PubMed

Advanced glycation end products in extracellular matrix proteins contribute to the failure of sensory nerve regeneration in diabetes.

Duran-Jimenez B, Dobler D, Moffatt S, Rabbani N, Streuli CH, Thornalley PJ, Tomlinson DR, Gardiner NJ.

Diabetes. 2009 Dec;58(12):2893-903. Epub 2009 Aug 31.PMID: 19720799 [PubMed - in process]Related articles

Highlights and hotspots of protein glycation in end-stage renal disease.

Thornalley PJ, Rabbani N.

Semin Dial. 2009 Jul-Aug;22(4):400-4.PMID: 19708990 [PubMed - in process]Related articles

The role of EUTox in uremic toxin research.

Vanholder R, Abou-Deif O, Argiles A, Baurmeister U, Beige J, Brouckaert P, Brunet P, Cohen G, De Deyn PP, Drüeke TB, Fliser D, Glorieux G, Herget-Rosenthal S, Hörl WH, Jankowski J, Jörres A, Massy ZA, Mischak H, Perna AF, Rodriguez-Portillo JM, Spasovski G, Stegmayr BG, Stenvinkel P, Thornalley PJ, Wanner C, Wiecek A.

Semin Dial. 2009 Jul-Aug;22(4):323-8.PMID: 19708975 [PubMed - in process]Related articles

Hyperglycemic kidney damage in an animal model of prolonged critical illness.

Vanhorebeek I, Gunst J, Ellger B, Boussemaere M, Lerut E, Debaveye Y, Rabbani N, Thornalley PJ, Schetz M, Van den Berghe G.

Kidney Int. 2009 Sep;76(5):512-20. Epub 2009 Jun 17.PMID: 19536085 [PubMed - indexed for MEDLINE]Related articles

Quantitation of markers of protein damage by glycation, oxidation, and nitration in peritoneal dialysis.

Rabbani N, Thornalley PJ.

Perit Dial Int. 2009 Feb;29 Suppl 2:S51-6. Review.PMID: 19270232 [PubMed - indexed for MEDLINE]Related articles

Protein damage in the ageing process: advances in quantitation and the importance of enzymatic defences.

Xue M, Adaikalakoteswari A, Rabbani N, Thornalley PJ.

SEB Exp Biol Ser. 2009;62:227-65. No abstract available. PMID: 19419000 [PubMed - in process]Related articles

Quantitative measurement of specific biomarkers for protein oxidation, nitration and glycation in Arabidopsis leaves.

Bechtold U, Rabbani N, Mullineaux PM, Thornalley PJ.

Plant J. 2009 Aug;59(4):661-71. Epub 2009 Apr 25.PMID: 19392687 [PubMed - indexed for MEDLINE]Related articles

Tissue-specific glucose toxicity induces mitochondrial damage in a burn injury model of critical illness.

Vanhorebeek I, Ellger B, De Vos R, Boussemaere M, Debaveye Y, Perre SV, Rabbani N, Thornalley PJ, Van den Berghe G.

Crit Care Med. 2009 Apr;37(4):1355-64.PMID: 19242345 [PubMed - indexed for MEDLINE]Related articles

High-dose thiamine therapy for patients with type 2 diabetes and microalbuminuria: a randomised, double-blind placebo-controlled pilot study.

Rabbani N, Alam SS, Riaz S, Larkin JR, Akhtar MW, Shafi T, Thornalley PJ.

Diabetologia. 2009 Feb;52(2):208-12. Epub 2008 Dec 5.PMID: 19057893 [PubMed - indexed for MEDLINE]Related articles

Glyoxalase II does not support methylglyoxal detoxification but serves as a general trypanothione thioesterase in African trypanosomes.

Wendler A, Irsch T, Rabbani N, Thornalley PJ, Krauth-Siegel RL.

Mol Biochem Parasitol. 2009 Jan;163(1):19-27. Epub 2008 Sep 19.PMID: 18848584 [PubMed - indexed for MEDLINE]Related articles

Dicarbonyls linked to damage in the powerhouse: glycation of mitochondrial proteins and oxidative stress.

Rabbani N, Thornalley PJ.

Biochem Soc Trans. 2008 Oct;36(Pt 5):1045-50.PMID: 18793186 [PubMed - indexed for MEDLINE]Related articlesFree article

Activation of NF-E2-related factor-2 reverses biochemical dysfunction of endothelial cells induced by hyperglycemia linked to vascular disease.

Xue M, Qian Q, Adaikalakoteswari A, Rabbani N, Babaei-Jadidi R, Thornalley PJ.

Diabetes. 2008 Oct;57(10):2809-17. Epub 2008 Jul 15.PMID: 18633117 [PubMed - indexed for MEDLINE]Related articlesFree article

Protein and nucleotide damage by glyoxal and methylglyoxal in physiological systems--role in ageing and disease.

Thornalley PJ.

Drug Metabol Drug Interact. 2008;23(1-2):125-50. Review.PMID: 18533367 [PubMed - indexed for MEDLINE]Related articlesFree article

Preparation of nucleotide advanced glycation endproducts--imidazopurinone adducts formed by glycation of deoxyguanosine with glyoxal and methylglyoxal.

Fleming T, Rabbani N, Thornalley PJ.

Ann N Y Acad Sci. 2008 Apr;1126:280-2.PMID: 18448831 [PubMed - indexed for MEDLINE]Related articlesFree article

Reversal of hyperglycemia-induced angiogenesis deficit of human endothelial cells by overexpression of glyoxalase 1 in vitro.

Ahmed U, Dobler D, Larkin SJ, Rabbani N, Thornalley PJ.

Ann N Y Acad Sci. 2008 Apr;1126:262-4.PMID: 18448827 [PubMed - indexed for MEDLINE]Related articlesFree article

The dicarbonyl proteome: proteins susceptible to dicarbonyl glycation at functional sites in health, aging, and disease.

Rabbani N, Thornalley PJ.

Ann N Y Acad Sci. 2008 Apr;1126:124-7.PMID: 18448805 [PubMed - indexed for MEDLINE]Related articles

Assay of 3-nitrotyrosine in tissues and body fluids by liquid chromatography with tandem mass spectrometric detection.

Rabbani N, Thornalley PJ.

Methods Enzymol. 2008;440:337-59. Review.PMID: 18423229 [PubMed - indexed for MEDLINE]Related articles

The potential role of thiamine (vitamin B1) in diabetic complications.

Thornalley PJ.

Curr Diabetes Rev. 2005 Aug;1(3):287-98. Review.PMID: 18220605 [PubMed - indexed for MEDLINE]Related articles

Dietary AGEs and ALEs and risk to human health by their interaction with the receptor for advanced glycation endproducts (RAGE)--an introduction.

Thornalley PJ.

Mol Nutr Food Res. 2007 Sep;51(9):1107-10. Review.PMID: 17854008 [PubMed - indexed for MEDLINE]Related articles

Accumulation of free adduct glycation, oxidation, and nitration products follows acute loss of renal function.

Rabbani N, Sebekova K, Sebekova K Jr, Heidland A, Thornalley PJ.

Kidney Int. 2007 Nov;72(9):1113-21. Epub 2007 Aug 29.PMID: 17728703 [PubMed - indexed for MEDLINE]Related articles

High prevalence of low plasma thiamine concentration in diabetes linked to a marker of vascular disease.

Thornalley PJ, Babaei-Jadidi R, Al Ali H, Rabbani N, Antonysunil A, Larkin J, Ahmed A, Rayman G, Bodmer CW.

Diabetologia. 2007 Oct;50(10):2164-70. Epub 2007 Aug 4.PMID: 17676306 [PubMed - indexed for MEDLINE]Related articlesFree article

High glucose increases angiopoietin-2 transcription in microvascular endothelial cells through methylglyoxal modification of mSin3A.

Yao D, Taguchi T, Matsumura T, Pestell R, Edelstein D, Giardino I, Suske G, Rabbani N, Thornalley PJ, Sarthy VP, Hammes HP, Brownlee M.

J Biol Chem. 2007 Oct 19;282(42):31038-45. Epub 2007 Aug 1.PMID: 17670746 [PubMed - indexed for MEDLINE]Related articlesFree article

Endogenous alpha-oxoaldehydes and formation of protein and nucleotide advanced glycation endproducts in tissue damage.

Thornalley PJ.

Novartis Found Symp. 2007;285:229-43; discussion 243-6. Review.PMID: 17590998 [PubMed - indexed for MEDLINE]Related articles

Advanced glycation endproducts: what is their relevance to diabetic complications?

Ahmed N, Thornalley PJ.

Diabetes Obes Metab. 2007 May;9(3):233-45. Review.PMID: 17391149 [PubMed - indexed for MEDLINE]Related articles

Methylglyoxal modification of mSin3A links glycolysis to angiopoietin-2 transcription.

Yao D, Taguchi T, Matsumura T, Pestell R, Edelstein D, Giardino I, Suske G, Ahmed N, Thornalley PJ, Sarthy VP, Hammes HP, Brownlee M.

Cell. 2007 Feb 9;128(3):625. No abstract available. PMID: 17387784 [PubMed - indexed for MEDLINE]Related articles

Stimulation of suicidal erythrocyte death by methylglyoxal.

Nicolay JP, Schneider J, Niemoeller OM, Artunc F, Portero-Otin M, Haik G Jr, Thornalley PJ, Schleicher E, Wieder T, Lang F.

Cell Physiol Biochem. 2006;18(4-5):223-32.PMID: 17167227 [PubMed - indexed for MEDLINE]Related articles

Effect of storage, processing and cooking on glucosinolate content of Brassica vegetables.

Song L, Thornalley PJ.

Food Chem Toxicol. 2007 Feb;45(2):216-24. Epub 2006 Aug 30.PMID: 17011103 [PubMed - indexed for MEDLINE]Related articles

Advanced glycation end products in renal failure.

Thornalley PJ.

J Ren Nutr. 2006 Jul;16(3):178-84. Review.PMID: 16825015 [PubMed - indexed for MEDLINE]Related articles

Increased dicarbonyl metabolism in endothelial cells in hyperglycemia induces anoikis and impairs angiogenesis by RGD and GFOGER motif modification.

Dobler D, Ahmed N, Song L, Eboigbodin KE, Thornalley PJ.

Diabetes. 2006 Jul;55(7):1961-9.PMID: 16804064 [PubMed - indexed for MEDLINE]Related articlesFree article

Unease on the role of glyoxalase 1 in high-anxiety-related behaviour.

Thornalley PJ.

Trends Mol Med. 2006 May;12(5):195-9. Epub 2006 Apr 17.PMID: 16616641 [PubMed - indexed for MEDLINE]Related articles

Measurement of protein glycation, glycated peptides, and glycation free adducts.

Thornalley PJ.

Perit Dial Int. 2005 Nov-Dec;25(6):522-33. Review.PMID: 16419322 [PubMed - indexed for MEDLINE]Related articlesFree article

Methylglyoxal modification of mSin3A links glycolysis to angiopoietin-2 transcription.

Yao D, Taguchi T, Matsumura T, Pestell R, Edelstein D, Giardino I, Suske G, Ahmed N, Thornalley PJ, Sarthy VP, Hammes HP, Brownlee M.

Cell. 2006 Jan 27;124(2):275-86. Epub 2006 Jan 12. Retraction in: Yao D, Taguchi T, Matsumura T, Pestell R, Edelstein D, Giardino I, Suske G, Ahmed N, Thornalley PJ, Sarthy VP, Hammes HP, Brownlee M. Cell. 2007 Feb 9;128(3):625. PMID: 16413606 [PubMed - indexed for MEDLINE]Related articles

Glycation, receptor-mediated cell activation and vascular complications of diabetes.

Thornalley PJ.

Diab Vasc Dis Res. 2004 May;1(1):21-2. No abstract available. PMID: 16305051 [PubMed - indexed for MEDLINE]Related articles

Analysis of glucosinolates, isothiocyanates, and amine degradation products in vegetable extracts and blood plasma by LC-MS/MS.

Song L, Morrison JJ, Botting NP, Thornalley PJ.

Anal Biochem. 2005 Dec 15;347(2):234-43. Epub 2005 Oct 21.PMID: 16289008 [PubMed - indexed for MEDLINE]Related articles

Glycated and oxidized protein degradation products are indicators of fasting and postprandial hyperglycemia in diabetes.

Ahmed N, Babaei-Jadidi R, Howell SK, Thornalley PJ, Beisswenger PJ.

Diabetes Care. 2005 Oct;28(10):2465-71.PMID: 16186281 [PubMed - indexed for MEDLINE]Related articlesFree article

Glycation free adduct accumulation in renal disease: the new AGE.

Thornalley PJ.

Pediatr Nephrol. 2005 Nov;20(11):1515-22. Epub 2005 Aug 24. Review.PMID: 16133053 [PubMed - indexed for MEDLINE]Related articles

High-dose thiamine therapy counters dyslipidemia and advanced glycation of plasma protein in streptozotocin-induced diabetic rats.

Karachalias N, Babaei-Jadidi R, Kupich C, Ahmed N, Thornalley PJ.

Ann N Y Acad Sci. 2005 Jun;1043:777-83.PMID: 16037305 [PubMed - indexed for MEDLINE]Related articles

Advanced glycation end product free adducts are cleared by dialysis.

Agalou S, Ahmed N, Thornalley PJ, Dawnay A.

Ann N Y Acad Sci. 2005 Jun;1043:734-9.PMID: 16037300 [PubMed - indexed for MEDLINE]Related articles

Increased protein glycation in cirrhosis and therapeutic strategies to prevent it.

Ahmed N, Lüthen R, Häussinger D, Sebeková K, Schinzel R, Voelker W, Heidland A, Thornalley PJ.

Ann N Y Acad Sci. 2005 Jun;1043:718-24.PMID: 16037298 [PubMed - indexed for MEDLINE]Related articles

Peptide mapping of human serum albumin modified minimally by methylglyoxal in vitro and in vivo.

Ahmed N, Thornalley PJ.

Ann N Y Acad Sci. 2005 Jun;1043:260-6.PMID: 16037246 [PubMed - indexed for MEDLINE]Related articles

Dicarbonyl intermediates in the maillard reaction.

Thornalley PJ.

Ann N Y Acad Sci. 2005 Jun;1043:111-7.PMID: 16037229 [PubMed - indexed for MEDLINE]Related articles

Degradation products of proteins damaged by glycation, oxidation and nitration in clinical type 1 diabetes.

Ahmed N, Babaei-Jadidi R, Howell SK, Beisswenger PJ, Thornalley PJ.

Diabetologia. 2005 Aug;48(8):1590-603. Epub 2005 Jun 30.PMID: 15988580 [PubMed - indexed for MEDLINE]Related articles

Assay of advanced glycation endproducts in selected beverages and food by liquid chromatography with tandem mass spectrometric detection.

Ahmed N, Mirshekar-Syahkal B, Kennish L, Karachalias N, Babaei-Jadidi R, Thornalley PJ.

Mol Nutr Food Res. 2005 Jul;49(7):691-9.PMID: 15945118 [PubMed - indexed for MEDLINE]Related articles

Profound mishandling of protein glycation degradation products in uremia and dialysis.

Agalou S, Ahmed N, Babaei-Jadidi R, Dawnay A, Thornalley PJ.

J Am Soc Nephrol. 2005 May;16(5):1471-85. Epub 2005 Mar 30.PMID: 15800128 [PubMed - indexed for MEDLINE]Related articlesFree article

Methylglyoxal administration induces diabetes-like microvascular changes and perturbs the healing process of cutaneous wounds.

Berlanga J, Cibrian D, Guillén I, Freyre F, Alba JS, Lopez-Saura P, Merino N, Aldama A, Quintela AM, Triana ME, Montequin JF, Ajamieh H, Urquiza D, Ahmed N, Thornalley PJ.

Clin Sci (Lond). 2005 Jul;109(1):83-95.PMID: 15755259 [PubMed - indexed for MEDLINE]Related articles

Protein glycation, oxidation and nitration adduct residues and free adducts of cerebrospinal fluid in Alzheimer's disease and link to cognitive impairment.

Ahmed N, Ahmed U, Thornalley PJ, Hager K, Fleischer G, Münch G.

J Neurochem. 2005 Jan;92(2):255-63.PMID: 15663474 [PubMed - indexed for MEDLINE]Related articles

High-dose thiamine therapy counters dyslipidaemia in streptozotocin-induced diabetic rats.

Babaei-Jadidi R, Karachalias N, Kupich C, Ahmed N, Thornalley PJ.

Diabetologia. 2004 Dec;47(12):2235-46. Epub 2004 Dec 11.PMID: 15662560 [PubMed - indexed for MEDLINE]Related articles

Nepsilon-(Carboxymethyl)lysine and 3-DG-imidazolone are major AGE structures in protein modification by 3-deoxyglucosone.

Jono T, Nagai R, Lin X, Ahmed N, Thornalley PJ, Takeya M, Horiuchi S.

J Biochem. 2004 Sep;136(3):351-8.PMID: 15598892 [PubMed - indexed for MEDLINE]Related articles

Processing of protein glycation, oxidation and nitrosation adducts in the liver and the effect of cirrhosis.

Ahmed N, Thornalley PJ, Lüthen R, Häussinger D, Sebekova K, Schinzel R, Voelker W, Heidland A.

J Hepatol. 2004 Dec;41(6):913-9.PMID: 15582123 [PubMed - indexed for MEDLINE]Related articles

Transcription factor Nrf2 is essential for induction of NAD(P)H:quinone oxidoreductase 1, glutathione S-transferases, and glutamate cysteine ligase by broccoli seeds and isothiocyanates.

McWalter GK, Higgins LG, McLellan LI, Henderson CJ, Song L, Thornalley PJ, Itoh K, Yamamoto M, Hayes JD.

J Nutr. 2004 Dec;134(12 Suppl):3499S-3506S.PMID: 15570060 [PubMed - indexed for MEDLINE]Related articlesFree article