PubMed

Direct bone formation during distraction osteogenesis does not require TNFalpha receptors and elevated serum TNFalpha fails to inhibit bone formation in TNFR1 deficient mice.

Wahl EC, Aronson J, Liu L, Skinner RA, Miller MJ, Cockrell GE, Fowlkes JL, Thrailkill KM, Bunn RC, Ronis MJ, Lumpkin CK Jr.

Bone. 2009 Sep 17. [Epub ahead of print]PMID: 19772956 [PubMed - as supplied by publisher]Related articles

Restoration of Regenerative Osteoblastogenesis in Aged Mice: Modulation of TNF.

Wahl EC, Aronson J, Liu L, Fowlkes JL, Thrailkill KM, Bunn RC, Skinner RA, Miller MJ, Cockrell GE, Clark LM, Ou Y, Isales CM, Badger TM, Ronis MJ, Sims J, Lumpkin CK.

J Bone Miner Res. 2009 Jul 6. [Epub ahead of print]PMID: 19580462 [PubMed - as supplied by publisher]Related articles

Microalbuminuria in type 1 diabetes is associated with enhanced excretion of the endocytic multiligand receptors megalin and cubilin.

Thrailkill KM, Nimmo T, Bunn RC, Cockrell GE, Moreau CS, Mackintosh S, Edmondson RD, Fowlkes JL.

Diabetes Care. 2009 Jul;32(7):1266-8. Epub 2009 Apr 14.PMID: 19366958 [PubMed - indexed for MEDLINE]Related articlesFree article

Matrix metalloproteinases: their potential role in the pathogenesis of diabetic nephropathy.

Thrailkill KM, Clay Bunn R, Fowlkes JL.

Endocrine. 2009 Feb;35(1):1-10. Epub 2008 Oct 30. Review.PMID: 18972226 [PubMed - indexed for MEDLINE]Related articlesFree article

Runt-related transcription factor 2 (RUNX2) and RUNX2-related osteogenic genes are down-regulated throughout osteogenesis in type 1 diabetes mellitus.

Fowlkes JL, Bunn RC, Liu L, Wahl EC, Coleman HN, Cockrell GE, Perrien DS, Lumpkin CK Jr, Thrailkill KM.

Endocrinology. 2008 Apr;149(4):1697-704. Epub 2007 Dec 27.PMID: 18162513 [PubMed - indexed for MEDLINE]Related articlesFree article

Matrix metalloproteinase-2 dysregulation in type 1 diabetes.

Thrailkill KM, Bunn RC, Moreau CS, Cockrell GE, Simpson PM, Coleman HN, Frindik JP, Kemp SF, Fowlkes JL.

Diabetes Care. 2007 Sep;30(9):2321-6. Epub 2007 Jun 11. Erratum in: Diabetes Care. 2007 Dec;30(12):3154. PMID: 17563344 [PubMed - indexed for MEDLINE]Related articlesFree article

Severe deficiencies of IGF-I, IGF-II, IGFBP-3, ALS and paradoxically high-normal bone mass in a child with insulin-resistance syndrome (Rabson-Mendenhall type).

Fowlkes JL, Bunn RC, Coleman HN, Hall B, Reid MC, Thrailkill KM.

Growth Horm IGF Res. 2007 Oct;17(5):399-407. Epub 2007 Jun 7.PMID: 17560154 [PubMed - indexed for MEDLINE]Related articles

A novel rat model for the study of deficits in bone formation in type-2 diabetes.

Liu Z, Aronson J, Wahl EC, Liu L, Perrien DS, Kern PA, Fowlkes JL, Thrailkill KM, Bunn RC, Cockrell GE, Skinner RA, Lumpkin CK Jr.

Acta Orthop. 2007 Feb;78(1):46-55.PMID: 17453392 [PubMed - indexed for MEDLINE]Related articles

Effects of systemic and local administration of recombinant human IGF-I (rhIGF-I) on de novo bone formation in an aged mouse model.

Fowlkes JL, Thrailkill KM, Liu L, Wahl EC, Bunn RC, Cockrell GE, Perrien DS, Aronson J, Lumpkin CK Jr.

J Bone Miner Res. 2006 Sep;21(9):1359-66.PMID: 16939394 [PubMed - indexed for MEDLINE]Related articlesFree article

Efficacy and safety of mecasermin rinfabate.

Kemp SF, Fowlkes JL, Thrailkill KM.

Expert Opin Biol Ther. 2006 May;6(5):533-8.PMID: 16610982 [PubMed - indexed for MEDLINE]Related articles

Investigational agents for the treatment of growth hormone-insensitivity syndrome.

Kemp SF, Thrailkill KM.

Expert Opin Investig Drugs. 2006 Apr;15(4):409-15. Review.PMID: 16548790 [PubMed - indexed for MEDLINE]Related articles

Physiological matrix metalloproteinase concentrations in serum during childhood and adolescence, using Luminex Multiplex technology.

Thrailkill KM, Moreau CS, Cockrell G, Simpson P, Goel R, North P, Fowlkes JL, Bunn RC.

Clin Chem Lab Med. 2005;43(12):1392-9.PMID: 16309379 [PubMed - indexed for MEDLINE]Related articlesFree article

Is insulin an anabolic agent in bone? Dissecting the diabetic bone for clues.

Thrailkill KM, Lumpkin CK Jr, Bunn RC, Kemp SF, Fowlkes JL.

Am J Physiol Endocrinol Metab. 2005 Nov;289(5):E735-45. Review.PMID: 16215165 [PubMed - indexed for MEDLINE]Related articlesFree article

Bone formation is impaired in a model of type 1 diabetes.

Thrailkill KM, Liu L, Wahl EC, Bunn RC, Perrien DS, Cockrell GE, Skinner RA, Hogue WR, Carver AA, Fowlkes JL, Aronson J, Lumpkin CK Jr.

Diabetes. 2005 Oct;54(10):2875-81.PMID: 16186388 [PubMed - indexed for MEDLINE]Related articlesFree article

SomatoKine: is there a use in treating growth disorders?

Kemp SF, Thrailkill KM.

Curr Opin Investig Drugs. 2005 Apr;6(4):373-7. Review.PMID: 15898344 [PubMed - indexed for MEDLINE]Related articles

The effects of co-therapy with recombinant human insulin-like growth factor I and insulin on serum leptin levels in adolescents with type 1 diabetes mellitus.

Thrailkill KM, Fowlkes JL, Hyde JF, Litton JC.

Pediatr Diabetes. 2001 Mar;2(1):25-9.PMID: 15016207 [PubMed]Related articles

Regulation of insulin-like growth factor (IGF)-I action by matrix metalloproteinase-3 involves selective disruption of IGF-I/IGF-binding protein-3 complexes.

Fowlkes JL, Serra DM, Bunn RC, Thrailkill KM, Enghild JJ, Nagase H.

Endocrinology. 2004 Feb;145(2):620-6. Epub 2003 Nov 6.PMID: 14605000 [PubMed - indexed for MEDLINE]Related articlesFree article

Insulin-like growth factor-I in diabetes mellitus: its physiology, metabolic effects, and potential clinical utility.

Thrailkill KM.

Diabetes Technol Ther. 2000 Spring;2(1):69-80. Review.PMID: 11467325 [PubMed - indexed for MEDLINE]Related articles

Pediatric diabetes management in Appalachian Kentucky: adherence of primary care physicians to ADA guidelines.

Schoepflin HM, Thrailkill KM.

J Ky Med Assoc. 1999 Oct;97(10):473-81.PMID: 10544554 [PubMed - indexed for MEDLINE]Related articles

MMPs are IGFBP-degrading proteinases: implications for cell proliferation and tissue growth.

Fowlkes JL, Serra DM, Nagase H, Thrailkill KM.

Ann N Y Acad Sci. 1999 Jun 30;878:696-9. No abstract available. PMID: 10415811 [PubMed - indexed for MEDLINE]Related articles

Characterization of matrix metalloproteinases in human urine: alterations during adolescence.

Thrailkill KM, Kumar S, Rosenberg CK, Auten KJ, Fowlkes JL.

Pediatr Nephrol. 1999 Apr;13(3):223-9.PMID: 10353410 [PubMed - indexed for MEDLINE]Related articles

Cotherapy with recombinant human insulin-like growth factor I and insulin improves glycemic control in type 1 diabetes. RhIGF-I in IDDM Study Group.

Thrailkill KM, Quattrin T, Baker L, Kuntze JE, Compton PG, Martha PM Jr.

Diabetes Care. 1999 Apr;22(4):585-92.PMID: 10189536 [PubMed - indexed for MEDLINE]Related articlesFree article

Insulin-like growth factor binding protein (IGFBP) substrate zymography. A new tool to identify and characterize IGFBP-degrading proteinases.

Fowlkes JL, Thrailkill KM, Serra DM, Nagase H.

Endocrine. 1997 Aug;7(1):33-6.PMID: 9449028 [PubMed - indexed for MEDLINE]Related articles

Heparin-binding, highly basic regions within the thyroglobulin type-1 repeat of insulin-like growth factor (IGF)-binding proteins (IGFBPs) -3, -5, and -6 inhibit IGFBP-4 degradation.

Fowlkes JL, Thrailkill KM, George-Nascimento C, Rosenberg CK, Serra DM.

Endocrinology. 1997 Jun;138(6):2280-5.PMID: 9165012 [PubMed - indexed for MEDLINE]Related articlesFree article

Insulin-like growth factor (IGF)-binding protein-3 (IGFBP-3) functions as an IGF-reversible inhibitor of IGFBP-4 proteolysis.

Fowlkes JL, Serra DM, Rosenberg CK, Thrailkill KM.

J Biol Chem. 1995 Nov 17;270(46):27481-8.PMID: 7499205 [PubMed - indexed for MEDLINE]Related articlesFree article

Differentiation of MC3T3-E1 osteoblasts is associated with temporal changes in the expression of IGF-I and IGFBPs.

Thrailkill KM, Siddhanti SR, Fowlkes JL, Quarles LD.

Bone. 1995 Sep;17(3):307-13.PMID: 8541146 [PubMed - indexed for MEDLINE]Related articles

Characterization of insulin-like growth factor-binding protein 5-degrading proteases produced throughout murine osteoblast differentiation.

Thrailkill KM, Quarles LD, Nagase H, Suzuki K, Serra DM, Fowlkes JL.

Endocrinology. 1995 Aug;136(8):3527-33.PMID: 7543045 [PubMed - indexed for MEDLINE]Related articles

Matrix metalloproteinases as insulin-like growth factor binding protein-degrading proteinases.

Fowlkes JL, Thrailkill KM, Serra DM, Suzuki K, Nagase H.

Prog Growth Factor Res. 1995;6(2-4):255-63. Review.PMID: 8817668 [PubMed - indexed for MEDLINE]Related articles

Proteolysis of insulin-like growth factor binding protein-3 during rat pregnancy: a role for matrix metalloproteinases.

Fowlkes JL, Suzuki K, Nagase H, Thrailkill KM.

Endocrinology. 1994 Dec;135(6):2810-3.PMID: 7527335 [PubMed - indexed for MEDLINE]Related articles

Role of serum in the developmental expression of alkaline phosphatase in MC3T3-E1 osteoblasts.

Yohay DA, Zhang J, Thrailkill KM, Arthur JM, Quarles LD.

J Cell Physiol. 1994 Mar;158(3):467-75.PMID: 8126070 [PubMed - indexed for MEDLINE]Related articles

Three distinct forms of insulin-like growth factor binding proteins are released by decidual cells in culture.

Clemmons DR, Thrailkill KM, Handwerger S, Busby WH Jr.

Endocrinology. 1990 Aug;127(2):643-50.PMID: 1695566 [PubMed - indexed for MEDLINE]Related articles

Insulin stimulates the synthesis and release of prolactin from human decidual cells.

Thrailkill KM, Golander A, Underwood LE, Richards RG, Handwerger S.

Endocrinology. 1989 Jun;124(6):3010-4.PMID: 2656248 [PubMed - indexed for MEDLINE]Related articles

Insulin-like growth factor I stimulates the synthesis and release of prolactin from human decidual cells.

Thrailkill KM, Golander A, Underwood LE, Handwerger S.

Endocrinology. 1988 Dec;123(6):2930-4.PMID: 2973977 [PubMed - indexed for MEDLINE]Related articles

Effects of ibuprofen on a porcine model of acute respiratory failure.

Kopolovic R, Thrailkill KM, Martin DT, Ambrose T, Vento M, Carey LC, Cloutier CT.

J Surg Res. 1984 Apr;36(4):300-5.PMID: 6708494 [PubMed - indexed for MEDLINE]Related articles

Intracellular population genetics: evidence for random drift of mitochondrial allele frequencies in Saccharomyces cerevisiae and Schizosaccharomyces pombe.

Thrailkill KM, Birky CW Jr.

Genetics. 1980 Sep;96(1):237-62.PMID: 7009322 [PubMed - indexed for MEDLINE]Related articlesFree article