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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
2001 1
2003 1
2004 1
2006 1
2007 3
2009 6
2010 2
2011 2
2012 3
2013 4
2014 4
2016 2
2017 1
2018 2
2019 1
2020 3
2021 4
2022 4
2023 1
2024 0

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41 results

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Page 1
Effect of different iodine levels on the DNA methylation of PRKAA2, ITGA6, THEM4 and PRL genes in PI3K-AKT signaling pathway and population-based validation from autoimmune thyroiditis patients.
Ren B, Wan S, Wu H, Qu M, Chen Y, Liu L, Jin M, Zhou Z, Shen H. Ren B, et al. Eur J Nutr. 2022 Oct;61(7):3571-3583. doi: 10.1007/s00394-022-02907-x. Epub 2022 May 27. Eur J Nutr. 2022. PMID: 35622138
This study analyzed the DNA methylation levels of PRKAA2, ITGA6, PRL and THEM4 genes related to PI3K-AKT signaling pathway, compared the DNA methylation levels between cases and controls from different water iodine levels in Shandong Province of China, and evaluated the co …
This study analyzed the DNA methylation levels of PRKAA2, ITGA6, PRL and THEM4 genes related to PI3K-AKT signaling pathway, compared …
Exosomal miR-183-5p Shuttled by M2 Polarized Tumor-Associated Macrophage Promotes the Development of Colon Cancer via Targeting THEM4 Mediated PI3K/AKT and NF-kappaB Pathways.
Zhang S, Li D, Zhao M, Yang F, Sang C, Yan C, Wang Z, Li Y. Zhang S, et al. Front Oncol. 2021 Jun 25;11:672684. doi: 10.3389/fonc.2021.672684. eCollection 2021. Front Oncol. 2021. PMID: 34249713 Free PMC article.
Overexpression of miR-183-5p in M2-TAM aggravated M2-TAM-mediated promotive effects on CC cells, with down-regulating miR-183-5p reversed M2-TAM-mediated tumor-promotive effects. Mechanically, miR-183-5p targeted THEM4 and inhibited its mRNA and protein expression. Overexp …
Overexpression of miR-183-5p in M2-TAM aggravated M2-TAM-mediated promotive effects on CC cells, with down-regulating miR-183-5p reversed M2 …
Enolase-phosphatase 1 acts as an oncogenic driver in glioma.
Wang B, Xu X, Liu X, Wang D, Zhuang H, He X, Han T, Hong J. Wang B, et al. J Cell Physiol. 2021 Feb;236(2):1184-1194. doi: 10.1002/jcp.29926. Epub 2020 Jul 11. J Cell Physiol. 2021. PMID: 32654229
Mechanistically, we found that ENOPH1 activates the PI3K/AKT/mTOR signaling pathway by regulating THEM4. In conclusion, ENOPH1 is an important mediator that promotes glioma cell proliferation and migration....
Mechanistically, we found that ENOPH1 activates the PI3K/AKT/mTOR signaling pathway by regulating THEM4. In conclusion, ENOPH1 is an …
ELOVL2: a novel tumor suppressor attenuating tamoxifen resistance in breast cancer.
Jeong D, Ham J, Kim HW, Kim H, Ji HW, Yun SH, Park JE, Lee KS, Jo H, Han JH, Jung SY, Lee S, Lee ES, Kang HS, Kim SJ. Jeong D, et al. Am J Cancer Res. 2021 Jun 15;11(6):2568-2589. eCollection 2021. Am J Cancer Res. 2021. PMID: 34249416 Free PMC article.
A group of genes in the AKT and ERa signaling pathways, e.g., THEM4, which play crucial roles in drug resistance, were found to be regulated by ELOVL2. ...
A group of genes in the AKT and ERa signaling pathways, e.g., THEM4, which play crucial roles in drug resistance, were found to be re …
Vitamin D inhibits COX-2 expression and inflammatory response by targeting thioesterase superfamily member 4.
Wang Q, He Y, Shen Y, Zhang Q, Chen D, Zuo C, Qin J, Wang H, Wang J, Yu Y. Wang Q, et al. J Biol Chem. 2014 Apr 25;289(17):11681-11694. doi: 10.1074/jbc.M113.517581. Epub 2014 Mar 10. J Biol Chem. 2014. PMID: 24619416 Free PMC article.
Knockdown of both vitamin D receptor and THEM4 attenuated the inhibitory effect of 1,25(OH)2D on COX-2 expression in macrophages. A functional vitamin D-responsive element in the THEM4 promoter was identified by chromatin immunoprecipitation and luciferase reporter …
Knockdown of both vitamin D receptor and THEM4 attenuated the inhibitory effect of 1,25(OH)2D on COX-2 expression in macrophages. A f …
Allelic expression imbalance screening of genes in chromosome 1q21-24 region to identify functional variants for Type 2 diabetes susceptibility.
Mondal AK, Sharma NK, Elbein SC, Das SK. Mondal AK, et al. Physiol Genomics. 2013 Jul 2;45(13):509-20. doi: 10.1152/physiolgenomics.00048.2013. Epub 2013 May 14. Physiol Genomics. 2013. PMID: 23673729 Free PMC article.
Six AEI single nucleotide polymorphisms, including rs13320 (P = 1.35E-04) in THEM4, were associated with glucose homeostasis traits in the MAGIC dataset. ...Our study indicates the role of a cis-regulatory SNP in THEM4 that may influence T2D predisposition by modula …
Six AEI single nucleotide polymorphisms, including rs13320 (P = 1.35E-04) in THEM4, were associated with glucose homeostasis traits i …
Genetic determinants influencing human serum metabolome among African Americans.
Yu B, Zheng Y, Alexander D, Morrison AC, Coresh J, Boerwinkle E. Yu B, et al. PLoS Genet. 2014 Mar 13;10(3):e1004212. doi: 10.1371/journal.pgen.1004212. eCollection 2014 Mar. PLoS Genet. 2014. PMID: 24625756 Free PMC article.
Fourteen genes were identified within the nineteen loci, and four of them contained non-synonymous substitutions in four enzyme-encoding genes (KLKB1, SIAE, CPS1, and NAT8); the other significant loci consist of eight other enzyme-encoding genes (ACE, GATM, ACY3, ACSM2B, THEM4 …
Fourteen genes were identified within the nineteen loci, and four of them contained non-synonymous substitutions in four enzyme-encoding gen …
Correlation of structure and function in the human hotdog-fold enzyme hTHEM4.
Zhao H, Lim K, Choudry A, Latham JA, Pathak MC, Dominguez D, Luo L, Herzberg O, Dunaway-Mariano D. Zhao H, et al. Biochemistry. 2012 Aug 21;51(33):6490-2. doi: 10.1021/bi300968n. Epub 2012 Aug 9. Biochemistry. 2012. PMID: 22871024 Free PMC article.
Human THEM4 (hTHEM4) is comprised of a catalytically active hotdog-fold acyl-CoA thioesterase domain and an N-terminal domain of unknown fold and function. hTHEM4 has been linked to Akt1 regulation and cell apoptosis. ...
Human THEM4 (hTHEM4) is comprised of a catalytically active hotdog-fold acyl-CoA thioesterase domain and an N-terminal domain of unkn …
A novel genomic-clinicopathologic nomogram to improve prognosis prediction of hepatocellular carcinoma.
Ni FB, Lin Z, Fan XH, Shi KQ, Ao JY, Wang XD, Chen RC. Ni FB, et al. Clin Chim Acta. 2020 May;504:88-97. doi: 10.1016/j.cca.2020.02.001. Epub 2020 Feb 4. Clin Chim Acta. 2020. PMID: 32032609
As results, 9 mRNAs were finally identified as prognostic indicators, including RGCC, CDH15, XRN2, RAB3IL1, THEM4, PIF1, MANBA, FKTN and GABARAPL1, and used to establish a 9-mRNA classifier. ...
As results, 9 mRNAs were finally identified as prognostic indicators, including RGCC, CDH15, XRN2, RAB3IL1, THEM4, PIF1, MANBA, FKTN …
41 results