubMed - in process]Related articlesFree article

Directed engineering of umbilical cord blood stem cells to produce C-peptide and insulin.

Denner L, Bodenburg Y, Zhao JG, Howe M, Cappo J, Tilton RG, Copland JA, Forraz N, McGuckin C, Urban R.

Cell Prolif. 2007 Jun;40(3):367-80.PMID: 17531081 [PubMed - indexed for MEDLINE]Related articles

Diabetes-induced changes in the renal cortical proteome assessed with two-dimensional gel electrophoresis and mass spectrometry.

Tilton RG, Haidacher SJ, Lejeune WS, Zhang X, Zhao Y, Kurosky A, Brasier AR, Denner L.

Proteomics. 2007 May;7(10):1729-42.PMID: 17436268 [PubMed - indexed for MEDLINE]Related articles

Angiotensin II induces IL-6 expression and the Jak-STAT3 pathway in aortic adventitia of LDL receptor-deficient mice.

Recinos A 3rd, LeJeune WS, Sun H, Lee CY, Tieu BC, Lu M, Hou T, Boldogh I, Tilton RG, Brasier AR.

Atherosclerosis. 2007 Sep;194(1):125-33. Epub 2006 Nov 15.PMID: 17109863 [PubMed - indexed for MEDLINE]Related articlesFree article

RhoA mediates angiotensin II-induced phospho-Ser536 nuclear factor kappaB/RelA subunit exchange on the interleukin-6 promoter in VSMCs.

Cui R, Tieu B, Recinos A, Tilton RG, Brasier AR.

Circ Res. 2006 Sep 29;99(7):723-30. Epub 2006 Sep 7.PMID: 16960103 [PubMed - indexed for MEDLINE]Related articlesFree article

Myofibroblast transdifferentiation of mesothelial cells is mediated by RAGE and contributes to peritoneal fibrosis in uraemia.

De Vriese AS, Tilton RG, Mortier S, Lameire NH.

Nephrol Dial Transplant. 2006 Sep;21(9):2549-55. Epub 2006 Jun 6.PMID: 16757496 [PubMed - indexed for MEDLINE]Related articlesFree article

Diabetes-induced activation of canonical and noncanonical nuclear factor-kappaB pathways in renal cortex.

Starkey JM, Haidacher SJ, LeJeune WS, Zhang X, Tieu BC, Choudhary S, Brasier AR, Denner LA, Tilton RG.

Diabetes. 2006 May;55(5):1252-9.PMID: 16644679 [PubMed - indexed for MEDLINE]Related articlesFree article

Renal effects of a neutralising RAGE-antibody in long-term streptozotocin-diabetic mice.

Jensen LJ, Denner L, Schrijvers BF, Tilton RG, Rasch R, Flyvbjerg A.

J Endocrinol. 2006 Mar;188(3):493-501.PMID: 16522729 [PubMed - indexed for MEDLINE]Related articlesFree article

A neutralizing VEGF antibody prevents glomerular hypertrophy in a model of obese type 2 diabetes, the Zucker diabetic fatty rat.

Schrijvers BF, Flyvbjerg A, Tilton RG, Lameire NH, De Vriese AS.

Nephrol Dial Transplant. 2006 Feb;21(2):324-9. Epub 2005 Oct 25.PMID: 16249198 [PubMed - indexed for MEDLINE]Related articlesFree article

Growth factor antagonists for the treatment of diabetic vascular complications.

Tilton RG, Dixon RA, Brock TA.

Expert Opin Investig Drugs. 1997 Nov;6(11):1671-84.PMID: 15989571 [PubMed]Related articles

Pathophysiological role of vascular endothelial growth factor in the remnant kidney.

Schrijvers BF, Flyvbjerg A, Tilton RG, Rasch R, Lameire NH, De Vriese AS.

Nephron Exp Nephrol. 2005;101(1):e9-15. Epub 2005 May 27.PMID: 15925906 [PubMed - indexed for MEDLINE]Related articles

Inhibition of vascular endothelial growth factor (VEGF) does not affect early renal changes in a rat model of lean type 2 diabetes.

Schrijvers BF, De Vriese AS, Tilton RG, Van de Voorde J, Denner L, Lameire NH, Flyvbjerg A.

Horm Metab Res. 2005 Jan;37(1):21-5.PMID: 15702434 [PubMed - indexed for MEDLINE]Related articles

Endothelin-mediated remodeling in aortas of diabetic rats.

Fukuda G, Khan ZA, Barbin YP, Farhangkhoee H, Tilton RG, Chakrabarti S.

Diabetes Metab Res Rev. 2005 Jul-Aug;21(4):367-75.PMID: 15580650 [PubMed - indexed for MEDLINE]Related articles

Long-term renal effects of a neutralizing RAGE antibody in obese type 2 diabetic mice.

Flyvbjerg A, Denner L, Schrijvers BF, Tilton RG, Mogensen TH, Paludan SR, Rasch R.

Diabetes. 2004 Jan;53(1):166-72.PMID: 14693711 [PubMed - indexed for MEDLINE]Related articlesFree article

Angiogenesis induced by tumor necrosis factor-agr; is mediated by alpha4 integrins.

Vanderslice P, Munsch CL, Rachal E, Erichsen D, Sughrue KM, Truong AN, Wygant JN, McIntyre BW, Eskin SG, Tilton RG, Polverini PJ.

Angiogenesis. 1998;2(3):265-75.PMID: 14517466 [PubMed - as supplied by publisher]Related articles

Inhibition of the interaction of AGE-RAGE prevents hyperglycemia-induced fibrosis of the peritoneal membrane.

De Vriese AS, Flyvbjerg A, Mortier S, Tilton RG, Lameire NH.

J Am Soc Nephrol. 2003 Aug;14(8):2109-18.PMID: 12874465 [PubMed - indexed for MEDLINE]Related articlesFree article

Functional Role for Selectins in the Pathogenesis of Cerebral Ischemia.

Tilton RG, Berens KL.

Drug News Perspect. 2002 Jul;15(6):351-357.PMID: 12677231 [PubMed - as supplied by publisher]Related articles

Differential efficacy of a synthetic antagonist of VLA-4 during the course of chronic relapsing experimental autoimmune encephalomyelitis.

Cannella B, Gaupp S, Tilton RG, Raine CS.

J Neurosci Res. 2003 Feb 1;71(3):407-16.PMID: 12526029 [PubMed - indexed for MEDLINE]Related articles

Amelioration of long-term renal changes in obese type 2 diabetic mice by a neutralizing vascular endothelial growth factor antibody.

Flyvbjerg A, Dagnaes-Hansen F, De Vriese AS, Schrijvers BF, Tilton RG, Rasch R.

Diabetes. 2002 Oct;51(10):3090-4.PMID: 12351452 [PubMed - indexed for MEDLINE]Related articlesFree article

Diabetic vascular dysfunction: links to glucose-induced reductive stress and VEGF.

Tilton RG.

Microsc Res Tech. 2002 Jun 1;57(5):390-407. Review.PMID: 12112445 [PubMed - indexed for MEDLINE]Related articles

Compensatory glomerular growth after unilateral nephrectomy is VEGF dependent.

Flyvbjerg A, Schrijvers BF, De Vriese AS, Tilton RG, Rasch R.

Am J Physiol Endocrinol Metab. 2002 Aug;283(2):E362-6.PMID: 12110543 [PubMed - indexed for MEDLINE]Related articlesFree article

High protein-induced glomerular hypertrophy is vascular endothelial growth factor-dependent.

Schrijvers BF, Rasch R, Tilton RG, Flyvbjerg A.

Kidney Int. 2002 May;61(5):1600-4.PMID: 11967009 [PubMed - indexed for MEDLINE]Related articlesFree article

Therapeutic potential of endothelin receptor antagonists and nitric oxide donors in pulmonary hypertension.

Tilton RG, Brock TA, Dixon RA.

Expert Opin Investig Drugs. 2001 Jul;10(7):1291-308. Review.PMID: 11772252 [PubMed - indexed for MEDLINE]Related articles

Vascular dysfunction induced by AGE is mediated by VEGF via mechanisms involving reactive oxygen species, guanylate cyclase, and protein kinase C.

Ido Y, Chang KC, Lejeune WS, Bjercke RJ, Reiser KM, Williamson JR, Tilton RG.

Microcirculation. 2001 Aug;8(4):251-63.PMID: 11528533 [PubMed - indexed for MEDLINE]Related articles

Vascular endothelial growth factor is essential for hyperglycemia-induced structural and functional alterations of the peritoneal membrane.

De Vriese AS, Tilton RG, Stephan CC, Lameire NH.

J Am Soc Nephrol. 2001 Aug;12(8):1734-41.PMID: 11461947 [PubMed - indexed for MEDLINE]Related articlesFree article

Requirement for p38 and p44/p42 mitogen-activated protein kinases in RAGE-mediated nuclear factor-kappaB transcriptional activation and cytokine secretion.

Yeh CH, Sturgis L, Haidacher J, Zhang XN, Sherwood SJ, Bjercke RJ, Juhasz O, Crow MT, Tilton RG, Denner L.

Diabetes. 2001 Jun;50(6):1495-504.PMID: 11375353 [PubMed - indexed for MEDLINE]Related articlesFree article

Antibodies against vascular endothelial growth factor improve early renal dysfunction in experimental diabetes.

de Vriese AS, Tilton RG, Elger M, Stephan CC, Kriz W, Lameire NH.

J Am Soc Nephrol. 2001 May;12(5):993-1000.PMID: 11316858 [PubMed - indexed for MEDLINE]Related articlesFree article

Attenuation of pulmonary vascular hypertension and cardiac hypertrophy with sitaxsentan sodium, an orally active ET(A) receptor antagonist.

Tilton RG, Munsch CL, Sherwood SJ, Chen SJ, Chen YF, Wu C, Block N, Dixon RA, Brock TA.

Pulm Pharmacol Ther. 2000;13(2):87-97.PMID: 10799286 [PubMed - indexed for MEDLINE]Related articles

Role for nitric oxide in the hyperpermeability and hemodynamic changes induced by intravenous VEGF.

Tilton RG, Chang KC, LeJeune WS, Stephan CC, Brock TA, Williamson JR.

Invest Ophthalmol Vis Sci. 1999 Mar;40(3):689-96.PMID: 10067972 [PubMed - indexed for MEDLINE]Related articlesFree article

Role for heparin-binding growth factors in glucose-induced vascular dysfunction.

Stephan CC, Chang KC, LeJeune W, Erichsen D, Bjercke RJ, Rege A, Biediger RJ, Kogan TP, Brock TA, Williamson JR, Tilton RG.

Diabetes. 1998 Nov;47(11):1771-8.PMID: 9792547 [PubMed - indexed for MEDLINE]Related articlesFree article

Nitric oxide production by cultured human aortic smooth muscle cells: stimulation by fluid flow.

Papadaki M, Tilton RG, Eskin SG, McIntire LV.

Am J Physiol. 1998 Feb;274(2 Pt 2):H616-26.PMID: 9486266 [PubMed - indexed for MEDLINE]Related articlesFree article

Diabetes impairs sciatic nerve hyperemia induced by surgical trauma: implications for diabetic neuropathy.

Ido Y, Chang K, LeJeune W, Tilton RG, Monafo WW, Williamson JR.

Am J Physiol. 1997 Jul;273(1 Pt 1):E174-84.PMID: 9252494 [PubMed - indexed for MEDLINE]Related articles

Increased sciatic nerve blood flow in diabetic rats: assessment by "molecular" vs. particulate microspheres.

Chang K, Ido Y, LeJeune W, Williamson JR, Tilton RG.

Am J Physiol. 1997 Jul;273(1 Pt 1):E164-73.PMID: 9252493 [PubMed - indexed for MEDLINE]Related articles

Vascular dysfunction induced by elevated glucose levels in rats is mediated by vascular endothelial growth factor.

Tilton RG, Kawamura T, Chang KC, Ido Y, Bjercke RJ, Stephan CC, Brock TA, Williamson JR.

J Clin Invest. 1997 May 1;99(9):2192-202.PMID: 9151791 [PubMed - indexed for MEDLINE]Related articlesFree article

Discordant effects of guanidines on renal structure and function and on regional vascular dysfunction and collagen changes in diabetic rats.

Nyengaard JR, Chang K, Berhorst S, Reiser KM, Williamson JR, Tilton RG.

Diabetes. 1997 Jan;46(1):94-106.PMID: 8971088 [PubMed - indexed for MEDLINE]Related articles

Inhibition of inducible nitric oxide synthase prevents myocardial and systemic vascular barrier dysfunction during early cardiac allograft rejection.

Worrall NK, Chang K, Suau GM, Allison WS, Misko TP, Sullivan PM, Tilton RG, Williamson JR, Ferguson TB Jr.

Circ Res. 1996 May;78(5):769-79.PMID: 8620596 [PubMed - indexed for MEDLINE]Related articlesFree article

Effect of aminoguanidine on the frequency of neuroaxonal dystrophy in the superior mesenteric sympathetic autonomic ganglia of rats with streptozocin-induced diabetes.

Schmidt RE, Dorsey DA, Beaudet LN, Reiser KM, Williamson JR, Tilton RG.

Diabetes. 1996 Mar;45(3):284-90.PMID: 8593931 [PubMed - indexed for MEDLINE]Related articles

Experimental allergic encephalomyelitis in the rat is inhibited by aminoguanidine, an inhibitor of nitric oxide synthase.

Zhao W, Tilton RG, Corbett JA, McDaniel ML, Misko TP, Williamson JR, Cross AH, Hickey WF.

J Neuroimmunol. 1996 Feb;64(2):123-33.PMID: 8632054 [PubMed - indexed for MEDLINE]Related articles

Inhibition of sorbitol dehydrogenase. Effects on vascular and neural dysfunction in streptozocin-induced diabetic rats.

Tilton RG, Chang K, Nyengaard JR, Van den Enden M, Ido Y, Williamson JR.

Diabetes. 1995 Feb;44(2):234-42.PMID: 7859946 [PubMed - indexed for MEDLINE]Related articles

Modulation of in vivo alloreactivity by inhibition of inducible nitric oxide synthase.

Worrall NK, Lazenby WD, Misko TP, Lin TS, Rodi CP, Manning PT, Tilton RG, Williamson JR, Ferguson TB Jr.

J Exp Med. 1995 Jan 1;181(1):63-70.PMID: 7528779 [PubMed - indexed for MEDLINE]Related articlesFree article

Endotoxin-induced uveitis in the rat is attenuated by inhibition of nitric oxide production.

Tilton RG, Chang K, Corbett JA, Misko TP, Currie MG, Bora NS, Kaplan HJ, Williamson JR.

Invest Ophthalmol Vis Sci. 1994 Jul;35(8):3278-88.PMID: 7519183 [PubMed - indexed for MEDLINE]Related articlesFree article

Aminoguanidine, an inhibitor of inducible nitric oxide synthase, ameliorates experimental autoimmune encephalomyelitis in SJL mice.

Cross AH, Misko TP, Lin RF, Hickey WF, Trotter JL, Tilton RG.

J Clin Invest. 1994 Jun;93(6):2684-90.PMID: 7515395 [PubMed - indexed for MEDLINE]Related articlesFree article

Effects of combined insulin and sorbinil treatment on diabetes-induced vascular dysfunction in rats.

Pugliese G, Tilton RG, Speedy A, Oates PJ, Williamson JR.

Metabolism. 1994 Apr;43(4):492-500.PMID: 8159110 [PubMed - indexed for MEDLINE]Related articles

Inhibition of nitric oxide formation by guanidines.

Hasan K, Heesen BJ, Corbett JA, McDaniel ML, Chang K, Allison W, Wolffenbuttel BH, Williamson JR, Tilton RG.

Eur J Pharmacol. 1993 Nov 2;249(1):101-6.PMID: 7506664 [PubMed - indexed for MEDLINE]Related articles