PubMed

The role of perforin and granzymes in diabetes.

Thomas HE, Trapani JA, Kay TW.

Cell Death Differ. 2009 Nov 20. [Epub ahead of print]PMID: 19927156 [PubMed - as supplied by publisher]Related articles

Bad news for beta-cell apoptosis.

Thomas HE, Biden TJ.

Diabetes. 2009 Aug;58(8):1725-7. No abstract available. PMID: 19638530 [PubMed - indexed for MEDLINE]Related articlesFree article

XIAP discriminates between type I and type II FAS-induced apoptosis.

Jost PJ, Grabow S, Gray D, McKenzie MD, Nachbur U, Huang DC, Bouillet P, Thomas HE, Borner C, Silke J, Strasser A, Kaufmann T.

Nature. 2009 Aug 20;460(7258):1035-9. Epub 2009 Jul 22.PMID: 19626005 [PubMed - indexed for MEDLINE]Related articles

Comparison of gas-solid chromatography and MM2 force field molecular binding energies for greenhouse gases on a carbonaceous surface.

Rybolt TR, Bivona KT, Thomas HE, O'Dell CM.

J Colloid Interface Sci. 2009 Oct 1;338(1):287-92. Epub 2009 Jun 6.PMID: 19560156 [PubMed - in process]Related articles

Beta cell apoptosis in diabetes.

Thomas HE, McKenzie MD, Angstetra E, Campbell PD, Kay TW.

Apoptosis. 2009 Dec;14(12):1389-404.PMID: 19322660 [PubMed - in process]Related articles

Interferon signalling in pancreatic beta cells.

Thomas HE, Graham KL, Angstetra E, McKenzie MD, Dudek NL, Kay TW.

Front Biosci. 2009 Jan 1;14:644-56. Review.PMID: 19273092 [PubMed - indexed for MEDLINE]Related articles

Cytotoxic T cell mechanisms of beta cell destruction in non-obese diabetic mice.

Kay TW, Dudek NL, Graham K, Estella E, Angstetra E, McKenzie MD, Allison J, Thomas HE.

Novartis Found Symp. 2008;292:68-78; discussion 78-84, 122-9, 202-3.PMID: 19203093 [PubMed - indexed for MEDLINE]Related articles

Grazing incidence X-ray diffraction of a photoaligned nematic semiconductor.

Dröge S, Al Khalifah MS, O'Neill M, Thomas HE, Simmonds HS, Emyr Macdonald J, Aldred MP, Vlachos P, Kitney SP, Löbbert A, Kelly SM.

J Phys Chem B. 2009 Jan 8;113(1):49-53.PMID: 19195100 [PubMed]Related articles

Grazing Incidence X-ray Diffraction of a Photoaligned Nematic Semiconductor.

Dröge S, Al Khalifah MS, O'Neill M, Thomas HE, Simmonds HS, Macdonald JE, Aldred MP, Vlachos P, Kitney SP, Löbbert A, Kelly SM.

J Phys Chem B. 2008 Dec 12. [Epub ahead of print]PMID: 19072322 [PubMed - as supplied by publisher]Related articles

In vivo effects of cytokines on pancreatic beta-cells in models of type I diabetes dependent on CD4(+) T lymphocytes.

Angstetra E, Graham KL, Emmett S, Dudek NL, Darwiche R, Ayala-Perez R, Allison J, Santamaria P, Kay TW, Thomas HE.

Immunol Cell Biol. 2009 Feb;87(2):178-85. Epub 2008 Nov 18.PMID: 19015667 [PubMed - indexed for MEDLINE]Related articles

Local vessel injury following percutaneous coronary intervention does not promote early mobilisation of endothelial progenitor cells in the absence of myocardial necrosis.

Thomas HE, Avery PJ, Ahmed JM, Edwards R, Purcell I, Zaman AG, Arthur HM, Keavney BD.

Heart. 2009 Apr;95(7):555-8. Epub 2008 Oct 31.PMID: 18977801 [PubMed - indexed for MEDLINE]Related articles

Transformation of reactive iron minerals in a permeable reactive barrier (biowall) used to treat TCE in groundwater.

He YT, Wilson JT, Wilkin RT.

Environ Sci Technol. 2008 Sep 1;42(17):6690-6.PMID: 18800550 [PubMed - indexed for MEDLINE]Related articles

Cytotoxic T-lymphocyte-mediated killing of human pancreatic islet cells in vitro.

Campbell PD, Estella E, Dudek NL, Jhala G, Thomas HE, Kay TW, Mannering SI.

Hum Immunol. 2008 Sep;69(9):543-51. Epub 2008 Jul 17.PMID: 18639598 [PubMed - indexed for MEDLINE]Related articles

Binding energies for alkane molecules on a carbon surface from gas-solid chromatography and molecular mechanics.

Rybolt TR, Wells CE, Thomas HE, Goodwin CM, Blakely JL, Turner JD.

J Colloid Interface Sci. 2008 Sep 1;325(1):282-6. Epub 2008 Jun 27.PMID: 18621381 [PubMed]Related articles

Circulating endothelial progenitor cell numbers are not associated with donor organ age or allograft vasculopathy in cardiac transplant recipients.

Thomas HE, Parry G, Dark JH, Arthur HM, Keavney BD.

Atherosclerosis. 2009 Feb;202(2):612-6. Epub 2008 May 20.PMID: 18589426 [PubMed - indexed for MEDLINE]Related articles

Autoimmunity to both proinsulin and IGRP is required for diabetes in nonobese diabetic 8.3 TCR transgenic mice.

Krishnamurthy B, Mariana L, Gellert SA, Colman PG, Harrison LC, Lew AM, Santamaria P, Thomas HE, Kay TW.

J Immunol. 2008 Apr 1;180(7):4458-64.PMID: 18354167 [PubMed - indexed for MEDLINE]Related articlesFree article

Circulating endothelial progenitor cells exhibit diurnal variation.

Thomas HE, Redgrave R, Cunnington MS, Avery P, Keavney BD, Arthur HM.

Arterioscler Thromb Vasc Biol. 2008 Mar;28(3):e21-2. No abstract available. PMID: 18296584 [PubMed - indexed for MEDLINE]Related articlesFree article

Proapoptotic BH3-only protein Bid is essential for death receptor-induced apoptosis of pancreatic beta-cells.

McKenzie MD, Carrington EM, Kaufmann T, Strasser A, Huang DC, Kay TW, Allison J, Thomas HE.

Diabetes. 2008 May;57(5):1284-92. Epub 2008 Feb 5.PMID: 18252892 [PubMed - indexed for MEDLINE]Related articlesFree article

Evaluation of promoters for driving efficient transgene expression in neonatal porcine islets.

Londrigan SL, Brady JL, Sutherland RM, Hawthorne WJ, Thomas HE, Jhala G, Cowan PJ, Kay TW, O'Connell PJ, Lew AM.

Xenotransplantation. 2007 Mar;14(2):119-25.PMID: 17381686 [PubMed - indexed for MEDLINE]Related articles

Responses against islet antigens in NOD mice are prevented by tolerance to proinsulin but not IGRP.

Krishnamurthy B, Dudek NL, McKenzie MD, Purcell AW, Brooks AG, Gellert S, Colman PG, Harrison LC, Lew AM, Thomas HE, Kay TW.

J Clin Invest. 2006 Dec;116(12):3258-65.PMID: 17143333 [PubMed - indexed for MEDLINE]Related articlesFree article

SOCS-1 protects from virally-induced CD8 T cell mediated type 1 diabetes.

Barral AM, Thomas HE, Ling EM, Darwiche R, Rodrigo E, Christen U, Ejrnaes M, Wolfe T, Kay TW, von Herrath MG.

J Autoimmun. 2006 Nov;27(3):166-73. Epub 2006 Oct 10.PMID: 17045460 [PubMed - indexed for MEDLINE]Related articles

Cytotoxic T-cells from T-cell receptor transgenic NOD8.3 mice destroy beta-cells via the perforin and Fas pathways.

Dudek NL, Thomas HE, Mariana L, Sutherland RM, Allison J, Estella E, Angstetra E, Trapani JA, Santamaria P, Lew AM, Kay TW.

Diabetes. 2006 Sep;55(9):2412-8.PMID: 16936188 [PubMed - indexed for MEDLINE]Related articlesFree article

Granzyme B-mediated death of pancreatic beta-cells requires the proapoptotic BH3-only molecule bid.

Estella E, McKenzie MD, Catterall T, Sutton VR, Bird PI, Trapani JA, Kay TW, Thomas HE.

Diabetes. 2006 Aug;55(8):2212-9.PMID: 16873683 [PubMed - indexed for MEDLINE]Related articlesFree article

IL-1 beta breaks tolerance through expansion of CD25+ effector T cells.

O'Sullivan BJ, Thomas HE, Pai S, Santamaria P, Iwakura Y, Steptoe RJ, Kay TW, Thomas R.

J Immunol. 2006 Jun 15;176(12):7278-87.PMID: 16751371 [PubMed - indexed for MEDLINE]Related articlesFree article

Perforin and Fas induced by IFNgamma and TNFalpha mediate beta cell death by OT-I CTL.

McKenzie MD, Dudek NL, Mariana L, Chong MM, Trapani JA, Kay TW, Thomas HE.

Int Immunol. 2006 Jun;18(6):837-46. Epub 2006 Mar 30.PMID: 16574667 [PubMed - indexed for MEDLINE]Related articlesFree article

A critical role for granzyme B, in addition to perforin and TNFalpha, in alloreactive CTL-induced mouse pancreatic beta cell death.

Sutton VR, Estella E, Li C, Chen M, Thomas HE, Kay TW, Trapani JA.

Transplantation. 2006 Jan 27;81(2):146-54.PMID: 16436955 [PubMed - indexed for MEDLINE]Related articles

Perturbations in nuclear factor-kappaB or c-Jun N-terminal kinase pathways in pancreatic beta cells confer susceptibility to cytokine-induced cell death.

Thomas HE, Angstetra E, Fernandes RV, Mariana L, Irawaty W, Jamieson EL, Dudek NL, Kay TW.

Immunol Cell Biol. 2006 Feb;84(1):20-7. Epub 2005 Nov 7.PMID: 16277639 [PubMed - indexed for MEDLINE]Related articles

Adsorption energies for a nanoporous carbon from gas-solid chromatography and molecular mechanics.

Rybolt TR, Ziegler KA, Thomas HE, Boyd JL, Ridgeway ME.

J Colloid Interface Sci. 2006 Apr 1;296(1):41-50. Epub 2005 Sep 15.PMID: 16168430 [PubMed]Related articles

Cr(VI) reduction and immobilization by magnetite under alkaline pH conditions: the role of passivation.

He YT, Traina SJ.

Environ Sci Technol. 2005 Jun 15;39(12):4499-504.PMID: 16047786 [PubMed - indexed for MEDLINE]Related articles

Transgenic expression of dominant-negative Fas-associated death domain protein in beta cells protects against Fas ligand-induced apoptosis and reduces spontaneous diabetes in nonobese diabetic mice.

Allison J, Thomas HE, Catterall T, Kay TW, Strasser A.

J Immunol. 2005 Jul 1;175(1):293-301.PMID: 15972661 [PubMed - indexed for MEDLINE]Related articlesFree article

Inhibited Cr(VI) reduction by aqueous Fe(II) under hyperalkaline conditions.

He YT, Chen CC, Traina SJ.

Environ Sci Technol. 2004 Nov 1;38(21):5535-9.PMID: 15575269 [PubMed - indexed for MEDLINE]Related articles

Severe pancreatitis with exocrine destruction and increased islet neogenesis in mice with suppressor of cytokine signaling-1 deficiency.

Chen Y, Chong MM, Darwiche R, Thomas HE, Kay TW.

Am J Pathol. 2004 Sep;165(3):913-21.PMID: 15331415 [PubMed - indexed for MEDLINE]Related articlesFree article

Bcl-2 protection of islet allografts is unmasked by costimulation blockade.

Sutherland RM, Allison J, Thomas HE, Brady JL, Kay TW, Lew AM.

Transplantation. 2004 May 27;77(10):1610-3.PMID: 15239630 [PubMed - indexed for MEDLINE]Related articles

Renal function and survival after renal artery stent revascularization may be influenced by embolic debris.

Dorros G, Jaff M, Mathiak L, He T, Minor R, Harner R, McCurdy S, Krause P.

J Invasive Cardiol. 2004 Apr;16(4):189-95.PMID: 15152144 [PubMed - indexed for MEDLINE]Related articles

Suppressor of cytokine signaling-1 overexpression protects pancreatic beta cells from CD8+ T cell-mediated autoimmune destruction.

Chong MM, Chen Y, Darwiche R, Dudek NL, Irawaty W, Santamaria P, Allison J, Kay TW, Thomas HE.

J Immunol. 2004 May 1;172(9):5714-21.PMID: 15100317 [PubMed - indexed for MEDLINE]Related articlesFree article

Virally induced inflammation triggers fratricide of Fas-ligand-expressing beta-cells.

Christen U, Darwiche R, Thomas HE, Wolfe T, Rodrigo E, Chervonsky A, Flavell RA, von Herrath MG.

Diabetes. 2004 Mar;53(3):591-6.PMID: 14988242 [PubMed - indexed for MEDLINE]Related articlesFree article

Predicting second gas-solid virial coefficients using calculated molecular properties on various carbon surfaces.

Rybolt TR, Janeksela VE, Hooper DN, Thomas HE, Carrington NA, Williamson EJ.

J Colloid Interface Sci. 2004 Apr 1;272(1):35-45.PMID: 14985020 [PubMed - indexed for MEDLINE]Related articles

IL-1 receptor deficiency slows progression to diabetes in the NOD mouse.

Thomas HE, Irawaty W, Darwiche R, Brodnicki TC, Santamaria P, Allison J, Kay TW.

Diabetes. 2004 Jan;53(1):113-21.PMID: 14693705 [PubMed - indexed for MEDLINE]Related articlesFree article

Activated macrophages require T cells for xenograft rejection under the kidney capsule.

Zhan Y, Brady JL, Irawaty W, Thomas HE, Kay TW, Lew AM.

Immunol Cell Biol. 2003 Dec;81(6):451-8.PMID: 14636242 [PubMed - indexed for MEDLINE]Related articlesFree article

Fas is detectable on beta cells in accelerated, but not spontaneous, diabetes in nonobese diabetic mice.

Darwiche R, Chong MM, Santamaria P, Thomas HE, Kay TW.

J Immunol. 2003 Jun 15;170(12):6292-7.PMID: 12794162 [PubMed - indexed for MEDLINE]Related articlesFree article

The role of cytokines as effectors of tissue destruction in autoimmunity.

Kay TW, Darwiche R, Irawaty W, Chong MM, Pennington HL, Thomas HE.

Adv Exp Med Biol. 2003;520:73-86. No abstract available. PMID: 12613573 [PubMed - indexed for MEDLINE]Related articles

Transmembrane TNF and IFNgamma induce caspase-independent death of primary mouse pancreatic beta cells.

Irawaty W, Kay TW, Thomas HE.

Autoimmunity. 2002 Sep;35(6):369-75.PMID: 12568116 [PubMed - indexed for MEDLINE]Related articles

Suppressor of cytokine signaling-1 regulates the sensitivity of pancreatic beta cells to tumor necrosis factor.

Chong MM, Thomas HE, Kay TW.

J Biol Chem. 2002 Aug 2;277(31):27945-52. Epub 2002 May 24.PMID: 12032139 [PubMed - indexed for MEDLINE]Related articlesFree article

Multicenter Palmaz stent renal artery stenosis revascularization registry report: four-year follow-up of 1,058 successful patients.

Dorros G, Jaff M, Mathiak L, He T; Multicenter Registry Participants.

Catheter Cardiovasc Interv. 2002 Feb;55(2):182-8.PMID: 11835644 [PubMed - indexed for MEDLINE]Related articles

Interleukin-1 plus gamma-interferon-induced pancreatic beta-cell dysfunction is mediated by beta-cell nitric oxide production.

Thomas HE, Darwiche R, Corbett JA, Kay TW.

Diabetes. 2002 Feb;51(2):311-6.PMID: 11812737 [PubMed - indexed for MEDLINE]Related articlesFree article

gamma-Interferon signaling in pancreatic beta-cells is persistent but can be terminated by overexpression of suppressor of cytokine signaling-1.

Chong MM, Thomas HE, Kay TW.

Diabetes. 2001 Dec;50(12):2744-51.PMID: 11723057 [PubMed - indexed for MEDLINE]Related articlesFree article

How beta cells die in type 1 diabetes.

Thomas HE, Kay TW.

Curr Dir Autoimmun. 2001;4:144-70. Review. No abstract available. PMID: 11569401 [PubMed - indexed for MEDLINE]Related articles

Lack of expression of Gp-130 makes pancreatic beta cell lines unresponsive to the IL-6 family of cytokines.

Naselli G, Deaizpurua HJ, Thomas HE, Johnston AM, Kay TW.

Int J Exp Diabetes Res. 2001;1(4):239-48.PMID: 11467415 [PubMed - indexed for MEDLINE]Related articlesFree article

Molar Refractivity and Connectivity Index Correlations for Henry's Law Virial Coefficients of Odorous Sulfur Compounds on Carbon and for Gas-Chromatographic Retention Indices.

Rybolt TR, Hooper DN, Stensby JB, Thomas HE, Baker ML Jr.

J Colloid Interface Sci. 2001 Feb 1;234(1):168-177.PMID: 11161504 [PubMed - as supplied by publisher]Related articles

Virus-induced autoimmune diabetes: most beta-cells die through inflammatory cytokines and not perforin from autoreactive (anti-viral) cytotoxic T-lymphocytes.

Seewaldt S, Thomas HE, Ejrnaes M, Christen U, Wolfe T, Rodrigo E, Coon B, Michelsen B, Kay TW, von Herrath MG.

Diabetes. 2000 Nov;49(11):1801-9.PMID: 11078446 [PubMed - indexed for MEDLINE]Related articlesFree article