PubMed

The mtDNA nt7778 G/T polymorphism affects autoimmune diseases and reproductive performance in the mouse.

Yu X, Wester-Rosenlöf L, Gimsa U, Holzhueter SA, Marques A, Jonas L, Hagenow K, Kunz M, Nizze H, Tiedge M, Holmdahl R, Ibrahim SM.

Hum Mol Genet. 2009 Dec 15;18(24):4689-4698. Epub 2009 Sep 16.PMID: 19759059 [PubMed - as supplied by publisher]Related articles

Galectin-1 induced activation of the mitochondrial apoptotic pathway: evidence for a connection between death-receptor and mitochondrial pathways in human Jurkat T lymphocytes.

Lange F, Brandt B, Tiedge M, Jonas L, Jeschke U, Pöhland R, Walzel H.

Histochem Cell Biol. 2009 Aug;132(2):211-23. Epub 2009 Apr 18.PMID: 19381674 [PubMed - indexed for MEDLINE]Related articles

Prevention of spontaneous immune-mediated diabetes development in the LEW.1AR1-iddm rat by selective CD8+ T cell transfer is associated with a cytokine shift in the pancreas-draining lymph nodes.

Arndt T, Wedekind D, Weiss H, Tiedge M, Lenzen S, Hedrich HJ, Jörns A.

Diabetologia. 2009 Jul;52(7):1381-90. Epub 2009 Apr 15.PMID: 19367386 [PubMed - indexed for MEDLINE]Related articles

The mutation of the LEW.1AR1-iddm rat maps to the telomeric end of rat chromosome 1.

Weiss H, Arndt T, Jörns A, Lenzen S, Cuppen E, Hedrich HJ, Tiedge M, Wedekind D.

Mamm Genome. 2008 Apr;19(4):292-7. Epub 2008 Mar 21.PMID: 18357488 [PubMed - indexed for MEDLINE]Related articles

Galectin-1 induced activation of the apoptotic death-receptor pathway in human Jurkat T lymphocytes.

Brandt B, Büchse T, Abou-Eladab EF, Tiedge M, Krause E, Jeschke U, Walzel H.

Histochem Cell Biol. 2008 May;129(5):599-609. Epub 2008 Feb 21.PMID: 18288482 [PubMed - indexed for MEDLINE]Related articles

Cell loss during pseudoislet formation hampers profound improvements in islet lentiviral transduction efficacy for transplantation purposes.

Callewaert H, Gysemans C, Cardozo AK, Elsner M, Tiedge M, Eizirik DL, Mathieu C.

Cell Transplant. 2007;16(5):527-37.PMID: 17708342 [PubMed - indexed for MEDLINE]Related articles

[New aspects of pancreatic beta cell functions and their possible therapeutic applications]

Tiedge M.

Dtsch Med Wochenschr. 2006 Dec;131 Suppl 8:S226-30. Review. German. PMID: 17139575 [PubMed - indexed for MEDLINE]Related articles

Improved metabolic stimulus for glucose-induced insulin secretion through GK and PFK-2/FBPase-2 coexpression in insulin-producing RINm5F cells.

Baltrusch S, Langer S, Massa L, Tiedge M, Lenzen S.

Endocrinology. 2006 Dec;147(12):5768-76. Epub 2006 Sep 15.PMID: 16980436 [PubMed - indexed for MEDLINE]Related articlesFree article

Effects of N-glycan processing inhibitors on signaling events and induction of apoptosis in galectin-1-stimulated Jurkat T lymphocytes.

Walzel H, Fahmi AA, Eldesouky MA, Abou-Eladab EF, Waitz G, Brock J, Tiedge M.

Glycobiology. 2006 Dec;16(12):1262-71. Epub 2006 Aug 17.PMID: 16917081 [PubMed - indexed for MEDLINE]Related articlesFree article

Effects of polyinosinic-polycytidylic acid and adoptive transfer of immune cells in the Lew.1AR1-iddm rat and in its coisogenic LEW.1AR1 background strain.

Wedekind D, Weiss H, Jörns A, Lenzen S, Tiedge M, Hedrich HJ.

Autoimmunity. 2005 Jun;38(4):265-75.PMID: 16206509 [PubMed - indexed for MEDLINE]Related articles

Interaction of glucokinase with the liver regulatory protein is conferred by leucine-asparagine motifs of the enzyme.

Baltrusch S, Francini F, Lenzen S, Tiedge M.

Diabetes. 2005 Oct;54(10):2829-37.PMID: 16186382 [PubMed - indexed for MEDLINE]Related articlesFree article

Genetic analysis of the LEW.1AR1-iddm rat: an animal model for spontaneous diabetes mellitus.

Weiss H, Bleich A, Hedrich HJ, Kölsch B, Elsner M, Jörns A, Lenzen S, Tiedge M, Wedekind D.

Mamm Genome. 2005 Jun;16(6):432-41.PMID: 16075370 [PubMed - indexed for MEDLINE]Related articles

Importance of mitochondrial superoxide dismutase expression in insulin-producing cells for the toxicity of reactive oxygen species and proinflammatory cytokines.

Lortz S, Gurgul-Convey E, Lenzen S, Tiedge M.

Diabetologia. 2005 Aug;48(8):1541-8. Epub 2005 Jun 29.PMID: 15986238 [PubMed - indexed for MEDLINE]Related articles

Immune cell infiltration, cytokine expression, and beta-cell apoptosis during the development of type 1 diabetes in the spontaneously diabetic LEW.1AR1/Ztm-iddm rat.

Jörns A, Günther A, Hedrich HJ, Wedekind D, Tiedge M, Lenzen S.

Diabetes. 2005 Jul;54(7):2041-52.PMID: 15983205 [PubMed - indexed for MEDLINE]Related articlesFree article

Beta cell regeneration meets autoimmunity: PAX4 variants in type 1 diabetes.

Tiedge M.

Diabetologia. 2005 May;48(5):803-4. No abstract available. PMID: 15838687 [PubMed - indexed for MEDLINE]Related articles

Glucokinase is an integral component of the insulin granules in glucose-responsive insulin secretory cells and does not translocate during glucose stimulation.

Arden C, Harbottle A, Baltrusch S, Tiedge M, Agius L.

Diabetes. 2004 Sep;53(9):2346-52.PMID: 15331544 [PubMed - indexed for MEDLINE]Related articlesFree article

Mitochondrial catalase overexpression protects insulin-producing cells against toxicity of reactive oxygen species and proinflammatory cytokines.

Gurgul E, Lortz S, Tiedge M, Jörns A, Lenzen S.

Diabetes. 2004 Sep;53(9):2271-80.PMID: 15331536 [PubMed - indexed for MEDLINE]Related articlesFree article

Cytokines activate genes of the endocytotic pathway in insulin-producing RINm5F cells.

Souza KL, Elsner M, Mathias PC, Lenzen S, Tiedge M.

Diabetologia. 2004 Jul;47(7):1292-302. Epub 2004 Jul 10.PMID: 15248046 [PubMed - indexed for MEDLINE]Related articles

Interaction of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase (PFK-2/FBPase-2) with glucokinase activates glucose phosphorylation and glucose metabolism in insulin-producing cells.

Massa L, Baltrusch S, Okar DA, Lange AJ, Lenzen S, Tiedge M.

Diabetes. 2004 Apr;53(4):1020-9.PMID: 15047617 [PubMed - indexed for MEDLINE]Related articlesFree article

Pathology of the pancreas and other organs in the diabetic LEW.1AR1/Ztm- iddm rat, a new model of spontaneous insulin-dependent diabetes mellitus.

Jörns A, Kubat B, Tiedge M, Wedekind D, Hedrich HJ, Klöppel G, Lenzen S.

Virchows Arch. 2004 Feb;444(2):183-9. Epub 2004 Jan 20.PMID: 14735361 [PubMed - indexed for MEDLINE]Related articles

Cytokines and nitric oxide inhibit the enzyme activity of catalase but not its protein or mRNA expression in insulin-producing cells.

Sigfrid LA, Cunningham JM, Beeharry N, Lortz S, Tiedge M, Lenzen S, Carlsson C, Green IC.

J Mol Endocrinol. 2003 Dec;31(3):509-18.PMID: 14664711 [PubMed - indexed for MEDLINE]Related articlesFree article

Mechanism underlying resistance of human pancreatic beta cells against toxicity of streptozotocin and alloxan.

Elsner M, Tiedge M, Lenzen S.

Diabetologia. 2003 Dec;46(12):1713-4. Epub 2003 Nov 12. No abstract available. PMID: 14614558 [PubMed - indexed for MEDLINE]Related articles

Sequential inactivation of reactive oxygen species by combined overexpression of SOD isoforms and catalase in insulin-producing cells.

Lortz S, Tiedge M.

Free Radic Biol Med. 2003 Mar 15;34(6):683-8.PMID: 12633745 [PubMed - indexed for MEDLINE]Related articles

Improvement of the mitochondrial antioxidant defense status prevents cytokine-induced nuclear factor-kappaB activation in insulin-producing cells.

Azevedo-Martins AK, Lortz S, Lenzen S, Curi R, Eizirik DL, Tiedge M.

Diabetes. 2003 Jan;52(1):93-101.PMID: 12502498 [PubMed - indexed for MEDLINE]Related articlesFree article

Importance of the GLUT2 glucose transporter for pancreatic beta cell toxicity of alloxan.

Elsner M, Tiedge M, Guldbakke B, Munday R, Lenzen S.

Diabetologia. 2002 Nov;45(11):1542-9. Epub 2002 Oct 2.PMID: 12436338 [PubMed - indexed for MEDLINE]Related articles

Thyroxine induces pancreatic beta cell apoptosis in rats.

Jörns A, Tiedge M, Lenzen S.

Diabetologia. 2002 Jun;45(6):851-5. Epub 2002 May 17.PMID: 12107729 [PubMed - indexed for MEDLINE]Related articles

Gradual loss of pancreatic beta-cell insulin, glucokinase and GLUT2 glucose transporter immunoreactivities during the time course of nutritionally induced type-2 diabetes in Psammomys obesus (sand rat).

Jörns A, Tiedge M, Ziv E, Shafrir E, Lenzen S.

Virchows Arch. 2002 Jan;440(1):63-9.PMID: 11942578 [PubMed - indexed for MEDLINE]Related articles

The LEW.1AR1/Ztm-iddm rat: a new model of spontaneous insulin-dependent diabetes mellitus.

Lenzen S, Tiedge M, Elsner M, Lortz S, Weiss H, Jörns A, Klöppel G, Wedekind D, Prokop CM, Hedrich HJ.

Diabetologia. 2001 Sep;44(9):1189-96.PMID: 11596676 [PubMed - indexed for MEDLINE]Related articles

Characterization of glucokinase-binding protein epitopes by a phage-displayed peptide library. Identification of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase as a novel interaction partner.

Baltrusch S, Lenzen S, Okar DA, Lange AJ, Tiedge M.

J Biol Chem. 2001 Nov 23;276(47):43915-23. Epub 2001 Aug 24.PMID: 11522786 [PubMed - indexed for MEDLINE]Related articlesFree article

Recovery of pancreatic beta cells in response to long-term normoglycemia after pancreas or islet transplantation in severely streptozotocin diabetic adult rats.

Jörns A, Klempnauer J, Tiedge M, Lenzen S.

Pancreas. 2001 Aug;23(2):186-96.PMID: 11484921 [PubMed - indexed for MEDLINE]Related articles

Relative importance of transport and alkylation for pancreatic beta-cell toxicity of streptozotocin.

Elsner M, Guldbakke B, Tiedge M, Munday R, Lenzen S.

Diabetologia. 2000 Dec;43(12):1528-33.PMID: 11151762 [PubMed - indexed for MEDLINE]Related articles

Differential regulation of [Ca2+]i oscillations in mouse pancreatic islets by glucose, alpha-ketoisocaproic acid, glyceraldehyde and glycolytic intermediates.

Lenzen S, Lerch M, Peckmann T, Tiedge M.

Biochim Biophys Acta. 2000 Sep 1;1523(1):65-72.PMID: 11099859 [PubMed - indexed for MEDLINE]Related articles

Importance of lactate dehydrogenase for the regulation of glycolytic flux and insulin secretion in insulin-producing cells.

Alcazar O, Tiedge M, Lenzen S.

Biochem J. 2000 Dec 1;352 Pt 2:373-80.PMID: 11085930 [PubMed - indexed for MEDLINE]Related articlesFree article

Protection of insulin-producing RINm5F cells against cytokine-mediated toxicity through overexpression of antioxidant enzymes.

Lortz S, Tiedge M, Nachtwey T, Karlsen AE, Nerup J, Lenzen S.

Diabetes. 2000 Jul;49(7):1123-30.PMID: 10909968 [PubMed - indexed for MEDLINE]Related articlesFree article

Importance of cysteine residues for the stability and catalytic activity of human pancreatic beta cell glucokinase.

Tiedge M, Richter T, Lenzen S.

Arch Biochem Biophys. 2000 Mar 15;375(2):251-60.PMID: 10700381 [PubMed - indexed for MEDLINE]Related articles

Engineering of a glucose-responsive surrogate cell for insulin replacement therapy of experimental insulin-dependent diabetes.

Tiedge M, Elsner M, McClenaghan NH, Hedrich HJ, Grube D, Klempnauer J, Lenzen S.

Hum Gene Ther. 2000 Feb 10;11(3):403-14.PMID: 10697115 [PubMed - indexed for MEDLINE]Related articles

Protection against the co-operative toxicity of nitric oxide and oxygen free radicals by overexpression of antioxidant enzymes in bioengineered insulin-producing RINm5F cells.

Tiedge M, Lortz S, Munday R, Lenzen S.

Diabetologia. 1999 Jul;42(7):849-55.PMID: 10440128 [PubMed - indexed for MEDLINE]Related articles

Effect of superoxide dismutase, catalase, chelating agents, and free radical scavengers on the toxicity of alloxan to isolated pancreatic islets in vitro.

Jörns A, Tiedge M, Lenzen S, Munday R.

Free Radic Biol Med. 1999 May;26(9-10):1300-4.PMID: 10381203 [PubMed - indexed for MEDLINE]Related articles

Metabolic regulation, activity state, and intracellular binding of glucokinase in insulin-secreting cells.

Tiedge M, Steffeck H, Elsner M, Lenzen S.

Diabetes. 1999 Mar;48(3):514-23.PMID: 10078551 [PubMed - indexed for MEDLINE]Related articlesFree article

Nutrient-dependent distribution of insulin and glucokinase immunoreactivities in rat pancreatic beta cells.

Jörns A, Tiedge M, Lenzen S.

Virchows Arch. 1999 Jan;434(1):75-82.PMID: 10071239 [PubMed - indexed for MEDLINE]Related articles

Enhanced oxygen delivery reverses anaerobic metabolic states in prolonged sandwich rat hepatocyte culture.

Bader A, Frühauf N, Tiedge M, Drinkgern M, De Bartolo L, Borlak JT, Steinhoff G, Haverich A.

Exp Cell Res. 1999 Jan 10;246(1):221-32.PMID: 9882531 [PubMed - indexed for MEDLINE]Related articles

Complementary action of antioxidant enzymes in the protection of bioengineered insulin-producing RINm5F cells against the toxicity of reactive oxygen species.

Tiedge M, Lortz S, Munday R, Lenzen S.

Diabetes. 1998 Oct;47(10):1578-85.PMID: 9753295 [PubMed - indexed for MEDLINE]Related articlesFree article

Molecular characterization of the glucose-sensing mechanism in the clonal insulin-secreting BRIN-BD11 cell line.

McClenaghan NH, Elsner M, Tiedge M, Lenzen S.

Biochem Biophys Res Commun. 1998 Jan 14;242(2):262-6.PMID: 9446781 [PubMed - indexed for MEDLINE]Related articles

Comparative toxicity of alloxan, N-alkylalloxans and ninhydrin to isolated pancreatic islets in vitro.

Jörns A, Munday R, Tiedge M, Lenzen S.

J Endocrinol. 1997 Nov;155(2):283-93.PMID: 9415063 [PubMed - indexed for MEDLINE]Related articlesFree article

Relation between antioxidant enzyme gene expression and antioxidative defense status of insulin-producing cells.

Tiedge M, Lortz S, Drinkgern J, Lenzen S.

Diabetes. 1997 Nov;46(11):1733-42.PMID: 9356019 [PubMed - indexed for MEDLINE]Related articles

Modulation of human glucokinase intrinsic activity by SH reagents mirrors post-translational regulation of enzyme activity.

Tiedge M, Krug U, Lenzen S.

Biochim Biophys Acta. 1997 Feb 8;1337(2):175-90.PMID: 9048894 [PubMed - indexed for MEDLINE]Related articles

Effects of sodium butyrate on glucose transporter and glucose-phosphorylating enzyme gene expression in RINm5F insulinoma cells.

Tiedge M, Lenzen S.

J Mol Endocrinol. 1996 Aug;17(1):19-26.PMID: 8863183 [PubMed - indexed for MEDLINE]Related articles

Loss of GLUT2 glucose transporter expression in pancreatic beta cells from diabetic Chinese hamsters.

Jörns A, Tiedge M, Sickel E, Lenzen S.

Virchows Arch. 1996 Jun;428(3):177-85.PMID: 8688972 [PubMed - indexed for MEDLINE]Related articles

Effect of metformin on SGLT1, GLUT2, and GLUT5 hexose transporter gene expression in small intestine from rats.

Lenzen S, Lortz S, Tiedge M.

Biochem Pharmacol. 1996 Apr 12;51(7):893-6.PMID: 8651938 [PubMed - indexed for MEDLINE]Related articles

Low antioxidant enzyme gene expression in pancreatic islets compared with various other mouse tissues.

Lenzen S, Drinkgern J, Tiedge M.

Free Radic Biol Med. 1996;20(3):463-6.PMID: 8720919 [PubMed - indexed for MEDLINE]Related articles