PubMed

Glut9 is a major regulator of urate homeostasis and its genetic inactivation induces hyperuricosuria and urate nephropathy.

Preitner F, Bonny O, Laverrière A, Rotman S, Firsov D, Da Costa A, Metref S, Thorens B.

Proc Natl Acad Sci U S A. 2009 Sep 8;106(36):15501-6. Epub 2009 Aug 21.PMID: 19706426 [PubMed - in process]Related articles

Expression of the NH(2)-terminal fragment of RasGAP in pancreatic beta-cells increases their resistance to stresses and protects mice from diabetes.

Yang JY, Walicki J, Jaccard E, Dubuis G, Bulat N, Hornung JP, Thorens B, Widmann C.

Diabetes. 2009 Nov;58(11):2596-606. Epub 2009 Aug 20.PMID: 19696184 [PubMed - in process]Related articles

Metabolic effects of diets differing in glycaemic index depend on age and endogenous glucose-dependent insulinotrophic polypeptide in mice.

Isken F, Weickert MO, Tschöp MH, Nogueiras R, Möhlig M, Abdelrahman A, Klaus S, Thorens B, Pfeiffer AF.

Diabetologia. 2009 Oct;52(10):2159-68. Epub 2009 Jul 31.PMID: 19644669 [PubMed - in process]Related articles

Mouse GLUT9: evidences for a urate uniporter.

Bibert S, Hess SK, Firsov D, Thorens B, Geering K, Horisberger JD, Bonny O.

Am J Physiol Renal Physiol. 2009 Sep;297(3):F612-9. Epub 2009 Jul 8.PMID: 19587147 [PubMed - indexed for MEDLINE]Related articles

Involvement of 4E-BP1 in the protection induced by HDLs on pancreatic beta-cells.

Pétremand J, Bulat N, Butty AC, Poussin C, Rütti S, Au K, Ghosh S, Mooser V, Thorens B, Yang JY, Widmann C, Waeber G.

Mol Endocrinol. 2009 Oct;23(10):1572-86. Epub 2009 Jul 2.PMID: 19574449 [PubMed - in process]Related articles

Glucagon-like peptide-1 protects beta-cells against apoptosis by increasing the activity of an IGF-2/IGF-1 receptor autocrine loop.

Cornu M, Yang JY, Jaccard E, Poussin C, Widmann C, Thorens B.

Diabetes. 2009 Aug;58(8):1816-25. Epub 2009 Apr 28.PMID: 19401425 [PubMed - indexed for MEDLINE]Related articlesFree article

Glucose-dependent insulinotropic polypeptide (GIP) and its receptor (GIPR): cellular localization, lesion-affected expression, and impaired regenerative axonal growth.

Buhren BA, Gasis M, Thorens B, Müller HW, Bosse F.

J Neurosci Res. 2009 Jun;87(8):1858-70.PMID: 19170165 [PubMed - indexed for MEDLINE]Related articles

Glucose sensing and the pathogenesis of obesity and type 2 diabetes.

Thorens B.

Int J Obes (Lond). 2008 Dec;32 Suppl 6:S62-71. Review.PMID: 19079282 [PubMed - indexed for MEDLINE]Related articles

PVHL is a regulator of glucose metabolism and insulin secretion in pancreatic beta cells.

Zehetner J, Danzer C, Collins S, Eckhardt K, Gerber PA, Ballschmieter P, Galvanovskis J, Shimomura K, Ashcroft FM, Thorens B, Rorsman P, Krek W.

Genes Dev. 2008 Nov 15;22(22):3135-46.PMID: 19056893 [PubMed - indexed for MEDLINE]Related articlesFree article

Different transcriptional control of metabolism and extracellular matrix in visceral and subcutaneous fat of obese and rimonabant treated mice.

Poussin C, Hall D, Minehira K, Galzin AM, Tarussio D, Thorens B.

PLoS One. 2008;3(10):e3385.PMID: 19030233 [PubMed - indexed for MEDLINE]Related articlesFree article

Intestinal gluconeogenesis is a key factor for early metabolic changes after gastric bypass but not after gastric lap-band in mice.

Troy S, Soty M, Ribeiro L, Laval L, Migrenne S, Fioramonti X, Pillot B, Fauveau V, Aubert R, Viollet B, Foretz M, Leclerc J, Duchampt A, Zitoun C, Thorens B, Magnan C, Mithieux G, Andreelli F.

Cell Metab. 2008 Sep;8(3):201-11.PMID: 18762021 [PubMed - indexed for MEDLINE]Related articles

Blocking VLDL secretion causes hepatic steatosis but does not affect peripheral lipid stores or insulin sensitivity in mice.

Minehira K, Young SG, Villanueva CJ, Yetukuri L, Oresic M, Hellerstein MK, Farese RV Jr, Horton JD, Preitner F, Thorens B, Tappy L.

J Lipid Res. 2008 Sep;49(9):2038-44. Epub 2008 Jun 1.PMID: 18515909 [PubMed - indexed for MEDLINE]Related articlesFree article

Deficiency of glucose-dependent insulinotropic polypeptide receptor prevents ovariectomy-induced obesity in mice.

Isken F, Pfeiffer AF, Nogueiras R, Osterhoff MA, Ristow M, Thorens B, Tschöp MH, Weickert MO.

Am J Physiol Endocrinol Metab. 2008 Aug;295(2):E350-5. Epub 2008 May 27.PMID: 18505834 [PubMed - indexed for MEDLINE]Related articlesFree article

Exendin-4 protects beta-cells from interleukin-1 beta-induced apoptosis by interfering with the c-Jun NH2-terminal kinase pathway.

Ferdaoussi M, Abdelli S, Yang JY, Cornu M, Niederhauser G, Favre D, Widmann C, Regazzi R, Thorens B, Waeber G, Abderrahmani A.

Diabetes. 2008 May;57(5):1205-15. Epub 2008 Feb 5.PMID: 18252896 [PubMed - indexed for MEDLINE]Related articlesFree article

Increasing GLP-1-induced beta-cell proliferation by silencing the negative regulators of signaling cAMP response element modulator-alpha and DUSP14.

Klinger S, Poussin C, Debril MB, Dolci W, Halban PA, Thorens B.

Diabetes. 2008 Mar;57(3):584-93. Epub 2007 Nov 19.PMID: 18025410 [PubMed - indexed for MEDLINE]Related articlesFree article

Development and preclinical assessment of a bioartificial pancreas.

Thorens B.

Swiss Med Wkly. 2007 Mar 2;137 Suppl 155:68S-71S. Review.PMID: 17874505 [PubMed - indexed for MEDLINE]Related articles

Brain glucose sensing, counterregulation, and energy homeostasis.

Marty N, Dallaporta M, Thorens B.

Physiology (Bethesda). 2007 Aug;22:241-51. Review.PMID: 17699877 [PubMed - indexed for MEDLINE]Related articlesFree article

GLUT2 and the incretin receptors are involved in glucose-induced incretin secretion.

Cani PD, Holst JJ, Drucker DJ, Delzenne NM, Thorens B, Burcelin R, Knauf C.

Mol Cell Endocrinol. 2007 Sep 30;276(1-2):18-23. Epub 2007 Jun 29.PMID: 17681422 [PubMed - indexed for MEDLINE]Related articles

Expression of the gene encoding the high-Km glucose transporter 2 by the early postimplantation mouse embryo is essential for neural tube defects associated with diabetic embryopathy.

Li R, Thorens B, Loeken MR.

Diabetologia. 2007 Mar;50(3):682-9. Epub 2007 Jan 18.PMID: 17235524 [PubMed - indexed for MEDLINE]Related articles

Tetracycline-regulated expression of VEGF-A in beta cells induces angiogenesis: improvement of engraftment following transplantation.

Mathe Z, Dupraz P, Rinsch C, Thorens B, Bosco D, Zbinden M, Morel P, Berney T, Pepper MS.

Cell Transplant. 2006;15(7):621-36.PMID: 17176614 [PubMed - indexed for MEDLINE]Related articles

Maintenance of hepatic nuclear factor 6 in postnatal islets impairs terminal differentiation and function of beta-cells.

Tweedie E, Artner I, Crawford L, Poffenberger G, Thorens B, Stein R, Powers AC, Gannon M.

Diabetes. 2006 Dec;55(12):3264-70.PMID: 17130469 [PubMed - indexed for MEDLINE]Related articlesFree article

[The entero-islet axis: role of the intestine and glycemic regulation]

Thorens B.

Journ Annu Diabetol Hotel Dieu. 2006:67-73. Review. French. No abstract available. PMID: 17051850 [PubMed - indexed for MEDLINE]Related articles

Peroxisome proliferator-activated receptor-alpha-null mice have increased white adipose tissue glucose utilization, GLUT4, and fat mass: Role in liver and brain.

Knauf C, Rieusset J, Foretz M, Cani PD, Uldry M, Hosokawa M, Martinez E, Bringart M, Waget A, Kersten S, Desvergne B, Gremlich S, Wahli W, Seydoux J, Delzenne NM, Thorens B, Burcelin R.

Endocrinology. 2006 Sep;147(9):4067-78. Epub 2006 Jun 15.PMID: 16777972 [PubMed - indexed for MEDLINE]Related articlesFree article

GLUT8 is dispensable for embryonic development but influences hippocampal neurogenesis and heart function.

Membrez M, Hummler E, Beermann F, Haefliger JA, Savioz R, Pedrazzini T, Thorens B.

Mol Cell Biol. 2006 Jun;26(11):4268-76.PMID: 16705176 [PubMed - indexed for MEDLINE]Related articlesFree article

A toggle for type 2 diabetes?

Thorens B.

N Engl J Med. 2006 Apr 13;354(15):1636-8. No abstract available. PMID: 16611957 [PubMed - indexed for MEDLINE]Related articles

[Gluco-incretin hormones in insulin secretion]

Thorens B.

Med Sci (Paris). 2005 Dec;21 Spec No:40-3. Review. French. PMID: 16598904 [PubMed - indexed for MEDLINE]Related articles

Evidence from glut2-null mice that glucose is a critical physiological regulator of feeding.

Bady I, Marty N, Dallaporta M, Emery M, Gyger J, Tarussio D, Foretz M, Thorens B.

Diabetes. 2006 Apr;55(4):988-95.PMID: 16567520 [PubMed - indexed for MEDLINE]Related articlesFree article

A missing sugar prevents glucose entry: a new twist on insulin secretion.

Thorens B.

Cell Metab. 2006 Jan;3(1):3-5.PMID: 16399498 [PubMed - indexed for MEDLINE]Related articles

Regulation of glucagon secretion by glucose transporter type 2 (glut2) and astrocyte-dependent glucose sensors.

Marty N, Dallaporta M, Foretz M, Emery M, Tarussio D, Bady I, Binnert C, Beermann F, Thorens B.

J Clin Invest. 2005 Dec;115(12):3545-53.PMID: 16322792 [PubMed - indexed for MEDLINE]Related articlesFree article

GLUT8 subcellular localization and absence of translocation to the plasma membrane in PC12 cells and hippocampal neurons.

Widmer M, Uldry M, Thorens B.

Endocrinology. 2005 Nov;146(11):4727-36. Epub 2005 Aug 18.PMID: 16109784 [PubMed - indexed for MEDLINE]Related articlesFree article

Expression of an uncleavable N-terminal RasGAP fragment in insulin-secreting cells increases their resistance toward apoptotic stimuli without affecting their glucose-induced insulin secretion.

Yang JY, Walicki J, Abderrahmani A, Cornu M, Waeber G, Thorens B, Widmann C.

J Biol Chem. 2005 Sep 23;280(38):32835-42. Epub 2005 Jul 25.PMID: 16046410 [PubMed - indexed for MEDLINE]Related articlesFree article

Short-term overexpression of a constitutively active form of AMP-activated protein kinase in the liver leads to mild hypoglycemia and fatty liver.

Foretz M, Ancellin N, Andreelli F, Saintillan Y, Grondin P, Kahn A, Thorens B, Vaulont S, Viollet B.

Diabetes. 2005 May;54(5):1331-9.PMID: 15855317 [PubMed - indexed for MEDLINE]Related articlesFree article

Physiology of GLP-1--lessons from glucoincretin receptor knockout mice.

Thorens B.

Horm Metab Res. 2004 Nov-Dec;36(11-12):766-70. Review.PMID: 15655706 [PubMed - indexed for MEDLINE]Related articles

Immunocytochemical localization of the glucose transporter 2 (GLUT2) in the adult rat brain. II. Electron microscopic study.

Arluison M, Quignon M, Thorens B, Leloup C, Penicaud L.

J Chem Neuroanat. 2004 Nov;28(3):137-46.PMID: 15482900 [PubMed - indexed for MEDLINE]Related articles

Distribution and anatomical localization of the glucose transporter 2 (GLUT2) in the adult rat brain--an immunohistochemical study.

Arluison M, Quignon M, Nguyen P, Thorens B, Leloup C, Penicaud L.

J Chem Neuroanat. 2004 Nov;28(3):117-36.PMID: 15482899 [PubMed - indexed for MEDLINE]Related articles

Transcript profiling suggests that differential metabolic adaptation of mice to a high fat diet is associated with changes in liver to muscle lipid fluxes.

de Fourmestraux V, Neubauer H, Poussin C, Farmer P, Falquet L, Burcelin R, Delorenzi M, Thorens B.

J Biol Chem. 2004 Dec 3;279(49):50743-53. Epub 2004 Sep 17.PMID: 15377667 [PubMed - indexed for MEDLINE]Related articlesFree article

Partial gene deletion of endothelial nitric oxide synthase predisposes to exaggerated high-fat diet-induced insulin resistance and arterial hypertension.

Cook S, Hugli O, Egli M, Ménard B, Thalmann S, Sartori C, Perrin C, Nicod P, Thorens B, Vollenweider P, Scherrer U, Burcelin R.

Diabetes. 2004 Aug;53(8):2067-72.PMID: 15277387 [PubMed - indexed for MEDLINE]Related articlesFree article

[GIP and GLP-1: multiplicity of regulator mechanisms for insulin secretion]

Thorens B.

Journ Annu Diabetol Hotel Dieu. 2004:111-25. Review. French. No abstract available. PMID: 15259310 [PubMed - indexed for MEDLINE]Related articles

Gut-derived signaling molecules and vagal afferents in the control of glucose and energy homeostasis.

Thorens B, Larsen PJ.

Curr Opin Clin Nutr Metab Care. 2004 Jul;7(4):471-8. Review.PMID: 15192452 [PubMed - indexed for MEDLINE]Related articles

Mechanisms of glucose sensing and multiplicity of glucose sensors.

Thorens B.

Ann Endocrinol (Paris). 2004 Feb;65(1):9-12. Review. No abstract available. PMID: 15122086 [PubMed - indexed for MEDLINE]Related articles

Gluco-incretins control insulin secretion at multiple levels as revealed in mice lacking GLP-1 and GIP receptors.

Preitner F, Ibberson M, Franklin I, Binnert C, Pende M, Gjinovci A, Hansotia T, Drucker DJ, Wollheim C, Burcelin R, Thorens B.

J Clin Invest. 2004 Feb;113(4):635-45.PMID: 14966573 [PubMed - indexed for MEDLINE]Related articlesFree article

Regulated exocytosis of an H+/myo-inositol symporter at synapses and growth cones.

Uldry M, Steiner P, Zurich MG, Béguin P, Hirling H, Dolci W, Thorens B.

EMBO J. 2004 Feb 11;23(3):531-40. Epub 2004 Jan 29.PMID: 14749729 [PubMed - indexed for MEDLINE]Related articlesFree article

[Gluco-incretin hormones in insulin secretion and diabetes]

Thorens B.

Med Sci (Paris). 2003 Aug-Sep;19(8-9):860-3. Review. French. PMID: 14593618 [PubMed - indexed for MEDLINE]Related articlesFree article

Impaired glucose homeostasis in mice lacking the alpha1b-adrenergic receptor subtype.

Burcelin R, Uldry M, Foretz M, Perrin C, Dacosta A, Nenniger-Tosato M, Seydoux J, Cotecchia S, Thorens B.

J Biol Chem. 2004 Jan 9;279(2):1108-15. Epub 2003 Oct 27.PMID: 14581480 [PubMed - indexed for MEDLINE]Related articlesFree article

The JNK binding domain of islet-brain 1 inhibits IL-1 induced JNK activity and apoptosis but not the transcription of key proapoptotic or protective genes in insulin-secreting cell lines.

Nikulina MA, Sandhu N, Shamim Z, Andersen NA, Oberson A, Dupraz P, Thorens B, Karlsen AE, Bonny C, Mandrup-Poulsen T.

Cytokine. 2003 Oct;24(1-2):13-24.PMID: 14561487 [PubMed - indexed for MEDLINE]Related articles

Gonadotropin-releasing hormone secretion from hypothalamic neurons: stimulation by insulin and potentiation by leptin.

Burcelin R, Thorens B, Glauser M, Gaillard RC, Pralong FP.

Endocrinology. 2003 Oct;144(10):4484-91. Epub 2003 Jul 3.PMID: 12960084 [PubMed - indexed for MEDLINE]Related articlesFree article

Clustering of cardiovascular risk factors mimicking the human metabolic syndrome X in eNOS null mice.

Cook S, Hugli O, Egli M, Vollenweider P, Burcelin R, Nicod P, Thorens B, Scherrer U.

Swiss Med Wkly. 2003 Jun 28;133(25-26):360-3.PMID: 12947532 [PubMed - indexed for MEDLINE]Related articlesFree article

Simple-sugar meals target GLUT2 at enterocyte apical membranes to improve sugar absorption: a study in GLUT2-null mice.

Gouyon F, Caillaud L, Carriere V, Klein C, Dalet V, Citadelle D, Kellett GL, Thorens B, Leturque A, Brot-Laroche E.

J Physiol. 2003 Nov 1;552(Pt 3):823-32. Epub 2003 Aug 22.PMID: 12937289 [PubMed - indexed for MEDLINE]Related articlesFree article

The SLC2 family of facilitated hexose and polyol transporters.

Uldry M, Thorens B.

Pflugers Arch. 2004 Feb;447(5):480-9. Epub 2003 May 16. Review. Erratum in: Pflugers Arch. 2004 May;448(2):259-60. PMID: 12750891 [PubMed - indexed for MEDLINE]Related articles

GLUT4, AMP kinase, but not the insulin receptor, are required for hepatoportal glucose sensor-stimulated muscle glucose utilization.

Burcelin R, Crivelli V, Perrin C, Da Costa A, Mu J, Kahn BB, Birnbaum MJ, Kahn CR, Vollenweider P, Thorens B.

J Clin Invest. 2003 May;111(10):1555-62.PMID: 12750405 [PubMed - indexed for MEDLINE]Related articlesFree article