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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
2005 2
2007 1
2009 2
2010 5
2011 3
2012 3
2013 2
2014 6
2015 4
2016 7
2017 6
2018 5
2019 8
2020 18
2021 12
2022 8
2023 15
2024 9

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101 results

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Page 1
Past, present and future of therapeutic strategies against amyloid-beta peptides in Alzheimer's disease: a systematic review.
Jeremic D, Jiménez-Díaz L, Navarro-López JD. Jeremic D, et al. Ageing Res Rev. 2021 Dec;72:101496. doi: 10.1016/j.arr.2021.101496. Epub 2021 Oct 21. Ageing Res Rev. 2021. PMID: 34687956 Free article. Review.
Alzheimer's disease (AD) is the most prevalent neurodegenerative disease in ageing, affecting around 46 million people worldwide but few treatments are currently available. ...Therefore, many amyloid-targeted therapies have been investigated. Here, we will sy …
Alzheimer's disease (AD) is the most prevalent neurodegenerative disease in ageing, affecting around 46 million people worldwi …
Efficacy of innovative therapies in myasthenia gravis: A systematic review, meta-analysis and network meta-analysis.
Saccà F, Pane C, Espinosa PE, Sormani MP, Signori A. Saccà F, et al. Eur J Neurol. 2023 Dec;30(12):3854-3867. doi: 10.1111/ene.15872. Epub 2023 May 30. Eur J Neurol. 2023. PMID: 37204031
The aim of this study was to perform a meta-analysis and network meta-analysis of randomized and placebo-controlled trials of innovative therapies in MG with available efficacy data. METHODS: We assessed statistical heterogeneity across trials based on the Cochrane Q test …
The aim of this study was to perform a meta-analysis and network meta-analysis of randomized and placebo-controlled trials of innovative …
Recent Antifungal Pipeline Developments against Candida auris: A Systematic Review.
Treviño-Rangel RJ, González GM, Montoya AM, Rojas OC, Elizondo-Zertuche M, Álvarez-Villalobos NA. Treviño-Rangel RJ, et al. J Fungi (Basel). 2022 Oct 28;8(11):1144. doi: 10.3390/jof8111144. J Fungi (Basel). 2022. PMID: 36354911 Free PMC article. Review.
A systematic search in MEDLINE, EMBASE, Web of Science, and Scopus up to 27 June 2022 was conducted to find relevant articles reporting data of in vitro activity and in vivo efficacy of investigational antifungals against C. auris. These included new additions to existing …
A systematic search in MEDLINE, EMBASE, Web of Science, and Scopus up to 27 June 2022 was conducted to find relevant articles reporting data …
Intravenous thrombolytic treatment and endovascular thrombectomy for ischaemic wake-up stroke.
Roaldsen MB, Lindekleiv H, Mathiesen EB. Roaldsen MB, et al. Cochrane Database Syst Rev. 2021 Dec 1;12(12):CD010995. doi: 10.1002/14651858.CD010995.pub3. Cochrane Database Syst Rev. 2021. PMID: 34850380 Free PMC article. Review.
However, recent studies suggest benefit from recanalisation therapies in selected patients. OBJECTIVES: To assess the effects of intravenous thrombolysis and endovascular thrombectomy versus control in people with acute ischaemic stroke presenting on awakening from sleep. …
However, recent studies suggest benefit from recanalisation therapies in selected patients. OBJECTIVES: To assess the effects of intr …
Cannabinoid therapies in the management of sleep disorders: A systematic review of preclinical and clinical studies.
Suraev AS, Marshall NS, Vandrey R, McCartney D, Benson MJ, McGregor IS, Grunstein RR, Hoyos CM. Suraev AS, et al. Sleep Med Rev. 2020 Oct;53:101339. doi: 10.1016/j.smrv.2020.101339. Epub 2020 May 16. Sleep Med Rev. 2020. PMID: 32603954
Promising preliminary evidence provides the rationale for future randomised controlled trials of cannabinoid therapies in individuals with sleep apnea, insomnia, post-traumatic stress disorder-related nightmares, restless legs syndrome, rapid eye movement sleep beha …
Promising preliminary evidence provides the rationale for future randomised controlled trials of cannabinoid therapies in indi …
Behavioral and psychological treatments for chronic insomnia disorder in adults: an American Academy of Sleep Medicine systematic review, meta-analysis, and GRADE assessment.
Edinger JD, Arnedt JT, Bertisch SM, Carney CE, Harrington JJ, Lichstein KL, Sateia MJ, Troxel WM, Zhou ES, Kazmi U, Heald JL, Martin JL. Edinger JD, et al. J Clin Sleep Med. 2021 Feb 1;17(2):263-298. doi: 10.5664/jcsm.8988. J Clin Sleep Med. 2021. PMID: 33164741 Free PMC article.
Evidence for the following interventions is presented in this review: cognitive-behavioral therapy for insomnia, brief therapies for insomnia, stimulus control, sleep restriction therapy, relaxation training, sleep hygiene, biofeedback, paradoxical intention, intensive sle …
Evidence for the following interventions is presented in this review: cognitive-behavioral therapy for insomnia, brief therapies for …
New biologics and targeted therapies in systemic lupus: From new molecular targets to new indications. A systematic review.
Felten R, Scherlinger M, Mertz P, Chasset F, Arnaud L. Felten R, et al. Joint Bone Spine. 2023 Mar;90(2):105523. doi: 10.1016/j.jbspin.2023.105523. Epub 2023 Jan 7. Joint Bone Spine. 2023. PMID: 36623799
For each investigational drug, we considered only the study at the most advanced stage of clinical development. ...CONCLUSION: The pipeline of investigational drugs in SLE is highly diversified and will hopefully enable more optimal Treat-To-Target with the goal of …
For each investigational drug, we considered only the study at the most advanced stage of clinical development. ...CONCLUSION: The pi …
Funding breakthrough therapies: A systematic review and recommendation.
Hanna E, Toumi M, Dussart C, Borissov B, Dabbous O, Badora K, Auquier P. Hanna E, et al. Health Policy. 2018 Mar;122(3):217-229. doi: 10.1016/j.healthpol.2017.11.012. Epub 2017 Dec 2. Health Policy. 2018. PMID: 29223847 Review.
BACKGROUND: Advanced therapy medicinal products (ATMPs) are innovative therapies likely associated with high prices. Payers need guidance to create a balance between ensuring patient access to breakthrough therapies and maintaining the financial sustainability of th …
BACKGROUND: Advanced therapy medicinal products (ATMPs) are innovative therapies likely associated with high prices. Payers need guid …
Cytokine Pathways and Investigational Target Therapies in Hidradenitis Suppurativa.
Del Duca E, Morelli P, Bennardo L, Di Raimondo C, Nisticò SP. Del Duca E, et al. Int J Mol Sci. 2020 Nov 10;21(22):8436. doi: 10.3390/ijms21228436. Int J Mol Sci. 2020. PMID: 33182701 Free PMC article.
BACKGROUND: Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease affecting areas with a high density of apocrine glands and characterized by subcutaneous nodules that may evolve into fistulas with pus secretion. ...We will discuss the pathogenetic role of v …
BACKGROUND: Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease affecting areas with a high density of apocrine glan …
Current and prospective disease-modifying therapies for amyotrophic lateral sclerosis.
Morren JA, Galvez-Jimenez N. Morren JA, et al. Expert Opin Investig Drugs. 2012 Mar;21(3):297-320. doi: 10.1517/13543784.2012.657303. Epub 2012 Feb 6. Expert Opin Investig Drugs. 2012. PMID: 22303913 Review.
AREAS COVERED: An extensive literature search was undertaken using Medline and the Cochrane Systematic Review and Clinical Trial databases. Riluzole and investigational ALS drugs are discussed. Riluzole is the only approved disease-modifying therapy despite its mode …
AREAS COVERED: An extensive literature search was undertaken using Medline and the Cochrane Systematic Review and Clinical Trial databases. …
101 results