PubMed

Mechanisms of biphasic insulin-granule exocytosis - roles of the cytoskeleton, small GTPases and SNARE proteins.

Wang Z, Thurmond DC.

J Cell Sci. 2009 Apr 1;122(Pt 7):893-903. Review.PMID: 19295123 [PubMed - indexed for MEDLINE]Related articlesFree article

Munc18c depletion selectively impairs the sustained phase of insulin release.

Oh E, Thurmond DC.

Diabetes. 2009 May;58(5):1165-74. Epub 2009 Feb 2.PMID: 19188424 [PubMed - indexed for MEDLINE]Related articlesFree article

Munc18c is not rate-limiting for glucose and long-chain fatty acid uptake in the heart.

Habets DD, Thurmond DC, Coumans WA, Bonen A, Glatz JF, Luiken JJ.

Mol Cell Biochem. 2009 Feb;322(1-2):81-6. Epub 2008 Nov 14.PMID: 19009238 [PubMed - indexed for MEDLINE]Related articles

The tyrosine phosphorylation of Munc18c induces a switch in binding specificity from syntaxin 4 to Doc2beta.

Jewell JL, Oh E, Bennett SM, Meroueh SO, Thurmond DC.

J Biol Chem. 2008 Aug 1;283(31):21734-46. Epub 2008 Jun 9.PMID: 18541526 [PubMed - indexed for MEDLINE]Related articlesFree article

Filamentous actin regulates insulin exocytosis through direct interaction with Syntaxin 4.

Jewell JL, Luo W, Oh E, Wang Z, Thurmond DC.

J Biol Chem. 2008 Apr 18;283(16):10716-26. Epub 2008 Feb 19.PMID: 18285343 [PubMed - indexed for MEDLINE]Related articlesFree article

WNK1 is a novel regulator of Munc18c-syntaxin 4 complex formation in soluble NSF attachment protein receptor (SNARE)-mediated vesicle exocytosis.

Oh E, Heise CJ, English JM, Cobb MH, Thurmond DC.

J Biol Chem. 2007 Nov 9;282(45):32613-22. Epub 2007 Sep 11.PMID: 17848561 [PubMed - indexed for MEDLINE]Related articlesFree article

Doc2beta is a novel Munc18c-interacting partner and positive effector of syntaxin 4-mediated exocytosis.

Ke B, Oh E, Thurmond DC.

J Biol Chem. 2007 Jul 27;282(30):21786-97. Epub 2007 Jun 4.PMID: 17548353 [PubMed - indexed for MEDLINE]Related articlesFree article

Glucose-stimulated Cdc42 signaling is essential for the second phase of insulin secretion.

Wang Z, Oh E, Thurmond DC.

J Biol Chem. 2007 Mar 30;282(13):9536-46. Epub 2007 Feb 8.PMID: 17289663 [PubMed - indexed for MEDLINE]Related articlesFree article

Caveolin-1 functions as a novel Cdc42 guanine nucleotide dissociation inhibitor in pancreatic beta-cells.

Nevins AK, Thurmond DC.

J Biol Chem. 2006 Jul 14;281(28):18961-72. Epub 2006 May 19.PMID: 16714282 [PubMed - indexed for MEDLINE]Related articlesFree article

The stimulus-induced tyrosine phosphorylation of Munc18c facilitates vesicle exocytosis.

Oh E, Thurmond DC.

J Biol Chem. 2006 Jun 30;281(26):17624-34. Epub 2006 Apr 25.PMID: 16638745 [PubMed - indexed for MEDLINE]Related articlesFree article

Essential role for membrane lipid rafts in interleukin-1beta-induced nitric oxide release from insulin-secreting cells: potential regulation by caveolin-1+.

Veluthakal R, Chvyrkova I, Tannous M, McDonald P, Amin R, Hadden T, Thurmond DC, Quon MJ, Kowluru A.

Diabetes. 2005 Sep;54(9):2576-85.PMID: 16123345 [PubMed - indexed for MEDLINE]Related articlesFree article

Syntaxin 4 facilitates biphasic glucose-stimulated insulin secretion from pancreatic beta-cells.

Spurlin BA, Thurmond DC.

Mol Endocrinol. 2006 Jan;20(1):183-93. Epub 2005 Aug 11.PMID: 16099818 [PubMed - indexed for MEDLINE]Related articlesFree article

Munc18c heterozygous knockout mice display increased susceptibility for severe glucose intolerance.

Oh E, Spurlin BA, Pessin JE, Thurmond DC.

Diabetes. 2005 Mar;54(3):638-47.PMID: 15734838 [PubMed - indexed for MEDLINE]Related articlesFree article

A direct interaction between Cdc42 and vesicle-associated membrane protein 2 regulates SNARE-dependent insulin exocytosis.

Nevins AK, Thurmond DC.

J Biol Chem. 2005 Jan 21;280(3):1944-52. Epub 2004 Nov 9.PMID: 15537656 [PubMed - indexed for MEDLINE]Related articlesFree article

Platelets from Munc18c heterozygous mice exhibit normal stimulus-induced release.

Schraw TD, Crawford GL, Ren Q, Choi W, Thurmond DC, Pessin J, Whiteheart SW.

Thromb Haemost. 2004 Oct;92(4):829-37.PMID: 15467915 [PubMed - indexed for MEDLINE]Related articles

Syntaxin 4 transgenic mice exhibit enhanced insulin-mediated glucose uptake in skeletal muscle.

Spurlin BA, Park SY, Nevins AK, Kim JK, Thurmond DC.

Diabetes. 2004 Sep;53(9):2223-31.PMID: 15331531 [PubMed - indexed for MEDLINE]Related articlesFree article

Insulin resistance in tetracycline-repressible Munc18c transgenic mice.

Spurlin BA, Thomas RM, Nevins AK, Kim HJ, Kim YJ, Noh HL, Shulman GI, Kim JK, Thurmond DC.

Diabetes. 2003 Aug;52(8):1910-7.PMID: 12882905 [PubMed - indexed for MEDLINE]Related articlesFree article

Glucose regulates the cortical actin network through modulation of Cdc42 cycling to stimulate insulin secretion.

Nevins AK, Thurmond DC.

Am J Physiol Cell Physiol. 2003 Sep;285(3):C698-710. Epub 2003 May 21.PMID: 12760905 [PubMed - indexed for MEDLINE]Related articlesFree article

Glucose-stimulated insulin secretion is coupled to the interaction of actin with the t-SNARE (target membrane soluble N-ethylmaleimide-sensitive factor attachment protein receptor protein) complex.

Thurmond DC, Gonelle-Gispert C, Furukawa M, Halban PA, Pessin JE.

Mol Endocrinol. 2003 Apr;17(4):732-42. Epub 2003 Jan 16.PMID: 12554769 [PubMed - indexed for MEDLINE]Related articlesFree article

Glucosamine-induced insulin resistance is coupled to O-linked glycosylation of Munc18c.

Chen G, Liu P, Thurmond DC, Elmendorf JS.

FEBS Lett. 2003 Jan 16;534(1-3):54-60.PMID: 12527361 [PubMed - indexed for MEDLINE]Related articles

Molecular machinery involved in the insulin-regulated fusion of GLUT4-containing vesicles with the plasma membrane (review).

Thurmond DC, Pessin JE.

Mol Membr Biol. 2001 Oct-Dec;18(4):237-45. Review.PMID: 11780752 [PubMed - indexed for MEDLINE]Related articles

Syntaxin 4 heterozygous knockout mice develop muscle insulin resistance.

Yang C, Coker KJ, Kim JK, Mora S, Thurmond DC, Davis AC, Yang B, Williamson RA, Shulman GI, Pessin JE.

J Clin Invest. 2001 May;107(10):1311-8.PMID: 11375421 [PubMed - indexed for MEDLINE]Related articlesFree article

Insulin-stimulated GLUT4 translocation requires the CAP-dependent activation of TC10.

Chiang SH, Baumann CA, Kanzaki M, Thurmond DC, Watson RT, Neudauer CL, Macara IG, Pessin JE, Saltiel AR.

Nature. 2001 Apr 19;410(6831):944-8.PMID: 11309621 [PubMed - indexed for MEDLINE]Related articles

Munc18c regulates insulin-stimulated glut4 translocation to the transverse tubules in skeletal muscle.

Khan AH, Thurmond DC, Yang C, Ceresa BP, Sigmund CD, Pessin JE.

J Biol Chem. 2001 Feb 9;276(6):4063-9. Epub 2000 Oct 27.PMID: 11054418 [PubMed - indexed for MEDLINE]Related articlesFree article

CAP defines a second signalling pathway required for insulin-stimulated glucose transport.

Baumann CA, Ribon V, Kanzaki M, Thurmond DC, Mora S, Shigematsu S, Bickel PE, Pessin JE, Saltiel AR.

Nature. 2000 Sep 14;407(6801):202-7.PMID: 11001060 [PubMed - indexed for MEDLINE]Related articles

Discrimination of GLUT4 vesicle trafficking from fusion using a temperature-sensitive Munc18c mutant.

Thurmond DC, Pessin JE.

EMBO J. 2000 Jul 17;19(14):3565-75.PMID: 10899111 [PubMed - indexed for MEDLINE]Related articlesFree article

Munc18c function is required for insulin-stimulated plasma membrane fusion of GLUT4 and insulin-responsive amino peptidase storage vesicles.

Thurmond DC, Kanzaki M, Khan AH, Pessin JE.

Mol Cell Biol. 2000 Jan;20(1):379-88.PMID: 10594040 [PubMed - indexed for MEDLINE]Related articlesFree article

Molecular basis of insulin-stimulated GLUT4 vesicle trafficking. Location! Location! Location!

Pessin JE, Thurmond DC, Elmendorf JS, Coker KJ, Okada S.

J Biol Chem. 1999 Jan 29;274(5):2593-6. Review. No abstract available. PMID: 9915783 [PubMed - indexed for MEDLINE]Related articlesFree article

Regulation of insulin-stimulated GLUT4 translocation by Munc18c in 3T3L1 adipocytes.

Thurmond DC, Ceresa BP, Okada S, Elmendorf JS, Coker K, Pessin JE.

J Biol Chem. 1998 Dec 11;273(50):33876-83.PMID: 9837979 [PubMed - indexed for MEDLINE]Related articlesFree article

Regulation of the action of steroid/thyroid hormone receptors by medium-chain fatty acids.

Thurmond DC, Baillie RA, Goodridge AG.

J Biol Chem. 1998 Jun 19;273(25):15373-81.PMID: 9624119 [PubMed - indexed for MEDLINE]Related articlesFree article

Nutritional and hormonal regulation of the gene for malic enzyme.

Goodridge AG, Thurmond DC, Baillie RA, Hodnett DW, Xu G.

Z Ernahrungswiss. 1998;37 Suppl 1:8-13.PMID: 9558723 [PubMed - indexed for MEDLINE]Related articles

Characterization of thyroid hormone response elements in the gene for chicken malic enzyme. Factors that influence triiodothyronine responsiveness.

Thurmond DC, Goodridge AG.

J Biol Chem. 1998 Jan 16;273(3):1613-22.PMID: 9430703 [PubMed - indexed for MEDLINE]Related articlesFree article

The chicken malic enzyme gene: structural organization and identification of triiodothyronine response elements in the 5'-flanking DNA.

Hodnett DW, Fantozzi DA, Thurmond DC, Klautky SA, MacPhee KG, Estrem ST, Xu G, Goodridge AG.

Arch Biochem Biophys. 1996 Oct 15;334(2):309-24.PMID: 8900406 [PubMed - indexed for MEDLINE]Related articles

Malic enzyme gene in chick embryo hepatocytes in culture: clofibrate regulates responsiveness to triiodothyronine.

Carlisle TL, Roncero C, el Khadir-Mounier C, Thurmond DC, Goodridge AG.

J Lipid Res. 1996 Oct;37(10):2088-97.PMID: 8906586 [PubMed - indexed for MEDLINE]Related articlesFree article

Nutritional and hormonal regulation of expression of the gene for malic enzyme.

Goodridge AG, Klautky SA, Fantozzi DA, Baillie RA, Hodnett DW, Chen W, Thurmond DC, Xu G, Roncero C.

Prog Nucleic Acid Res Mol Biol. 1996;52:89-122. Review.PMID: 8821259 [PubMed - indexed for MEDLINE]Related articles

Abnormal polyunsaturated lipid metabolism in the obese Zucker rat, with partial metabolic correction by gamma-linolenic acid administration.

Phinney SD, Tang AB, Thurmond DC, Nakamura MT, Stern JS.

Metabolism. 1993 Sep;42(9):1127-40.PMID: 8412765 [PubMed - indexed for MEDLINE]Related articles

Time-dependent effects of progressive gamma-linolenate feeding on hyperphagia, weight gain, and erythrocyte fatty acid composition during growth of Zucker obese rats.

Thurmond DC, Tang AB, Nakamura MT, Stern JS, Phinney SD.

Obes Res. 1993 Mar;1(2):118-25.PMID: 16353349 [PubMed - indexed for MEDLINE]Related articles